CALML3-AS1

Summary

CALML3-AS1 (CALML3 antisense RNA 1, HGNC:44682) is a long non-coding RNA gene on chromosome 10p15.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44682
Approved symbol	CALML3-AS1
Name	CALML3 antisense RNA 1
Location	10p15.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000205488
Ensembl biotype	lncRNA
Entrez	100132159
RNAcentral	URS000075E62E — lncRNA, 3709 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000542093, ENST00000543008, ENST00000545372, ENST00000651240, ENST00000770238, ENST00000770239, ENST00000770240, ENST00000770241, ENST00000770242

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000542093 — 3 exons

Exon	Start	End
ENSE00002224620	5521916	5522129
ENSE00002278950	5526133	5526246
ENSE00004132063	5516432	5517512

Expression profiles

Bgee: expression breadth ubiquitous, 143 present calls, max score 90.72.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0825 / max 15.8332, expressed in 29 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108094	0.0660	26
108095	0.0165	10

Top tissues by expression

222 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	90.72	gold quality
esophagus mucosa	UBERON:0002469	83.93	gold quality
skin of leg	UBERON:0001511	77.22	gold quality
esophagus squamous epithelium	UBERON:0006920	76.94	gold quality
skin of abdomen	UBERON:0001416	76.19	gold quality
zone of skin	UBERON:0000014	74.39	gold quality
vagina	UBERON:0000996	72.69	gold quality
sperm	CL:0000019	72.19	gold quality
gingival epithelium	UBERON:0001949	70.09	gold quality
esophagus	UBERON:0001043	70.04	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	67.20	gold quality
gingiva	UBERON:0001828	66.65	gold quality
mouth mucosa	UBERON:0003729	63.32	gold quality
minor salivary gland	UBERON:0001830	63.20	gold quality
oral cavity	UBERON:0000167	63.14	gold quality
tonsil	UBERON:0002372	62.85	gold quality
mammalian vulva	UBERON:0000997	62.57	gold quality
saliva-secreting gland	UBERON:0001044	62.18	gold quality
upper lobe of lung	UBERON:0008948	61.44	silver quality
ectocervix	UBERON:0012249	61.27	gold quality
lower lobe of lung	UBERON:0008949	61.24	silver quality
pancreatic ductal cell	CL:0002079	61.06	silver quality
prefrontal cortex	UBERON:0000451	60.79	gold quality
cortical plate	UBERON:0005343	60.18	gold quality
adult mammalian kidney	UBERON:0000082	59.31	gold quality
descending thoracic aorta	UBERON:0002345	59.21	gold quality
uterine cervix	UBERON:0000002	58.86	gold quality
parotid gland	UBERON:0001831	56.97	gold quality
endothelial cell	CL:0000115	56.65	gold quality
upper leg skin	UBERON:0004262	56.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Long noncoding RNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316 (PMID:30177388)
• Upregulation of lncRNA CALML3-AS1 promotes cell proliferation and metastasis in cervical cancer via activation of the Wnt/beta-catenin pathway. (PMID:31298313)
• LncRNA CALML3-AS1 regulates chondrocyte apoptosis by acting as a sponge for miR-146a. (PMID:34282692)
• LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression via sponging miR-20a-5p/RBM38 axis. (PMID:35351042)
• LncRNA CALML3-AS1 modulated by m[6]A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression. (PMID:37884580)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.