CAHM

Summary

CAHM (colon adenocarcinoma hypermethylated, HGNC:42860) is a long non-coding RNA gene on chromosome 6q26.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42860
Approved symbol	CAHM
Name	colon adenocarcinoma hypermethylated
Location	6q26
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00468
Ensembl gene	ENSG00000270419
Ensembl biotype	lncRNA
OMIM	615930
Entrez	100526820
RNAcentral	URS000075CE0F — lncRNA, 903 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000604200, ENST00000816692, ENST00000816693, ENST00000816694, ENST00000816695, ENST00000816696, ENST00000816697, ENST00000816698, ENST00000816699, ENST00000816700, ENST00000816701, ENST00000816702, ENST00000816703, ENST00000816704, ENST00000816705, ENST00000816706, ENST00000816707, ENST00000816708, ENST00000816709, ENST00000816710, ENST00000816711, ENST00000816712, ENST00000816713, ENST00000816714

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000604200 — 1 exons

Exon	Start	End
ENSE00003985303	163412146	163413960

Expression profiles

Bgee: expression breadth ubiquitous, 169 present calls, max score 94.52.

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.52	gold quality
sperm	CL:0000019	87.25	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.20	gold quality
tibial nerve	UBERON:0001323	83.63	gold quality
sural nerve	UBERON:0015488	82.57	gold quality
endothelial cell	CL:0000115	82.36	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	81.28	gold quality
spinal cord	UBERON:0002240	78.65	gold quality
ventricular zone	UBERON:0003053	77.31	gold quality
apex of heart	UBERON:0002098	76.26	gold quality
granulocyte	CL:0000094	75.64	gold quality
right testis	UBERON:0004534	75.60	gold quality
amygdala	UBERON:0001876	75.50	gold quality
left testis	UBERON:0004533	75.16	gold quality
putamen	UBERON:0001874	74.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	74.61	gold quality
medial globus pallidus	UBERON:0002477	74.29	silver quality
caudate nucleus	UBERON:0001873	74.06	gold quality
substantia nigra	UBERON:0002038	74.00	gold quality
gastrocnemius	UBERON:0001388	73.92	gold quality
monocyte	CL:0000576	73.90	gold quality
pancreatic ductal cell	CL:0002079	73.79	silver quality
muscle of leg	UBERON:0001383	73.71	gold quality
testis	UBERON:0000473	73.56	gold quality
hypothalamus	UBERON:0001898	73.53	gold quality
leukocyte	CL:0000738	73.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.14	gold quality
nucleus accumbens	UBERON:0001882	72.59	gold quality
anterior cingulate cortex	UBERON:0009835	72.22	gold quality
ganglionic eminence	UBERON:0004023	72.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Both the frequency of detection and the amount of methylated CAHM DNA released into plasma increased with increasing cancer stage. Methylated CAHM DNA shows promise as a plasma biomarker for use in screening for CRC. (PMID:24799664)
• DNMT1 Mediated CAHM Repression Promotes Glioma Invasion via SPAK/JNK Pathway. (PMID:34227028)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.