BRWD1-AS1

Summary

BRWD1-AS1 (BRWD1 antisense RNA 1, HGNC:40614) is a long non-coding RNA gene on chromosome 21q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40614
Approved symbol	BRWD1-AS1
Name	BRWD1 antisense RNA 1
Location	21q22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000238141
Ensembl biotype	lncRNA
Entrez	100874093
RNAcentral	URS000024778E — lncRNA, 691 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000423274, ENST00000603064, ENST00000715799

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423274 — 3 exons

Exon	Start	End
ENSE00001712159	39317045	39317209
ENSE00004082571	39315668	39315815
ENSE00004082573	39322802	39323218

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 86.41.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7719 / max 63.6030, expressed in 744 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189157	1.7719	744

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.41	gold quality
left testis	UBERON:0004533	66.56	gold quality
testis	UBERON:0000473	66.36	gold quality
right testis	UBERON:0004534	65.93	gold quality
ganglionic eminence	UBERON:0004023	64.71	gold quality
ventricular zone	UBERON:0003053	63.36	gold quality
colonic epithelium	UBERON:0000397	61.55	silver quality
sural nerve	UBERON:0015488	61.32	silver quality
skeletal muscle tissue	UBERON:0001134	59.16	silver quality
calcaneal tendon	UBERON:0003701	54.12	silver quality
liver	UBERON:0002107	54.05	silver quality
monocyte	CL:0000576	53.38	gold quality
lymph node	UBERON:0000029	52.53	gold quality
duodenum	UBERON:0002114	52.20	gold quality
gall bladder	UBERON:0002110	52.09	gold quality
islet of Langerhans	UBERON:0000006	52.02	gold quality
mucosa of stomach	UBERON:0001199	51.94	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.88	gold quality
endometrium	UBERON:0001295	51.32	silver quality
prefrontal cortex	UBERON:0000451	51.11	gold quality
placenta	UBERON:0001987	51.02	gold quality
cortex of kidney	UBERON:0001225	50.69	gold quality
bone marrow	UBERON:0002371	50.18	silver quality
blood	UBERON:0000178	49.96	gold quality
adrenal tissue	UBERON:0018303	49.93	silver quality
tonsil	UBERON:0002372	49.49	gold quality
granulocyte	CL:0000094	49.14	silver quality
right lobe of liver	UBERON:0001114	49.00	silver quality
vermiform appendix	UBERON:0001154	48.93	gold quality
superior frontal gyrus	UBERON:0002661	48.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.