BRD10

Summary

BRD10 (bromodomain containing 10, HGNC:23378) is a protein-coding gene on chromosome 9p24.1, encoding Uncharacterized bromodomain-containing protein 10 (Q5HYC2).

Predicted to be located in nucleus.

Source: NCBI Gene 158358 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 454 total
• MANE Select transcript: NM_001017969

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23378
Approved symbol	BRD10
Name	bromodomain containing 10
Location	9p24.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20375
Ensembl gene	ENSG00000183354
Ensembl biotype	protein_coding
Entrez	158358

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000381461, ENST00000399933, ENST00000436015, ENST00000443149, ENST00000513355, ENST00000540714

RefSeq mRNA: 1 — MANE Select: NM_001017969 NM_001017969

Canonical transcript exons

ENST00000399933 — 8 exons

Exon	Start	End
ENSE00001488661	5919022	5923309
ENSE00001540841	5968019	5969436
ENSE00001540843	5988345	5988545
ENSE00001635174	5954016	5954095
ENSE00001791565	5944871	5944960
ENSE00003484761	5929044	5929159
ENSE00003626549	5924658	5924845
ENSE00003849730	6007195	6008482

Expression profiles

Bgee: expression breadth ubiquitous, 253 present calls, max score 96.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.2202 / max 74.3740, expressed in 1615 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
99848	3.3171	1373
99845	0.8384	435
99847	0.6556	349
99846	0.4033	192
99843	0.0058	1

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelial cell of pancreas	CL:0000083	96.53	gold quality
pancreatic ductal cell	CL:0002079	95.05	gold quality
cerebellar vermis	UBERON:0004720	93.63	gold quality
sural nerve	UBERON:0015488	92.99	gold quality
medial globus pallidus	UBERON:0002477	92.90	gold quality
calcaneal tendon	UBERON:0003701	92.86	gold quality
kidney epithelium	UBERON:0004819	92.20	gold quality
globus pallidus	UBERON:0001875	91.60	gold quality
tendon	UBERON:0000043	91.54	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.50	gold quality
corpus callosum	UBERON:0002336	91.35	gold quality
cortical plate	UBERON:0005343	90.75	gold quality
tibialis anterior	UBERON:0001385	90.30	gold quality
deltoid	UBERON:0001476	90.25	gold quality
medulla oblongata	UBERON:0001896	89.88	gold quality
inferior vagus X ganglion	UBERON:0005363	89.87	gold quality
tendon of biceps brachii	UBERON:0008188	89.63	gold quality
tibia	UBERON:0000979	89.62	gold quality
oviduct epithelium	UBERON:0004804	89.51	gold quality
subthalamic nucleus	UBERON:0001906	89.33	gold quality
cauda epididymis	UBERON:0004360	89.31	gold quality
adrenal tissue	UBERON:0018303	89.26	gold quality
mammary duct	UBERON:0001765	89.14	gold quality
epithelium of mammary gland	UBERON:0003244	89.04	gold quality
saphenous vein	UBERON:0007318	89.03	gold quality
superior vestibular nucleus	UBERON:0007227	88.98	gold quality
substantia nigra pars compacta	UBERON:0001965	88.61	gold quality
dorsal plus ventral thalamus	UBERON:0001897	88.60	gold quality
visceral pleura	UBERON:0002401	88.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.25

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

90 targeting BRD10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-590-3P	99.96	74.34	6478
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Brd10	ENSMUSG00000046138
rattus_norvegicus	Brd10	ENSRNOG00000026942

Protein

Protein identifiers

Uncharacterized bromodomain-containing protein 10 — Q5HYC2 (reviewed: Q5HYC2)

All UniProt accessions (4): F5H4E5, H0YFF4, H0YGV4, Q5HYC2

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Nucleus.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5HYC2-1	1	yes
Q5HYC2-2	2

RefSeq proteins (1): NP_001017969* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001487	Bromodomain	Domain
IPR036427	Bromodomain-like_sf	Homologous_superfamily
IPR040214	BRD10	Family
IPR056522	KIAA2026_hel	Domain

Pfam: PF00439, PF23450

UniProt features (16 total): compositionally biased region 7, region of interest 6, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5HYC2-F1	46.10	0.12

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 79 (showing top): TATTATA_MIR374, ATGCAGT_MIR217, GGGCATT_MIR365, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, ATGTACA_MIR493, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, GAGCCAG_MIR149, ARID5B_TARGET_GENES, NKX2_2_TARGET_GENES, ZBTB12_TARGET_GENES, ZNF407_TARGET_GENES, MIR8485, MIR548AJ_3P_MIR548X_3P, MIR1277_5P, MIR548AE_3P_MIR548AQ_3P

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

470 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BRD10	RIC1	Q4ADV7	679
BRD10	ERMP1	Q7Z2K6	602
BRD10	SLC66A3	Q8N755	516
BRD10	SLC16A13	Q7RTY0	509
BRD10	ETAA1	Q9NY74	477
BRD10	PLGRKT	Q9HBL7	447
BRD10	UBTD1	Q9HAC8	447
BRD10	RANBP6	O60518	446
BRD10	NUDT11	Q96G61	439
BRD10	CFAP73	A6NFT4	418
BRD10	SPATA6L	Q8N4H0	412
BRD10	MKLN1	Q9UL63	409
BRD10	MLANA	Q16655	387
BRD10	C1orf174	Q8IYL3	374
BRD10	OSER1	Q9NX31	370
BRD10	DMAC1	Q96GE9	370

IntAct

8 interactions, top by confidence:

A	B	Type	Score
BRD10	KRT18	psi-mi:“MI:0915”(physical association)	0.400
MYC		psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
BRD10		psi-mi:“MI:0915”(physical association)	0.000
ezrA	BRD10	psi-mi:“MI:0915”(physical association)	0.000
BRD10	CREB1	psi-mi:“MI:0915”(physical association)	0.000
ATXN1	BRD10	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (21): KIAA2026 (Synthetic Growth Defect), KIAA2026 (Affinity Capture-MS), KIAA2026 (Proximity Label-MS), KIAA2026 (Affinity Capture-RNA), KIAA2026 (Proximity Label-MS), KIAA2026 (Cross-Linking-MS (XL-MS)), KIAA2026 (Protein-RNA), KIAA2026 (Cross-Linking-MS (XL-MS)), KIAA2026 (Cross-Linking-MS (XL-MS)), KIAA2026 (Affinity Capture-MS), KIAA2026 (Affinity Capture-RNA), KIAA2026 (Proximity Label-MS), KIAA2026 (Proximity Label-MS), KIAA2026 (Proximity Label-MS), KIAA2026 (Proximity Label-MS)

ESM2 similar proteins: A0A1L8GR68, A2CG63, E9Q9M8, F7AQ22, G3V8T1, O75152, O75376, P49140, P51826, P97432, Q13625, Q14596, Q17R98, Q1LY51, Q3TYA6, Q4KKX4, Q4LE39, Q4R6F6, Q501R9, Q505G8, Q5F3Z9, Q5HYC2, Q5RC94, Q5XJV7, Q60974, Q68FE8, Q69Z61, Q6A098, Q6NXK2, Q6NZF1, Q6PJT7, Q6ZNC4, Q86YI8, Q8BFU3, Q8BJ05, Q8CCH7, Q8CG79, Q8CHY6, Q8K2W6, Q8ND24

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

454 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	422
Likely benign	17
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2672 predictions. Top by Δscore:

Variant	Effect	Δscore
9:5892550:GA:G	donor_gain	1.0000
9:5892552:G:GG	donor_gain	1.0000
9:5906878:A:AG	acceptor_gain	1.0000
9:5906883:A:AG	acceptor_gain	1.0000
9:5906883:AG:A	acceptor_gain	1.0000
9:5906884:G:GA	acceptor_gain	1.0000
9:5906884:GG:G	acceptor_gain	1.0000
9:5906996:GTG:G	donor_gain	1.0000
9:5906999:G:GG	donor_gain	1.0000
9:5907000:T:A	donor_loss	1.0000
9:5924652:GCTTA:G	donor_loss	1.0000
9:5924653:CTTA:C	donor_loss	1.0000
9:5924654:TTA:T	donor_loss	1.0000
9:5924655:TACC:T	donor_loss	1.0000
9:5924656:A:AC	donor_gain	1.0000
9:5924656:ACCTG:A	donor_loss	1.0000
9:5924657:C:CA	donor_loss	1.0000
9:5924657:C:CC	donor_gain	1.0000
9:5924716:A:AC	donor_gain	1.0000
9:5924717:C:CC	donor_gain	1.0000
9:5924841:GGCTC:G	acceptor_gain	1.0000
9:5924843:CTC:C	acceptor_gain	1.0000
9:5924844:TC:T	acceptor_gain	1.0000
9:5924845:CC:C	acceptor_gain	1.0000
9:5924846:C:CC	acceptor_gain	1.0000
9:5924847:T:G	acceptor_loss	1.0000
9:5924851:A:AC	acceptor_gain	1.0000
9:5924851:A:C	acceptor_gain	1.0000
9:5924856:A:AC	acceptor_gain	1.0000
9:5924856:A:C	acceptor_gain	1.0000

AlphaMissense

13635 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:5929081:A:G	W821R	1.000
9:5929081:A:T	W821R	1.000
9:5929101:A:G	L814P	1.000
9:5944935:A:G	L773P	1.000
9:5968847:C:G	G462R	1.000
9:5920300:A:T	V1899D	0.999
9:5922151:A:T	V1282D	0.999
9:5929068:A:G	L825S	0.999
9:5929079:C:A	W821C	0.999
9:5929079:C:G	W821C	0.999
9:5929089:A:G	L818S	0.999
9:5929104:C:G	R813P	0.999
9:5944935:A:T	L773H	0.999
9:5944952:G:C	C767W	0.999
9:5944954:A:G	C767R	0.999
9:5968781:A:C	Y484D	0.999
9:5968783:A:T	I483N	0.999
9:5968786:C:G	R482P	0.999
9:5968803:G:C	F476L	0.999
9:5968803:G:T	F476L	0.999
9:5968804:A:G	F476S	0.999
9:5968805:A:G	F476L	0.999
9:5968810:G:T	P474Q	0.999
9:5968812:A:C	F473L	0.999
9:5968812:A:T	F473L	0.999
9:5968813:A:G	F473S	0.999
9:5968814:A:G	F473L	0.999
9:5968823:A:C	Y470D	0.999
9:5968840:T:A	D464V	0.999
9:5968846:C:A	G462V	0.999

dbSNP variants (sampled 300 via entrez): RS1000001896 (9:6009235 C>A,G,T), RS1000006235 (9:5888399 A>T), RS1000054310 (9:5899100 A>G), RS1000068489 (9:6002453 T>C,G), RS1000070152 (9:5899702 A>G), RS1000104161 (9:5973062 G>C,T), RS1000106327 (9:5960778 A>G), RS1000107178 (9:5968769 G>C,T), RS1000116506 (9:5893641 G>C), RS1000121993 (9:5908139 T>G), RS1000147098 (9:5964931 A>G), RS1000161351 (9:5996691 T>C), RS1000162093 (9:5892027 T>C,G), RS1000163552 (9:6002263 T>C), RS1000205838 (9:5987261 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST006988_5	Blond vs. brown/black hair color	6.000000e-10
GCST007563_32	Allergic disease (asthma, hay fever or eczema)	4.000000e-08
GCST008916_119	Asthma	1.000000e-15
GCST008916_20	Asthma	5.000000e-36
GCST008916_26	Asthma	3.000000e-64
GCST009798_28	Asthma	4.000000e-18
GCST009798_74	Asthma	2.000000e-15
GCST009798_8	Asthma	5.000000e-67
GCST90000025_462	Appendicular lean mass	3.000000e-12

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0003924	hair color
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10758713	BRD10		0.00	0

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, decreases methylation	4
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
bisphenol F	decreases expression, affects cotreatment	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
entinostat	decreases expression	1
jinfukang	decreases expression	1
Sunitinib	increases expression	1
Vorinostat	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Indomethacin	decreases expression, affects cotreatment	1
Ozone	affects expression, increases abundance	1
Urethane	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Aflatoxin B1	decreases methylation	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.