C11orf91

Summary

C11orf91 (chromosome 11 open reading frame 91, HGNC:34444) is a protein-coding gene on chromosome 11p13, encoding Uncharacterized protein C11orf91 (Q3C1V1).

At a glance

• Clinical variants (ClinVar): 5 total
• MANE Select transcript: NM_001166692

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34444
Approved symbol	C11orf91
Name	chromosome 11 open reading frame 91
Location	11p13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000205177
Ensembl biotype	protein_coding
Entrez	100131378

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000379011, ENST00000531145

RefSeq mRNA: 1 — MANE Select: NM_001166692 NM_001166692

CCDS: CCDS53615

Canonical transcript exons

ENST00000379011 — 2 exons

Exon	Start	End
ENSE00002156713	33700245	33700826
ENSE00003619391	33698261	33698514

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 85.63.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0871 / max 8.5706, expressed in 24 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119203	0.0776	19
119204	0.0094	4

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.63	silver quality
lower esophagus mucosa	UBERON:0035834	77.49	gold quality
left testis	UBERON:0004533	74.39	gold quality
esophagus mucosa	UBERON:0002469	73.77	gold quality
testis	UBERON:0000473	73.69	gold quality
right testis	UBERON:0004534	73.61	gold quality
upper lobe of left lung	UBERON:0008952	70.85	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.05	gold quality
metanephros cortex	UBERON:0010533	69.01	gold quality
right lung	UBERON:0002167	68.89	gold quality
mucosa of stomach	UBERON:0001199	67.68	gold quality
minor salivary gland	UBERON:0001830	66.74	gold quality
omental fat pad	UBERON:0010414	65.23	gold quality
esophagus	UBERON:0001043	64.50	gold quality
gastrocnemius	UBERON:0001388	64.31	gold quality
saliva-secreting gland	UBERON:0001044	63.73	gold quality
adipose tissue	UBERON:0001013	63.20	gold quality
body of stomach	UBERON:0001161	63.15	gold quality
heart left ventricle	UBERON:0002084	62.72	gold quality
thoracic mammary gland	UBERON:0005200	62.11	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.77	gold quality
vagina	UBERON:0000996	61.51	gold quality
left uterine tube	UBERON:0001303	61.51	gold quality
muscle of leg	UBERON:0001383	61.35	gold quality
apex of heart	UBERON:0002098	60.62	gold quality
lung	UBERON:0002048	59.45	gold quality
skin of leg	UBERON:0001511	59.19	gold quality
right coronary artery	UBERON:0001625	59.13	gold quality
skin of abdomen	UBERON:0001416	59.12	gold quality
stomach	UBERON:0000945	59.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

23 targeting C11orf91, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-549A-3P	99.54	68.17	825
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-297	99.40	69.58	1418
HSA-MIR-5580-5P	99.38	66.96	1139
HSA-MIR-133A-5P	99.28	69.13	941
HSA-MIR-642A-3P	99.23	67.67	1258
HSA-MIR-642B-3P	99.23	67.67	1258
HSA-MIR-6797-3P	99.17	66.94	668
HSA-MIR-6076	98.61	65.69	637
HSA-MIR-4536-5P	98.47	64.39	657
HSA-MIR-4773	98.35	67.30	1710
HSA-MIR-5585-5P	97.95	68.80	1024
HSA-MIR-4305	97.94	68.63	533
HSA-MIR-1302	97.92	67.27	844
HSA-MIR-4298	97.26	66.59	765
HSA-MIR-591	96.29	68.16	611

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	A930018P22Rik	ENSMUSG00000032671
rattus_norvegicus	C3h11orf91	ENSRNOG00000010963

Protein

Protein identifiers

Uncharacterized protein C11orf91 — Q3C1V1 (reviewed: Q3C1V1)

All UniProt accessions (2): Q3C1V1, H0YDE1

Isoforms (2)

UniProt ID	Names	Canonical?
Q3C1V1-1	1	yes
Q3C1V1-2	2

RefSeq proteins (1): NP_001160164* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR040027	C11orf91-like	Family

Pfam: PF17669

UniProt features (7 total): sequence conflict 3, chain 1, region of interest 1, compositionally biased region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q3C1V1-F1	66.12	0.15

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 30 (showing top): MARTENS_TRETINOIN_RESPONSE_DN, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, HHEX_TARGET_GENES, RBM34_TARGET_GENES, UBN1_TARGET_GENES, MIR203A_3P, MIR4773, MIR133A_5P, MIR6758_5P, MIR6856_5P, BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_UP, BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_RUXOLITINIB_UP, GSE15324_ELF4_KO_VS_WT_NAIVE_CD8_TCELL_UP, GSE17721_CTRL_VS_CPG_0.5H_BMDC_DN, GSE17721_LPS_VS_POLYIC_24H_BMDC_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

116 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
C11orf91	FBXO3	Q9UK99	604
C11orf91	TCP11L1	Q9NUJ3	507
C11orf91	OR13C5	Q8NGS8	507
C11orf91	CCDC73	Q6ZRK6	447
C11orf91	KIAA1549L	Q6ZVL6	446
C11orf91	IFTAP	Q86VG3	434
C11orf91	DEPDC7	Q96QD5	418
C11orf91	QSER1	Q2KHR3	415
C11orf91	COMMD9	Q9P000	400
C11orf91	ABTB2	Q8N961	399
C11orf91	ARL14EP	Q8N8R7	397
C11orf91	IMMP1L	Q96LU5	395
C11orf91	SEC31B	Q9NQW1	380
C11orf91	DNAJC24	Q6P3W2	370
C11orf91	DCDC1	P59894	368

IntAct

0 interactions, top by confidence:

BioGRID (1): C11orf91 (Synthetic Lethality)

ESM2 similar proteins: A0A1B0GTI1, A7X8B3, A7X8B5, A7X8B7, A7X8B9, A7X8C2, A7X8C4, A7X8C7, A7X8C9, A7X8D2, A7X8D4, A7XW16, A7XW20, A7XW25, A8WFF7, O15054, O43151, O55087, P03186, P03234, P03333, P06186, P06401, P0C674, P0C675, P17473, P28925, P46695, Q00175, Q3C1V1, Q3KSP9, Q5NCY0, Q63449, Q66619, Q66HC8, Q6S6U0, Q6VUC0, Q7YR42, Q80WJ1, Q86UU5

Diamond homologs: A8WFF7, Q3C1V1, Q9D1Z2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

5 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	4
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

387 predictions. Top by Δscore:

Variant	Effect	Δscore
11:33698510:TGTGT:T	acceptor_gain	1.0000
11:33700244:CAGCT:C	donor_gain	1.0000
11:33700614:T:TA	donor_gain	1.0000
11:33698511:GTGT:G	acceptor_gain	0.9900
11:33698512:TGT:T	acceptor_gain	0.9900
11:33698513:GT:G	acceptor_gain	0.9900
11:33698514:TCT:T	acceptor_loss	0.9900
11:33698515:C:CA	acceptor_loss	0.9900
11:33698515:C:CC	acceptor_gain	0.9900
11:33700243:A:AC	donor_gain	0.9900
11:33700244:C:CC	donor_gain	0.9900
11:33700244:CAG:C	donor_gain	0.9900
11:33700265:T:TA	donor_gain	0.9900
11:33700266:C:A	donor_gain	0.9900
11:33700611:T:TA	donor_gain	0.9900
11:33698518:C:CT	acceptor_gain	0.9800
11:33700593:T:TA	donor_gain	0.9800
11:33700297:AAT:A	donor_gain	0.9700
11:33698519:A:T	acceptor_gain	0.9600
11:33700243:ACAG:A	donor_gain	0.9600
11:33700244:CAGC:C	donor_gain	0.9600
11:33700246:G:C	donor_gain	0.9600
11:33700615:C:A	donor_gain	0.9600
11:33700241:GCA:G	donor_loss	0.9400
11:33700242:CACAG:C	donor_loss	0.9400
11:33700243:A:AG	donor_loss	0.9400
11:33700244:CA:C	donor_gain	0.9400
11:33700287:C:CA	donor_gain	0.9400
11:33700589:G:A	donor_gain	0.9400
11:33700134:C:CT	donor_gain	0.9300

AlphaMissense

1209 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:33700294:C:A	K149N	0.994
11:33700294:C:G	K149N	0.994
11:33700283:A:G	L153S	0.993
11:33700617:A:G	W42R	0.993
11:33700617:A:T	W42R	0.993
11:33700615:C:A	W42C	0.991
11:33700615:C:G	W42C	0.991
11:33700672:G:C	F23L	0.991
11:33700672:G:T	F23L	0.991
11:33700674:A:G	F23L	0.991
11:33700417:G:C	F108L	0.987
11:33700417:G:T	F108L	0.987
11:33700419:A:G	F108L	0.987
11:33700673:A:G	F23S	0.986
11:33700289:A:G	L151P	0.985
11:33700304:A:G	I146T	0.982
11:33700258:G:C	F161L	0.981
11:33700258:G:T	F161L	0.981
11:33700260:A:G	F161L	0.981
11:33700301:C:G	R147P	0.980
11:33700673:A:C	F23C	0.980
11:33700310:A:G	L144P	0.978
11:33698492:T:A	K173N	0.975
11:33698492:T:G	K173N	0.975
11:33700304:A:C	I146S	0.973
11:33700603:G:C	F46L	0.973
11:33700603:G:T	F46L	0.973
11:33700605:A:G	F46L	0.973
11:33700616:C:G	W42S	0.973
11:33700274:A:G	I156T	0.971

dbSNP variants (sampled 300 via entrez): RS1000323866 (11:33699489 T>C), RS1000340633 (11:33703574 G>A), RS1000660125 (11:33697998 C>A), RS1000793588 (11:33705069 T>C), RS1000904572 (11:33699411 A>C,G), RS1000917536 (11:33703873 G>A,C,T), RS1001305860 (11:33704072 C>G,T), RS1002135019 (11:33704538 A>G), RS1002206682 (11:33698777 T>C), RS1002358554 (11:33704695 G>A), RS1002404576 (11:33699014 T>C), RS1002696609 (11:33698711 C>G,T), RS1002798975 (11:33708185 T>A,C), RS1002899056 (11:33701837 C>G,T), RS1003031182 (11:33707543 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

10 total (human), top 10 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
propionaldehyde	increases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Resveratrol	decreases expression	1
Allergens	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	decreases expression, affects cotreatment	1
Smoke	increases expression	1
Tobacco Smoke Pollution	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.