BRIX1

Summary

BRIX1 (biogenesis of ribosomes BRX1, HGNC:24170) is a protein-coding gene on chromosome 5p13.2, encoding Ribosome biogenesis protein BRX1 homolog (Q8TDN6). Required for biogenesis of the 60S ribosomal subunit. It is a common-essential gene (DepMap: required in 98.8% of cancer cell lines).

Enables RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Located in chromosome and nucleolus.

Source: NCBI Gene 55299 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 70 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 98.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_018321

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24170
Approved symbol	BRIX1
Name	biogenesis of ribosomes BRX1
Location	5p13.2
Locus type	gene with protein product
Status	Approved
Aliases	BRIX, FLJ11100
Ensembl gene	ENSG00000113460
Ensembl biotype	protein_coding
OMIM	618466
Entrez	55299

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 10 protein_coding, 3 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000336767, ENST00000506023, ENST00000510834, ENST00000510960, ENST00000515798, ENST00000938601, ENST00000938602, ENST00000938603, ENST00000938604, ENST00000938605, ENST00000938606, ENST00000938607, ENST00000938608, ENST00000970234

RefSeq mRNA: 1 — MANE Select: NM_018321 NM_018321

CCDS: CCDS34143

Canonical transcript exons

ENST00000336767 — 10 exons

Exon	Start	End
ENSE00001356736	34925226	34925996
ENSE00002081894	34915711	34915897
ENSE00003476270	34922695	34922768
ENSE00003536705	34924847	34924975
ENSE00003539978	34918364	34918475
ENSE00003551289	34919840	34919883
ENSE00003566933	34922217	34922287
ENSE00003581596	34922539	34922588
ENSE00003639570	34923133	34923234
ENSE00003656598	34923001	34923051

Expression profiles

Bgee: expression breadth ubiquitous, 195 present calls, max score 92.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.7209 / max 237.8671, expressed in 1803 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
56086	24.1598	1791
56084	1.9637	647
56085	1.4731	769
56083	0.1243	52

Top tissues by expression

262 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	92.15	gold quality
ventricular zone	UBERON:0003053	90.10	gold quality
ganglionic eminence	UBERON:0004023	90.04	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.68	gold quality
islet of Langerhans	UBERON:0000006	89.59	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.57	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.37	gold quality
cortical plate	UBERON:0005343	88.81	gold quality
adrenal tissue	UBERON:0018303	88.71	gold quality
rectum	UBERON:0001052	88.68	gold quality
left uterine tube	UBERON:0001303	88.02	gold quality
esophagus mucosa	UBERON:0002469	87.67	gold quality
omental fat pad	UBERON:0010414	87.66	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.61	gold quality
peritoneum	UBERON:0002358	87.59	gold quality
left adrenal gland cortex	UBERON:0035825	87.55	gold quality
left adrenal gland	UBERON:0001234	87.43	gold quality
ectocervix	UBERON:0012249	87.27	gold quality
left ovary	UBERON:0002119	87.15	gold quality
descending thoracic aorta	UBERON:0002345	87.14	gold quality
body of uterus	UBERON:0009853	87.08	gold quality
popliteal artery	UBERON:0002250	87.07	gold quality
tibial artery	UBERON:0007610	87.07	gold quality
buccal mucosa cell	CL:0002336	87.01	gold quality
right adrenal gland cortex	UBERON:0035827	87.00	gold quality
right adrenal gland	UBERON:0001233	86.80	gold quality
left coronary artery	UBERON:0001626	86.77	gold quality
esophagus	UBERON:0001043	86.70	gold quality
endocervix	UBERON:0000458	86.61	gold quality
adipose tissue of abdominal region	UBERON:0007808	86.55	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7249	no	481.88
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

48 targeting BRIX1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.8% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• BRIX1 promotes ribosome synthesis and enhances glycolysis by selected translation of GLUT1 in colorectal cancer. (PMID:38282151)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	bxdc2	ENSDARG00000098935
mus_musculus	Brix1	ENSMUSG00000022247
rattus_norvegicus	Brix1	ENSRNOG00000018021
drosophila_melanogaster	CG11583	FBGN0035524
caenorhabditis_elegans		WBGENE00019678

Protein

Protein identifiers

Ribosome biogenesis protein BRX1 homolog — Q8TDN6 (reviewed: Q8TDN6)

Alternative names: Brix domain-containing protein 2

All UniProt accessions (1): Q8TDN6

UniProt curated annotations — full annotation on UniProt →

Function. Required for biogenesis of the 60S ribosomal subunit.

Subcellular location. Nucleus. Nucleolus.

Similarity. Belongs to the BRX1 family.

RefSeq proteins (1): NP_060791* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007109	Brix	Domain
IPR026532	BRX1	Family

Pfam: PF04427

UniProt features (13 total): sequence conflict 3, cross-link 3, compositionally biased region 2, modified residue 2, chain 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

10 structures.

PDB	Method	Resolution (Å)
8FKV	ELECTRON MICROSCOPY	2.47
8FKW	ELECTRON MICROSCOPY	2.5
8FKX	ELECTRON MICROSCOPY	2.59
8FKY	ELECTRON MICROSCOPY	2.67
8FKQ	ELECTRON MICROSCOPY	2.76
8FKT	ELECTRON MICROSCOPY	2.81
8FKU	ELECTRON MICROSCOPY	2.82
8FKP	ELECTRON MICROSCOPY	2.85
8FKS	ELECTRON MICROSCOPY	2.88
8FKR	ELECTRON MICROSCOPY	2.89

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TDN6-F1	81.68	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 261, 276, 160, 314, 322

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 147 (showing top): GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_RIBOSOME_ASSEMBLY, WEI_MYCN_TARGETS_WITH_E_BOX, MUELLER_PLURINET, GOBP_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY, WCTCNATGGY_UNKNOWN, MODULE_206, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, DODD_NASOPHARYNGEAL_CARCINOMA_UP, FISCHER_DREAM_TARGETS

GO Biological Process (3): ribosomal large subunit assembly (GO:0000027), rRNA processing (GO:0006364), ribosome biogenesis (GO:0042254)

GO Molecular Function (3): RNA binding (GO:0003723), rRNA binding (GO:0019843), protein binding (GO:0005515)

GO Cellular Component (3): chromosome (GO:0005694), nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	2
protein-RNA complex assembly	1
ribosome assembly	1
ribosomal large subunit biogenesis	1
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
ribonucleoprotein complex biogenesis	1
nucleic acid binding	1
RNA binding	1
binding	1
nuclear lumen	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

3236 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BRIX1	WDR12	Q9GZL7	720
BRIX1	DDX18	Q9NVP1	661
BRIX1	ABT1	Q9ULW3	621
BRIX1	NIP7	Q9Y221	611
BRIX1	RPF1	Q9H9Y2	575
BRIX1	BMS1	Q14692	563
BRIX1	PDCD11	Q14690	554
BRIX1	RPF2	Q9H7B2	543
BRIX1	NIFK	Q9BYG3	540
BRIX1	LYAR	Q9NX58	501
BRIX1	RRP1B	Q14684	498
BRIX1	PWP1	Q13610	491
BRIX1	DHX32	Q7L7V1	483
BRIX1	RRP1	P56182	482
BRIX1	BOP1	Q14137	479

IntAct

258 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:0914”(association)	0.900
BRIX1	EBNA1BP2	psi-mi:“MI:0915”(physical association)	0.810
EBNA1BP2	BRIX1	psi-mi:“MI:0915”(physical association)	0.810
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
NPM1	NVL	psi-mi:“MI:0914”(association)	0.610
BRIX1	HNRNPU	psi-mi:“MI:0915”(physical association)	0.560
BRIX1	RPL13	psi-mi:“MI:0915”(physical association)	0.560
RPS6	IPO7	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MAGEB10	GTPBP10	psi-mi:“MI:0914”(association)	0.530
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
ILF2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
PUM3	RRP8	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530

BioGRID (421): BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BRIX1 (Co-fractionation)

ESM2 similar proteins: A0A1D8PF11, G1STW0, O13019, O13672, O57592, O76732, P0DJ14, P0DKK7, P12970, P15125, P15126, P17076, P29453, P32429, P35685, P46223, P49196, P49692, P62424, P62425, P80455, Q02892, Q29375, Q2TBQ5, Q3SZZ0, Q4QQT6, Q4R5C2, Q54PX9, Q54ZD1, Q5ADQ6, Q5ANA1, Q5I7K9, Q5RAN2, Q6FRV0, Q74ZK6, Q8SSG1, Q8TDN6, Q8UVY2, Q90YW2, Q966C6

Diamond homologs: P34524, Q08235, Q3SZZ0, Q4QQT6, Q54JN0, Q5RAN2, Q8TDN6, Q8UVY2, Q9C928, Q9DCA5, Q9HGL6, Q9LE16, Q9VZE6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 207 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	25	22.3×	4e-25
Peptide chain elongation	23	22.1×	4e-23
Viral mRNA Translation	23	22.1×	4e-23
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	23	21.9×	4e-23
Selenocysteine synthesis	23	20.9×	1e-22
Eukaryotic Translation Termination	23	20.9×	1e-22
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	23	20.5×	1e-22
SRP-dependent cotranslational protein targeting to membrane	27	20.5×	5e-26

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of DNA recombination	5	30.7×	5e-05
cytoplasmic translation	25	25.3×	1e-25
chromosome condensation	5	23.0×	2e-04
negative regulation of mRNA splicing, via spliceosome	5	20.9×	3e-04
ribosomal large subunit biogenesis	8	19.4×	2e-06
rRNA processing	18	13.9×	3e-13
translation	23	12.9×	2e-16
ribosomal small subunit biogenesis	10	12.4×	2e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

70 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

797 predictions. Top by Δscore:

Variant	Effect	Δscore
5:34915898:GTAG:G	donor_loss	1.0000
5:34918442:GACT:G	donor_gain	1.0000
5:34919838:A:AG	acceptor_gain	1.0000
5:34919839:G:GG	acceptor_gain	1.0000
5:34919894:A:T	donor_gain	1.0000
5:34922213:TTAG:T	acceptor_loss	1.0000
5:34922215:A:T	acceptor_loss	1.0000
5:34922216:G:A	acceptor_loss	1.0000
5:34922216:GGTTT:G	acceptor_gain	1.0000
5:34922260:C:G	donor_gain	1.0000
5:34922285:GTG:G	donor_gain	1.0000
5:34922285:GTGGT:G	donor_loss	1.0000
5:34922286:TGGTA:T	donor_loss	1.0000
5:34922288:G:GG	donor_gain	1.0000
5:34922288:GT:G	donor_loss	1.0000
5:34922289:T:A	donor_loss	1.0000
5:34922589:G:GG	donor_gain	1.0000
5:34922684:A:AG	acceptor_gain	1.0000
5:34922693:A:AG	acceptor_gain	1.0000
5:34922694:G:GT	acceptor_gain	1.0000
5:34922694:GTT:G	acceptor_gain	1.0000
5:34922694:GTTC:G	acceptor_gain	1.0000
5:34922694:GTTCA:G	acceptor_gain	1.0000
5:34922764:ACCCT:A	donor_gain	1.0000
5:34922765:CCCT:C	donor_gain	1.0000
5:34922766:CCT:C	donor_gain	1.0000
5:34922767:CT:C	donor_gain	1.0000
5:34922767:CTGTA:C	donor_loss	1.0000
5:34922768:TGTA:T	donor_loss	1.0000
5:34922769:G:GG	donor_gain	1.0000

AlphaMissense

2356 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:34919847:A:C	K93N	1.000
5:34919847:A:T	K93N	1.000
5:34922286:T:A	W129R	1.000
5:34922286:T:C	W129R	1.000
5:34922725:G:A	G156E	1.000
5:34923172:T:C	F201L	1.000
5:34923174:T:A	F201L	1.000
5:34923174:T:G	F201L	1.000
5:34923224:G:C	R218P	1.000
5:34924881:G:A	G233E	1.000
5:34918392:T:C	L63P	0.999
5:34918407:G:T	R68I	0.999
5:34918428:G:C	R75T	0.999
5:34918429:A:C	R75S	0.999
5:34918429:A:T	R75S	0.999
5:34918430:C:G	H76D	0.999
5:34919845:A:G	K93E	0.999
5:34919846:A:T	K93I	0.999
5:34922221:G:A	C107Y	0.999
5:34922222:T:G	C107W	0.999
5:34922237:T:G	C112W	0.999
5:34922244:T:C	C115R	0.999
5:34922558:G:A	G136R	0.999
5:34922558:G:C	G136R	0.999
5:34922559:G:A	G136E	0.999
5:34922568:C:A	A139D	0.999
5:34922580:T:A	V143D	0.999
5:34922713:T:C	L152P	0.999
5:34922729:C:A	N157K	0.999
5:34922729:C:G	N157K	0.999

dbSNP variants (sampled 300 via entrez): RS1000154959 (5:34916318 G>A,C), RS1000450483 (5:34916667 A>C,T), RS1000994229 (5:34921861 C>G,T), RS1001205374 (5:34920461 C>T), RS1001336712 (5:34922155 A>G), RS1001426201 (5:34920830 TG>T), RS1001577269 (5:34916337 G>A), RS1001629751 (5:34916128 G>A), RS1001808508 (5:34914542 C>A,T), RS1002583428 (5:34915257 C>A,T), RS1002635613 (5:34915057 A>C,T), RS1002827133 (5:34921632 G>A), RS1003096879 (5:34919301 G>A,C,T), RS1003431751 (5:34917470 A>G), RS1003621702 (5:34917228 T>A)

Disease associations

OMIM: gene MIM:618466 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009391_1913	Metabolite levels	1.000000e-20

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010464	beta-aminoisobutyric acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066494 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.86	Kd	1383	nM	CHEMBL5653589
5.86	ED50	1383	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2147958: Binding affinity to human BRIX1 incubated for 45 mins by Kinobead based pull down assay	kd	1.3829	uM

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment, increases expression	4
trichostatin A	affects expression, decreases reaction	2
(+)-JQ1 compound	decreases expression	2
Estradiol	affects expression, increases expression	2
Aflatoxin B1	decreases expression, increases expression, affects cotreatment	2
afuresertib	decreases expression	1
FR900359	increases phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	decreases expression	1
coumarin	increases phosphorylation	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	decreases expression	1
bisphenol S	increases expression	1
jinfukang	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Atrazine	increases expression	1
Calcitriol	decreases expression, affects cotreatment	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Fluorouracil	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Nickel	affects expression, decreases reaction	1
Progesterone	decreases expression	1
Ribonucleotides	affects binding	1
Rotenone	increases expression	1
Silicon Dioxide	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651000	Binding	Binding affinity to human BRIX1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.