CALN1

Summary

CALN1 (calneuron 1, HGNC:13248) is a protein-coding gene on chromosome 7q11.22, encoding Calcium-binding protein 8 (Q9BXU9). Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.

This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 83698 — RefSeq curated summary.

At a glance

• GWAS associations: 21
• Clinical variants (ClinVar): 63 total — 1 pathogenic
• MANE Select transcript: NM_031468

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13248
Approved symbol	CALN1
Name	calneuron 1
Location	7q11.22
Locus type	gene with protein product
Status	Approved
Aliases	CABP8
Ensembl gene	ENSG00000183166
Ensembl biotype	protein_coding
OMIM	607176
Entrez	83698

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000329008, ENST00000395275, ENST00000395276, ENST00000431984, ENST00000446128

RefSeq mRNA: 3 — MANE Select: NM_031468 NM_001017440, NM_001363460, NM_031468

CCDS: CCDS47603, CCDS5541

Canonical transcript exons

ENST00000395275 — 7 exons

Exon	Start	End
ENSE00001290293	71810336	71810492
ENSE00001521165	71779491	71787902
ENSE00001521170	72412058	72412338
ENSE00001559780	72403251	72403442
ENSE00003441893	72106151	72106294
ENSE00003615375	72278686	72278810
ENSE00003785070	72023657	72023769

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 97.11.

FANTOM5 (CAGE): breadth broad, TPM avg 2.9647 / max 298.0607, expressed in 301 samples.

FANTOM5 promoters (15 alternative TSS)

Promoter ID	TPM avg	Samples expressed
84263	1.0450	143
84271	0.6515	83
84272	0.5109	80
84259	0.1923	83
84255	0.1127	59
84256	0.0866	41
84264	0.0726	33
84258	0.0656	36
84270	0.0610	18
84257	0.0552	25

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar vermis	UBERON:0004720	97.11	gold quality
pons	UBERON:0000988	96.07	gold quality
cerebellum	UBERON:0002037	94.01	gold quality
substantia nigra pars reticulata	UBERON:0001966	93.72	gold quality
cerebellar cortex	UBERON:0002129	93.72	gold quality
cerebellar hemisphere	UBERON:0002245	93.63	gold quality
substantia nigra pars compacta	UBERON:0001965	93.01	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.48	gold quality
entorhinal cortex	UBERON:0002728	92.17	gold quality
lateral globus pallidus	UBERON:0002476	91.60	gold quality
Brodmann (1909) area 46	UBERON:0006483	90.70	gold quality
middle temporal gyrus	UBERON:0002771	89.86	gold quality
cortical plate	UBERON:0005343	89.18	gold quality
inferior vagus X ganglion	UBERON:0005363	87.79	gold quality
postcentral gyrus	UBERON:0002581	87.57	gold quality
parietal lobe	UBERON:0001872	86.85	gold quality
primary visual cortex	UBERON:0002436	86.63	gold quality
Brodmann (1909) area 23	UBERON:0013554	86.52	gold quality
occipital lobe	UBERON:0002021	86.19	gold quality
prefrontal cortex	UBERON:0000451	86.01	gold quality
superior frontal gyrus	UBERON:0002661	85.86	gold quality
medulla oblongata	UBERON:0001896	85.72	gold quality
nucleus accumbens	UBERON:0001882	85.28	gold quality
spinal cord	UBERON:0002240	84.96	gold quality
caudate nucleus	UBERON:0001873	84.90	gold quality
subthalamic nucleus	UBERON:0001906	84.40	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.39	gold quality
Ammon’s horn	UBERON:0001954	84.38	gold quality
midbrain	UBERON:0001891	84.05	gold quality
substantia nigra	UBERON:0002038	83.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.21

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYCN

miRNA regulators (miRDB)

283 targeting CALN1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-32-5P	99.98	75.21	1964

Literature-anchored findings (GeneRIF, showing 7)

• CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca(2+)-sensing by these family members. (PMID:19338761)
• The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent. (PMID:26116628)
• provide strong evidence that CALN1 is a target of miR-137. (PMID:26163462)
• detected the first genome-wide significant association of schizophrenia with CALN1, which is a predicted target of MIR137, and thus provide new evidence for the associations between MIR137 targets and schizophrenia (PMID:26206863)
• this report has further supported for associations of genetic variants in the ITIH4 and CALN1 genes with schizophrenia and provided the first evidence that the variants regulate ITIH4 AND CALN1 expression in the dorsolateral prefrontal cortex (PMID:26991396)
• CALN1 gene encoding calneuron 1 had the strongest correlation with CYP11B2 (aldosterone synthase) among genes encoding Ca2+-binding proteins in Aldosterone-producing Adenoma. (PMID:29109191)
• up regulation serum exosomal miR-675 and down regulation of CALN1 in tumor specimen was also found to be associated with the metastatic phenotype in osteosarcoma patients. (PMID:29626470)

Cross-species orthologs

16 orthologs

Organism	Symbol	Gene ID
danio_rerio	caln2	ENSDARG00000069766
danio_rerio	caln1	ENSDARG00000088898
mus_musculus	Caln1	ENSMUSG00000060371
rattus_norvegicus		ENSRNOG00000080098
drosophila_melanogaster	TpnC4	FBGN0033027
drosophila_melanogaster	CG13526	FBGN0034774
drosophila_melanogaster	CG5024	FBGN0039373
drosophila_melanogaster	CG17770	FBGN0039374
drosophila_melanogaster	CG30378	FBGN0050378
caenorhabditis_elegans		WBGENE00000285
caenorhabditis_elegans		WBGENE00000287
caenorhabditis_elegans	pat-10	WBGENE00003934
caenorhabditis_elegans		WBGENE00006583
caenorhabditis_elegans		WBGENE00008453
caenorhabditis_elegans	F35C12.3	WBGENE00009408
caenorhabditis_elegans		WBGENE00015264

Paralogs (20): CABP7 (ENSG00000100314), CABP5 (ENSG00000105507), CALML4 (ENSG00000129007), CALM2 (ENSG00000143933), CETN2 (ENSG00000147400), CETN3 (ENSG00000153140), CABP1 (ENSG00000157782), CALM3 (ENSG00000160014), CABP2 (ENSG00000167791), CALML6 (ENSG00000169885), EFCAB3 (ENSG00000172421), EFCAB12 (ENSG00000172771), CABP4 (ENSG00000175544), CETN1 (ENSG00000177143), CALML3 (ENSG00000178363), CALML5 (ENSG00000178372), CALM1 (ENSG00000198668), EFCAB2 (ENSG00000203666), EFCAB7 (ENSG00000203965), EFCAB9 (ENSG00000214360)

Protein

Protein identifiers

Calcium-binding protein 8 — Q9BXU9 (reviewed: Q9BXU9)

Alternative names: Calneuron I, Calneuron-1

All UniProt accessions (3): A4D1Z1, E9PFU3, Q9BXU9

UniProt curated annotations — full annotation on UniProt →

Function. Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning.

Subunit / interactions. Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.

Subcellular location. Golgi apparatus. trans-Golgi network membrane. Cytoplasm. Perinuclear region. Cell membrane.

Tissue specificity. Brain specific.

Domain organisation. The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BXU9-2	1	yes
Q9BXU9-1	2

RefSeq proteins (3): NP_001017440, NP_001350389, NP_113656* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001751	S100/CaBP7/8-like_CS	Conserved_site
IPR002048	EF_hand_dom	Domain
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR018247	EF_Hand_1_Ca_BS	Binding_site
IPR051111	Ca-binding_regulatory	Family

Pfam: PF13499

UniProt features (18 total): binding site 9, topological domain 2, domain 2, chain 1, splice variant 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BXU9-F1	53.55	0.01

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (9): 95; 102; 127; 129; 131; 133; 138; 91; 93

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 197 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, AAGTCCA_MIR422B_MIR422A, AAGCCAT_MIR135A_MIR135B, LHX3_01, CACCAGC_MIR138, CCATCCA_MIR432, MORF_RAD51L3, GOBP_CELL_CELL_SIGNALING, SRF_Q5_01, GOCC_TRANS_GOLGI_NETWORK, GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY, MYOD_01, MORF_CTSB, MORF_IL4, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN

GO Biological Process (0):

GO Molecular Function (3): calcium ion binding (GO:0005509), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (6): plasma membrane (GO:0005886), trans-Golgi network membrane (GO:0032588), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
metal ion binding	1
binding	1
cation binding	1
membrane	1
cell periphery	1
trans-Golgi network	1
organelle membrane	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2244 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CALN1	AUTS2	Q8WXX7	647
CALN1	NCS1	P36610	623
CALN1	ISM1	B1AKI9	612
CALN1	GALNT17	Q6IS24	516
CALN1	CNR1	P21554	482
CALN1	ADORA2A	P29274	476
CALN1	TMEM236	Q5W0B7	471
CALN1	DRD2	P14416	458
CALN1	A0A0B4J2G0	A0A0B4J2G0	439
CALN1	IQSEC3	Q9UPP2	423
CALN1	NEURL1B	A8MQ27	408
CALN1	PI4KB	P78405	395
CALN1	S100G	P29377	363
CALN1	CALML4	Q96GE6	349
CALN1	TBC1D22A	Q8WUA7	347

IntAct

35 interactions, top by confidence:

A	B	Type	Score
FATE1	CALN1	psi-mi:“MI:0915”(physical association)	0.560
	CALN1	psi-mi:“MI:0915”(physical association)	0.560
SEC22A	CALN1	psi-mi:“MI:0915”(physical association)	0.560
PLP1	CALN1	psi-mi:“MI:0915”(physical association)	0.560
DNAJC30	CALN1	psi-mi:“MI:0915”(physical association)	0.560
CALN1	USE1	psi-mi:“MI:0915”(physical association)	0.560
MAL	CALN1	psi-mi:“MI:0915”(physical association)	0.560
SLPI	CALN1	psi-mi:“MI:0915”(physical association)	0.560
CALN1	LIME1	psi-mi:“MI:0915”(physical association)	0.560
CALN1	DCAF6	psi-mi:“MI:0915”(physical association)	0.400
CALN1	CNR1	psi-mi:“MI:0403”(colocalization)	0.380
CALN1	CNR1	psi-mi:“MI:2364”(proximity)	0.380
CALN1	CETN1	psi-mi:“MI:0914”(association)	0.350
CALN1	FATE1	psi-mi:“MI:0915”(physical association)	0.000
	CALN1	psi-mi:“MI:0915”(physical association)	0.000
DNAJC30	CALN1	psi-mi:“MI:0915”(physical association)	0.000
USE1	CALN1	psi-mi:“MI:0915”(physical association)	0.000
SEC22A	CALN1	psi-mi:“MI:0915”(physical association)	0.000
PLP1	CALN1	psi-mi:“MI:0915”(physical association)	0.000
MAL	CALN1	psi-mi:“MI:0915”(physical association)	0.000
CALN1	SLPI	psi-mi:“MI:0915”(physical association)	0.000
CALN1	LIME1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (15): DCAF6 (Affinity Capture-MS), CALN1 (Two-hybrid), CALN1 (Two-hybrid), CALN1 (Two-hybrid), CALN1 (Two-hybrid), CALN1 (Two-hybrid), CALN1 (Two-hybrid), CALN1 (Two-hybrid), LIME1 (Two-hybrid), SYCE1L (Two-hybrid), CETN1 (Affinity Capture-MS), DCAF6 (Affinity Capture-MS), CALN1 (Affinity Capture-MS), CALN1 (Affinity Capture-MS), CALN1 (Affinity Capture-RNA)

ESM2 similar proteins: A2AHC3, A4FU69, A5WUN7, A7E379, A8MWE9, D3Z6S9, D3Z8E6, D3ZSP7, D4AEC2, O43149, O88196, P53804, Q06190, Q06BI3, Q08AD1, Q12923, Q13009, Q13129, Q3UMB5, Q4R8X0, Q5RBH9, Q5SSH7, Q5SW75, Q5T5Y3, Q60610, Q66HC0, Q6DGK9, Q6IRN6, Q6NZK8, Q76I76, Q80VH0, Q80X60, Q86WZ0, Q8C115, Q8C1B1, Q8C9R9, Q8CDN1, Q8ND61, Q8WWI1, Q99J45

Diamond homologs: A6H742, A7E3Q8, O50064, O59945, O88818, P0CM54, P0CM55, P13796, P13797, P19179, P32599, P46939, P48451, P54680, Q06BI3, Q14651, Q24214, Q25088, Q3V0K9, Q55G87, Q61233, Q63598, Q66H96, Q6DG81, Q6P698, Q7F0J0, Q7G188, Q7XHW4, Q84UL5, Q866X0, Q86V35, Q91ZM8, Q99K51, Q9BXU9, Q9FJ70, Q9FKI0, Q9JJG7, Q9N4M4, Q9SJ84, Q9SVG9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	41
Likely benign	4
Benign	3

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
563416	GRCh37/hg19 7q11.22(chr7:67638834-71764461)x1	Pathogenic

SpliceAI

4314 predictions. Top by Δscore:

Variant	Effect	Δscore
7:71810331:CCTA:C	donor_loss	1.0000
7:71810332:CTA:C	donor_loss	1.0000
7:71810333:TACC:T	donor_loss	1.0000
7:71810334:A:AC	donor_gain	1.0000
7:71810334:A:T	donor_loss	1.0000
7:71810334:ACCT:A	donor_gain	1.0000
7:71810334:ACCTC:A	donor_gain	1.0000
7:71810335:C:CA	donor_loss	1.0000
7:71810335:C:CC	donor_gain	1.0000
7:71810335:CCT:C	donor_gain	1.0000
7:71810335:CCTC:C	donor_gain	1.0000
7:71810335:CCTCC:C	donor_gain	1.0000
7:71810337:T:TA	donor_gain	1.0000
7:71810386:T:TA	donor_gain	1.0000
7:71810488:TCAAA:T	acceptor_gain	1.0000
7:71810489:CAAA:C	acceptor_gain	1.0000
7:71810489:CAAAC:C	acceptor_gain	1.0000
7:71810490:AAA:A	acceptor_gain	1.0000
7:71810491:AA:A	acceptor_gain	1.0000
7:71810492:ACT:A	acceptor_loss	1.0000
7:71810493:C:CA	acceptor_loss	1.0000
7:71810493:C:CC	acceptor_gain	1.0000
7:71810494:T:C	acceptor_loss	1.0000
7:71810495:G:C	acceptor_gain	1.0000
7:72023652:CTCA:C	donor_gain	1.0000
7:72023653:TCA:T	donor_loss	1.0000
7:72023654:CA:C	donor_loss	1.0000
7:72023655:A:AC	donor_gain	1.0000
7:72023655:AC:A	donor_gain	1.0000
7:72023655:ACCTG:A	donor_gain	1.0000

AlphaMissense

1754 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:71787815:A:G	L249P	1.000
7:71787823:A:C	S246R	1.000
7:71787823:A:T	S246R	1.000
7:71787825:T:G	S246R	1.000
7:71787832:G:C	F243L	1.000
7:71787832:G:T	F243L	1.000
7:71787834:A:G	F243L	1.000
7:71787842:G:T	A240D	1.000
7:71787857:A:G	L235P	1.000
7:71810449:A:G	L182P	1.000
7:72023741:G:C	F139L	1.000
7:72023741:G:T	F139L	1.000
7:72023742:A:C	F139C	1.000
7:72023742:A:G	F139S	1.000
7:72023743:A:G	F139L	1.000
7:72023745:T:A	E138V	1.000
7:72023750:A:C	F136L	1.000
7:72023750:A:T	F136L	1.000
7:72023751:A:G	F136S	1.000
7:72023752:A:G	F136L	1.000
7:72106158:G:C	D127E	1.000
7:72106158:G:T	D127E	1.000
7:72106159:T:A	D127V	1.000
7:72106159:T:G	D127A	1.000
7:72106160:C:G	D127H	1.000
7:72106162:A:G	L126S	1.000
7:72106174:A:T	I122N	1.000
7:72106183:A:G	L119P	1.000
7:72106183:A:T	L119Q	1.000
7:72106198:G:C	P114R	1.000

dbSNP variants (sampled 300 via entrez): RS1000010558 (7:72125098 G>A,C), RS1000011206 (7:72118151 C>T), RS1000014273 (7:72289615 C>T), RS1000015111 (7:72080266 T>C), RS1000015887 (7:72118271 A>G), RS1000016511 (7:72390161 C>T), RS1000019659 (7:71976195 A>G,T), RS1000020291 (7:72492575 G>A), RS1000020423 (7:72267211 C>T), RS1000022560 (7:71821942 ATTT>A,ATT,ATTTT), RS1000025077 (7:71941831 G>A), RS1000026727 (7:71936134 A>G), RS1000027130 (7:72412375 T>G), RS1000028437 (7:72124567 G>C), RS1000038114 (7:71935899 C>A)

Disease associations

OMIM: gene MIM:607176 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

21 associations (top):

Study	Trait	p-value
GCST001112_6	Lifetime average cigarettes per day in chronic obstructive pulmonary disease	3.000000e-06
GCST001621_24	Airflow obstruction	2.000000e-06
GCST002337_132	Amyotrophic lateral sclerosis (sporadic)	4.000000e-06
GCST004946_32	Schizophrenia	3.000000e-08
GCST005316_396	Intelligence (MTAG)	3.000000e-08
GCST005316_6	Intelligence (MTAG)	1.000000e-13
GCST005316_7	Intelligence (MTAG)	3.000000e-12
GCST005803_15	Corneal astigmatism	9.000000e-06
GCST006269_747	General cognitive ability	1.000000e-08
GCST006913_4	Sedentary behaviour duration	4.000000e-09
GCST007006_5	Logical memory (delayed recall) in normal cognition	6.000000e-07
GCST007201_71	Schizophrenia	4.000000e-08
GCST007576_187	Chronotype	9.000000e-11
GCST008595_185	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy)	1.000000e-10
GCST009524_115	Household income (MTAG)	2.000000e-08
GCST010002_253	Refractive error	2.000000e-09
GCST010094_2	Emotional recognition	5.000000e-07
GCST010173_11	Triglyceride levels	2.000000e-24
GCST010244_242	Triglyceride levels	2.000000e-27
GCST012490_303	Femur bone mineral density x serum urate levels interaction	9.000000e-10
GCST90000050_45	Age at first birth	4.000000e-08

EFO canonical traits (12, from GWAS)

EFO ID	Trait name
EFO:0003892	pulmonary function measurement
EFO:0004337	intelligence
EFO:1002040	Corneal astigmatism
EFO:0008002	physical activity measurement
EFO:0004874	memory performance
EFO:0008328	chronotype measurement
EFO:0004784	self reported educational attainment
EFO:0009695	household income
EFO:0008329	facial emotion recognition measurement
EFO:0004530	triglyceride measurement
EFO:0004531	urate measurement
EFO:0009101	age at first birth measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation, affects methylation, decreases expression	3
sodium arsenite	affects methylation, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Aflatoxin B1	affects expression, affects methylation	2
p-Chloromercuribenzoic Acid	decreases expression, affects cotreatment	2
bisphenol F	increases methylation	1
methyleugenol	decreases expression	1
bisphenol A	affects cotreatment, increases methylation	1
terbufos	increases methylation	1
arsenite	increases methylation	1
benzo(e)pyrene	affects methylation	1
aflatoxin B2	affects methylation	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
Grape Seed Proanthocyanidins	decreases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, decreases expression	1
(+)-JQ1 compound	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	increases expression	1
Carbamazepine	affects expression	1
Catechin	affects cotreatment, decreases expression	1
Copper	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Doxorubicin	decreases expression	1
Fonofos	increases methylation	1
Ethyl Methanesulfonate	decreases expression	1
Formaldehyde	decreases expression	1
Chlordecone	affects response to substance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.