C1QTNF1-AS1

Summary

C1QTNF1-AS1 (C1QTNF1 antisense RNA 1, HGNC:44351) is a long non-coding RNA gene on chromosome 17q25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44351
Approved symbol	C1QTNF1-AS1
Name	C1QTNF1 antisense RNA 1
Location	17q25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000265096
Ensembl biotype	lncRNA
Entrez	100507410
RNAcentral	URS000075D5C6 — lncRNA, 970 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000577521, ENST00000581579, ENST00000685228, ENST00000826454, ENST00000826455, ENST00000826456, ENST00000826457

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577521 — 3 exons

Exon	Start	End
ENSE00002685230	79027376	79027655
ENSE00002718556	79019592	79019616
ENSE00002732789	79019959	79020236

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 90.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3006 / max 21.1521, expressed in 131 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
168537	0.1388	67
168536	0.1105	54
168538	0.0513	22

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	90.19	gold quality
left ventricle myocardium	UBERON:0006566	88.85	gold quality
right adrenal gland	UBERON:0001233	85.84	gold quality
right adrenal gland cortex	UBERON:0035827	85.70	gold quality
left adrenal gland	UBERON:0001234	85.58	gold quality
left adrenal gland cortex	UBERON:0035825	85.39	gold quality
adrenal cortex	UBERON:0001235	84.23	gold quality
adrenal gland	UBERON:0002369	83.28	gold quality
decidua	UBERON:0002450	78.70	gold quality
heart right ventricle	UBERON:0002080	77.56	silver quality
kidney epithelium	UBERON:0004819	76.79	gold quality
spleen	UBERON:0002106	75.59	gold quality
placenta	UBERON:0001987	75.06	gold quality
cardiac atrium	UBERON:0002081	72.55	gold quality
right atrium auricular region	UBERON:0006631	71.93	gold quality
nasal cavity epithelium	UBERON:0005384	70.87	gold quality
upper arm skin	UBERON:0004263	70.64	gold quality
apex of heart	UBERON:0002098	69.69	gold quality
heart left ventricle	UBERON:0002084	69.31	gold quality
adrenal tissue	UBERON:0018303	69.31	gold quality
cardiac ventricle	UBERON:0002082	69.29	gold quality
heart	UBERON:0000948	69.15	gold quality
sperm	CL:0000019	66.74	gold quality
epithelial cell of pancreas	CL:0000083	66.07	gold quality
pancreatic ductal cell	CL:0002079	65.01	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.69	gold quality
tibia	UBERON:0000979	64.52	silver quality
parotid gland	UBERON:0001831	63.42	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	63.34	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Overexpression of C1QTNF1-AS1 down-regulated miR-221-3p and subsequently up-regulated SOCS3, thereby inhibiting hepatocellular carcinoma cell proliferation, migration and invasion and promoting apoptosis through the JAK/STAT signaling pathway. (PMID:31069760)
• Overexpression of C1QTNF1-AS1 could downregulate miR-221-3p thereby inhibited the proliferation, migration and invasion of hepatocellular carcinoma cells. (PMID:31222560)
• C1QTNF1-AS1 regulates the occurrence and development of hepatocellular carcinoma by regulating miR-221-3p/SOCS3. (PMID:33566260)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.