CACSTL1

Summary

CACSTL1 (chromosomal aberration CCDC6::RET stimulating lncRNA 1, HGNC:56690) is a long non-coding RNA gene on chromosome 14q24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56690
Approved symbol	CACSTL1
Name	chromosomal aberration CCDC6::RET stimulating lncRNA 1
Location	14q24.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	CASTL1
Ensembl gene	ENSG00000269945
Ensembl biotype	lncRNA
Entrez	142592836

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000602396

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000602396 — 1 exons

Exon	Start	End
ENSE00003421465	71219100	71222724

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 96.30.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	96.30	silver quality
superior frontal gyrus	UBERON:0002661	69.57	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.19	gold quality
cerebellar hemisphere	UBERON:0002245	66.94	gold quality
right frontal lobe	UBERON:0002810	66.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.41	gold quality
frontal cortex	UBERON:0001870	64.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.50	gold quality
prefrontal cortex	UBERON:0000451	63.39	gold quality
cerebral cortex	UBERON:0000956	62.92	gold quality
anterior cingulate cortex	UBERON:0009835	62.58	gold quality
primary visual cortex	UBERON:0002436	61.96	gold quality
sural nerve	UBERON:0015488	61.22	silver quality
brain	UBERON:0000955	57.93	gold quality
Ammon’s horn	UBERON:0001954	54.42	gold quality
endometrium	UBERON:0001295	53.02	gold quality
caudate nucleus	UBERON:0001873	52.40	gold quality
placenta	UBERON:0001987	52.24	silver quality
cortex of kidney	UBERON:0001225	51.30	silver quality
nucleus accumbens	UBERON:0001882	50.23	gold quality
blood	UBERON:0000178	49.93	silver quality
amygdala	UBERON:0001876	49.93	gold quality
putamen	UBERON:0001874	49.53	gold quality
substantia nigra	UBERON:0002038	49.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	48.94	gold quality
islet of Langerhans	UBERON:0000006	47.60	silver quality
gall bladder	UBERON:0002110	46.78	gold quality
monocyte	CL:0000576	46.70	silver quality
lymph node	UBERON:0000029	46.03	silver quality
smooth muscle tissue	UBERON:0001135	44.43	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.28

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.