C10orf95

Summary

C10orf95 (chromosome 10 open reading frame 95, HGNC:25880) is a protein-coding gene on chromosome 10q24.32, encoding Uncharacterized protein C10orf95 (Q9H7T3).

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 3 total
• MANE Select transcript: NM_001363580

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25880
Approved symbol	C10orf95
Name	chromosome 10 open reading frame 95
Location	10q24.32
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14280
Ensembl gene	ENSG00000120055
Ensembl biotype	protein_coding
Entrez	79946

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000625129

RefSeq mRNA: 1 — MANE Select: NM_001363580 NM_001363580

CCDS: CCDS91337

Canonical transcript exons

ENST00000625129 — 2 exons

Exon	Start	End
ENSE00003755842	102449837	102451147
ENSE00003760058	102451386	102451543

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 91.75.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8372 / max 57.8031, expressed in 338 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111173	0.3417	193
111174	0.2625	160
111175	0.1580	84
111172	0.0644	22
111171	0.0105	2

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	91.75	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.29	gold quality
cerebellar vermis	UBERON:0004720	79.38	silver quality
nasal cavity epithelium	UBERON:0005384	78.73	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.05	silver quality
secondary oocyte	CL:0000655	77.24	gold quality
nasal cavity mucosa	UBERON:0001826	76.49	gold quality
vena cava	UBERON:0004087	76.49	gold quality
epithelium of bronchus	UBERON:0002031	76.05	gold quality
bronchus	UBERON:0002185	75.94	gold quality
oocyte	CL:0000023	74.72	gold quality
gluteal muscle	UBERON:0002000	74.53	gold quality
bronchial epithelial cell	CL:0002328	73.74	gold quality
gingival epithelium	UBERON:0001949	73.72	gold quality
triceps brachii	UBERON:0001509	73.35	gold quality
oviduct epithelium	UBERON:0004804	72.83	silver quality
type B pancreatic cell	CL:0000169	72.06	gold quality
olfactory bulb	UBERON:0002264	72.01	gold quality
body of tongue	UBERON:0011876	71.79	gold quality
cardia of stomach	UBERON:0001162	71.69	gold quality
corpus epididymis	UBERON:0004359	71.54	silver quality
nipple	UBERON:0002030	71.46	gold quality
fallopian tube	UBERON:0003889	71.30	gold quality
tongue	UBERON:0001723	71.02	gold quality
parotid gland	UBERON:0001831	70.96	gold quality
ventral tegmental area	UBERON:0002691	70.86	gold quality
epithelium of nasopharynx	UBERON:0001951	70.83	gold quality
gingiva	UBERON:0001828	70.74	gold quality
mucosa of paranasal sinus	UBERON:0005030	70.59	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	70.48	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.13
E-MTAB-5061	yes	5.77

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

15 targeting C10orf95, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-7150	99.62	66.80	1322
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-4437	99.52	65.29	1266
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-4786-3P	99.36	68.35	1390
HSA-MIR-583	98.71	67.44	1791
HSA-MIR-6873-5P	98.45	66.14	1417
HSA-MIR-3135A	96.41	65.30	494
HSA-MIR-6786-5P	89.01	59.75	103

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	2310034G01Rik	ENSMUSG00000099655
rattus_norvegicus	C1h10orf95	ENSRNOG00000066499

Protein

Protein identifiers

Uncharacterized protein C10orf95 — Q9H7T3 (reviewed: Q9H7T3)

All UniProt accessions (1): A0A1B0GTG0

RefSeq proteins (1): NP_001350509* (*=MANE)

Domains & families (InterPro)

UniProt features (7 total): compositionally biased region 4, region of interest 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H7T3-F1	53.98	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 34 (showing top): MARTENS_TRETINOIN_RESPONSE_DN, PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, STK33_DN, STK33_NOMO_DN, STK33_SKM_DN, SUPT16H_TARGET_GENES, ZFP3_TARGET_GENES, ZNF563_TARGET_GENES, MIR6873_5P, BLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_INFECTION_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_THYMIC_STROMAL_CELL_UP, DESCARTES_MAIN_FETAL_CILIATED_EPITHELIAL_CELLS, DESCARTES_FETAL_LUNG_CILIATED_EPITHELIAL_CELLS, TRAVAGLINI_LUNG_CILIATED_CELL

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

4 interactions, top by confidence:

A	B	Type	Score
C10orf95	NUS1	psi-mi:“MI:0915”(physical association)	0.400
NUS1	C10orf95	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): C10orf95 (Affinity Capture-RNA)

ESM2 similar proteins: A0A172M490, A2WPU3, A6NEL3, B2GHI7, D5SGZ8, P02338, P03291, P04016, P0C8M9, P0CV93, P11294, P12913, P12914, P14310, P16759, P23251, P25307, P25315, P25316, P25572, P25825, P25908, P27898, P36297, P52167, P57672, P59978, P75320, P75602, P9WKM4, P9WKM5, Q01900, Q06261, Q08600, Q0JMV4, Q12639, Q13536, Q28470, Q2KIH8, Q52282

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1329 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000311109 (10:102450330 G>A,C), RS1001039711 (10:102451346 C>A,T), RS1001606031 (10:102450249 C>G,T), RS1001645490 (10:102449948 T>C), RS1001824160 (10:102449474 C>G), RS1001876584 (10:102449908 C>A,T), RS1002540914 (10:102452120 C>G,T), RS1003483904 (10:102453099 A>C), RS1003862213 (10:102453414 C>G,T), RS1005352172 (10:102453476 G>A,T), RS1007445497 (10:102451073 C>T), RS1008448855 (10:102449490 G>A), RS1009112424 (10:102450226 C>T), RS1010309009 (10:102449557 T>C), RS1010335129 (10:102450647 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST001942_1	Prostate cancer	5.000000e-10
GCST005038_102	Allergic disease (asthma, hay fever or eczema)	2.000000e-08
GCST005956_50	Waist-to-hip ratio adjusted for BMI	8.000000e-06
GCST005958_15	Waist-to-hip ratio adjusted for BMI (age >50)	4.000000e-06
GCST005962_36	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	6.000000e-07

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
licochalcone B	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Vorinostat	affects cotreatment, decreases expression	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Cisplatin	affects cotreatment, increases expression	1
Diazinon	increases methylation	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression	1
Silicon Dioxide	decreases expression	1
Smoke	decreases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	increases methylation	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.