CAND2

Summary

CAND2 (cullin associated and neddylation dissociated 2 (putative), HGNC:30689) is a protein-coding gene on chromosome 3p25.2, encoding Cullin-associated NEDD8-dissociated protein 2 (O75155). Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.

Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of DNA-templated transcription; and protein ubiquitination. Located in cytosol.

Source: NCBI Gene 23066 — RefSeq curated summary.

At a glance

• GWAS associations: 27
• Clinical variants (ClinVar): 272 total
• MANE Select transcript: NM_001162499

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30689
Approved symbol	CAND2
Name	cullin associated and neddylation dissociated 2 (putative)
Location	3p25.2
Locus type	gene with protein product
Status	Approved
Aliases	TIP120B, KIAA0667, Tp120b
Ensembl gene	ENSG00000144712
Ensembl biotype	protein_coding
OMIM	610403
Entrez	23066

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000295989, ENST00000446928, ENST00000456430, ENST00000466558, ENST00000626378, ENST00000650119, ENST00000856238, ENST00000917140, ENST00000949513, ENST00000949514

RefSeq mRNA: 2 — MANE Select: NM_001162499 NM_001162499, NM_012298

CCDS: CCDS43053, CCDS54554

Canonical transcript exons

ENST00000456430 — 15 exons

Exon	Start	End
ENSE00000966686	12803488	12803631
ENSE00000966687	12810059	12810324
ENSE00000966688	12812990	12813095
ENSE00000966689	12813246	12813388
ENSE00000966690	12815141	12815433
ENSE00000966691	12815867	12816008
ENSE00000966692	12816374	12817876
ENSE00000966695	12827440	12827604
ENSE00001161869	12820086	12820181
ENSE00001619886	12807306	12807460
ENSE00001650494	12825470	12825639
ENSE00001723434	12796680	12796788
ENSE00001794332	12833755	12834803
ENSE00003515140	12808210	12808333
ENSE00004472062	12831465	12831572

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 99.13.

FANTOM5 (CAGE): breadth broad, TPM avg 4.2475 / max 114.1299, expressed in 854 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
35393	4.0083	835
35392	0.2392	138

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.13	gold quality
vastus lateralis	UBERON:0001379	98.60	gold quality
gluteal muscle	UBERON:0002000	98.53	gold quality
quadriceps femoris	UBERON:0001377	98.43	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	98.19	gold quality
biceps brachii	UBERON:0001507	98.06	gold quality
triceps brachii	UBERON:0001509	97.94	gold quality
skeletal muscle tissue	UBERON:0001134	97.55	gold quality
sperm	CL:0000019	96.84	gold quality
deltoid	UBERON:0001476	96.79	gold quality
gastrocnemius	UBERON:0001388	96.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.31	gold quality
muscle organ	UBERON:0001630	96.12	gold quality
body of tongue	UBERON:0011876	96.02	gold quality
male germ cell	CL:0000015	95.69	gold quality
left ventricle myocardium	UBERON:0006566	95.69	gold quality
diaphragm	UBERON:0001103	95.41	gold quality
endothelial cell	CL:0000115	95.40	gold quality
muscle of leg	UBERON:0001383	95.34	gold quality
tibialis anterior	UBERON:0001385	95.07	gold quality
middle temporal gyrus	UBERON:0002771	94.82	gold quality
muscle tissue	UBERON:0002385	94.80	gold quality
heart right ventricle	UBERON:0002080	94.20	gold quality
Brodmann (1909) area 23	UBERON:0013554	94.11	gold quality
myocardium	UBERON:0002349	93.62	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.12	gold quality
apex of heart	UBERON:0002098	91.62	gold quality
adult organism	UBERON:0007023	90.02	gold quality
oocyte	CL:0000023	90.01	gold quality
cardiac ventricle	UBERON:0002082	89.53	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.27
E-MTAB-9543	no	1.22

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYOD1

miRNA regulators (miRDB)

25 targeting CAND2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-1200	99.71	70.42	1838
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-544B	99.18	67.41	1632
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-4324	99.04	70.14	1569
HSA-MIR-4424	98.91	70.33	1145
HSA-MIR-4724-5P	98.87	67.75	1324
HSA-MIR-7851-3P	98.72	64.88	980
HSA-MIR-490-3P	97.79	65.54	606
HSA-MIR-4308	97.56	67.13	1385
HSA-MIR-6890-3P	97.50	65.71	997
HSA-MIR-7160-3P	96.40	64.15	462
HSA-MIR-3622B-5P	94.62	64.58	835

Literature-anchored findings (GeneRIF, showing 7)

• TIP120B was induced in C2C12 myoblasts when these cells differentiated into myotubes (TIP120B). (PMID:12207886)
• TIP120B is a specific substrate of KIAA10; both are highly expressed in human skeletal muscle, suggesting that KIAA10 may regulate TIP120B homeostasis specifically in this tissue. (PMID:12692129)
• Based on these results it is unlikely CAND2 and WNT7a are the major genes that causes clubfoot. (PMID:19159115)
• results suggest that MyoD and TIP120B potentiate each other at gene expression and post-translation levels, respectively, which may promote myogenesis cooperatively (PMID:22613845)
• NEURL rs12415501 and CAND2 rs4642101 are significantly associated with postoperative atrial fibrillation susceptibility after coronary artery bypass grafting among Chinese population (PMID:27203392)
• The work developed the tool and performed “interaction analyses within chromatin regulatory circuitry” (IACRC); analysis found CAND2 may be a novel obesity susceptibility gene. (PMID:29717274)
• Muscle-specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling. (PMID:34605609)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Cand2	ENSMUSG00000030319
rattus_norvegicus	Cand2	ENSRNOG00000010473
drosophila_melanogaster	Cand1	FBGN0027568
caenorhabditis_elegans		WBGENE00013606

Paralogs (1): CAND1 (ENSG00000111530)

Protein

Protein identifiers

Cullin-associated NEDD8-dissociated protein 2 — O75155 (reviewed: O75155)

Alternative names: Cullin-associated and neddylation-dissociated protein 2, Epididymis tissue protein Li 169, TBP-interacting protein of 120 kDa B, p120 CAND2

All UniProt accessions (3): O75155, A0A3B3ISC4, F8WBB8

UniProt curated annotations — full annotation on UniProt →

Function. Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.

Subunit / interactions. Binds TBP, CNOT3 and UBE3C.

Subcellular location. Nucleus.

Tissue specificity. Expressed in epididymis (at protein level).

Post-translational modifications. Ubiquitinated and targeted for proteasomal degradation.

Similarity. Belongs to the CAND family.

Isoforms (2)

UniProt ID	Names	Canonical?
O75155-1	1	yes
O75155-2	2

RefSeq proteins (2): NP_001155971, NP_036430 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011989	ARM-like	Homologous_superfamily
IPR013932	TATA-bd_TIP120	Domain
IPR016024	ARM-type_fold	Homologous_superfamily
IPR039852	CAND1/CAND2	Family

Pfam: PF08623, PF13513, PF25782

UniProt features (136 total): helix 75, repeat 26, turn 9, strand 9, sequence variant 8, splice variant 3, initiator methionine 1, chain 1, region of interest 1, compositionally biased region 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8VVY	ELECTRON MICROSCOPY	3.49

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75155-F1	87.14	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 101 (showing top): BROWNE_HCMV_INFECTION_14HR_DN, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, CERVERA_SDHB_TARGETS_1_UP, MULLIGHAN_MLL_SIGNATURE_1_UP, GOMF_TRANSCRIPTION_FACTOR_BINDING, DODD_NASOPHARYNGEAL_CARCINOMA_DN, GOMF_TBP_CLASS_PROTEIN_BINDING, WONG_ADULT_TISSUE_STEM_MODULE, MARTENS_TRETINOIN_RESPONSE_DN, KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP, CHICAS_RB1_TARGETS_CONFLUENT, LEE_BMP2_TARGETS_DN, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP, PLASARI_TGFB1_TARGETS_10HR_DN, PEDRIOLI_MIR31_TARGETS_DN

GO Biological Process (3): SCF complex assembly (GO:0010265), protein ubiquitination (GO:0016567), positive regulation of DNA-templated transcription (GO:0045893)

GO Molecular Function (2): TBP-class protein binding (GO:0017025), protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), cytosol (GO:0005829)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein-containing complex assembly	1
protein modification by small protein conjugation	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
general transcription initiation factor binding	1
binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
cellular anatomical structure	1

Protein interactions and networks

STRING

745 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CAND2	TBP	P20226	694
CAND2	NEURL1	O76050	635
CAND2	SYNPO2L	Q9H987	581
CAND2	SKP1	P34991	476
CAND2	NEDD8	Q15843	470
CAND2	CUX2	O14529	447
CAND2	AOPEP	Q8N6M6	447
CAND2	GPR50	Q13585	438
CAND2	CUL1	Q13616	423
CAND2	MTNR1A	P48039	418
CAND2	ELOC	Q15369	410
CAND2	LRRC58	Q96CX6	407
CAND2	ZFHX3	Q15911	398
CAND2	ZNF860	A6NHJ4	392
CAND2	RBX1	P62877	390

IntAct

96 interactions, top by confidence:

A	B	Type	Score
SCN2B	EXOC5	psi-mi:“MI:0914”(association)	0.640
SDC2	PDPK1	psi-mi:“MI:0914”(association)	0.640
IL13RA2	CHEK1	psi-mi:“MI:0914”(association)	0.640
CAND2	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
CAND2	SYP	psi-mi:“MI:0915”(physical association)	0.560
CAND2	FHL2	psi-mi:“MI:0915”(physical association)	0.560
EGFR	NDUFA4	psi-mi:“MI:0914”(association)	0.530
ARRDC4	WWP2	psi-mi:“MI:0914”(association)	0.530
CXCR4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
HTR2C	KLRG2	psi-mi:“MI:0914”(association)	0.530
LPAR4	POTEF	psi-mi:“MI:0914”(association)	0.530
NPY2R	RTL8C	psi-mi:“MI:0914”(association)	0.530
EFNB2	FAM171A2	psi-mi:“MI:0914”(association)	0.530
PTGER3	PIK3R2	psi-mi:“MI:0914”(association)	0.530
EPHA1	EXOC5	psi-mi:“MI:0914”(association)	0.530
RNF7	SOCS7	psi-mi:“MI:0914”(association)	0.530
STOM	EI24	psi-mi:“MI:0914”(association)	0.510
CAND2	GLP1R	psi-mi:“MI:0915”(physical association)	0.510
	CAND2	psi-mi:“MI:0914”(association)	0.460
	TK2	psi-mi:“MI:0915”(physical association)	0.400
TPTE	ILVBL	psi-mi:“MI:0914”(association)	0.350
BCL2L14		psi-mi:“MI:0914”(association)	0.350
P2RY6	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC15A3		psi-mi:“MI:0914”(association)	0.350
UNC93B1		psi-mi:“MI:0914”(association)	0.350
P2RY6		psi-mi:“MI:0914”(association)	0.350
P2RY6	RAVER1	psi-mi:“MI:0914”(association)	0.350
	ZFC3H1	psi-mi:“MI:0914”(association)	0.350
TEX101	PSMD12	psi-mi:“MI:0914”(association)	0.350

BioGRID (138): CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS), CAND2 (Co-fractionation), CAND2 (Co-fractionation), NAA15 (Co-fractionation), CAND2 (Affinity Capture-MS), CAND2 (Affinity Capture-MS)

ESM2 similar proteins: A0JMW2, A2VE70, A5WW24, A7E2Y6, B9EJR8, E0CZ22, E1BP36, E7FBU4, O35638, O43156, O70576, O75155, Q08AM6, Q0P5A6, Q0V9L1, Q16401, Q5IFJ8, Q5JTH9, Q5R6L5, Q5ZIW5, Q5ZKD5, Q66L58, Q68F38, Q6DCF2, Q6P5B0, Q6ZQ73, Q7TMY7, Q80W92, Q80WQ2, Q84ZC0, Q86Y56, Q8C0Y0, Q8K2V6, Q8NDA8, Q8WVM7, Q91V83, Q96T76, Q99M76, Q9BPX3, Q9D071

Diamond homologs: A7MBJ5, G5ED41, O75155, P97536, Q5BAH2, Q5R6L5, Q6ZQ38, Q6ZQ73, Q86KD1, Q86VP6, Q8L5Y6, Q9R0L4, Q9VKY2

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
CNOT3	unknown	CAND2	binding
UBE3C	“down-regulates quantity by destabilization”	CAND2	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 124 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of cytosolic calcium ion concentration	10	10.8×	2e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

272 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	231
Likely benign	14
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

2687 predictions. Top by Δscore:

Variant	Effect	Δscore
3:12803484:GCA:G	acceptor_loss	1.0000
3:12803485:CAG:C	acceptor_loss	1.0000
3:12803486:A:G	acceptor_loss	1.0000
3:12803629:GTG:G	donor_gain	1.0000
3:12803632:G:GG	donor_gain	1.0000
3:12803632:GTGA:G	donor_loss	1.0000
3:12803633:T:G	donor_loss	1.0000
3:12803634:GAGTG:G	donor_loss	1.0000
3:12808205:TGCA:T	acceptor_loss	1.0000
3:12808206:GCAGG:G	acceptor_loss	1.0000
3:12808207:CA:C	acceptor_loss	1.0000
3:12808208:A:AG	acceptor_gain	1.0000
3:12808209:G:GT	acceptor_gain	1.0000
3:12808209:GGC:G	acceptor_gain	1.0000
3:12808209:GGCT:G	acceptor_gain	1.0000
3:12808299:G:GT	donor_gain	1.0000
3:12808326:C:G	donor_gain	1.0000
3:12810321:CTCGG:C	donor_loss	1.0000
3:12810322:TCGG:T	donor_loss	1.0000
3:12810323:CGG:C	donor_loss	1.0000
3:12810325:G:GA	donor_loss	1.0000
3:12810325:G:GG	donor_gain	1.0000
3:12812985:TGCA:T	acceptor_loss	1.0000
3:12812987:CAGGG:C	acceptor_loss	1.0000
3:12812988:A:AG	acceptor_gain	1.0000
3:12812988:AG:A	acceptor_gain	1.0000
3:12812988:AGG:A	acceptor_gain	1.0000
3:12812988:AGGG:A	acceptor_gain	1.0000
3:12812989:G:GA	acceptor_loss	1.0000
3:12812989:G:GG	acceptor_gain	1.0000

AlphaMissense

7960 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:12796788:G:C	R23T	1.000
3:12796788:G:T	R23M	1.000
3:12803493:T:C	M25T	1.000
3:12803494:G:A	M25I	1.000
3:12803494:G:C	M25I	1.000
3:12803494:G:T	M25I	1.000
3:12803508:T:C	L30P	1.000
3:12803619:T:C	L67P	1.000
3:12827455:T:C	F1076L	1.000
3:12827457:T:A	F1076L	1.000
3:12827457:T:G	F1076L	1.000
3:12796781:G:A	D21N	0.999
3:12796781:G:C	D21H	0.999
3:12796782:A:C	D21A	0.999
3:12796782:A:G	D21G	0.999
3:12796782:A:T	D21V	0.999
3:12796783:C:A	D21E	0.999
3:12796783:C:G	D21E	0.999
3:12803488:G:C	R23S	0.999
3:12803488:G:T	R23S	0.999
3:12803489:T:C	F24L	0.999
3:12803491:C:A	F24L	0.999
3:12803491:C:G	F24L	0.999
3:12803493:T:A	M25K	0.999
3:12803495:G:C	A26P	0.999
3:12803496:C:A	A26D	0.999
3:12803586:T:C	L56P	0.999
3:12803594:G:C	D59H	0.999
3:12803595:A:C	D59A	0.999
3:12803595:A:T	D59V	0.999

dbSNP variants (sampled 300 via entrez): RS1000253727 (3:12826462 G>A,C), RS1000300230 (3:12832517 C>T), RS1000300696 (3:12810689 A>G), RS1000354316 (3:12831670 G>C), RS1000374868 (3:12794680 CTTTTTTTTTTTT>C,CT,CTTTT,CTTTTT,CTTTTTT,CTTTTTTT,CTTTTTTTT,CTTTTTTTTT,CTTTTTTTTTT,CTTTTTTTTTTT,CTTTTTTTTTTTTT,CTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTTTTTT), RS1000443222 (3:12812740 A>G), RS1000447550 (3:12801651 C>G), RS1000519062 (3:12816977 G>A), RS1000545848 (3:12833265 TGCTTACACTCCG>T), RS1000550195 (3:12816844 G>A), RS1000732004 (3:12826638 C>T), RS1000736165 (3:12806073 T>C,G), RS1000761758 (3:12826815 G>A), RS1000787754 (3:12806013 G>C), RS1000872007 (3:12801477 G>A,T)

Disease associations

OMIM: gene MIM:610403 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

27 associations (top):

Study	Trait	p-value
GCST004826_1	P wave duration	2.000000e-08
GCST005956_72	Waist-to-hip ratio adjusted for BMI	1.000000e-07
GCST005957_11	Waist-to-hip ratio adjusted for BMI (age <50)	9.000000e-06
GCST005958_19	Waist-to-hip ratio adjusted for BMI (age >50)	2.000000e-06
GCST005962_29	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	9.000000e-09
GCST006014_6	Creatine kinase levels	8.000000e-11
GCST006061_37	Atrial fibrillation	5.000000e-23
GCST006061_75	Atrial fibrillation	4.000000e-22
GCST006414_74	Atrial fibrillation	2.000000e-24
GCST008161_95	Waist circumference adjusted for body mass index	3.000000e-06
GCST010724_6	HOMA-B (corrected for HOMA-IR)	1.000000e-07
GCST010796_261	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-13
GCST010796_262	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-12
GCST010796_263	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-13
GCST010796_264	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-13
GCST010796_265	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-09
GCST010796_266	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-09
GCST010796_267	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-09
GCST010796_268	Electrocardiogram morphology (amplitude at temporal datapoints)	5.000000e-09
GCST010796_269	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-08
GCST010796_270	Electrocardiogram morphology (amplitude at temporal datapoints)	5.000000e-10
GCST010796_271	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-09
GCST010796_272	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-10
GCST010796_273	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-10
GCST010796_274	Electrocardiogram morphology (amplitude at temporal datapoints)	9.000000e-10
GCST90020025_1936	Waist-to-hip ratio adjusted for BMI	1.000000e-08
GCST90020027_167	Waist-hip index	3.000000e-09

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0005094	P wave duration
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004534	creatine kinase measurement
EFO:0007789	BMI-adjusted waist circumference
EFO:0004469	HOMA-B
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression	3
(+)-JQ1 compound	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
FR900359	increases phosphorylation	1
bisphenol A	decreases methylation	1
sodium arsenite	affects methylation	1
zinc chromate	decreases expression, increases abundance	1
chromium hexavalent ion	decreases expression, increases abundance	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Decitabine	affects expression	1
Acetaminophen	decreases expression	1
Arsenic	decreases methylation, increases abundance	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Carbamazepine	affects expression	1
Cisplatin	affects expression	1
Doxorubicin	decreases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Metals, Heavy	decreases methylation, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.