BRCA1-OT1

Summary

BRCA1-OT1 (BRCA1 overlapping transcript 1, HGNC:58363) is a long non-coding RNA gene on chromosome 17q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58363
Approved symbol	BRCA1-OT1
Name	BRCA1 overlapping transcript 1
Location	17q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC060780.1, lncRP11-242D8.1
Ensembl gene	ENSG00000267002
Ensembl biotype	lncRNA
Entrez	101929767

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000590740, ENST00000634503, ENST00000634994, ENST00000635600, ENST00000642336, ENST00000653081, ENST00000659136, ENST00000790351, ENST00000790352, ENST00000790353, ENST00000790354, ENST00000790355, ENST00000790356, ENST00000790357, ENST00000790358, ENST00000790359

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000590740 — 3 exons

Exon	Start	End
ENSE00002754344	43166980	43167262
ENSE00002782781	43160290	43164812
ENSE00002943744	43170126	43170403

Expression profiles

Bgee: expression breadth ubiquitous, 136 present calls, max score 97.08.

Top tissues by expression

137 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	97.08	gold quality
right uterine tube	UBERON:0001302	92.25	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.46	gold quality
primary visual cortex	UBERON:0002436	89.93	gold quality
cerebellar vermis	UBERON:0004720	89.62	gold quality
superior frontal gyrus	UBERON:0002661	87.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.36	gold quality
right lobe of thyroid gland	UBERON:0001119	87.04	gold quality
cerebellum	UBERON:0002037	86.96	gold quality
cerebellar cortex	UBERON:0002129	86.94	gold quality
cerebellar hemisphere	UBERON:0002245	86.84	gold quality
left ovary	UBERON:0002119	86.60	gold quality
ovary	UBERON:0000992	86.46	gold quality
thyroid gland	UBERON:0002046	86.45	gold quality
left lobe of thyroid gland	UBERON:0001120	86.29	gold quality
bone marrow cell	CL:0002092	85.72	gold quality
right ovary	UBERON:0002118	85.58	gold quality
nucleus accumbens	UBERON:0001882	85.46	gold quality
caudate nucleus	UBERON:0001873	85.16	gold quality
sural nerve	UBERON:0015488	84.72	gold quality
prostate gland	UBERON:0002367	84.70	gold quality
pituitary gland	UBERON:0000007	84.63	gold quality
right frontal lobe	UBERON:0002810	84.17	gold quality
cortex of kidney	UBERON:0001225	84.13	gold quality
putamen	UBERON:0001874	84.09	gold quality
uterine cervix	UBERON:0000002	83.81	gold quality
tonsil	UBERON:0002372	83.80	gold quality
endometrium	UBERON:0001295	83.62	gold quality
adenohypophysis	UBERON:0002196	83.52	gold quality
body of uterus	UBERON:0009853	83.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.77

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.