C2CD4D-AS1

Summary

C2CD4D-AS1 (C2CD4D and THEM5 antisense RNA 1, HGNC:54045) is a long non-coding RNA gene on chromosome 1q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54045
Approved symbol	C2CD4D-AS1
Name	C2CD4D and THEM5 antisense RNA 1
Location	1q21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234614
Ensembl biotype	lncRNA
Entrez	100132111
RNAcentral	URS0000CCDFFE — lncRNA, 2253 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000434182

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434182 — 3 exons

Exon	Start	End
ENSE00001652198	151841877	151842031
ENSE00001762340	151850233	151851549
ENSE00001779391	151844045	151844242

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 94.90.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9868 / max 65.1472, expressed in 213 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5252	0.8028	127
5256	0.1840	98

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.90	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.20	gold quality
colonic epithelium	UBERON:0000397	80.58	gold quality
pituitary gland	UBERON:0000007	79.69	gold quality
skin of leg	UBERON:0001511	79.22	gold quality
gall bladder	UBERON:0002110	78.71	gold quality
adenohypophysis	UBERON:0002196	78.64	gold quality
lymph node	UBERON:0000029	78.62	gold quality
skin of abdomen	UBERON:0001416	78.58	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.10	gold quality
right frontal lobe	UBERON:0002810	77.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.34	gold quality
spinal cord	UBERON:0002240	77.20	gold quality
zone of skin	UBERON:0000014	77.13	gold quality
lower esophagus mucosa	UBERON:0035834	76.78	gold quality
right lobe of liver	UBERON:0001114	76.69	gold quality
esophagus mucosa	UBERON:0002469	76.07	gold quality
tonsil	UBERON:0002372	75.89	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	75.77	gold quality
bone marrow cell	CL:0002092	75.66	gold quality
prefrontal cortex	UBERON:0000451	75.40	gold quality
adult mammalian kidney	UBERON:0000082	75.04	gold quality
islet of Langerhans	UBERON:0000006	74.96	gold quality
rectum	UBERON:0001052	74.83	gold quality
frontal cortex	UBERON:0001870	74.82	gold quality
granulocyte	CL:0000094	74.69	gold quality
vermiform appendix	UBERON:0001154	74.64	gold quality
anterior cingulate cortex	UBERON:0009835	74.57	gold quality
neocortex	UBERON:0001950	74.30	gold quality
tibial nerve	UBERON:0001323	73.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis. (PMID:34850664)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.