C21orf91-OT1

Summary

C21orf91-OT1 (C21orf91 overlapping transcript 1, HGNC:16729) is a long non-coding RNA gene on chromosome 21q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16729
Approved symbol	C21orf91-OT1
Name	C21orf91 overlapping transcript 1
Location	21q21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	D21S2089E
Ensembl gene	ENSG00000240770
Ensembl biotype	lncRNA
Entrez	246312
RNAcentral	URS000075C022 — lncRNA, 453 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000430401, ENST00000430815, ENST00000439392, ENST00000814176

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430401 — 3 exons

Exon	Start	End
ENSE00001635146	17792477	17792509
ENSE00001664132	17777404	17777619
ENSE00001717057	17787028	17787210

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 81.52.

Top tissues by expression

210 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.52	gold quality
monocyte	CL:0000576	61.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.35	gold quality
vermiform appendix	UBERON:0001154	56.19	gold quality
granulocyte	CL:0000094	54.86	gold quality
blood	UBERON:0000178	53.65	gold quality
rectum	UBERON:0001052	52.06	gold quality
upper leg skin	UBERON:0004262	51.41	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	50.28	silver quality
prefrontal cortex	UBERON:0000451	49.93	gold quality
right adrenal gland	UBERON:0001233	49.72	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	49.65	gold quality
right lobe of liver	UBERON:0001114	49.62	gold quality
islet of Langerhans	UBERON:0000006	49.54	gold quality
lymph node	UBERON:0000029	49.38	gold quality
ectocervix	UBERON:0012249	49.10	gold quality
caecum	UBERON:0001153	48.61	gold quality
left testis	UBERON:0004533	48.60	gold quality
spinal cord	UBERON:0002240	48.51	gold quality
calcaneal tendon	UBERON:0003701	48.51	silver quality
smooth muscle tissue	UBERON:0001135	48.43	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.94	gold quality
testis	UBERON:0000473	47.87	gold quality
corpus callosum	UBERON:0002336	47.36	gold quality
right lung	UBERON:0002167	47.30	gold quality
gastrocnemius	UBERON:0001388	47.27	silver quality
endocervix	UBERON:0000458	47.00	gold quality
right testis	UBERON:0004534	46.84	gold quality
tibial artery	UBERON:0007610	46.78	gold quality
upper lobe of left lung	UBERON:0008952	46.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.90

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.