C10orf62

Summary

C10orf62 (chromosome 10 open reading frame 62, HGNC:23294) is a protein-coding gene on chromosome 10q24.2, encoding Uncharacterized protein C10orf62 (Q5T681).

At a glance

• Clinical variants (ClinVar): 3 total
• MANE Select transcript: NM_001009997

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23294
Approved symbol	C10orf62
Name	chromosome 10 open reading frame 62
Location	10q24.2
Locus type	gene with protein product
Status	Approved
Aliases	bA548K23.1
Ensembl gene	ENSG00000203942
Ensembl biotype	protein_coding
Entrez	414157

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000370640

RefSeq mRNA: 1 — MANE Select: NM_001009997 NM_001009997

CCDS: CCDS31261

Canonical transcript exons

ENST00000370640 — 1 exons

Exon	Start	End
ENSE00001453205	97589721	97590934

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 98.14.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2882 / max 263.8847, expressed in 5 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
106451	0.2701	5
106450	0.0181	4

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	98.14	gold quality
right testis	UBERON:0004534	98.10	gold quality
sperm	CL:0000019	96.94	gold quality
testis	UBERON:0000473	94.91	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.90	gold quality
adult organism	UBERON:0007023	81.07	gold quality
left ventricle myocardium	UBERON:0006566	75.76	gold quality
cardiac muscle of right atrium	UBERON:0003379	75.62	gold quality
kidney epithelium	UBERON:0004819	68.41	gold quality
tibialis anterior	UBERON:0001385	67.24	silver quality
nasal cavity epithelium	UBERON:0005384	64.85	gold quality
pancreatic ductal cell	CL:0002079	64.79	silver quality
quadriceps femoris	UBERON:0001377	63.26	gold quality
deltoid	UBERON:0001476	62.45	gold quality
vastus lateralis	UBERON:0001379	61.91	gold quality
myocardium	UBERON:0002349	61.61	gold quality
apex of heart	UBERON:0002098	60.79	gold quality
cartilage tissue	UBERON:0002418	60.08	gold quality
cauda epididymis	UBERON:0004360	60.08	gold quality
mucosa of paranasal sinus	UBERON:0005030	58.29	gold quality
superficial temporal artery	UBERON:0001614	57.75	gold quality
heart left ventricle	UBERON:0002084	57.51	gold quality
cardiac ventricle	UBERON:0002082	57.32	gold quality
oocyte	CL:0000023	56.21	gold quality
right lobe of liver	UBERON:0001114	55.98	gold quality
parotid gland	UBERON:0001831	55.37	gold quality
epithelial cell of pancreas	CL:0000083	55.23	gold quality
heart right ventricle	UBERON:0002080	55.01	gold quality
corpus epididymis	UBERON:0004359	54.72	gold quality
endothelial cell	CL:0000115	54.46	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	4267.27
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

21 targeting C10orf62, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-3913-3P	99.74	66.53	938
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-6740-3P	99.48	68.49	1392
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-4742-5P	98.89	68.41	1542
HSA-MIR-6784-3P	98.39	64.88	662
HSA-MIR-6862-3P	97.92	64.86	531
HSA-MIR-8057	97.64	66.54	897
HSA-MIR-6849-3P	97.25	64.57	1371
HSA-MIR-874-5P	96.93	63.92	1014
HSA-MIR-3194-5P	96.80	64.90	1027
HSA-MIR-6858-3P	96.37	64.41	771
HSA-MIR-6815-5P	96.05	65.55	662
HSA-MIR-6865-5P	96.05	65.58	675

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	4933411K16Rik	ENSMUSG00000090369
rattus_norvegicus	MGC93861	ENSRNOG00000069762

Protein

Protein identifiers

Uncharacterized protein C10orf62 — Q5T681 (reviewed: Q5T681)

All UniProt accessions (1): Q5T681

RefSeq proteins (1): NP_001009997* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR037649	C10orf62	Family

Pfam: PF17729

UniProt features (11 total): compositionally biased region 5, region of interest 3, chain 1, sequence variant 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T681-F1	61.32	0.01

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 43

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 12 (showing top): MIR6740_3P, MIR4673, MIR3194_5P, GSE13306_RA_VS_UNTREATED_TREG_UP, GSE14026_TH1_VS_TH17_UP, GSE15324_ELF4_KO_VS_WT_NAIVE_CD8_TCELL_DN, GSE26928_EFF_MEMORY_VS_CXCR5_POS_CD4_TCELL_UP, chr10q24, GSE16450_CTRL_VS_IFNA_12H_STIM_MATURE_NEURON_CELL_LINE_UP, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY5_POST_POLARIZATION_UP, GSE34156_NOD2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_UP, GSE41176_UNSTIM_VS_ANTI_IGM_STIM_TAK1_KO_BCELL_3H_UP

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

762 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
C10orf62	CFAP141	Q5VU69	651
C10orf62	OR5M3	Q8NGP4	604
C10orf62	ZNF285	Q96NJ3	583
C10orf62	XAGE5	Q8WWM1	576
C10orf62	ARMCX6	Q7L4S7	574
C10orf62	DRG1	Q9Y295	479
C10orf62	TRAPPC6B	Q86SZ2	470
C10orf62	SLC12A9	Q9BXP2	450
C10orf62	PASK	Q96RG2	450
C10orf62	REC114	Q7Z4M0	446
C10orf62	NIBAN3	Q86XR2	433
C10orf62	ARHGAP11B	Q3KRB8	398
C10orf62	CDK17	Q00537	371
C10orf62	CST1	P01037	370
C10orf62	RNF185	Q96GF1	370

IntAct

39 interactions, top by confidence:

A	B	Type	Score
C10orf62	MDFI	psi-mi:“MI:0915”(physical association)	0.820
MDFI	C10orf62	psi-mi:“MI:0915”(physical association)	0.820
FXR2	C10orf62	psi-mi:“MI:0915”(physical association)	0.670
C10orf62	FXR2	psi-mi:“MI:0915”(physical association)	0.670
	C10orf62	psi-mi:“MI:0915”(physical association)	0.560
KRTAP5-9	C10orf62	psi-mi:“MI:0915”(physical association)	0.560
C10orf62	KRTAP10-9	psi-mi:“MI:0915”(physical association)	0.560
C10orf62	KRT40	psi-mi:“MI:0915”(physical association)	0.560
C10orf62		psi-mi:“MI:0915”(physical association)	0.560
C10orf62	KRTAP5-9	psi-mi:“MI:0915”(physical association)	0.560
KRT40	C10orf62	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-9	C10orf62	psi-mi:“MI:0915”(physical association)	0.560
TRAF3	C10orf62	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	C10orf62	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-1	C10orf62	psi-mi:“MI:0915”(physical association)	0.560
C10orf62	PFDN5	psi-mi:“MI:0915”(physical association)	0.560
C10orf62	KRTAP4-12	psi-mi:“MI:0915”(physical association)	0.370
C10orf62	PLSCR1	psi-mi:“MI:0915”(physical association)	0.370
FAM50A	C10orf62	psi-mi:“MI:0914”(association)	0.350

BioGRID (18): C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Two-hybrid), C10orf62 (Affinity Capture-MS)

ESM2 similar proteins: A0A023PZB3, A0A0D1C8C8, A0A182BSS2, A6ZT44, A6ZTA1, B3P309, B8QCG6, F2Z472, K9N4Q4, P04812, P0CA75, P0CJ15, P0CV29, P0DMD1, P0DQF2, P19815, P21739, P23498, P28549, P32772, P34646, P38839, P38881, P39035, P80195, P92528, Q02596, Q03556, Q04807, Q07967, Q09221, Q09953, Q23262, Q3SZQ3, Q4V7B4, Q4VKV7, Q59Y11, Q5H7N6, Q5T681, Q5UP16

Diamond homologs: Q5T681, Q6AYN3, Q80Y39

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

197 predictions. Top by Δscore:

Variant	Effect	Δscore
10:97590629:G:GT	donor_gain	0.6900
10:97590661:ATG:A	acceptor_gain	0.6900
10:97590662:T:TA	acceptor_gain	0.6800
10:97590874:C:T	donor_gain	0.6800
10:97590661:AT:A	acceptor_gain	0.6700
10:97590681:CAGGG:C	donor_loss	0.6700
10:97590684:GGTGA:G	donor_loss	0.6700
10:97590685:G:GA	donor_loss	0.6700
10:97590686:T:A	donor_loss	0.6700
10:97590683:GG:G	donor_gain	0.6600
10:97590684:GG:G	donor_gain	0.6600
10:97590414:G:GT	donor_gain	0.6500
10:97590418:T:TA	donor_gain	0.6500
10:97590419:A:AA	donor_gain	0.6500
10:97590662:T:G	acceptor_gain	0.6500
10:97590663:G:A	acceptor_gain	0.6500
10:97590687:G:GT	donor_loss	0.6400
10:97590256:A:G	donor_gain	0.6200
10:97590625:C:T	donor_gain	0.6200
10:97590630:C:T	donor_gain	0.6200
10:97590685:G:GG	donor_gain	0.6100
10:97590647:C:A	donor_gain	0.6000
10:97590689:G:C	donor_loss	0.5800
10:97590644:C:G	donor_gain	0.5700
10:97590689:G:GT	donor_gain	0.5600
10:97590688:A:G	donor_loss	0.5500
10:97590365:TCACC:T	donor_gain	0.5400
10:97590585:G:GT	donor_gain	0.5400
10:97590754:T:G	acceptor_gain	0.5400
10:97590504:A:AG	acceptor_gain	0.5300

AlphaMissense

1489 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:97590012:T:C	F39L	0.989
10:97590014:T:A	F39L	0.989
10:97590014:T:G	F39L	0.989
10:97590013:T:C	F39S	0.979
10:97589997:T:A	W34R	0.974
10:97589997:T:C	W34R	0.974
10:97590001:T:C	I35T	0.973
10:97589999:G:C	W34C	0.971
10:97589999:G:T	W34C	0.971
10:97590015:A:C	S40R	0.965
10:97590017:C:A	S40R	0.965
10:97590017:C:G	S40R	0.965
10:97590309:G:T	G138W	0.965
10:97590430:T:C	L178P	0.962
10:97590009:C:G	H38D	0.961
10:97590001:T:G	I35S	0.956
10:97590309:G:A	G138R	0.956
10:97590309:G:C	G138R	0.956
10:97590319:T:C	L141P	0.955
10:97590005:A:C	K36N	0.953
10:97590005:A:T	K36N	0.953
10:97590011:C:A	H38Q	0.949
10:97590011:C:G	H38Q	0.949
10:97590321:G:C	A142P	0.948
10:97590013:T:G	F39C	0.947
10:97590400:T:C	L168P	0.947
10:97590409:T:C	L171P	0.943
10:97590269:G:C	W124C	0.940
10:97590269:G:T	W124C	0.940
10:97590322:C:A	A142D	0.933

dbSNP variants (sampled 300 via entrez): RS1000194610 (10:97591148 T>A), RS1002456222 (10:97588546 T>C), RS1003075808 (10:97588983 G>GC), RS1005180264 (10:97590869 G>T), RS1005276865 (10:97590641 A>G), RS1007084345 (10:97591137 C>T), RS1007142595 (10:97590931 T>A,C), RS1007524706 (10:97589544 G>T), RS1007575292 (10:97589236 T>A), RS1008582700 (10:97588059 G>A), RS1008930676 (10:97588195 CTTTCTTTTTT>C), RS1012482351 (10:97590302 C>A), RS1012895434 (10:97590306 CA>C), RS1013488475 (10:97588864 G>A), RS1015537354 (10:97588875 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Antirheumatic Agents	increases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.