BTN3A3

Summary

BTN3A3 (butyrophilin subfamily 3 member A3, HGNC:1140) is a protein-coding gene on chromosome 6p22.2, encoding Butyrophilin subfamily 3 member A3 (O00478). Plays a role in T-cell responses in the adaptive immune response.

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).

Source: NCBI Gene 10384 — RefSeq curated summary.

At a glance

• GWAS associations: 25
• Clinical variants (ClinVar): 165 total
• MANE Select transcript: NM_006994

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1140
Approved symbol	BTN3A3
Name	butyrophilin subfamily 3 member A3
Location	6p22.2
Locus type	gene with protein product
Status	Approved
Aliases	BTF3, BTN3.3
Ensembl gene	ENSG00000111801
Ensembl biotype	protein_coding
OMIM	613595
Entrez	10384

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 23 protein_coding, 6 retained_intron

ENST00000244519, ENST00000361232, ENST00000467524, ENST00000471353, ENST00000474790, ENST00000477388, ENST00000480110, ENST00000482451, ENST00000483179, ENST00000487272, ENST00000487627, ENST00000490254, ENST00000494393, ENST00000496719, ENST00000497681, ENST00000878507, ENST00000878508, ENST00000878509, ENST00000878510, ENST00000878511, ENST00000878512, ENST00000878513, ENST00000878514, ENST00000878515, ENST00000878516, ENST00000949569, ENST00000949570, ENST00000949571, ENST00000949572

RefSeq mRNA: 3 — MANE Select: NM_006994 NM_001242803, NM_006994, NM_197974

CCDS: CCDS4611, CCDS4612

Canonical transcript exons

ENST00000244519 — 11 exons

Exon	Start	End
ENSE00001958420	26451675	26453415
ENSE00001968864	26443382	26443442
ENSE00001981559	26445704	26445985
ENSE00002216638	26443570	26443659
ENSE00003500939	26449662	26449688
ENSE00003526098	26443957	26444304
ENSE00003567268	26448728	26448754
ENSE00003567887	26448617	26448637
ENSE00003604511	26448248	26448448
ENSE00003684154	26450107	26450133
ENSE00003847502	26440504	26440648

Expression profiles

Bgee: expression breadth ubiquitous, 282 present calls, max score 97.16.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.4138 / max 210.1311, expressed in 1337 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66527	8.4138	1337

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	97.16	gold quality
spleen	UBERON:0002106	94.04	gold quality
leukocyte	CL:0000738	93.61	gold quality
monocyte	CL:0000576	93.46	gold quality
mononuclear cell	CL:0000842	93.36	gold quality
lymph node	UBERON:0000029	93.06	gold quality
vermiform appendix	UBERON:0001154	91.87	gold quality
gall bladder	UBERON:0002110	91.62	gold quality
jejunal mucosa	UBERON:0000399	90.95	gold quality
blood	UBERON:0000178	90.91	gold quality
colonic epithelium	UBERON:0000397	90.68	gold quality
caecum	UBERON:0001153	90.39	gold quality
rectum	UBERON:0001052	90.25	gold quality
right uterine tube	UBERON:0001302	90.06	gold quality
right lung	UBERON:0002167	89.80	gold quality
right adrenal gland	UBERON:0001233	89.68	gold quality
right adrenal gland cortex	UBERON:0035827	89.08	gold quality
apex of heart	UBERON:0002098	88.88	gold quality
left adrenal gland	UBERON:0001234	88.74	gold quality
left adrenal gland cortex	UBERON:0035825	88.67	gold quality
upper lobe of left lung	UBERON:0008952	88.42	gold quality
superficial temporal artery	UBERON:0001614	88.39	gold quality
adrenal gland	UBERON:0002369	88.33	gold quality
adrenal cortex	UBERON:0001235	88.25	gold quality
upper lobe of lung	UBERON:0008948	88.00	gold quality
body of uterus	UBERON:0009853	87.73	gold quality
lung	UBERON:0002048	87.39	gold quality
small intestine Peyer’s patch	UBERON:0003454	87.31	gold quality
small intestine	UBERON:0002108	87.02	gold quality
parietal pleura	UBERON:0002400	86.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.61

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting BTN3A3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-8062	99.88	68.43	995
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-383-3P	99.85	65.84	1359
HSA-MIR-130B-5P	99.83	68.50	1888
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-6505-5P	99.73	69.25	1595
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-4690-5P	99.65	66.24	813
HSA-MIR-488-3P	99.61	68.79	1731
HSA-MIR-3682-3P	99.58	67.63	865
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-12132	99.47	68.90	1341
HSA-MIR-569	99.42	66.32	1009
HSA-MIR-4480	99.42	66.02	735
HSA-MIR-888-5P	99.30	70.15	1855
HSA-MIR-3194-3P	98.83	66.22	1167
HSA-MIR-629-5P	98.78	68.72	1032
HSA-MIR-4703-5P	98.53	70.13	1645
HSA-MIR-3942-5P	98.52	69.51	1517
HSA-MIR-934	98.49	70.44	581
HSA-MIR-640	98.44	66.93	644
HSA-MIR-3691-3P	97.90	65.97	791

Literature-anchored findings (GeneRIF, showing 3)

• This study identified that CGPs was found to significantly correlate with the differential expression and methylation of genes encoding butyrophilin, subfamily 3, member A3. (PMID:25243493)
• Macrophage-specific silencing of BTN3A3 in breast cancer cells decreased cancer stem cell frequency and tumor growth. Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 monoclonal antibodies has a therapeutic effect on breast cancer. (PMID:30858559)
• Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population. (PMID:36804966)

Cross-species orthologs

0 orthologs

Paralogs (15): BTN3A1 (ENSG00000026950), CD276 (ENSG00000103855), BTN2A1 (ENSG00000112763), BTNL8 (ENSG00000113303), HHLA2 (ENSG00000114455), BTN2A2 (ENSG00000124508), BTN1A1 (ENSG00000124557), VTCN1 (ENSG00000134258), ICOSLG (ENSG00000160223), ERMAP (ENSG00000164010), BTNL9 (ENSG00000165810), BTNL3 (ENSG00000168903), BTN3A2 (ENSG00000186470), BTNL2 (ENSG00000204290), MOG (ENSG00000204655)

Protein

Protein identifiers

Butyrophilin subfamily 3 member A3 — O00478 (reviewed: O00478)

All UniProt accessions (9): O00478, A0A089GIA6, C9J3Q8, C9J877, C9JNZ3, C9JQT8, C9JUV8, C9JVU4, C9JZT5

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in T-cell responses in the adaptive immune response.

Subunit / interactions. Homodimer.

Subcellular location. Cell membrane.

Tissue specificity. Detected in peripheral blood mononuclear cells and in T-cells (at protein level). Detected in spleen and lymphocytes.

Post-translational modifications. N-glycosylated.

Similarity. Belongs to the immunoglobulin superfamily. BTN/MOG family.

Isoforms (2)

UniProt ID	Names	Canonical?
O00478-1	1	yes
O00478-2	2

RefSeq proteins (3): NP_001229732, NP_008925, NP_932078 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001870	B30.2/SPRY	Domain
IPR003599	Ig_sub	Domain
IPR003877	SPRY_dom	Domain
IPR003879	Butyrophylin_SPRY	Domain
IPR006574	PRY	Domain
IPR007110	Ig-like_dom	Domain
IPR013106	Ig_V-set	Domain
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR037954	SPRY_PRY_BTN3	Domain
IPR043136	B30.2/SPRY_sf	Homologous_superfamily
IPR050504	IgSF_BTN/MOG-like	Family
IPR053896	BTN3A2-like_Ig-C	Domain

Pfam: PF00622, PF07686, PF13765, PF22705

UniProt features (60 total): strand 32, turn 7, helix 5, domain 3, disulfide bond 2, splice variant 2, topological domain 2, signal peptide 1, chain 1, glycosylation site 1, sequence conflict 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
6J0G	X-RAY DIFFRACTION	1.6
6J0L	X-RAY DIFFRACTION	1.95
6J0K	X-RAY DIFFRACTION	2
4F8T	X-RAY DIFFRACTION	2.38
5ZZ3	X-RAY DIFFRACTION	3
9II6	ELECTRON MICROSCOPY	3.27
8ZJY	ELECTRON MICROSCOPY	3.7
8ZJZ	ELECTRON MICROSCOPY	3.8
8ZYR	ELECTRON MICROSCOPY	4.07

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O00478-F1	83.25	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 52–126, 166–220

Glycosylation sites (1): 115

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-8851680	Butyrophilin (BTN) family interactions
R-HSA-1280218	Adaptive Immune System
R-HSA-168256	Immune System

MSigDB gene sets: 388 (showing top): GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, WANG_CLIM2_TARGETS_UP, GNF2_CASP8, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, MODULE_151, ENK_UV_RESPONSE_KERATINOCYTE_UP, MORF_UBE2I, GOBP_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY, MORF_HDAC1, GOCC_CELL_SURFACE, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, ACTGCAG_MIR173P, WIELAND_UP_BY_HBV_INFECTION, GOBP_LEUKOCYTE_MEDIATED_IMMUNITY, GNF2_ZAP70

GO Biological Process (5): regulation of cytokine production (GO:0001817), T cell mediated immunity (GO:0002456), T cell receptor signaling pathway (GO:0050852), adaptive immune response (GO:0002250), immune system process (GO:0002376)

GO Molecular Function (2): signaling receptor binding (GO:0005102), protein binding (GO:0005515)

GO Cellular Component (6): nucleoplasm (GO:0005654), cytosol (GO:0005829), plasma membrane (GO:0005886), external side of plasma membrane (GO:0009897), membrane (GO:0016020), nuclear body (GO:0016604)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Adaptive Immune System	1
Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytokine production	1
regulation of gene expression	1
regulation of multicellular organismal process	1
lymphocyte mediated immunity	1
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	1
antigen receptor-mediated signaling pathway	1
immune response	1
biological_process	1
protein binding	1
binding	1
nuclear lumen	1
cytoplasm	1
membrane	1
cell periphery	1
plasma membrane	1
cell surface	1
side of membrane	1
nucleoplasm	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

799 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BTN3A3	XDH	P47989	968
BTN3A3	PLIN2	Q99541	917
BTN3A3	CLEC4G	Q6UXB4	824
BTN3A3	MFGE8	Q08431	777
BTN3A3	MUC1	P13931	585
BTN3A3	LTF	P02788	576
BTN3A3	PPL	O60437	570
BTN3A3	GOT2	P00505	542
BTN3A3	CIDEA	O60543	506
BTN3A3	MUC15	Q8N387	503
BTN3A3	OMG	P23515	490
BTN3A3	AASDH	Q4L235	460
BTN3A3	HLA-A	P01891	443
BTN3A3	B2M	P01884	440
BTN3A3	PLIN1	O60240	435

IntAct

19 interactions, top by confidence:

A	B	Type	Score
BTN3A3	BTN3A1	psi-mi:“MI:0915”(physical association)	0.560
BTN3A3	BTN3A1	psi-mi:“MI:0914”(association)	0.560
MCOLN3	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
BTN3A2	BTN3A3	psi-mi:“MI:0914”(association)	0.530
BTN3A3	LTF	psi-mi:“MI:0915”(physical association)	0.400
BTN3A3	HAVCR1	psi-mi:“MI:0915”(physical association)	0.400
BTN3A3	CTSL	psi-mi:“MI:0915”(physical association)	0.370
BTN3A3	ARL8B	psi-mi:“MI:0915”(physical association)	0.370
TRIM11	BTN3A3	psi-mi:“MI:0914”(association)	0.350
ATG16L1		psi-mi:“MI:0914”(association)	0.350
TRIM11	RABGAP1L	psi-mi:“MI:0914”(association)	0.350
TRIM68	BTN3A3	psi-mi:“MI:0914”(association)	0.350
U2AF1	MED19	psi-mi:“MI:2364”(proximity)	0.270
DDX6	RPSA2	psi-mi:“MI:2364”(proximity)	0.270
BTN3A3	metE	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (46): BTN3A3 (Affinity Capture-MS), BTN3A3 (Affinity Capture-MS), BTN3A3 (Affinity Capture-MS), BTN3A3 (Affinity Capture-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS), BTN3A3 (Proximity Label-MS)

ESM2 similar proteins: A0JN74, A6NCK2, A6NGJ6, A6NI03, B1H278, K7N6K2, O00478, O00481, P14373, P19474, Q13410, Q1ACD5, Q1ACD6, Q1ACD7, Q1ACD8, Q1XHU0, Q2YEM8, Q2YEM9, Q3ZEE5, Q587N6, Q5C8T6, Q5C8T8, Q5C8U1, Q5D7I9, Q5D7J0, Q5D7J1, Q5NCC9, Q5R996, Q62158, Q6MFZ5, Q7YR33, Q7YRV4, Q80V85, Q8BGE7, Q8NG06, Q923T7, Q96BQ3, Q96F44, Q99PP6, Q99PQ2

Diamond homologs: A0A0E4BZH1, A4QPC6, A7TZE6, A7TZF0, A7TZF3, A7TZG1, A7TZG3, A7XUX6, A7XUY5, A7XUZ6, A7XV04, A7XV07, A7XV14, A8MVZ5, O00478, O00481, O70355, P18892, P55803, P78410, Q13410, Q16653, Q29ZQ1, Q5R7W8, Q5R960, Q5R996, Q61885, Q62556, Q63345, Q6MG97, Q6UX41, Q6UXE8, Q6UXG8, Q7KYR7, Q7TST0, Q8BJE2, Q8WVV5, Q96KV6, Q96PL5, Q9BGS7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

165 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	112
Likely benign	13
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1614 predictions. Top by Δscore:

Variant	Effect	Δscore
6:26440646:GAA:G	donor_gain	0.9900
6:26448603:T:A	acceptor_gain	0.9900
6:26448755:G:GG	donor_gain	0.9900
6:26450101:TTTCA:T	acceptor_loss	0.9900
6:26450102:TTCA:T	acceptor_loss	0.9900
6:26450103:TCA:T	acceptor_loss	0.9900
6:26450104:CAG:C	acceptor_loss	0.9900
6:26450105:A:AG	acceptor_gain	0.9900
6:26450106:G:GA	acceptor_gain	0.9900
6:26450106:GA:G	acceptor_gain	0.9900
6:26450133:GGT:G	donor_loss	0.9900
6:26450134:G:GC	donor_loss	0.9900
6:26450135:TGA:T	donor_loss	0.9900
6:26450136:GAG:G	donor_loss	0.9900
6:26450947:A:AG	acceptor_gain	0.9900
6:26451165:GGC:G	donor_gain	0.9900
6:26451166:GC:G	donor_gain	0.9900
6:26451167:C:G	donor_gain	0.9900
6:26451673:AGCG:A	acceptor_gain	0.9900
6:26451674:GCGG:G	acceptor_gain	0.9900
6:26440649:G:GG	donor_gain	0.9800
6:26448433:GAAA:G	donor_gain	0.9800
6:26448444:AAGAG:A	donor_loss	0.9800
6:26448445:AGAGG:A	donor_loss	0.9800
6:26448446:G:GT	donor_gain	0.9800
6:26448446:GAG:G	donor_gain	0.9800
6:26448446:GAGGT:G	donor_loss	0.9800
6:26448447:AG:A	donor_loss	0.9800
6:26448448:GGTAT:G	donor_loss	0.9800
6:26448450:T:A	donor_loss	0.9800

AlphaMissense

3804 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:26451875:T:A	W407R	0.998
6:26451875:T:C	W407R	0.998
6:26451845:T:A	W397R	0.994
6:26451845:T:C	W397R	0.994
6:26451885:G:A	G410E	0.994
6:26451788:T:C	F378L	0.993
6:26451790:T:A	F378L	0.993
6:26451790:T:G	F378L	0.993
6:26451877:G:C	W407C	0.993
6:26451877:G:T	W407C	0.993
6:26451884:G:T	G410W	0.992
6:26451847:G:C	W397C	0.991
6:26451847:G:T	W397C	0.991
6:26451807:T:A	V384D	0.988
6:26451876:G:C	W407S	0.987
6:26451884:G:A	G410R	0.987
6:26451884:G:C	G410R	0.987
6:26452076:T:C	F474L	0.986
6:26452078:C:A	F474L	0.986
6:26452078:C:G	F474L	0.986
6:26451885:G:T	G410V	0.984
6:26451846:G:C	W397S	0.983
6:26451868:A:C	R404S	0.982
6:26451868:A:T	R404S	0.982
6:26452152:T:C	F499S	0.981
6:26444070:T:A	W67R	0.980
6:26444070:T:C	W67R	0.980
6:26452077:T:C	F474S	0.980
6:26444072:G:C	W67C	0.979
6:26444072:G:T	W67C	0.979

dbSNP variants (sampled 300 via entrez): RS1000131219 (6:26451294 A>C,G), RS1000329627 (6:26449482 A>G), RS1000446575 (6:26442945 G>A), RS1000742225 (6:26444809 C>T), RS1000940881 (6:26439434 C>T), RS1000976750 (6:26439107 G>C,T), RS1001137658 (6:26452569 C>T), RS1001168650 (6:26452164 C>A,T), RS1001624431 (6:26451055 T>G), RS1001946268 (6:26440901 T>C), RS1002174464 (6:26453573 T>C), RS1002381614 (6:26447553 G>C), RS1002554952 (6:26440326 T>C), RS1002757071 (6:26447893 G>A), RS1002786130 (6:26447320 A>G,T)

Disease associations

OMIM: gene MIM:613595 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

25 associations (top):

Study	Trait	p-value
GCST003476_8	Eyebrow thickness	3.000000e-07
GCST003477_7	Monobrow thickness	4.000000e-07
GCST004521_113	Autism spectrum disorder or schizophrenia	3.000000e-19
GCST004521_208	Autism spectrum disorder or schizophrenia	5.000000e-17
GCST004521_234	Autism spectrum disorder or schizophrenia	4.000000e-10
GCST004521_299	Autism spectrum disorder or schizophrenia	6.000000e-13
GCST004521_301	Autism spectrum disorder or schizophrenia	1.000000e-08
GCST004521_69	Autism spectrum disorder or schizophrenia	8.000000e-24
GCST004750_82	Squamous cell lung carcinoma	3.000000e-08
GCST006613_50	Triglycerides	9.000000e-11
GCST007268_22	Diastolic blood pressure	8.000000e-13
GCST010002_50	Refractive error	4.000000e-34
GCST010142_16	Fish- and plant-related diet	2.000000e-10
GCST010142_19	Fish- and plant-related diet	4.000000e-10
GCST010142_34	Fish- and plant-related diet	7.000000e-09
GCST010142_35	Fish- and plant-related diet	8.000000e-09
GCST010142_42	Fish- and plant-related diet	1.000000e-08
GCST010142_7	Fish- and plant-related diet	3.000000e-12
GCST010142_74	Fish- and plant-related diet	9.000000e-09
GCST010142_82	Fish- and plant-related diet	3.000000e-08
GCST010241_22	Apolipoprotein A1 levels	1.000000e-17
GCST010702_75	Subcortical volume (MOSTest)	3.000000e-11
GCST010703_272	Brain morphology (MOSTest)	7.000000e-16
GCST012226_51	Waist circumference adjusted for body mass index	9.000000e-10
GCST90000514_4	Gastroesophageal reflux disease	2.000000e-13

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004530	triglyceride measurement
EFO:0006336	diastolic blood pressure
EFO:0008111	diet measurement
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004346	neuroimaging measurement
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	5
Arsenic	affects expression, affects cotreatment, decreases expression, increases abundance	3
Cyclosporine	affects expression, increases expression	3
sulforaphane	decreases expression	2
(+)-JQ1 compound	decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
Tretinoin	increases expression	2
Valproic Acid	decreases expression, decreases methylation	2
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
cobaltous chloride	decreases expression	1
zinc chromate	increases abundance, increases expression	1
ochratoxin A	decreases acetylation	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
hydroquinone	decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
chromium hexavalent ion	increases abundance, increases expression	1
nutlin 3	affects cotreatment, increases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Arsenic Trioxide	decreases expression	1
Acetaminophen	decreases expression	1
Calcitriol	decreases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Fluorouracil	increases expression	1
Lead	affects expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.