BRINP3

Summary

BRINP3 (BMP/retinoic acid inducible neural specific 3, HGNC:22393) is a protein-coding gene on chromosome 1q31.1, encoding BMP/retinoic acid-inducible neural-specific protein 3 (Q76B58). Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.

This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 339479 — RefSeq curated summary.

At a glance

• GWAS associations: 24
• Clinical variants (ClinVar): 113 total
• MANE Select transcript: NM_199051

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:22393
Approved symbol	BRINP3
Name	BMP/retinoic acid inducible neural specific 3
Location	1q31.1
Locus type	gene with protein product
Status	Approved
Aliases	DBCCR1L, DBCCR1L1
Ensembl gene	ENSG00000162670
Ensembl biotype	protein_coding
OMIM	618390
Entrez	339479

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000367462, ENST00000445957, ENST00000463404, ENST00000631494, ENST00000633243, ENST00000956272

RefSeq mRNA: 2 — MANE Select: NM_199051 NM_001317188, NM_199051

CCDS: CCDS1373

Canonical transcript exons

ENST00000367462 — 8 exons

Exon	Start	End
ENSE00001370507	190281560	190281750
ENSE00003494147	190226082	190226318
ENSE00003564460	190097658	190099134
ENSE00003639993	190454655	190454940
ENSE00003663090	190160668	190160890
ENSE00003669051	190234372	190234477
ENSE00003676709	190264865	190265055
ENSE00003781667	190477448	190477864

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 87.78.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0536 / max 167.6098, expressed in 213 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter ID	TPM avg	Samples expressed
16400	0.8528	138
16393	0.4766	125
16402	0.1694	72
16399	0.1062	49
16397	0.0986	50
16401	0.0634	43
16398	0.0603	32
16392	0.0478	32
16396	0.0467	22
16395	0.0390	10

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.78	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.73	gold quality
endothelial cell	CL:0000115	84.04	gold quality
prefrontal cortex	UBERON:0000451	83.99	gold quality
primary visual cortex	UBERON:0002436	83.96	gold quality
right frontal lobe	UBERON:0002810	83.51	gold quality
amygdala	UBERON:0001876	83.21	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	82.94	gold quality
cingulate cortex	UBERON:0003027	82.09	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.98	gold quality
anterior cingulate cortex	UBERON:0009835	81.95	gold quality
neocortex	UBERON:0001950	81.56	gold quality
frontal cortex	UBERON:0001870	81.45	gold quality
hypothalamus	UBERON:0001898	80.72	gold quality
cortical plate	UBERON:0005343	80.51	gold quality
cerebral cortex	UBERON:0000956	79.99	gold quality
cerebellar hemisphere	UBERON:0002245	79.94	gold quality
cerebellar cortex	UBERON:0002129	79.89	gold quality
nucleus accumbens	UBERON:0001882	79.75	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.53	gold quality
Brodmann (1909) area 23	UBERON:0013554	79.23	gold quality
caudate nucleus	UBERON:0001873	79.07	gold quality
telencephalon	UBERON:0001893	79.06	gold quality
occipital lobe	UBERON:0002021	78.70	gold quality
cerebellum	UBERON:0002037	78.45	gold quality
temporal lobe	UBERON:0001871	78.43	gold quality
rectum	UBERON:0001052	77.70	gold quality
colonic epithelium	UBERON:0000397	76.68	gold quality
mucosa of transverse colon	UBERON:0004991	76.53	gold quality
putamen	UBERON:0001874	75.90	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	81.07
E-HCAD-25	yes	20.83
E-GEOD-93593	yes	5.18
E-ANND-3	no	4.02

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

79 targeting BRINP3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-12121	99.99	66.64	255
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345

Literature-anchored findings (GeneRIF, showing 14)

• BRINP3 is a mitochondrially localized protein that is selectively up-regulated in human gonadotropinomas; its actions to increase proliferation, migration, and invasion suggest it may play an important role in pituitary tumorigenesis (PMID:17138656)
• These data implicate FAM5C alleles in the risk of myocardial infarction and suggest further functional studies of FAM5C are required to identify the gene’s contribution to atherosclerosis (PMID:18430236)
• Loss of FAM5C is associated with tongue squamous cell carcinoma. (PMID:19787213)
• FAM5C mRNA expression was significantly higher in aggressive periodontitis diseased versus healthy sites, and was found to be correlated to the IL-1beta, IL-17A, IL-4 and RANKL mRNA levels. (PMID:20383335)
• findings suggest a protective effect of T allele in women with a history of myocardial infarction (MI;) genotype of FAM5C rs10920501 explained about 7percent of variability of age of onset of coronary heart disease in women who have had an MI; FAM5C remains a gene of interest in a complex disease process (PMID:22013132)
• expression does not contribute to chronic periodontitis (PMID:22355820)
• Hypermethylated FAM5C and MYLK in serum are strongly associated with the development of gastric cancer and can be used as potential biomarkers for diagnosis and pre-warning. (PMID:22377736)
• Under expression of BRINP3 is associated with the pathogenesis of ulcerative colitis. (PMID:25171508)
• Data show that family with sequence similarity 5 member C protein FAM5C-positive endothelium expressed intercellular adhesion molecule-1 (ICAM-1) or vascular cell adhesion molecule-1 (VCAM-1). (PMID:25251368)
• study provides evidence that the BRINP3 polymorphic variant rs1342913 and low level of BRINP3 expression are associated with peri-implantitis, independently from the presence of chronic periodontitis. (PMID:25887438)
• FAM5C is a risk factor for cerebral infarction in type 2 diabetic patients. (PMID:26717922)
• Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B rs16944, IL1R2 rs2071008, PLA2G7 rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 rs2065666 were associated with coronary heart disease (CHD), suggesting an important role of inflammation in the risk of CHD. (PMID:27461004)
• the association of serum OGN and FAM5C levels and muscle mass with bone mineral density (BMD), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus, is reported. (PMID:27836731)
• The results demonstrated that FAM5C is an N-glycosylated protein, and N-glycosylation by UGGT1 is necessary for the secretion of FAM5C. (PMID:28351617)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	brinp3a.2	ENSDARG00000061051
mus_musculus	Brinp3	ENSMUSG00000035131
rattus_norvegicus	Brinp3	ENSRNOG00000002811

Paralogs (2): BRINP1 (ENSG00000078725), BRINP2 (ENSG00000198797)

Protein

Protein identifiers

BMP/retinoic acid-inducible neural-specific protein 3 — Q76B58 (reviewed: Q76B58)

Alternative names: DBCCR1-like protein 1

All UniProt accessions (3): A0A0J9YVN8, B1AMP1, Q76B58

UniProt curated annotations — full annotation on UniProt →

Function. Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.

Subcellular location. Secreted. Mitochondrion.

Tissue specificity. Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.

Similarity. Belongs to the BRINP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q76B58-1	1	yes
Q76B58-2	2

RefSeq proteins (2): NP_001304117, NP_950252* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009030	Growth_fac_rcpt_cys_sf	Homologous_superfamily
IPR020864	MACPF	Domain
IPR033237	BRINP	Family
IPR057450	BRINP_EGF	Domain
IPR057671	BRINP_C	Domain

Pfam: PF01823, PF19052, PF25415

UniProt features (13 total): glycosylation site 6, splice variant 2, sequence conflict 2, signal peptide 1, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q76B58-F1	77.13	0.21

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (6): 168, 337, 456, 562, 609, 641

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 188 (showing top): BENPORATH_ES_WITH_H3K27ME3, GOBP_BEHAVIOR, TGCGCANK_UNKNOWN, GOBP_CELLULAR_RESPONSE_TO_LIPID, TTTGTAG_MIR520D, GOBP_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION, MORF_BRCA1, GOBP_GROWTH, TATTATA_MIR374, GOBP_NEUROGENESIS, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, CAGCTG_AP4_Q5, MORF_RAD51L3, CTCTAGA_MIR526C_MIR518F_MIR526A, GOBP_CELLULAR_RESPONSE_TO_RETINOIC_ACID

GO Biological Process (10): central nervous system neuron differentiation (GO:0021953), social behavior (GO:0035176), multicellular organism growth (GO:0035264), exploration behavior (GO:0035640), positive regulation of neuron differentiation (GO:0045666), negative regulation of mitotic cell cycle (GO:0045930), cellular response to retinoic acid (GO:0071300), nervous system development (GO:0007399), negative regulation of cell cycle (GO:0045786), regulation of cell cycle (GO:0051726)

GO Molecular Function (0):

GO Cellular Component (5): extracellular region (GO:0005576), cytoplasm (GO:0005737), mitochondrion (GO:0005739), dendrite (GO:0030425), neuronal cell body (GO:0043025)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
neuron differentiation	2
behavior	2
cell cycle	2
cellular anatomical structure	2
central nervous system development	1
biological process involved in intraspecies interaction between organisms	1
multicellular organismal process	1
developmental growth	1
positive regulation of cell differentiation	1
regulation of neuron differentiation	1
mitotic cell cycle	1
regulation of mitotic cell cycle	1
negative regulation of cell cycle	1
response to retinoic acid	1
cellular response to lipid	1
cellular response to oxygen-containing compound	1
system development	1
negative regulation of cellular process	1
regulation of cell cycle	1
regulation of cellular process	1
intracellular anatomical structure	1
cytoplasm	1
intracellular membrane-bounded organelle	1
neuron projection	1
dendritic tree	1
somatodendritic compartment	1
cell body	1

Protein interactions and networks

STRING

1136 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BRINP3	SLIT3	O75094	523
BRINP3	RRP15	Q9Y3B9	438
BRINP3	KCTD3	Q9Y597	429
BRINP3	GPATCH2	Q9NW75	407
BRINP3	ASTN1	O14525	405
BRINP3	ZNF684	Q5T5D7	398
BRINP3	CCDC17	Q96LX7	395
BRINP3	ANP32D	O95626	392
BRINP3	SLIT1	O75093	390
BRINP3	OGN	P20774	370
BRINP3	ADGRL4	Q9HBW9	367
BRINP3	OR5M11	Q96RB7	361
BRINP3	TMEM236	Q5W0B7	358
BRINP3	CCDC126	Q96EE4	355
BRINP3	OR5AR1	Q8NGP9	355

IntAct

9 interactions, top by confidence:

A	B	Type	Score
STIM2	PRKAB2	psi-mi:“MI:0914”(association)	0.640
BRINP3	BUB1	psi-mi:“MI:0914”(association)	0.530
PDGFRA	GXYLT2	psi-mi:“MI:0914”(association)	0.350
PSCA	METTL15	psi-mi:“MI:0914”(association)	0.350
SCGB2A2	RTL8C	psi-mi:“MI:0914”(association)	0.350
C1orf54	AGRN	psi-mi:“MI:0914”(association)	0.350

BioGRID (40): BRINP3 (Reconstituted Complex), BRINP3 (Affinity Capture-MS), BRINP2 (Affinity Capture-MS), DHFRL1 (Affinity Capture-MS), TXNDC15 (Affinity Capture-MS), BUB1 (Affinity Capture-MS), TUBA4A (Affinity Capture-MS), KIAA0232 (Affinity Capture-MS), TUBA1A (Affinity Capture-MS), CBWD1 (Affinity Capture-MS), NRP2 (Affinity Capture-MS), ATG2B (Affinity Capture-MS), EDEM2 (Affinity Capture-MS), DNAJB9 (Affinity Capture-MS), LRP5 (Affinity Capture-MS)

ESM2 similar proteins: A0A0A6YXX9, A0A1Z2R986, A2RTF1, C6KI89, E9Q355, F5HFJ7, O36400, P03425, P04853, P09258, P09728, P0DP43, P12554, P12556, P16772, P19758, P21526, P22229, P28907, P35740, P35771, Q04547, Q2TAV2, Q2YDM0, Q3TBN1, Q499E0, Q4R6B2, Q5BKX0, Q5E9L2, Q5RDR5, Q66000, Q66001, Q68FB2, Q6AY76, Q6DFY8, Q6ZRH7, Q76B58, Q77MP7, Q77NN4, Q783Y1

Diamond homologs: O60477, Q499E0, Q5E9L2, Q5RDR5, Q6DFY8, Q76B58, Q7ZZR3, Q8K1M7, Q8K1M8, Q920P3, Q925T8, Q9C0B6, Q90X85, A2VEC9, B3EWZ3, B3EWZ8, C5IAW9, D3YXG0, D3ZTD8, E9Q6D8, G5ECS8, O08721, O95450, P07357, P07358, P10643, P13671, P55314, P61134, P61135, P79331, P98136, P98137, P98167, Q13591, Q29RQ1, Q29RU4, Q5RAD0, Q62217, Q700K0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

113 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	107
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3398 predictions. Top by Δscore:

Variant	Effect	Δscore
1:190160663:CTTA:C	donor_loss	1.0000
1:190160665:TA:T	donor_loss	1.0000
1:190160666:A:AT	donor_loss	1.0000
1:190160667:C:CT	donor_loss	1.0000
1:190160887:TCAT:T	acceptor_gain	1.0000
1:190160888:CAT:C	acceptor_gain	1.0000
1:190160888:CATC:C	acceptor_gain	1.0000
1:190226076:TCTTA:T	donor_loss	1.0000
1:190226077:CTTA:C	donor_loss	1.0000
1:190226078:TTA:T	donor_loss	1.0000
1:190226079:TAC:T	donor_loss	1.0000
1:190226080:A:AC	donor_gain	1.0000
1:190226080:A:AT	donor_loss	1.0000
1:190226081:C:A	donor_loss	1.0000
1:190226081:C:CT	donor_gain	1.0000
1:190226081:CCTG:C	donor_gain	1.0000
1:190226081:CCTGA:C	donor_gain	1.0000
1:190226314:AAGCC:A	acceptor_gain	1.0000
1:190226315:AGCC:A	acceptor_gain	1.0000
1:190226316:GCC:G	acceptor_gain	1.0000
1:190226317:CC:C	acceptor_gain	1.0000
1:190226317:CCC:C	acceptor_gain	1.0000
1:190226318:CCT:C	acceptor_gain	1.0000
1:190226319:C:CC	acceptor_gain	1.0000
1:190226319:C:T	acceptor_gain	1.0000
1:190226319:CTT:C	acceptor_loss	1.0000
1:190226320:T:C	acceptor_gain	1.0000
1:190226320:T:TC	acceptor_gain	1.0000
1:190226328:C:CT	acceptor_gain	1.0000
1:190226329:A:T	acceptor_gain	1.0000

AlphaMissense

5088 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:190098026:A:G	C765R	1.000
1:190098141:G:C	C726W	1.000
1:190098143:A:G	C726R	1.000
1:190098211:A:G	L703P	1.000
1:190098271:A:G	L683P	1.000
1:190098310:C:T	G670D	1.000
1:190098433:A:G	L629P	1.000
1:190098451:T:A	E623V	1.000
1:190098581:G:C	H580D	1.000
1:190098582:G:C	S579R	1.000
1:190098582:G:T	S579R	1.000
1:190098584:T:G	S579R	1.000
1:190098597:A:C	N574K	1.000
1:190098597:A:T	N574K	1.000
1:190098645:G:C	C558W	1.000
1:190098647:A:G	C558R	1.000
1:190098705:C:A	K538N	1.000
1:190098705:C:G	K538N	1.000
1:190098771:G:C	S516R	1.000
1:190098771:G:T	S516R	1.000
1:190098773:T:G	S516R	1.000
1:190098898:C:G	C474S	1.000
1:190098899:A:T	C474S	1.000
1:190226248:G:C	C265W	1.000
1:190226249:C:T	C265Y	1.000
1:190226250:A:G	C265R	1.000
1:190234445:G:C	C217W	1.000
1:190234446:C:G	C217S	1.000
1:190234446:C:T	C217Y	1.000
1:190234447:A:G	C217R	1.000

dbSNP variants (sampled 300 via entrez): RS1000000976 (1:190148185 C>T), RS1000002036 (1:190422012 G>C), RS1000008107 (1:190244035 C>A), RS1000018133 (1:190187819 C>A,G), RS1000025429 (1:190304223 A>C), RS1000027406 (1:190406559 A>G), RS1000036656 (1:190181358 T>G), RS1000039607 (1:190268667 GACAA>G), RS1000040482 (1:190111037 G>T), RS1000043869 (1:190254909 G>T), RS1000054728 (1:190311678 AGTGT>A), RS1000055238 (1:190321885 T>G), RS1000063625 (1:190457939 T>C), RS1000067844 (1:190192647 C>G,T), RS1000084449 (1:190231107 A>G)

Disease associations

OMIM: gene MIM:618390 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

24 associations (top):

Study	Trait	p-value
GCST000110_7	Echocardiographic traits	6.000000e-06
GCST000635_21	Response to statin therapy	4.000000e-06
GCST002337_78	Amyotrophic lateral sclerosis (sporadic)	8.000000e-06
GCST002783_404	Body mass index	9.000000e-07
GCST002783_530	Body mass index	1.000000e-06
GCST002934_3	Zinc levels	8.000000e-07
GCST002974_2	Suicide ideation score in major depressive disorder	1.000000e-06
GCST003808_5	Non-response to selective serotonin reuptake inhibitors and depression	2.000000e-06
GCST004571_12	Iron status biomarkers (total iron binding capacity)	4.000000e-07
GCST004571_14	Iron status biomarkers (total iron binding capacity)	4.000000e-08
GCST004572_24	Iron status biomarkers (transferrin saturation)	4.000000e-07
GCST004572_26	Iron status biomarkers (transferrin saturation)	4.000000e-08
GCST004904_109	Body mass index	3.000000e-13
GCST004904_220	Body mass index	3.000000e-10
GCST006041_33	Major depressive disorder	1.000000e-06
GCST006617_1	Uterine fibroid size (maximum volume)	8.000000e-08
GCST007324_153	Adventurousness	1.000000e-12
GCST007325_273	General risk tolerance (MTAG)	1.000000e-13
GCST007576_23	Chronotype	2.000000e-10
GCST007576_311	Chronotype	6.000000e-10
GCST008158_24	Body mass index	5.000000e-06
GCST010988_264	Adult body size	6.000000e-15
GCST012033_2	Sleep (1/3-day periodicity)	2.000000e-12
GCST012034_2	Sleep (1/2-day periodicity)	1.000000e-08

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0004294	left atrial function
EFO:0004298	cardiovascular measurement
EFO:0004340	body mass index
EFO:0007619	suicide ideation measurement
EFO:0005658	response to selective serotonin reuptake inhibitor
EFO:0006334	total iron binding capacity
EFO:0009410	uterine fibroid measurement
EFO:0008579	risk-taking behaviour
EFO:0008328	chronotype measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression	2
Aflatoxin B1	decreases methylation, increases methylation	2
bisphenol F	increases expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
hydroxyhydroquinone	decreases expression	1
arsenite	increases methylation	1
sulforaphane	decreases expression	1
benzo(e)pyrene	decreases methylation	1
perfluoro-n-nonanoic acid	decreases expression	1
Venlafaxine Hydrochloride	increases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Methapyrilene	decreases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Rotenone	decreases expression	1
Cyclosporine	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.