CACNA1G-AS1

Summary

CACNA1G-AS1 (CACNA1G antisense RNA 1, HGNC:27377) is a long non-coding RNA gene on chromosome 17q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27377
Approved symbol	CACNA1G-AS1
Name	CACNA1G antisense RNA 1
Location	17q21.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	CAS1
Ensembl gene	ENSG00000250107
Ensembl biotype	lncRNA
Entrez	253962
RNAcentral	URS000075C011 — lncRNA, 1450 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000505495, ENST00000505793, ENST00000508920, ENST00000848404

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505495 — 2 exons

Exon	Start	End
ENSE00004277833	50556604	50557458
ENSE00004277838	50559305	50559460

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 83.11.

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.11	silver quality
prefrontal cortex	UBERON:0000451	65.63	gold quality
gingival epithelium	UBERON:0001949	65.24	gold quality
sural nerve	UBERON:0015488	64.34	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.81	gold quality
endocervix	UBERON:0000458	62.29	gold quality
ectocervix	UBERON:0012249	62.19	gold quality
calcaneal tendon	UBERON:0003701	62.00	gold quality
ventricular zone	UBERON:0003053	61.60	gold quality
cerebellar cortex	UBERON:0002129	61.58	gold quality
cerebellar hemisphere	UBERON:0002245	61.52	gold quality
germinal epithelium of ovary	UBERON:0001304	61.33	gold quality
cerebellum	UBERON:0002037	60.76	gold quality
superficial temporal artery	UBERON:0001614	60.56	gold quality
uterine cervix	UBERON:0000002	60.31	gold quality
frontal cortex	UBERON:0001870	60.16	gold quality
neocortex	UBERON:0001950	59.28	gold quality
smooth muscle tissue	UBERON:0001135	58.93	gold quality
hypothalamus	UBERON:0001898	58.75	gold quality
gingiva	UBERON:0001828	58.41	gold quality
right frontal lobe	UBERON:0002810	58.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	57.89	gold quality
ganglionic eminence	UBERON:0004023	57.76	silver quality
Brodmann (1909) area 9	UBERON:0013540	56.99	gold quality
anterior cingulate cortex	UBERON:0009835	56.60	gold quality
epithelium of nasopharynx	UBERON:0001951	56.47	gold quality
mucosa of paranasal sinus	UBERON:0005030	56.46	gold quality
primary visual cortex	UBERON:0002436	56.24	gold quality
cerebral cortex	UBERON:0000956	56.16	gold quality
lateral nuclear group of thalamus	UBERON:0002736	56.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• CACNA1G-AS1 promotes hepatocellular carcinoma progression through regulating the miR-2392/C1orf61 pathway. (PMID:30908634)
• Upregulated lncRNA CACNA1G-AS1 aggravates the progression of colorectal cancer by downregulating p53. (PMID:31957825)
• Long non-coding RNA CACNA1G-AS1 promotes proliferation and invasion and inhibits apoptosis by regulating expression of miR-205 in human keloid fibroblasts. (PMID:32495824)
• LncRNA CACNA1G-AS1 up-regulates FTH1 to inhibit ferroptosis and promote malignant phenotypes in ovarian cancer cells. (PMID:37304234)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.