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BORA

gene
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Also known as FLJ22624

Summary

BORA (BORA aurora kinase A activator, HGNC:24724) is a protein-coding gene on chromosome 13q21.33, encoding Protein aurora borealis (Q6PGQ7). Required for the activation of AURKA at the onset of mitosis. It is a selective cancer dependency (DepMap: 79.9% of cell lines).

BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).

Source: NCBI Gene 79866 — RefSeq curated summary.

At a glance

  • GWAS associations: 1
  • Clinical variants (ClinVar): 85 total — 1 pathogenic
  • Cancer dependency (DepMap): dependent in 79.9% of screened cell lines
  • MANE Select transcript: NM_024808

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:24724
Approved symbolBORA
NameBORA aurora kinase A activator
Location13q21.33
Locus typegene with protein product
StatusApproved
AliasesFLJ22624
Ensembl geneENSG00000136122
Ensembl biotypeprotein_coding
OMIM610510
Entrez79866

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 10 protein_coding, 2 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000377814, ENST00000390667, ENST00000464754, ENST00000471712, ENST00000613797, ENST00000618209, ENST00000651376, ENST00000651477, ENST00000652266, ENST00000864459, ENST00000864460, ENST00000864461, ENST00000940591, ENST00000940592

RefSeq mRNA: 4 — MANE Select: NM_024808 NM_001286746, NM_001286747, NM_001366664, NM_024808

CCDS: CCDS66560, CCDS9446

Canonical transcript exons

ENST00000390667 — 12 exons

ExonStartEnd
ENSE000016129267275369072753821
ENSE000016956687274594472746076
ENSE000017661217274650172747111
ENSE000017893737274498172745207
ENSE000035029017274450572744561
ENSE000035069477274353772743602
ENSE000035220857273128172731387
ENSE000036228987273796272738043
ENSE000036717797272792372728007
ENSE000036871217273496072735005
ENSE000038470487272892672729093
ENSE000038950317275515172756196

Expression profiles

Bgee: expression breadth ubiquitous, 211 present calls, max score 90.66.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.8863 / max 198.4478, expressed in 1612 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
1353318.07231591
1353320.5981358
1353300.215972

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
secondary oocyteCL:000065590.66gold quality
oocyteCL:000002389.47gold quality
ventricular zoneUBERON:000305386.85gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047384.23gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099182.22gold quality
leukocyteCL:000073878.72gold quality
monocyteCL:000057678.63gold quality
mononuclear cellCL:000084278.53gold quality
mucosa of transverse colonUBERON:000499178.39gold quality
bone marrowUBERON:000237178.33gold quality
rectumUBERON:000105278.10gold quality
ganglionic eminenceUBERON:000402377.90gold quality
embryoUBERON:000092277.83gold quality
granulocyteCL:000009477.70gold quality
bone marrow cellCL:000209276.00gold quality
mucosa of sigmoid colonUBERON:000499375.98gold quality
colonic mucosaUBERON:000031775.87gold quality
vermiform appendixUBERON:000115475.58gold quality
lymph nodeUBERON:000002975.27gold quality
stromal cell of endometriumCL:000225574.85gold quality
trabecular bone tissueUBERON:000248374.59gold quality
jejunal mucosaUBERON:000039974.52gold quality
calcaneal tendonUBERON:000370173.94gold quality
lower esophagus mucosaUBERON:003583473.79gold quality
adrenal tissueUBERON:001830373.50gold quality
duodenumUBERON:000211472.84gold quality
esophagus mucosaUBERON:000246972.81gold quality
colonic epitheliumUBERON:000039772.69gold quality
spleenUBERON:000210672.62gold quality
transverse colonUBERON:000115772.58gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no3.11

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1, E2F4

miRNA regulators (miRDB)

59 targeting BORA, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-3162-3P100.0065.37363
HSA-MIR-12118100.0065.881270
HSA-MIR-548C-3P99.9974.017587
HSA-MIR-150-5P99.9966.691976
HSA-MIR-6891-5P99.9866.531372
HSA-MIR-3173-3P99.9866.491217
HSA-MIR-548N99.9871.944170
HSA-MIR-302C-5P99.9772.563642
HSA-MIR-448799.9664.581252
HSA-MIR-23A-3P99.9574.243163
HSA-MIR-23B-3P99.9574.243163
HSA-MIR-23C99.9573.923192
HSA-MIR-4760-3P99.9370.502385
HSA-MIR-515-5P99.9269.822343
HSA-MIR-519E-5P99.9269.622358
HSA-MIR-477999.8666.501583
HSA-MIR-202-3P99.8471.411290
HSA-MIR-449599.8272.083080
HSA-MIR-204-5P99.7971.622439
HSA-MIR-211-5P99.7971.652440
HSA-MIR-4713-5P99.7867.801794
HSA-MIR-202-5P99.7867.65991
HSA-MIR-4524A-3P99.7266.852406
HSA-MIR-4755-5P99.7170.342716
HSA-MIR-5006-3P99.7170.262728
HSA-MIR-56799.6368.571219
HSA-MIR-1249-5P99.6166.552049
HSA-MIR-6797-5P99.6166.552084
HSA-MIR-432899.5771.064094
HSA-MIR-6832-3P99.5270.441726

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 79.9% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 13)

  • Study concludes that tight regulation of the Bora protein by its synthesis and degradation is critical for cell cycle progression. (PMID:18378770)
  • Plk1 controls Aurora A localization and function by regulating cellular levels of hBora. (PMID:18521620)
  • study reports that the synergistic action of Bora & the kinase Aurora A controls G2-M transition; Bora accumulates in G2 phase & promotes Aur-A-mediated activation of Polo-like kinase 1, leading to activation of cyclin-dependent kinase 1 & mitotic entry (PMID:18566290)
  • Recent advances in the understanding of the functional crosstalk between Plk1 and Aurora-A before and during mitosis. (PMID:19487276)
  • Following UV irradiation, ataxia telangiectasia-mutated- and Rad3-related protein phosphorylates Bora at Thr-501. The phosphorylated Thr-501 is subsequently recognized by the E3 ubiquitin ligase SCF-beta-TRCP, which targets Bora for degradation. (PMID:23592782)
  • Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex. (PMID:23970419)
  • Activation of Plk1 by Aurora-A may function as a bistable switch (PMID:24338364)
  • Bora was found to play a significant role in radiosensitivity through the regulation of MDC1 and DNA repair. (PMID:25742493)
  • These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry. (PMID:27068477)
  • the mechanism of Plk1 activation and the potential role of Bora phosphorylation by Cdk1, is reported. (PMID:27831827)
  • our findings demonstrated that Bora was overexpressed and served as an independent biomarker for poor prognosis in multiple adenocarcinomas. (PMID:28402276)
  • Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry. (PMID:33771996)
  • Aurora A kinase activation: Different means to different ends. (PMID:34287649)

Cross-species orthologs

5 orthologs

OrganismSymbolGene ID
danio_rerioboraENSDARG00000042688
mus_musculusBoraENSMUSG00000022070
rattus_norvegicusBoraENSRNOG00000024798
drosophila_melanogasterboraFBGN0259791
caenorhabditis_elegansWBGENE00010198

Protein

Protein identifiers

Protein aurora borealis — Q6PGQ7 (reviewed: Q6PGQ7)

All UniProt accessions (5): A0A087WV86, A0A087WVC9, A0A494C1R8, Q6PGQ7, H3BLY2

UniProt curated annotations — full annotation on UniProt →

Function. Required for the activation of AURKA at the onset of mitosis.

Subunit / interactions. Interacts with AURKA.

Post-translational modifications. Phosphorylated by AURKA.

Similarity. Belongs to the BORA family.

Isoforms (2)

UniProt IDNamesCanonical?
Q6PGQ7-11yes
Q6PGQ7-22

RefSeq proteins (4): NP_001273675, NP_001273676, NP_001353593, NP_079084* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR023252Aurora_borealis_proteinFamily

Pfam: PF15280

UniProt features (12 total): modified residue 6, sequence variant 2, chain 1, region of interest 1, sequence conflict 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q6PGQ7-F151.500.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 183, 191, 270, 325, 331, 354

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

IDPathway
R-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-1640170Cell Cycle
R-HSA-453274Mitotic G2-G2/M phases
R-HSA-69275G2/M Transition
R-HSA-69278Cell Cycle, Mitotic

MSigDB gene sets: 160 (showing top): chr13q21, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOBP_REGULATION_OF_NUCLEAR_DIVISION, GOBP_ORGANELLE_FISSION, GOBP_REGULATION_OF_SPINDLE_ORGANIZATION, PID_PLK1_PATHWAY, GOBP_REGULATION_OF_CELL_CYCLE, GOBP_MITOTIC_NUCLEAR_DIVISION, GOBP_MITOTIC_CELL_CYCLE, P300_01, FISCHER_DREAM_TARGETS, BASAKI_YBX1_TARGETS_UP, TAATGTG_MIR323, GOBP_REGULATION_OF_CELL_CYCLE_PROCESS

GO Biological Process (4): regulation of mitotic nuclear division (GO:0007088), regulation of protein localization (GO:0032880), cell division (GO:0051301), regulation of mitotic spindle organization (GO:0060236)

GO Molecular Function (2): protein kinase binding (GO:0019901), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), meiotic spindle (GO:0072687)

Reactome top-level categories

Rollup of top-4 pathways:

CategoryPathways
G2/M Transition2
Cell Cycle, Mitotic1
Mitotic G2-G2/M phases1
Cell Cycle1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure2
regulation of mitotic cell cycle1
regulation of cell cycle process1
regulation of nuclear division1
mitotic nuclear division1
intracellular protein localization1
regulation of localization1
cellular process1
mitotic spindle organization1
regulation of spindle organization1
kinase binding1
binding1
intracellular membrane-bounded organelle1
intracellular anatomical structure1
cytoplasm1
spindle1

Protein interactions and networks

STRING

1221 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
BORAAURKAO14965890
BORAPLK1P53350809
BORACDK1P06493741
BORANEDD9Q14511706
BORAAJUBAQ96IF1660
BORAECT2Q9H8V3632
BORATPX2Q9ULW0624
BORAPIBF1Q8WXW3602
BORAMZT1Q08AG7602
BORACLSPNQ9HAW4573
BORARACGAP1Q9H0H5564
BORAAURKBQ96GD4541
BORANDEL1Q9GZM8540
BORAMAP2P11137522
BORACCNB1P14635519

IntAct

70 interactions, top by confidence:

ABTypeScore
PLK1BORApsi-mi:“MI:0915”(physical association)0.850
DNAJB11HSPA5psi-mi:“MI:0914”(association)0.830
PLK1SPAG9psi-mi:“MI:0914”(association)0.790
DYNLL1BLTP3Bpsi-mi:“MI:0914”(association)0.730
AURKABORApsi-mi:“MI:0915”(physical association)0.660
BORAAURKApsi-mi:“MI:0217”(phosphorylation reaction)0.660
DYNLL2BLTP3Bpsi-mi:“MI:0914”(association)0.640
PLK1C1orf226psi-mi:“MI:0914”(association)0.560
RABGGTBPIPSLpsi-mi:“MI:0914”(association)0.530
PIGTZNF609psi-mi:“MI:0914”(association)0.530
WNT4TOMM40psi-mi:“MI:0914”(association)0.530
UBE3DSTIP1psi-mi:“MI:0914”(association)0.530
FHL2CNOT1psi-mi:“MI:0914”(association)0.530
SKP2DPYSL4psi-mi:“MI:0914”(association)0.530
DYNLT2BSNX2psi-mi:“MI:0914”(association)0.530
WNT7ALDLRpsi-mi:“MI:0914”(association)0.530
PLK1PPP6Cpsi-mi:“MI:0914”(association)0.530
FZR1TK1psi-mi:“MI:0914”(association)0.530
AURKAPLK1psi-mi:“MI:0914”(association)0.520
Plk1psi-mi:“MI:0915”(physical association)0.400
BORAOBI1psi-mi:“MI:0914”(association)0.350
Xpo1IFT56psi-mi:“MI:0914”(association)0.350

BioGRID (85): BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), PIBF1 (Affinity Capture-MS), NGDN (Affinity Capture-MS), RNF219 (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS), BORA (Affinity Capture-MS)

ESM2 similar proteins: A0JMF7, A2ARZ3, A5WUN7, A6H5Y1, A8PUI7, B0BM16, B1H1S4, B2GUZ2, F1QB81, F1R983, P10243, P51960, P52550, P86345, Q06190, Q08AD1, Q12912, Q16533, Q2T9I9, Q3KQW7, Q3T8J9, Q49A88, Q4KLP8, Q4R815, Q58EL7, Q5FBB7, Q5M864, Q5U3U6, Q5XG21, Q65Z40, Q66H35, Q68F53, Q6DJL7, Q6IRN6, Q6PGQ7, Q7Z5K2, Q7ZX27, Q801E2, Q80WQ8, Q8AXF4

Diamond homologs: Q5M864, Q5U3U6, Q6DJL7, Q6PGQ7, Q8BS90, Q9VVR2, Q2LYY4

SIGNOR signaling

10 interactions.

AEffectBMechanism
BORAup-regulatesAURKAbinding
PLK1down-regulatesBORAphosphorylation
CyclinB/CDK1“up-regulates activity”BORAphosphorylation
BORAup-regulatesPLK1phosphorylation
GSK3Bup-regulatesBORAphosphorylation
CyclinA2/CDK1“up-regulates activity”BORAphosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

85 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic1
Likely pathogenic0
Uncertain significance65
Likely benign3
Benign0

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
394318GRCh37/hg19 13q21.33-31.1(chr13:72174742-82221361)x1Pathogenic

SpliceAI

1797 predictions. Top by Δscore:

VariantEffectΔscore
13:72728923:TA:Tacceptor_loss1.0000
13:72728924:A:AGacceptor_gain1.0000
13:72728924:A:Cacceptor_loss1.0000
13:72728925:G:GAacceptor_gain1.0000
13:72728925:GT:Gacceptor_gain1.0000
13:72728925:GTT:Gacceptor_gain1.0000
13:72728925:GTTT:Gacceptor_gain1.0000
13:72728925:GTTTT:Gacceptor_gain1.0000
13:72728990:G:GTdonor_gain1.0000
13:72729094:G:GGdonor_gain1.0000
13:72734959:GAATA:Gacceptor_gain1.0000
13:72737960:A:AGacceptor_gain1.0000
13:72737961:G:GGacceptor_gain1.0000
13:72745110:G:GTdonor_gain1.0000
13:72745110:G:Tdonor_gain1.0000
13:72753684:T:TAacceptor_gain1.0000
13:72753687:CA:Cacceptor_loss1.0000
13:72753688:A:AGacceptor_gain1.0000
13:72753688:AGAT:Aacceptor_gain1.0000
13:72753688:AGATG:Aacceptor_gain1.0000
13:72753689:G:GTacceptor_gain1.0000
13:72753689:GA:Gacceptor_gain1.0000
13:72753689:GAT:Gacceptor_gain1.0000
13:72753689:GATG:Gacceptor_gain1.0000
13:72753689:GATGG:Gacceptor_gain1.0000
13:72753820:AGG:Adonor_loss1.0000
13:72753821:GGTAC:Gdonor_loss1.0000
13:72753822:G:Adonor_loss1.0000
13:72753823:T:Adonor_loss1.0000
13:72728008:G:GGdonor_gain0.9900

AlphaMissense

3741 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
13:72731299:T:AW58R0.999
13:72731299:T:CW58R0.999
13:72737962:T:CF103L0.998
13:72737964:T:AF103L0.998
13:72737964:T:GF103L0.998
13:72737963:T:CF103S0.997
13:72737995:T:AW114R0.997
13:72737995:T:CW114R0.997
13:72745051:A:CR194S0.997
13:72745051:A:TR194S0.997
13:72737965:T:CF104L0.996
13:72737967:C:AF104L0.996
13:72737967:C:GF104L0.996
13:72745050:G:CR194T0.996
13:72731293:T:CF56L0.995
13:72731295:T:AF56L0.995
13:72731295:T:GF56L0.995
13:72731301:G:CW58C0.995
13:72731301:G:TW58C0.995
13:72731315:T:CL63P0.995
13:72734994:G:CA99P0.995
13:72734998:T:AI100N0.995
13:72737966:T:CF104S0.995
13:72745047:G:CR193T0.995
13:72745048:A:CR193S0.995
13:72745048:A:TR193S0.995
13:72745050:G:TR194I0.995
13:72745056:T:CL196P0.995
13:72729013:T:CF25L0.994
13:72729015:T:AF25L0.994

dbSNP variants (sampled 300 via entrez): RS1000104366 (13:72751810 T>C), RS1000158630 (13:72754915 T>C,G), RS1000368767 (13:72729530 C>A,T), RS1000480381 (13:72748584 T>G), RS1000495450 (13:72756482 C>T), RS1000854631 (13:72743370 G>C), RS1000939267 (13:72755452 T>A,C), RS1000967028 (13:72743093 C>T), RS1001013345 (13:72728397 T>C), RS1001129843 (13:72736144 C>G), RS1001235073 (13:72751137 TA>T), RS1001269340 (13:72751507 A>G), RS1001376519 (13:72749417 G>A), RS1001417186 (13:72736454 A>G), RS1001430105 (13:72737229 G>A)

Disease associations

OMIM: gene MIM:610510 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

StudyTraitp-value
GCST90002396_551Mean reticulocyte volume5.000000e-19

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0010701mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

58 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Aciddecreases expression3
Resveratrolaffects cotreatment, increases expression2
Air Pollutantsaffects cotreatment, increases abundance, increases expression, decreases expression2
Formaldehydedecreases expression, increases expression2
Tretinoindecreases expression2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxidedecreases expression2
Cyclosporineincreases expression, affects expression2
Particulate Matterincreases abundance, increases expression, decreases expression2
dicrotophosdecreases expression1
lasiocarpinedecreases expression, increases metabolic processing1
triphenyl phosphateaffects expression1
alpha-pineneaffects cotreatment, increases expression, increases abundance1
bisphenol Adecreases expression1
riddelliinedecreases expression, increases metabolic processing1
sulforaphaneincreases expression1
sodium arseniteincreases expression1
potassium chromate(VI)affects cotreatment, decreases expression1
hydroquinonedecreases expression1
methacrylaldehydeincreases expression, increases abundance, affects cotreatment1
epigallocatechin gallateaffects cotreatment, decreases expression1
perfluoro-n-nonanoic aciddecreases expression1
ICG 001decreases expression1
abrineincreases expression1
palbociclibdecreases expression1
incobotulinumtoxinAdecreases expression1
(+)-JQ1 compounddecreases expression1
NSC668394decreases expression1
Dasatinibdecreases expression1
Decitabineaffects expression1
Sunitinibdecreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
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BioBTree
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Sources 75

This page pulls from 75 datasets indexed by BioBTree:

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