C1RL-AS1

Summary

C1RL-AS1 (C1RL antisense RNA 1, HGNC:27461) is a long non-coding RNA gene on chromosome 12p13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27461
Approved symbol	C1RL-AS1
Name	C1RL antisense RNA 1
Location	12p13.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	MATL2963
Ensembl gene	ENSG00000205885
Ensembl biotype	lncRNA
Entrez	283314
RNAcentral	URS000075A17C — lncRNA, 5402 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000382215, ENST00000435921, ENST00000535078, ENST00000536679, ENST00000541775, ENST00000811124, ENST00000811125, ENST00000811126, ENST00000811127, ENST00000811128, ENST00000811129, ENST00000811130, ENST00000811131, ENST00000811132, ENST00000811133, ENST00000811134, ENST00000811135, ENST00000811136, ENST00000811137, ENST00000811138, ENST00000811139, ENST00000811140, ENST00000811141, ENST00000811142, ENST00000811143, ENST00000811144, ENST00000811145

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000382215 — 8 exons

Exon	Start	End
ENSE00001491245	7118899	7119026
ENSE00001538225	7115130	7115219
ENSE00001538227	7111025	7111606
ENSE00001538229	7110298	7110572
ENSE00001786748	7112007	7112064
ENSE00002217914	7120506	7121027
ENSE00003587048	7119500	7119553
ENSE00004208737	7108559	7108947

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 87.83.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.3524 / max 134.9520, expressed in 1441 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123894	3.6198	1242
123893	2.0825	947
123892	0.4376	230
123891	0.2125	103

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	87.83	gold quality
right lobe of liver	UBERON:0001114	87.64	gold quality
bone marrow cell	CL:0002092	86.47	gold quality
liver	UBERON:0002107	85.61	gold quality
spleen	UBERON:0002106	84.19	gold quality
bone marrow	UBERON:0002371	84.06	gold quality
vermiform appendix	UBERON:0001154	82.73	gold quality
sural nerve	UBERON:0015488	82.61	gold quality
tonsil	UBERON:0002372	82.55	gold quality
right ovary	UBERON:0002118	82.08	gold quality
lymph node	UBERON:0000029	81.94	gold quality
left ovary	UBERON:0002119	81.92	gold quality
blood	UBERON:0000178	81.68	gold quality
ovary	UBERON:0000992	81.42	gold quality
metanephros cortex	UBERON:0010533	81.40	gold quality
gall bladder	UBERON:0002110	80.73	gold quality
rectum	UBERON:0001052	80.02	gold quality
urinary bladder	UBERON:0001255	80.01	gold quality
myometrium	UBERON:0001296	80.00	gold quality
body of uterus	UBERON:0009853	79.95	gold quality
granulocyte	CL:0000094	79.78	gold quality
endocervix	UBERON:0000458	79.70	gold quality
small intestine	UBERON:0002108	79.60	gold quality
small intestine Peyer’s patch	UBERON:0003454	79.55	gold quality
body of pancreas	UBERON:0001150	79.17	gold quality
cortex of kidney	UBERON:0001225	79.00	gold quality
uterine cervix	UBERON:0000002	78.85	gold quality
mucosa of stomach	UBERON:0001199	78.79	gold quality
smooth muscle tissue	UBERON:0001135	78.75	gold quality
tibial nerve	UBERON:0001323	78.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Association of Long Non-coding RNA C1RL-AS1 and PTPN6 Gene Polymorphisms with Ocular Behcet’s Disease in Han Chinese. (PMID:36745681)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.