CA5B

Summary

CA5B (carbonic anhydrase 5B, HGNC:1378) is a protein-coding gene on chromosome Xp22.2, encoding Carbonic anhydrase 5B, mitochondrial (Q9Y2D0). Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3.

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes carbonic anhydrase 5B. CA5B, and the related CA5A gene, has its expression localized in the mitochondria though CA5B has a wider tissue distribution than CA5A, which is restricted to the liver, kidneys, and skeletal muscle. A carbonic anhydrase pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci produce CA5BP1-CA5B readthrough transcripts.

Source: NCBI Gene 11238 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 99 total
• Druggable target: yes — 47 molecules with ChEMBL bioactivity
• MANE Select transcript: NM_007220

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1378
Approved symbol	CA5B
Name	carbonic anhydrase 5B
Location	Xp22.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000169239
Ensembl biotype	protein_coding
OMIM	300230
Entrez	11238

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 4 protein_coding, 4 retained_intron, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000318636, ENST00000380313, ENST00000380319, ENST00000474624, ENST00000478341, ENST00000478923, ENST00000479740, ENST00000496188, ENST00000498004, ENST00000948118

RefSeq mRNA: 1 — MANE Select: NM_007220 NM_007220

CCDS: CCDS14171

Canonical transcript exons

ENST00000318636 — 8 exons

Exon	Start	End
ENSE00001160614	15776714	15776869
ENSE00001160621	15775246	15775308
ENSE00001160639	15772496	15772614
ENSE00001278386	15782485	15788411
ENSE00001703659	15738270	15738352
ENSE00001780910	15764578	15764775
ENSE00001785912	15774302	15774397
ENSE00003633715	15749971	15750165

Expression profiles

Bgee: expression breadth ubiquitous, 186 present calls, max score 94.16.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.6958 / max 196.5526, expressed in 1113 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
195613	6.1397	940
195614	1.5560	483

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	94.16	gold quality
monocyte	CL:0000576	89.14	gold quality
mononuclear cell	CL:0000842	89.05	gold quality
leukocyte	CL:0000738	88.90	gold quality
tendon	UBERON:0000043	88.67	gold quality
granulocyte	CL:0000094	86.64	gold quality
adrenal tissue	UBERON:0018303	85.29	gold quality
ascending aorta	UBERON:0001496	84.69	gold quality
thoracic aorta	UBERON:0001515	84.46	gold quality
right coronary artery	UBERON:0001625	84.36	gold quality
tibial artery	UBERON:0007610	84.19	gold quality
aorta	UBERON:0000947	84.18	gold quality
popliteal artery	UBERON:0002250	84.18	gold quality
endocervix	UBERON:0000458	83.96	gold quality
descending thoracic aorta	UBERON:0002345	83.44	gold quality
left ovary	UBERON:0002119	83.08	gold quality
type B pancreatic cell	CL:0000169	82.84	gold quality
right ovary	UBERON:0002118	82.80	gold quality
tendon of biceps brachii	UBERON:0008188	82.77	gold quality
left coronary artery	UBERON:0001626	82.67	gold quality
olfactory bulb	UBERON:0002264	82.55	gold quality
ectocervix	UBERON:0012249	82.47	gold quality
smooth muscle tissue	UBERON:0001135	82.46	gold quality
coronary artery	UBERON:0001621	81.85	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.74	gold quality
islet of Langerhans	UBERON:0000006	81.61	gold quality
gall bladder	UBERON:0002110	81.52	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.31	gold quality
stromal cell of endometrium	CL:0002255	80.95	gold quality
skin of leg	UBERON:0001511	80.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

155 targeting CA5B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-627-3P	99.90	71.42	3316

Literature-anchored findings (GeneRIF, showing 3)

• activators enhanced kcat, with no effect on KM, favoring the RDS in the catalytic cycle; the activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II. (PMID:17174092)
• In 10 of 96 patients, mutations in CA5A were identified on both alleles but none in CA5B. Exhibiting decreased enzyme activity or thermal stability, all CAVA mutations were proven to cause disease, whereas the three variants showed no relevant effect (PMID:26913920)
• Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease. (PMID:36464834)

Cross-species orthologs

17 orthologs

Organism	Symbol	Gene ID
danio_rerio	ca5a	ENSDARG00000101778
mus_musculus	Car5b	ENSMUSG00000031373
rattus_norvegicus	Car5b	ENSRNOG00000029330
drosophila_melanogaster	CAH13	FBGN0033542
drosophila_melanogaster	CAH14	FBGN0034554
drosophila_melanogaster	CAH15	FBGN0034560
drosophila_melanogaster	CAH7	FBGN0037788
drosophila_melanogaster	CAH8	FBGN0038956
drosophila_melanogaster	CAH4	FBGN0039235
drosophila_melanogaster	CAH9	FBGN0039486
drosophila_melanogaster	CAH6	FBGN0039838
drosophila_melanogaster	CAH16	FBGN0040628
drosophila_melanogaster	CAH5	FBGN0040629
drosophila_melanogaster	CARPB	FBGN0052698
caenorhabditis_elegans		WBGENE00000279
caenorhabditis_elegans		WBGENE00000283
caenorhabditis_elegans	cah-6	WBGENE00000284

Paralogs (14): CA11 (ENSG00000063180), CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA9 (ENSG00000107159), CA14 (ENSG00000118298), CA6 (ENSG00000131686), CA1 (ENSG00000133742), CA10 (ENSG00000154975), CA3 (ENSG00000164879), CA4 (ENSG00000167434), CA7 (ENSG00000168748), CA5A (ENSG00000174990), CA8 (ENSG00000178538), CA13 (ENSG00000185015)

Protein

Protein identifiers

Carbonic anhydrase 5B, mitochondrial — Q9Y2D0 (reviewed: Q9Y2D0)

Alternative names: Carbonate dehydratase VB, Carbonic anhydrase VB

All UniProt accessions (4): Q9Y2D0, C9IZP3, C9JA11, H7C4G3

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3.

Subcellular location. Mitochondrion.

Tissue specificity. Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.

Activity regulation. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).

Similarity. Belongs to the alpha-carbonic anhydrase family.

RefSeq proteins (1): NP_009151* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001148	CA_dom	Domain
IPR018338	Carbonic_anhydrase_a-class_CS	Conserved_site
IPR023561	Carbonic_anhydrase_a-class	Family
IPR036398	CA_dom_sf	Homologous_superfamily

Pfam: PF00194

Enzyme classification (BRENDA):

• EC 4.2.1.1 — carbonic anhydrase (BRENDA: 178 organisms, 196 substrates, 2137 inhibitors, 263 Km, 291 kcat entries)

Substrate kinetics (BRENDA)

9 substrates with measured Km, best-characterized 9. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
CO2	0.012–4700	194
4-NITROPHENYL ACETATE	0.0024–30.53	16
H2CO3	0.434–112.7	16
HCO3-	9.3–37	4
P-NITROPHENYL ACETATE	3.86–6.8	4
4-NITROPHENYL PHOSPHATE	0.935–2.195	2
COS	1.86	1
HISTAMINE	7.9	1
CS2	—	0

Catalyzed reactions (Rhea), 1 shown:

• hydrogencarbonate + H(+) = CO2 + H2O (RHEA:10748)

UniProt features (7 total): binding site 4, transit peptide 1, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2D0-F1	83.33	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 130; 132; 155; 235–236

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-1475029	Reversible hydration of carbon dioxide
R-HSA-1430728	Metabolism

MSigDB gene sets: 104 (showing top): GOMF_CARBONATE_DEHYDRATASE_ACTIVITY, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, GOMF_HYDRO_LYASE_ACTIVITY, GOCC_MITOCHONDRIAL_MATRIX, WINNEPENNINCKX_MELANOMA_METASTASIS_DN, DODD_NASOPHARYNGEAL_CARCINOMA_DN, PR_Q2, chrXp22, DURAND_STROMA_S_UP, ZWANG_EGF_INTERVAL_DN, PTEN_DN.V2_UP, NOTCH_DN.V1_UP, KRAS.300_UP.V1_DN, KRAS.600_UP.V1_DN, KRAS.600.LUNG.BREAST_UP.V1_DN

GO Biological Process (1): response to bacterium (GO:0009617)

GO Molecular Function (5): carbonate dehydratase activity (GO:0004089), zinc ion binding (GO:0008270), protein binding (GO:0005515), lyase activity (GO:0016829), metal ion binding (GO:0046872)

GO Cellular Component (3): cytoplasm (GO:0005737), mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
response to other organism	1
hydro-lyase activity	1
transition metal ion binding	1
binding	1
catalytic activity	1
cation binding	1
intracellular anatomical structure	1
cellular anatomical structure	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrion	1
intracellular organelle lumen	1

Protein interactions and networks

STRING

1270 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CA5B	CYP24A1	Q07973	870
CA5B	ALB	P02768	556
CA5B	TG	P01266	540
CA5B	RNASE1	P07998	533
CA5B	FTH1	P02794	508
CA5B	ATRN	O75882	475
CA5B	MOSPD2	Q8NHP6	473
CA5B	AP1S2	P56377	437
CA5B	ASB9	Q96DX5	427
CA5B	SYAP1	Q96A49	403
CA5B	SLC4A4	Q9Y6R1	393
CA5B	TBC1D8	O95759	380
CA5B	TMEM59	Q9BXS4	375
CA5B	BLNK	Q8WV28	358
CA5B	MAGEB17	A8MXT2	358

IntAct

2 interactions, top by confidence:

A	B	Type	Score
CA5B	DBT	psi-mi:“MI:0915”(physical association)	0.560
CA5B	DBT	psi-mi:“MI:0914”(association)	0.560

BioGRID (8): CA5B (Affinity Capture-RNA), CA5B (Affinity Capture-RNA), DBT (Affinity Capture-MS), RPS4Y1 (Affinity Capture-MS), DBT (Affinity Capture-MS), CA5B (Co-fractionation), CA5B (Co-fractionation), CA5B (Affinity Capture-RNA)

ESM2 similar proteins: A9RBS1, B0BNN3, F4HQD4, P00915, P00916, P00917, P00918, P00919, P00920, P00921, P00922, P04080, P07450, P07451, P07452, P07630, P13634, P14141, P16015, P27139, P35217, P43166, P48282, P48284, P60575, P83299, Q1LZA1, Q3SZX4, Q5S1S4, Q60446, Q6ESI7, Q76LA0, Q7M316, Q7M317, Q84MD8, Q8AVL0, Q8CAA7, Q8GWT4, Q8HY33, Q8I030

Diamond homologs: A0A7H0DN92, A0JN41, B0BNN3, O57211, P00915, P00916, P00917, P00918, P00919, P00920, P00921, P04195, P07450, P07451, P07452, P07630, P0DSY1, P0DSY2, P13634, P14141, P16015, P20508, P23470, P23471, P23589, P27139, P35217, P35218, P43165, P43166, P48282, P48283, P61215, P83299, Q05909, Q1LZA1, Q3SZX4, Q5R4U0, Q5S1S4, Q66HG6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

99 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1769 predictions. Top by Δscore:

Variant	Effect	Δscore
X:15738351:AGG:A	donor_loss	1.0000
X:15738352:GGTA:G	donor_loss	1.0000
X:15738353:GT:G	donor_loss	1.0000
X:15750162:GCCT:G	donor_gain	1.0000
X:15774039:G:GT	donor_gain	1.0000
X:15774290:AT:A	acceptor_gain	1.0000
X:15774291:T:G	acceptor_gain	1.0000
X:15774291:T:TA	acceptor_gain	1.0000
X:15774299:CAGCT:C	acceptor_loss	1.0000
X:15774300:A:AG	acceptor_gain	1.0000
X:15774301:G:GG	acceptor_gain	1.0000
X:15774301:GCT:G	acceptor_gain	1.0000
X:15774301:GCTGC:G	acceptor_gain	1.0000
X:15774393:TAAAG:T	donor_loss	1.0000
X:15774394:AAAG:A	donor_loss	1.0000
X:15774395:AAGG:A	donor_loss	1.0000
X:15774396:AGGTA:A	donor_loss	1.0000
X:15774397:GG:G	donor_loss	1.0000
X:15774399:T:A	donor_loss	1.0000
X:15775245:GCTA:G	acceptor_gain	1.0000
X:15776868:AGGT:A	donor_loss	1.0000
X:15776870:GT:G	donor_loss	1.0000
X:15776871:T:A	donor_loss	1.0000
X:15782479:TTCTA:T	acceptor_loss	1.0000
X:15782480:TCTA:T	acceptor_loss	1.0000
X:15782482:TAGC:T	acceptor_loss	1.0000
X:15782483:A:AG	acceptor_gain	1.0000
X:15782483:AG:A	acceptor_loss	1.0000
X:15782484:G:GA	acceptor_gain	1.0000
X:15782484:GCT:G	acceptor_gain	1.0000

AlphaMissense

2078 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:15772549:C:G	H132D	1.000
X:15772552:T:A	W133R	1.000
X:15772552:T:C	W133R	1.000
X:15776789:G:T	G232W	1.000
X:15776790:G:A	G232E	1.000
X:15776828:T:A	W245R	1.000
X:15776828:T:C	W245R	1.000
X:15782585:T:A	V292D	1.000
X:15764632:C:A	P66H	0.999
X:15772543:C:G	H130D	0.999
X:15772551:C:A	H132Q	0.999
X:15772551:C:G	H132Q	0.999
X:15772554:G:C	W133C	0.999
X:15772554:G:T	W133C	0.999
X:15772555:G:T	G134W	0.999
X:15772580:A:T	E142V	0.999
X:15774303:T:C	L154P	0.999
X:15776777:T:A	W228R	0.999
X:15776777:T:C	W228R	0.999
X:15776789:G:A	G232R	0.999
X:15776789:G:C	G232R	0.999
X:15776790:G:T	G232V	0.999
X:15776792:T:C	S233P	0.999
X:15776796:T:C	L234P	0.999
X:15782550:C:A	N280K	0.999
X:15782550:C:G	N280K	0.999
X:15782551:T:C	F281L	0.999
X:15782553:C:A	F281L	0.999
X:15782553:C:G	F281L	0.999
X:15782554:C:A	R282S	0.999

dbSNP variants (sampled 300 via entrez): RS1000126800 (X:15777480 A>G), RS1000224946 (X:15747817 C>T), RS1000450493 (X:15738285 G>A), RS1000499115 (X:15778002 G>A,C), RS1000651563 (X:15780845 CTT>C), RS1000874949 (X:15760914 G>A), RS1000877607 (X:15737567 C>T), RS1000918524 (X:15770845 G>A), RS1000950986 (X:15753075 G>A), RS1000954311 (X:15760126 A>C), RS1000961270 (X:15745991 C>T), RS1001111848 (X:15749387 A>G), RS1001147548 (X:15787972 TACA>T), RS1001183587 (X:15750515 G>A,T), RS1001198211 (X:15788484 G>A)

Disease associations

OMIM: gene MIM:300230 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (3): CHEMBL2095180 (PROTEIN FAMILY), CHEMBL2111457 (PROTEIN FAMILY), CHEMBL3969 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

47 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 799,685 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL19	METHAZOLAMIDE	4	65
CHEMBL20	ACETAZOLAMIDE	4	28,768
CHEMBL750	ZONISAMIDE	4	16,649
CHEMBL18	ETHOXZOLAMIDE	4	3,042
CHEMBL220492	TOPIRAMATE	4	35,160
CHEMBL1054	TRICHLORMETHIAZIDE	4	11,619
CHEMBL1055	CHLORTHALIDONE	4	20,442
CHEMBL118	CELECOXIB	4	112,844
CHEMBL1200471	PYRITHIONE ZINC	4	24,834
CHEMBL1286	LEVETIRACETAM	4	13,997
CHEMBL17	DICHLORPHENAMIDE	4	9,022
CHEMBL21	SULFANILAMIDE	4	153,075
CHEMBL2105581	VERALIPRIDE	4	1,165
CHEMBL218490	DORZOLAMIDE	4	10,216
CHEMBL220491	BRINZOLAMIDE	4	8,355
CHEMBL255863	NILOTINIB	4	38,627
CHEMBL26	SULPIRIDE	4	58,543
CHEMBL325041	BORTEZOMIB	4	13,120
CHEMBL35	FUROSEMIDE	4	224,045
CHEMBL406	INDAPAMIDE	4	16,097
CHEMBL419	MAFENIDE	4
CHEMBL537	HYDROQUINONE	4
CHEMBL58323	LACOSAMIDE	4
CHEMBL609	TRIENTINE	4
CHEMBL6466	COUMARIN	4
CHEMBL865	VALDECOXIB	4
CHEMBL902	FAMOTIDINE	4
CHEMBL926	DOBUTAMINE	4
CHEMBL941	IMATINIB	4
CHEMBL1352	NITRIC ACID	3

PharmGKB: 1 entry (VIP=true, CPIC=false)

Binding affinities (BindingDB)

49 measured of 59 human assays (103 total across all organisms); most potent 49 below. Values come from heterogeneous assays and are not directly comparable.

Ligand	Measure	Value
3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid	EC50	0.0469 nM
(4S)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide	KI	3 nM
aliphatic sulfamate, 1	KI	3.7 nM
cid_694792	KI	60 nM
sulfonamide deriv., 7c	KI	60 nM
sulfonamide deriv., 5a	KI	61 nM
sulfonamide deriv., 7e	KI	61 nM
sulfonamide deriv., 8	KI	63 nM
sulfonamide deriv., 7d	KI	67 nM
sulfonamide deriv., 5f	KI	68 nM
sulfonamide deriv., 7h	KI	71 nM
sulfonamide deriv., 6	KI	72 nM
sulfonamide deriv., 7i	KI	73 nM
sulfonamide deriv., 7b	KI	75 nM
sulfonamide deriv., 7g	KI	75 nM
sulfonamide deriv., 5c	KI	77 nM
sulfonamide deriv., 5d	KI	84 nM
2-(hydrazinecarbonyl)-3-(2-methylphenyl)-1H-indole-5-sulfonamide	KI	107 nM
sulfonamide deriv., 7a	KI	108 nM
3-(2-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide	KI	110 nM
sulfonamide deriv., 5b	KI	161 nM
Topiramate, 3	KI	250 nM
sulfonamide deriv., 7f	KI	263 nM
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate	IC50	300 nM
JFD00715	KI	328 nM
trichloromethiazide, 6	KI	345 nM
bis-sulfamate, 3	KI	378 nM
aliphatic sulfamate, 2	KI	530 nM
3-(2-fluorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide	KI	621 nM
Investigational agent, 5	KI	810 nM
Investigational agent, 4	KI	850 nM
bis-sulfamate, 4	KI	890 nM
1,3,4-Thiadiazole-2-sulfonamide, 6	IC50	2700 nM
BMCL182567 Compound 6b	KI	2840 nM
amino-N-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}sulfonamide	KI	3450 nM
[2-(cycloheptylmethyl)-1,1-dioxo–benzothiophen-6-yl] sulfamate	KI	3600 nM
salicylic acid	KI	9900 nM
4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide	KD	10000 nM
phenol	KI	10200 nM
4-methylbenzene-1-sulfonamide	IC50	22100 nM
3,5-difluorophenol	KI	38800 nM
Dorzolamide, DZA	KI	50000 nM
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide	KI	54000 nM
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid	IC50	125000 nM
4-cyanophenol	KI	131000 nM
2,5-difluorophenol	KI	134000 nM
4-aminophenol	KI	159000 nM
benzene-1,3-diol	KI	795000 nM
1,2-Dihydroxybenzene, XI	KI	4e+06 nM

ChEMBL bioactivities

860 potent at pChembl≥5 of 894 total, top 50 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
11.00	Ki	0.01	nM	CYANIDE
11.00	Kd	0.01	nM	CHEMBL4446052
10.96	Kd	0.011	nM	CHEMBL4555622
10.96	Kd	0.011	nM	CHEMBL4444784
10.96	Kd	0.011	nM	CHEMBL4555586
10.92	Kd	0.012	nM	CHEMBL4463683
10.80	Kd	0.016	nM	CHEMBL4473602
10.70	Ki	0.02	nM	HYDROGEN SULFIDE
10.70	Kd	0.02	nM	CHEMBL4551069
10.70	Kd	0.02	nM	CHEMBL4451503
10.60	Kd	0.025	nM	CHEMBL4539340
10.52	Kd	0.03	nM	CHEMBL4578934
10.52	Kd	0.03	nM	CHEMBL4569008
10.52	Kd	0.03	nM	CHEMBL4456084
10.52	Kd	0.03	nM	CHEMBL4444201
10.52	Kd	0.03	nM	CHEMBL4588838
10.52	Kd	0.03	nM	CHEMBL4515586
10.52	Kd	0.03	nM	CHEMBL4450306
10.48	Kd	0.033	nM	CHEMBL4560953
10.40	Kd	0.04	nM	CHEMBL4543024
10.40	Kd	0.04	nM	CHEMBL4451500
10.39	Kd	0.041	nM	CHEMBL4567916
10.39	Kd	0.041	nM	CHEMBL4449149
10.30	Kd	0.05	nM	CHEMBL4562296
10.30	Kd	0.05	nM	CHEMBL4573963
10.29	Kd	0.051	nM	CHEMBL4443078
10.26	Kd	0.055	nM	CHEMBL4587295
10.26	Kd	0.055	nM	CHEMBL4558235
10.23	Kd	0.059	nM	CHEMBL4474833
10.22	Kd	0.06	nM	CHEMBL4165570
10.22	Kd	0.06	nM	CHEMBL4450456
10.21	Kd	0.062	nM	CHEMBL4461481
10.20	Kd	0.063	nM	CHEMBL4577993
10.20	Kd	0.063	nM	CHEMBL4558457
10.18	Kd	0.066	nM	CHEMBL4465027
10.14	Kd	0.073	nM	CHEMBL4553790
10.05	Kd	0.089	nM	CHEMBL4458989
10.05	Kd	0.09	nM	CHEMBL4465972
10.00	Kd	0.1	nM	CHEMBL4583164
9.96	Kd	0.11	nM	CHEMBL4166643
9.96	Kd	0.11	nM	CHEMBL4437818
9.96	Kd	0.11	nM	CHEMBL4441818
9.92	Ki	0.12	nM	SULFAMATE
9.92	Kd	0.12	nM	CHEMBL4449430
9.92	Kd	0.12	nM	CHEMBL4539233
9.89	Kd	0.13	nM	CHEMBL4464359
9.85	Kd	0.14	nM	CHEMBL4574321
9.85	Kd	0.14	nM	CHEMBL4572161
9.80	Kd	0.16	nM	CHEMBL4570253
9.80	Kd	0.16	nM	CHEMBL4457904

PubChem BioAssay actives

952 with measured affinity, of 1390 total; 50 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-benzylsulfanyl-N-butyl-4-chloro-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
4-bromo-N-(2-hydroxyethyl)-2-(2-phenylethylsulfanyl)-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
4-bromo-N-butyl-2-cyclohexylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
4-bromo-N-butyl-2-(2-phenylethylsulfanyl)-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
N-butyl-4-chloro-2-cyclohexylsulfonyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
2-benzylsulfanyl-4-chloro-N-cyclohexyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
N-butyl-4-chloro-2-(2-phenylethylsulfanyl)-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
methyl 4-[(4-chloro-2-cyclohexylsulfanyl-5-sulfamoylbenzoyl)amino]butanoate	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
N-benzyl-4-chloro-2-cyclohexylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
N-butyl-4-chloro-2-cyclohexylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
4-chloro-N-cyclohexyl-2-cyclohexylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
1-(2-chloro-3,5-dimethyl-4-sulfamoylphenyl)-N-[(E)-(4-methoxyphenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
N-[(E)-benzylideneamino]-1-(2,5-dimethyl-4-sulfamoylphenyl)-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
N-(3,5-dimethylpyrazol-1-yl)-1-(3,5-dimethyl-4-sulfamoylphenyl)-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
2-benzylsulfanyl-4-chloro-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
4-chloro-2-(2-phenylethylsulfanyl)-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
N-[(E)-benzylideneamino]-1-(2-chloro-3,5-dimethyl-4-sulfamoylphenyl)-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
methyl 1-(2-chloro-3,5-dimethyl-4-sulfamoylphenyl)-5-oxopyrrolidine-3-carboxylate	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
N-[(E)-(4-bromophenyl)methylideneamino]-1-(2-chloro-3,5-dimethyl-4-sulfamoylphenyl)-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
3-chloro-4-[4-(3,5-dimethylpyrazole-1-carbonyl)-2-oxopyrrolidin-1-yl]-2,6-dimethylbenzenesulfonamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
3-chloro-2,6-dimethyl-4-[2-oxo-4-(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)pyrrolidin-1-yl]benzenesulfonamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
4-chloro-2-phenylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
4-chloro-2-cyclohexylsulfanyl-5-sulfamoylbenzoic acid	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
1-(2,5-dimethyl-4-sulfamoylphenyl)-N-[(E)-(4-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
1-(2-chloro-3,5-dimethyl-4-sulfamoylphenyl)-N-[(E)-(4-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
1-(3,5-dimethyl-4-sulfamoylphenyl)-N-[(E)-(4-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
4-[4-(3,5-dimethylpyrazole-1-carbonyl)-2-oxopyrrolidin-1-yl]-2,6-dimethylbenzenesulfonamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
1-(2-chloro-3,5-dimethyl-4-sulfamoylphenyl)-N-[(E)-(4-chlorophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	<0.0001	uM
4-chloro-2-(2-phenylethylsulfanyl)-5-sulfamoylbenzoic acid	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
4-chloro-2-cyclohexylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	<0.0001	uM
sulfane	238688: Inhibitory activity against human carbonic anhydrase V expressed in Escherichia coli	ki	<0.0001	uM
Hydrogen Cyanide	238688: Inhibitory activity against human carbonic anhydrase V expressed in Escherichia coli	ki	<0.0001	uM
N-benzyl-2,4-dichloro-5-sulfamoylbenzamide	1361386: Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay	kd	0.0001	uM
methyl 4-[(2-benzylsulfanyl-4-chloro-5-sulfamoylbenzoyl)amino]butanoate	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
4-bromo-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
4-bromo-N-butyl-2-phenylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
N-butyl-4-chloro-2-phenylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
N-benzyl-4-chloro-2-cyclohexylsulfonyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
N-benzyl-4-chloro-2-phenylsulfanyl-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
4-chloro-2-cyclohexylsulfanyl-N-(2-methoxyethyl)-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
2-(benzenesulfonyl)-N-butyl-4-chloro-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
2,4-dibromo-N-butyl-5-sulfamoylbenzamide	1361386: Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay	kd	0.0001	uM
4-chloro-2-(2-phenylethylsulfonyl)-5-sulfamoylbenzamide	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM
N-[(E)-(4-bromophenyl)methylideneamino]-1-(3,5-dimethyl-4-sulfamoylphenyl)-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	0.0001	uM
4-[4-(hydrazinecarbonyl)-2-oxopyrrolidin-1-yl]-2,6-dimethylbenzenesulfonamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	0.0001	uM
3-chloro-4-[4-(hydrazinecarbonyl)-2-oxopyrrolidin-1-yl]-2,6-dimethylbenzenesulfonamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	0.0001	uM
1-(2-chloro-3,5-dimethyl-4-sulfamoylphenyl)-N-(3,5-dimethylpyrazol-1-yl)-5-oxopyrrolidine-3-carboxamide	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	0.0001	uM
1-[[1-(2-chloro-3,5-dimethyl-4-sulfamoylphenyl)-5-oxopyrrolidine-3-carbonyl]amino]-3-phenylthiourea	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	0.0001	uM
methyl 1-(2,5-dimethyl-4-sulfamoylphenyl)-5-oxopyrrolidine-3-carboxylate	1515319: Binding affinity to recombinant full length N-terminal His6x-tagged human CA5B expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay	kd	0.0001	uM
methyl 4-[(4-chloro-2-phenylsulfanyl-5-sulfamoylbenzoyl)amino]butanoate	1520084: Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	kd	0.0001	uM

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol S	decreases methylation, increases expression	2
bisphenol F	increases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
diisononyl phthalate	increases methylation	1
oryzalin	decreases activity, affects binding	1
arsenite	increases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	increases expression	1
di-n-butylphosphoric acid	affects expression	1
bisphenol B	increases expression	1
bisphenol AF	increases expression	1
Sunitinib	increases expression	1
Acetazolamide	affects binding, decreases activity	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	affects methylation	1
Atrazine	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Estradiol	decreases expression	1
Folic Acid	decreases expression	1
Ozone	affects expression, increases abundance	1
Silicon Dioxide	increases expression	1
Tretinoin	decreases expression	1
Triclosan	decreases expression	1
Tunicamycin	increases expression	1
Valproic Acid	increases expression	1
Thapsigargin	increases expression	1

ChEMBL screening assays

118 unique, capped per target: 117 binding, 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3386760	Binding	Inhibition of carbonic anhydrase (unknown origin)	Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses. — Bioorg Med Chem
CHEMBL4406727	ADMET	Inhibition of human recombinant carbonic anhydrase 5B preincubated with enzyme for 1 hr prior to testing by phenol red-based stopped-flow CO2 hydration assay	Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.