BZW1

Summary

BZW1 (basic leucine zipper and W2 domains 1, HGNC:18380) is a protein-coding gene on chromosome 2q33.1, encoding eIF5-mimic protein 2 (Q7L1Q6). Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function.

Enables RNA binding activity and cadherin binding activity. Involved in regulation of translational initiation. Located in cytoplasm.

Source: NCBI Gene 9689 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 41 total
• Druggable target: yes
• MANE Select transcript: NM_001207067

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18380
Approved symbol	BZW1
Name	basic leucine zipper and W2 domains 1
Location	2q33.1
Locus type	gene with protein product
Status	Approved
Aliases	BZAP45, KIAA0005, 5MP2
Ensembl gene	ENSG00000082153
Ensembl biotype	protein_coding
OMIM	619252
Entrez	9689

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 31 protein_coding, 4 retained_intron

ENST00000359893, ENST00000409226, ENST00000409600, ENST00000410110, ENST00000419090, ENST00000447069, ENST00000450637, ENST00000452206, ENST00000452790, ENST00000460660, ENST00000463310, ENST00000464483, ENST00000491576, ENST00000861037, ENST00000861038, ENST00000861039, ENST00000861040, ENST00000861041, ENST00000861042, ENST00000861043, ENST00000861044, ENST00000861045, ENST00000861046, ENST00000937470, ENST00000937471, ENST00000937472, ENST00000937473, ENST00000937474, ENST00000937475, ENST00000937476, ENST00000946635, ENST00000946636, ENST00000946637, ENST00000946638, ENST00000946639

RefSeq mRNA: 9 — MANE Select: NM_001207067 NM_001207067, NM_001207068, NM_001207069, NM_001321688, NM_001321690, NM_001321691, NM_001321693, NM_001321694, NM_014670

CCDS: CCDS56154, CCDS56155, CCDS56156

Canonical transcript exons

ENST00000409600 — 12 exons

Exon	Start	End
ENSE00000784375	200815667	200815761
ENSE00000784392	200817106	200817241
ENSE00000803307	200821183	200821305
ENSE00001588116	200819982	200820120
ENSE00001752836	200816325	200816390
ENSE00001897723	200811910	200811990
ENSE00002480570	200815341	200815517
ENSE00002589934	200822147	200827338
ENSE00003484208	200818755	200818901
ENSE00003532428	200818223	200818393
ENSE00003597525	200813208	200813281
ENSE00003787206	200817974	200818083

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 189.6153 / max 6337.7016, expressed in 1825 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24580	176.6488	1823
24578	6.5153	1677
24581	3.1055	1202
24582	1.1443	362
24579	0.8457	563
24583	0.6433	322
24584	0.3977	153
24585	0.1859	85
24586	0.1289	55

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
palpebral conjunctiva	UBERON:0001812	99.46	gold quality
amniotic fluid	UBERON:0000173	99.41	gold quality
adrenal tissue	UBERON:0018303	99.28	gold quality
germinal epithelium of ovary	UBERON:0001304	99.12	gold quality
choroid plexus epithelium	UBERON:0003911	99.10	gold quality
gingival epithelium	UBERON:0001949	99.06	gold quality
parietal pleura	UBERON:0002400	98.98	gold quality
mucosa of paranasal sinus	UBERON:0005030	98.92	gold quality
stromal cell of endometrium	CL:0002255	98.85	gold quality
cartilage tissue	UBERON:0002418	98.82	gold quality
cortical plate	UBERON:0005343	98.82	gold quality
epithelium of nasopharynx	UBERON:0001951	98.81	gold quality
synovial joint	UBERON:0002217	98.80	gold quality
gingiva	UBERON:0001828	98.79	gold quality
esophagus squamous epithelium	UBERON:0006920	98.79	gold quality
embryo	UBERON:0000922	98.76	gold quality
pleura	UBERON:0000977	98.75	gold quality
ventricular zone	UBERON:0003053	98.73	gold quality
ganglionic eminence	UBERON:0004023	98.72	gold quality
oral cavity	UBERON:0000167	98.71	gold quality
mucosa of sigmoid colon	UBERON:0004993	98.66	gold quality
superficial temporal artery	UBERON:0001614	98.50	gold quality
visceral pleura	UBERON:0002401	98.44	gold quality
right testis	UBERON:0004534	98.33	gold quality
pericardium	UBERON:0002407	98.30	gold quality
colonic mucosa	UBERON:0000317	98.29	gold quality
tongue squamous epithelium	UBERON:0006919	98.26	gold quality
islet of Langerhans	UBERON:0000006	98.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	98.17	gold quality
epithelium of esophagus	UBERON:0001976	98.17	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	30.58
E-CURD-46	yes	12.62
E-MTAB-10042	yes	4.36
E-CURD-112	yes	4.09
E-MTAB-6819	no	2185.42
E-MTAB-7052	no	1059.03
E-MTAB-6524	no	341.35
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYC

miRNA regulators (miRDB)

152 targeting BZW1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-548AE-3P	99.93	72.66	4867

Literature-anchored findings (GeneRIF, showing 12)

• Stimulates cell cycle regulation of histone H4 gene transcription. (PMID:11524015)
• BZW1 is a novel factor, promoting the growth of MEC cells (PMID:19446954)
• Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified. (PMID:21734401)
• results reveal a surprising role for BZW1 and BZW2 in maintaining homeostatic stringency of start codon selection, and taking into account recent biochemical, genetic and structural insights into eukaryotic initiation, suggest a model for BZW1 and BZW2 function (PMID:29470543)
• Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis. (PMID:31601833)
• Long noncoding RNA NEAT1 modifies cell proliferation, colony formation, apoptosis, migration and invasion via the miR4500/BZW1 axis in ovarian cancer. (PMID:32945505)
• LncRNA NEAT1 promotes glioma cancer progression via regulation of miR-98-5p/BZW1. (PMID:33393590)
• BZW1 promotes cell proliferation in prostate cancer by regulating TGF-beta1/Smad pathway. (PMID:33886419)
• BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2alpha Phosphorylation. (PMID:34951995)
• Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. (PMID:37828427)
• BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma. (PMID:38306570)
• [Overexpression of BZW1 promotes invasion and metastasis of gastric cancer cells by regulating Wnt/beta-catenin signaling and promoting epithelial-mesenchymal transition]. (PMID:38501421)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	bzw1a	ENSDARG00000010481
danio_rerio	bzw1b	ENSDARG00000099148
mus_musculus	Bzw1	ENSMUSG00000051223
rattus_norvegicus	Bzw1	ENSRNOG00000013977
drosophila_melanogaster	kra	FBGN0250753

Paralogs (1): BZW2 (ENSG00000136261)

Protein

Protein identifiers

eIF5-mimic protein 2 — Q7L1Q6 (reviewed: Q7L1Q6)

Alternative names: Basic leucine zipper and W2 domain-containing protein 1, Protein Orf

All UniProt accessions (7): Q7L1Q6, C9IZ80, C9J188, C9JFN4, C9JV57, C9JWF5, H0Y503

UniProt curated annotations — full annotation on UniProt →

Function. Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function. Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Similarity. Belongs to the BZW family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q7L1Q6-1	1	yes
Q7L1Q6-2	2
Q7L1Q6-3	3
Q7L1Q6-4	4

RefSeq proteins (9): NP_001193996, NP_001193997, NP_001193998, NP_001308617, NP_001308619, NP_001308620, NP_001308622, NP_001308623, NP_055485 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003307	W2_domain	Domain
IPR016024	ARM-type_fold	Homologous_superfamily
IPR043510	W2_5MP1/2	Domain
IPR051245	eIF5-mimic_regulator	Family
IPR057397	HEAT_5MP1_2	Domain

Pfam: PF02020, PF25504

UniProt features (12 total): modified residue 4, splice variant 3, chain 1, domain 1, region of interest 1, compositionally biased region 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7L1Q6-F1	91.23	0.83

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 1, 12, 411, 413, 368

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 247 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, TAATAAT_MIR126, AAGTCCA_MIR422B_MIR422A, TTTGTAG_MIR520D, AAGCCAT_MIR135A_MIR135B, MORF_RAD21, DARWICHE_SKIN_TUMOR_PROMOTER_UP, GOBP_TRANSLATIONAL_INITIATION, DARWICHE_PAPILLOMA_RISK_LOW_UP, DARWICHE_PAPILLOMA_RISK_HIGH_UP, DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP, MORF_HDAC2, MODULE_149

GO Biological Process (2): regulation of translational initiation (GO:0006446), regulation of translation (GO:0006417)

GO Molecular Function (3): RNA binding (GO:0003723), cadherin binding (GO:0045296), protein binding (GO:0005515)

GO Cellular Component (2): cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
translational initiation	1
regulation of translation	1
translation	1
post-transcriptional regulation of gene expression	1
regulation of protein metabolic process	1
nucleic acid binding	1
cell adhesion molecule binding	1
binding	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1346 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
BZW1	TOMM70	O94826	635
BZW1	NIF3L1	Q9GZT8	554
BZW1	PSTPIP1	O43586	489
BZW1	HYCC2	Q8IXS8	479
BZW1	PPIL3	Q9H2H8	473
BZW1	EIF5	P55010	458
BZW1	LRIG3	Q6UXM1	418
BZW1	HAND1	O96004	400
BZW1	DNAJB1	P25685	388
BZW1	TYW5	A2RUC4	370
BZW1	MAP3K11	Q16584	368
BZW1	HSPA1A	P08107	365
BZW1	KCTD18	Q6PI47	360
BZW1	EIF1	P41567	357
BZW1	ASZ1	Q8WWH4	348

IntAct

78 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
BZW2	BZW1	psi-mi:“MI:0914”(association)	0.560
GYPB	TCAF2	psi-mi:“MI:0914”(association)	0.530
SLCO4C1	CLGN	psi-mi:“MI:0914”(association)	0.530
STOM	EI24	psi-mi:“MI:0914”(association)	0.510
ORF38	PPT1	psi-mi:“MI:0914”(association)	0.500
	ANP32A	psi-mi:“MI:0915”(physical association)	0.500
	MYL12B	psi-mi:“MI:0914”(association)	0.460
M	NPEPPSL1	psi-mi:“MI:0914”(association)	0.350
M2	ESYT2	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
KSR1	FBLL1	psi-mi:“MI:0914”(association)	0.350
KSR1		psi-mi:“MI:0914”(association)	0.350
P2RY6	ESYT2	psi-mi:“MI:0914”(association)	0.350
UNC93B1		psi-mi:“MI:0914”(association)	0.350
P2RY6		psi-mi:“MI:0914”(association)	0.350
P2RY6	RAVER1	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
	NBAS	psi-mi:“MI:0914”(association)	0.350
PA	ESYT2	psi-mi:“MI:0914”(association)	0.350
	TNPO2	psi-mi:“MI:0914”(association)	0.350
	CLIC1	psi-mi:“MI:0914”(association)	0.350

BioGRID (231): BZW1 (Affinity Capture-MS), BZW1 (Affinity Capture-MS), BZW1 (Affinity Capture-MS), BZW2 (Affinity Capture-MS), PRPF31 (Affinity Capture-MS), ENPP1 (Affinity Capture-MS), SCCPDH (Affinity Capture-MS), RNF138 (Affinity Capture-MS), TMEM43 (Affinity Capture-MS), BZW1 (Affinity Capture-MS), ADPRHL2 (Co-fractionation), BZW1 (Co-fractionation), BZW1 (Co-fractionation), EIF5 (Co-fractionation), ETF1 (Co-fractionation)

ESM2 similar proteins: A0A3Q1LSX9, A2APV2, A2AT37, A2VD00, A4II09, B0KWH8, B1AZI6, B1MTK1, B2KI97, B3MS75, B3NU52, B4GW22, B4I0W6, B4JM29, B4L2J8, B4NC41, B4Q034, C0H906, C1FXW9, F4IUX6, Q09161, Q16UN6, Q1LUC1, Q1LXC9, Q29G82, Q2L4X1, Q3UYV9, Q4R6R4, Q56A27, Q5R7L4, Q5ZJZ6, Q5ZL42, Q5ZLT7, Q5ZMW3, Q6DDM4, Q6DIE2, Q6GQ80, Q6GQD0, Q6P2Z0, Q6P7P5

Diamond homologs: P47823, P56287, Q0P8J8, Q13144, Q54RF3, Q5R7L4, Q5ZLT7, Q64350, Q6P2Z0, Q6P7P5, Q7L1Q6, Q8AVM7, Q8CHW4, Q9CQC6, A3DNI8, C5A2A8, O58312, P38431, P48724, P55010, P55871, P55876, P56329, P59325, Q07205, Q09689, Q1LUC1, Q22918, Q26891, Q2L4X1, Q41969, Q4R6R4, Q54LA1, Q5R4L0, Q5ZL42, Q74M98, Q803N9, Q8TWR5, Q8U3I5, Q91VK1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

41 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1661 predictions. Top by Δscore:

Variant	Effect	Δscore
2:200813205:TAGG:T	acceptor_loss	1.0000
2:200813206:A:AG	acceptor_gain	1.0000
2:200813206:AG:A	acceptor_gain	1.0000
2:200813207:G:A	acceptor_gain	1.0000
2:200813207:G:GG	acceptor_gain	1.0000
2:200813207:GGGT:G	acceptor_gain	1.0000
2:200813279:GAG:G	donor_gain	1.0000
2:200813280:AGGTA:A	donor_loss	1.0000
2:200813282:GTAA:G	donor_loss	1.0000
2:200813283:T:A	donor_loss	1.0000
2:200815338:CAGA:C	acceptor_loss	1.0000
2:200815339:A:AG	acceptor_gain	1.0000
2:200815339:AGAT:A	acceptor_gain	1.0000
2:200815340:G:GA	acceptor_gain	1.0000
2:200815340:GA:G	acceptor_gain	1.0000
2:200815340:GAT:G	acceptor_gain	1.0000
2:200815340:GATG:G	acceptor_gain	1.0000
2:200815340:GATGA:G	acceptor_gain	1.0000
2:200815513:GCTGG:G	donor_gain	1.0000
2:200815514:CTGG:C	donor_gain	1.0000
2:200815515:TGG:T	donor_gain	1.0000
2:200815515:TGGG:T	donor_loss	1.0000
2:200815516:GG:G	donor_gain	1.0000
2:200815516:GGG:G	donor_gain	1.0000
2:200815517:GG:G	donor_gain	1.0000
2:200815518:G:A	donor_loss	1.0000
2:200815518:G:GG	donor_gain	1.0000
2:200815519:T:G	donor_loss	1.0000
2:200815644:ATTTT:A	acceptor_gain	1.0000
2:200815648:T:A	acceptor_gain	1.0000

AlphaMissense

2787 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:200813249:T:A	L11Q	1.000
2:200813255:G:A	G13D	1.000
2:200813266:A:G	K17E	1.000
2:200813268:A:C	K17N	1.000
2:200813268:A:T	K17N	1.000
2:200813273:G:C	R19T	1.000
2:200813273:G:T	R19I	1.000
2:200813274:A:C	R19S	1.000
2:200813274:A:T	R19S	1.000
2:200813275:A:G	K20E	1.000
2:200813276:A:T	K20I	1.000
2:200813277:A:C	K20N	1.000
2:200813277:A:T	K20N	1.000
2:200813279:G:C	R21T	1.000
2:200813279:G:T	R21I	1.000
2:200813280:A:C	R21S	1.000
2:200813280:A:T	R21S	1.000
2:200815371:T:C	F32S	1.000
2:200815437:T:C	L54P	1.000
2:200815449:G:A	G58E	1.000
2:200815506:G:A	G77D	1.000
2:200815506:G:T	G77V	1.000
2:200815673:G:A	G83D	1.000
2:200815675:G:C	G84R	1.000
2:200815676:G:A	G84D	1.000
2:200816346:C:A	R120S	1.000
2:200816352:A:G	K122E	1.000
2:200816354:A:C	K122N	1.000
2:200816354:A:T	K122N	1.000
2:200816355:T:C	Y123H	1.000

dbSNP variants (sampled 300 via entrez): RS1000137662 (2:200817763 T>C), RS1000181290 (2:200811719 T>A,C), RS1000418010 (2:200821538 T>C), RS1000549560 (2:200810516 A>G), RS1000552903 (2:200827612 T>A,G), RS1000609594 (2:200819103 A>G), RS1000745490 (2:200824435 G>A), RS1000789194 (2:200821809 G>A,T), RS1001177406 (2:200814615 A>G), RS1001320098 (2:200821118 G>A,T), RS1001435417 (2:200812674 T>G), RS1001467473 (2:200824055 A>G), RS1001606875 (2:200823791 T>TTTG), RS1001799825 (2:200825036 T>A,C), RS1001880456 (2:200814874 A>C,G)

Disease associations

OMIM: gene MIM:619252 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5724746 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.24	Kd	570.8	nM	CHEMBL3752910
6.24	ED50	570.8	nM	CHEMBL3752910
5.59	Kd	2538	nM	CHEMBL5653589
5.59	ED50	2538	nM	CHEMBL5653589

PubChem BioAssay actives

2 with measured affinity, of 10 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2147966: Binding affinity to human BZW1 incubated for 45 mins by Kinobead based pull down assay	kd	0.5708	uM
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2147966: Binding affinity to human BZW1 incubated for 45 mins by Kinobead based pull down assay	kd	2.5381	uM

CTD chemical–gene interactions

57 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	4
sodium arsenite	affects methylation, decreases expression, increases expression	3
Tobacco Smoke Pollution	increases expression	2
Valproic Acid	decreases methylation, increases expression	2
dicrotophos	decreases expression	1
2,4,6-tribromophenol	decreases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, decreases expression, affects localization	1
decabromobiphenyl ether	decreases expression	1
tetrahydropalmatine	decreases expression	1
beta-lapachone	increases expression	1
tetrabromobisphenol A	decreases expression	1
ochratoxin A	affects cotreatment, increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
CGP 52608	affects binding, increases reaction	1
deguelin	decreases expression	1
fenpyroximate	decreases expression	1
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	decreases expression	1
bisphenol B	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pyrachlostrobin	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
bisphenol S	increases expression	1
jinfukang	decreases expression	1
picoxystrobin	decreases expression	1
bisphenol AF	increases expression	1
Rosiglitazone	affects cotreatment, increases expression, decreases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Pioglitazone	affects cotreatment, increases expression, decreases reaction	1
Arsenic Trioxide	increases expression	1

ChEMBL screening assays

7 unique, capped per target: 7 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651008	Binding	Binding affinity to human BZW1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

6 cell lines: 5 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2T6	Abcam HEK293T BZW1 KO	Transformed cell line	Female
CVCL_E1SI	HAP1 BZW1 (-) 1	Cancer cell line	Male
CVCL_E1SJ	HAP1 BZW1 (-) 2	Cancer cell line	Male
CVCL_E1SK	HAP1 BZW1 (-) 3	Cancer cell line	Male
CVCL_E1SL	HAP1 BZW1 (-) 4	Cancer cell line	Male
CVCL_F1LU	HyCyte A-549 KO-hBZW1	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.