C1QTNF1

Summary

C1QTNF1 (C1q and TNF related 1, HGNC:14324) is a protein-coding gene on chromosome 17q25.3, encoding Complement C1q tumor necrosis factor-related protein 1 (Q9BXJ1).

Enables collagen binding activity. Involved in several processes, including negative regulation of platelet aggregation; positive regulation of aldosterone secretion; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space and plasma membrane.

Source: NCBI Gene 114897 — RefSeq curated summary.

At a glance

• GWAS associations: 16
• Clinical variants (ClinVar): 82 total
• MANE Select transcript: NM_030968

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14324
Approved symbol	C1QTNF1
Name	C1q and TNF related 1
Location	17q25.3
Locus type	gene with protein product
Status	Approved
Aliases	CTRP1, ZSIG37, GIP, FLJ90694
Ensembl gene	ENSG00000173918
Ensembl biotype	protein_coding
OMIM	610365
Entrez	114897

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 30 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000311661, ENST00000339142, ENST00000354124, ENST00000392445, ENST00000578229, ENST00000579760, ENST00000580454, ENST00000580474, ENST00000581774, ENST00000582295, ENST00000582625, ENST00000583904, ENST00000885300, ENST00000885301, ENST00000885302, ENST00000885303, ENST00000885304, ENST00000885305, ENST00000885306, ENST00000885307, ENST00000885308, ENST00000951174, ENST00000951175, ENST00000951176, ENST00000951177, ENST00000951178, ENST00000951179, ENST00000951180, ENST00000951181, ENST00000951182, ENST00000951183, ENST00000951184

RefSeq mRNA: 4 — MANE Select: NM_030968 NM_030968, NM_153372, NM_198593, NM_198594

CCDS: CCDS11761, CCDS11762

Canonical transcript exons

ENST00000579760 — 4 exons

Exon	Start	End
ENSE00001511972	79024169	79024494
ENSE00001552012	79047538	79049788
ENSE00003610222	79046555	79046694
ENSE00003715766	79043955	79044123

Expression profiles

Bgee: expression breadth ubiquitous, 219 present calls, max score 99.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.2663 / max 626.7269, expressed in 1280 samples.

FANTOM5 promoters (19 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163154	10.4295	1120
163152	3.2902	709
163157	3.1337	957
163155	1.3776	494
163156	0.9788	468
163151	0.7136	326
163160	0.6800	337
163149	0.3156	71
163159	0.2795	171
163153	0.2612	127

Top tissues by expression

272 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right coronary artery	UBERON:0001625	99.00	gold quality
popliteal artery	UBERON:0002250	98.94	gold quality
tibial artery	UBERON:0007610	98.94	gold quality
left coronary artery	UBERON:0001626	98.89	gold quality
right atrium auricular region	UBERON:0006631	98.68	gold quality
aorta	UBERON:0000947	98.53	gold quality
coronary artery	UBERON:0001621	98.52	gold quality
descending thoracic aorta	UBERON:0002345	98.52	gold quality
ascending aorta	UBERON:0001496	98.26	gold quality
thoracic aorta	UBERON:0001515	98.26	gold quality
cardiac atrium	UBERON:0002081	97.62	gold quality
omental fat pad	UBERON:0010414	97.61	gold quality
peritoneum	UBERON:0002358	97.53	gold quality
right lobe of thyroid gland	UBERON:0001119	97.46	gold quality
apex of heart	UBERON:0002098	97.06	gold quality
adipose tissue of abdominal region	UBERON:0007808	97.03	gold quality
left lobe of thyroid gland	UBERON:0001120	96.63	gold quality
left adrenal gland cortex	UBERON:0035825	95.82	gold quality
heart left ventricle	UBERON:0002084	95.77	gold quality
subcutaneous adipose tissue	UBERON:0002190	95.63	gold quality
left adrenal gland	UBERON:0001234	95.29	gold quality
cardiac ventricle	UBERON:0002082	95.26	gold quality
heart	UBERON:0000948	95.10	gold quality
left uterine tube	UBERON:0001303	94.55	gold quality
mucosa of stomach	UBERON:0001199	94.35	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	94.19	gold quality
thyroid gland	UBERON:0002046	94.15	gold quality
right adrenal gland	UBERON:0001233	94.03	gold quality
right ovary	UBERON:0002118	93.86	gold quality
adrenal cortex	UBERON:0001235	93.80	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-10596	yes	178.73
E-CURD-112	yes	15.13
E-ANND-3	yes	9.40

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

3 targets.

Target	Regulation
CYP11B2	Activation
NR4A1	Activation
NR4A2	Activation

miRNA regulators (miRDB)

61 targeting C1QTNF1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-10394-5P	99.65	66.83	1852
HSA-MIR-1205	99.65	66.76	1826
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-298	99.63	67.56	1916
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-409-3P	99.50	66.33	1192
HSA-MIR-4489	99.50	65.56	785
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-7109-5P	99.18	66.13	1057
HSA-MIR-4292	99.16	65.57	1767

Literature-anchored findings (GeneRIF, showing 32)

• molecular cloning, gene expression, and subcellular localization of GIP (PMID:12409230)
• The review describes the potential role of C1qTNF1 as an intracellular regulator of signal transduction (PMID:16386877)
• These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues. (PMID:16806199)
• CTRP1 enhances the production of aldosterone. CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. (PMID:18171693)
• CTRP1 may be considered a novel adipokine, providing an important framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. (PMID:18783346)
• CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. (PMID:23000311)
• CTRP1 is a novel adipokine associated with type 2 diabetes mellitus in humans. (PMID:24827430)
• The levels of circulating CTRP1 are associated with coronary artery disease in men. (PMID:24945145)
• Increased plasma CTRP1 was independently associated with type 2 diabetes. Profiling of plasma adipokines such as CTRP1 is particularly important to obtain a greater understanding of their contribution to the type 2 diabetic state. (PMID:24965225)
• The variation of plasma CTRP-1 and IL-6 concentrations may play an important role in reflecting the degree of inflammation in CHD and the severity of coronary arterial atherosclerosis. (PMID:25635749)
• the strong association of CTRP1 with insulin resistance in NAFLD (PMID:25767880)
• Increased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction. (PMID:27169633)
• CTRP1 has a role in linking dysregulation of lipid metabolism and inflammatory responses in macrophages (PMID:27175610)
• High serum CTRP1 level is associated with Type 2 diabetes mellitus. (PMID:28207876)
• In cultured endothelial cells, treatment of CTRP1 led to increased permeability to fluorescent-labelled dextran and apparent formation of paracellular holes as observed after disturbed flow exposure, which was evidently reduced in the presence of a CTRP1-specific neutralizing antibody. (PMID:28625919)
• CTRP1 may participate in the process of vasculitis and blood coagulation during the acute phase of Kawasaki Disease (PMID:29360808)
• A single bout of high-intensity interval exercise may stimulate CTRP1 and CTRP9 secretions in healthy men. (PMID:29953821)
• serum levels significantly elevated in both early-onset and late-onset pre-eclampsia (PMID:30103635)
• High serum CTRP1 levels are associated with coronary artery disease. (PMID:31081425)
• These findings suggest that CTRP1 potentially indicates poor prognosis in Glioblastoma (GBM) and promotes the progression of human GBM. (PMID:31183364)
• Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease. (PMID:31965030)
• Hypomethylation of C1q/tumor necrosis factor-related protein-1 promoter region in whole blood and risks for coronary artery aneurysms in Kawasaki disease. (PMID:32081468)
• Methylation of CpG sites in C1QTNF1 (C1q and tumor necrosis factor related protein 1) differs by gender in acute coronary syndrome in Han population: a case-control study. (PMID:32383048)
• C1q/tumor necrosis factor-related protein-1 attenuates microglia autophagy and inflammatory response by regulating the Akt/mTOR pathway. (PMID:32569781)
• CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus. (PMID:33060724)
• CTRP1 decreases ABCA1 expression and promotes lipid accumulation through the miR-424-5p/FoxO1 pathway in THP-1 macrophage-derived foam cells. (PMID:34288211)
• C1q Tumor Necrosis Factor-Related Protein 1: A Promising Therapeutic Target for Atherosclerosis. (PMID:34840267)
• Novel Adipokines CTRP1, CTRP9, and FGF21 in Pediatric Type 1 and Type 2 Diabetes: A Cross-Sectional Analysis. (PMID:35172300)
• C1q/TNF-related protein-1: Potential biomarker for early diagnosis of autism spectrum disorder. (PMID:35202556)
• CTRP1 prevents high fat diet-induced obesity and improves glucose homeostasis in obese and STZ-induced diabetic mice. (PMID:36195912)
• CTRP1: A novel player in cardiovascular and metabolic diseases. (PMID:36812667)
• The association between complement C1q tumour necrosis factor-related protein-1 (CTRP-1) level and metabolic syndrome. (PMID:37155309)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	c1qtnf1	ENSDARG00000088878
mus_musculus	C1qtnf1	ENSMUSG00000017446
rattus_norvegicus	C1qtnf1	ENSRNOG00000003259

Paralogs (23): C1QTNF3 (ENSG00000082196), COL19A1 (ENSG00000082293), PDCD7 (ENSG00000090470), COL10A1 (ENSG00000123500), C1QL1 (ENSG00000131094), C1QTNF6 (ENSG00000133466), C1QL2 (ENSG00000144119), COL8A1 (ENSG00000144810), C1QTNF2 (ENSG00000145861), C1QC (ENSG00000159189), C1QTNF7 (ENSG00000163145), C1QL3 (ENSG00000165985), COL8A2 (ENSG00000171812), C1QTNF4 (ENSG00000172247), C1QB (ENSG00000173369), C1QA (ENSG00000173372), ADIPOQ (ENSG00000181092), OTOL1 (ENSG00000182447), C1QTNF8 (ENSG00000184471), C1QL4 (ENSG00000186897), C1QTNF9B (ENSG00000205863), C1QTNF5 (ENSG00000223953), C1QTNF9 (ENSG00000240654)

Protein

Protein identifiers

Complement C1q tumor necrosis factor-related protein 1 — Q9BXJ1 (reviewed: Q9BXJ1)

Alternative names: G protein-coupled receptor-interacting protein

All UniProt accessions (2): Q9BXJ1, A0A0C4DFP7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BXJ1-1	1	yes
Q9BXJ1-2	2

RefSeq proteins (4): NP_112230, NP_699203, NP_940995, NP_940996 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001073	C1q_dom	Domain
IPR008160	Collagen	Repeat
IPR008983	Tumour_necrosis_fac-like_dom	Homologous_superfamily
IPR050392	Collagen/C1q_domain	Family

Pfam: PF00386, PF01391

UniProt features (12 total): domain 2, region of interest 2, compositionally biased region 2, signal peptide 1, chain 1, sequence variant 1, sequence conflict 1, glycosylation site 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BXJ1-F1	74.80	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 93

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 334 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, GOBP_MEMORY, GOBP_REGULATION_OF_CELL_ACTIVATION, REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS, GOBP_COGNITION, GOBP_BEHAVIOR, GOBP_REGULATION_OF_WOUND_HEALING, GOBP_REGULATION_OF_COAGULATION, GOCC_SECRETORY_GRANULE, GOCC_COLLAGEN_TRIMER, GOBP_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION, GOBP_ADULT_BEHAVIOR, GOBP_PLATELET_ACTIVATION, GOBP_INSULIN_SECRETION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

GO Biological Process (8): positive regulation of cytosolic calcium ion concentration (GO:0007204), negative regulation of platelet activation (GO:0010544), positive regulation of gene expression (GO:0010628), regulation of glucose metabolic process (GO:0010906), positive regulation of MAPK cascade (GO:0043410), positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897), negative regulation of platelet aggregation (GO:0090331), positive regulation of aldosterone secretion (GO:2000860)

GO Molecular Function (3): collagen binding (GO:0005518), identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (4): collagen trimer (GO:0005581), obsolete extracellular space (GO:0005615), plasma membrane (GO:0005886), extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
positive regulation of intracellular signal transduction	2
regulation of biological quality	1
regulation of platelet activation	1
platelet activation	1
negative regulation of blood coagulation	1
negative regulation of cell activation	1
gene expression	1
regulation of gene expression	1
positive regulation of macromolecule biosynthetic process	1
glucose metabolic process	1
regulation of carbohydrate metabolic process	1
regulation of small molecule metabolic process	1
MAPK cascade	1
regulation of MAPK cascade	1
phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
negative regulation of platelet activation	1
negative regulation of homotypic cell-cell adhesion	1
platelet aggregation	1
regulation of platelet aggregation	1
aldosterone secretion	1
positive regulation of mineralocorticoid secretion	1
regulation of aldosterone secretion	1
protein-containing complex binding	1
protein binding	1
binding	1
protein-containing complex	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

308 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
C1QTNF1	AVPR2	P30518	766
C1QTNF1	ERFE	Q4G0M1	624
C1QTNF1	C1QTNF12	Q5T7M4	541
C1QTNF1	TNF	P01375	528
C1QTNF1	C1QL1	O75973	490
C1QTNF1	C1QTNF6	Q9BXI9	475
C1QTNF1	C1QL3	Q5VWW1	466
C1QTNF1	C1QL4	Q86Z23	458
C1QTNF1	C1QL2	Q7Z5L3	455
C1QTNF1	SCRIB	Q14160	437
C1QTNF1	ARHGEF7	Q14155	429
C1QTNF1	ADIPOR1	Q96A54	322
C1QTNF1	PINLYP	A6NC86	308
C1QTNF1	GIT1	Q9Y2X7	305
C1QTNF1	NUTM2F	A1L443	290

IntAct

20 interactions, top by confidence:

A	B	Type	Score
C1QTNF1	SGTA	psi-mi:“MI:0915”(physical association)	0.670
SGTA	C1QTNF1	psi-mi:“MI:0915”(physical association)	0.670
PRPF31	C1QTNF1	psi-mi:“MI:0915”(physical association)	0.560
LNX1	C1QTNF1	psi-mi:“MI:0915”(physical association)	0.560
C1QTNF1	PRPF31	psi-mi:“MI:0915”(physical association)	0.560
C1QTNF1	LNX1	psi-mi:“MI:0915”(physical association)	0.560
CACNA1A	C1QTNF1	psi-mi:“MI:0915”(physical association)	0.370
C1QTNF1	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	C1QTNF1	psi-mi:“MI:0915”(physical association)	0.370
C1QTNF1	PLOD2	psi-mi:“MI:0914”(association)	0.350
ZNF75A	TPP2	psi-mi:“MI:0914”(association)	0.350
C1QTNF1	CALU	psi-mi:“MI:0914”(association)	0.350
C1QTNF1	UBQLN4	psi-mi:“MI:0915”(physical association)	0.000
UBQLN4	C1QTNF1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (53): C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Two-hybrid), C14orf119 (Two-hybrid), UBL5 (Two-hybrid), C1QTNF1 (Two-hybrid), C1QTNF1 (Reconstituted Complex)

ESM2 similar proteins: A1A5X5, A4IH36, D4AB34, O93449, O95150, O97605, O97626, P04088, P04924, P09529, P10600, P15203, P16047, P17125, P17491, P27093, P36939, P36940, P41047, P42917, P48023, P50591, P50592, P59694, P59695, P63306, P63307, P63308, Q04999, Q07258, Q5UBV8, Q5XIG2, Q6PGN1, Q80WL1, Q861W5, Q8BGU2, Q8BMF8, Q8IUK8, Q8K3Y7, Q8R2Z0

Diamond homologs: A0A060WQA3, A5PN28, A6NHN0, O75973, O88992, P02745, P02746, P02747, P14106, P25067, P25318, P31720, P31721, P31722, P83371, P98085, P98086, Q02105, Q05A80, Q2KIV9, Q2KIX7, Q3Y5Z3, Q4ZJM7, Q4ZJM9, Q5E9E3, Q5FVH0, Q5RJ80, Q5VWW1, Q60994, Q69DL0, Q6IMN6, Q7Z5L3, Q86Z23, Q8BVD7, Q8CFR0, Q8K479, Q8R066, Q9BXJ0, Q9BXJ1, Q9BXJ2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	74
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1896 predictions. Top by Δscore:

Variant	Effect	Δscore
17:48960881:CCTA:C	donor_loss	1.0000
17:48960882:CTA:C	donor_loss	1.0000
17:48960883:TAC:T	donor_loss	1.0000
17:48960884:ACC:A	donor_loss	1.0000
17:48960885:CCT:C	donor_loss	1.0000
17:48961722:CTCA:C	donor_loss	1.0000
17:48961723:TCACC:T	donor_loss	1.0000
17:48961724:CAC:C	donor_loss	1.0000
17:48961725:A:AC	donor_gain	1.0000
17:48961725:A:C	donor_loss	1.0000
17:48961726:C:CC	donor_gain	1.0000
17:48961726:CCT:C	donor_gain	1.0000
17:48961816:CCAG:C	acceptor_gain	1.0000
17:48961817:CAGC:C	acceptor_gain	1.0000
17:48961819:GC:G	acceptor_loss	1.0000
17:48961820:C:CC	acceptor_gain	1.0000
17:48964308:A:AC	donor_gain	1.0000
17:48964308:ACT:A	donor_gain	1.0000
17:48964309:C:CA	donor_gain	1.0000
17:48964309:CT:C	donor_gain	1.0000
17:48964309:CTC:C	donor_gain	1.0000
17:48967145:A:C	donor_loss	1.0000
17:48967146:C:CA	donor_loss	1.0000
17:48967254:C:CC	acceptor_gain	1.0000
17:48958726:G:C	acceptor_gain	0.9900
17:48958726:G:GC	acceptor_gain	0.9900
17:48960880:CCCTA:C	donor_loss	0.9900
17:48960983:GGGAG:G	acceptor_gain	0.9900
17:48960984:GGAG:G	acceptor_gain	0.9900
17:48960985:GAG:G	acceptor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000052875 (17:79029233 C>T), RS1000147926 (17:79034630 T>A), RS1000263656 (17:79033762 C>G), RS1000310947 (17:79040173 T>C), RS1000356766 (17:79049130 C>A), RS1000441905 (17:79043712 T>C), RS1000507572 (17:79032514 TG>T), RS1000518387 (17:79028027 C>T), RS1000600914 (17:79032313 G>A), RS1000794359 (17:79030606 T>C), RS1000834538 (17:79044303 G>T), RS1001055639 (17:79030388 C>T), RS1001057895 (17:79037861 G>A), RS1001084750 (17:79025501 A>G), RS1001185582 (17:79024598 G>A)

Disease associations

OMIM: gene MIM:610365 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

16 associations (top):

Study	Trait	p-value
GCST000998_5	Coronary heart disease	2.000000e-08
GCST004773_13	Type 2 diabetes	4.000000e-08
GCST005194_178	Coronary artery disease	6.000000e-09
GCST005196_219	Coronary artery disease	1.000000e-09
GCST005414_22	Type 2 diabetes	3.000000e-08
GCST007267_47	Systolic blood pressure	5.000000e-14
GCST007329_29	Automobile speeding propensity	3.000000e-08
GCST009523_61	Household income	2.000000e-08
GCST010661_10	Blood glucose levels	7.000000e-06
GCST010662_16	Systolic blood pressure	2.000000e-07
GCST011320_33	Type 2 diabetes or prostate cancer (pleiotropy)	3.000000e-09
GCST012226_797	Waist circumference adjusted for body mass index	1.000000e-08
GCST012227_342	Hip circumference adjusted for BMI	3.000000e-10
GCST90000025_597	Appendicular lean mass	9.000000e-15
GCST90002384_418	Hemoglobin	7.000000e-09
GCST90013406_159	Liver enzyme levels (alkaline phosphatase)	4.000000e-17

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0008579	risk-taking behaviour
EFO:0009695	household income
EFO:0004468	glucose measurement
EFO:0007789	BMI-adjusted waist circumference
EFO:0008039	BMI-adjusted hip circumference
EFO:0004980	appendicular lean mass
EFO:0004509	hemoglobin measurement
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	decreases expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
bisphenol F	affects cotreatment, increases expression	1
aminomethylphosphonic acid (AMPA)	increases expression	1
bisphenol A	affects cotreatment, increases expression	1
sulforaphane	decreases expression	1
sodium arsenite	decreases expression	1
tetrabromobisphenol A	increases expression	1
zinc chromate	increases abundance, increases expression	1
cupric chloride	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	decreases reaction, affects cotreatment, increases expression	1
chromium hexavalent ion	increases abundance, increases expression	1
pentabromodiphenyl ether	increases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
bisphenol AF	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Glyphosate	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Catechin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Endosulfan	decreases expression	1
Folic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.