CAPG

Summary

CAPG (capping actin protein, gelsolin like, HGNC:1474) is a protein-coding gene on chromosome 2p11.2, encoding Macrophage-capping protein (P40121). Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments.

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene.

Source: NCBI Gene 822 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 72 total
• Druggable target: yes
• MANE Select transcript: NM_001747

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1474
Approved symbol	CAPG
Name	capping actin protein, gelsolin like
Location	2p11.2
Locus type	gene with protein product
Status	Approved
Aliases	MCP
Ensembl gene	ENSG00000042493
Ensembl biotype	protein_coding
OMIM	153615
Entrez	822

Gene structure

Transcript identifiers

Ensembl transcripts: 53 — 47 protein_coding, 3 protein_coding_CDS_not_defined, 3 retained_intron

ENST00000263867, ENST00000409275, ENST00000409670, ENST00000409724, ENST00000409921, ENST00000415012, ENST00000439385, ENST00000447219, ENST00000449030, ENST00000453973, ENST00000459793, ENST00000471064, ENST00000479651, ENST00000483659, ENST00000491267, ENST00000880826, ENST00000880827, ENST00000880828, ENST00000880829, ENST00000880830, ENST00000880831, ENST00000880832, ENST00000880833, ENST00000880834, ENST00000880835, ENST00000880836, ENST00000880837, ENST00000880838, ENST00000880839, ENST00000880840, ENST00000880841, ENST00000880842, ENST00000880843, ENST00000880844, ENST00000918269, ENST00000918270, ENST00000918271, ENST00000918272, ENST00000918273, ENST00000918274, ENST00000918275, ENST00000918276, ENST00000918277, ENST00000951332, ENST00000951333, ENST00000951334, ENST00000951335, ENST00000951336, ENST00000951337, ENST00000951338, ENST00000951339, ENST00000951340, ENST00000951341

RefSeq mRNA: 6 — MANE Select: NM_001747 NM_001256139, NM_001256140, NM_001320732, NM_001320733, NM_001320734, NM_001747

CCDS: CCDS1974, CCDS58715

Canonical transcript exons

ENST00000263867 — 10 exons

Exon	Start	End
ENSE00001516724	85410317	85410366
ENSE00001713657	85394753	85394958
ENSE00003464947	85399136	85399285
ENSE00003473983	85395538	85395626
ENSE00003474428	85401785	85401957
ENSE00003486018	85402123	85402158
ENSE00003511275	85398020	85398152
ENSE00003583273	85401529	85401683
ENSE00003693166	85401165	85401329
ENSE00003785536	85398690	85398782

Expression profiles

Bgee: expression breadth ubiquitous, 258 present calls, max score 98.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 54.1535 / max 1148.8970, expressed in 1642 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29408	26.5233	983
29410	21.0126	1369
29407	2.6010	211
29409	1.1855	298
29411	0.9325	640
29399	0.5631	226
29404	0.3044	125
29412	0.3029	155
29403	0.2430	104
29405	0.1854	88

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	98.76	gold quality
lower esophagus mucosa	UBERON:0035834	98.60	gold quality
mononuclear cell	CL:0000842	98.42	gold quality
leukocyte	CL:0000738	98.39	gold quality
esophagus mucosa	UBERON:0002469	98.20	gold quality
skin of abdomen	UBERON:0001416	98.09	gold quality
left lobe of thyroid gland	UBERON:0001120	98.04	gold quality
granulocyte	CL:0000094	97.94	gold quality
right lobe of thyroid gland	UBERON:0001119	97.92	gold quality
skin of leg	UBERON:0001511	97.76	gold quality
metanephros cortex	UBERON:0010533	97.74	gold quality
upper lobe of left lung	UBERON:0008952	97.72	gold quality
right lung	UBERON:0002167	97.46	gold quality
upper lobe of lung	UBERON:0008948	97.42	gold quality
thyroid gland	UBERON:0002046	97.32	gold quality
zone of skin	UBERON:0000014	96.66	gold quality
ectocervix	UBERON:0012249	96.20	gold quality
gingiva	UBERON:0001828	96.03	gold quality
bone marrow	UBERON:0002371	95.86	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.82	gold quality
mouth mucosa	UBERON:0003729	95.59	gold quality
endocervix	UBERON:0000458	95.58	gold quality
gingival epithelium	UBERON:0001949	95.56	gold quality
minor salivary gland	UBERON:0001830	95.51	gold quality
mucosa of transverse colon	UBERON:0004991	95.48	gold quality
vagina	UBERON:0000996	95.38	gold quality
blood	UBERON:0000178	95.19	gold quality
ventricular zone	UBERON:0003053	95.16	gold quality
rectum	UBERON:0001052	94.95	gold quality
calcaneal tendon	UBERON:0003701	94.85	gold quality

Single-cell (SCXA)

Detected in 22 experiment(s), a significant marker in 21.

Experiment	Marker?	Max mean expression
E-HCAD-24	yes	1598.66
E-MTAB-5061	yes	843.52
E-MTAB-6701	yes	112.77
E-HCAD-1	yes	81.67
E-HCAD-4	yes	80.31
E-CURD-122	yes	72.45
E-CURD-88	yes	43.65
E-HCAD-6	yes	43.04
E-MTAB-10287	yes	29.27
E-GEOD-134144	yes	27.67
E-CURD-112	yes	27.48
E-HCAD-10	yes	25.71
E-MTAB-8410	yes	19.41
E-MTAB-10042	yes	17.13
E-MTAB-8142	yes	14.98

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HIF1A

miRNA regulators (miRDB)

8 targeting CAPG, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-328-5P	99.08	64.65	1000
HSA-MIR-6885-5P	98.71	64.33	902
HSA-MIR-3665	97.73	65.08	975
HSA-MIR-939-5P	97.10	65.80	1579
HSA-MIR-1343-5P	96.48	66.06	1506

Literature-anchored findings (GeneRIF, showing 36)

• CapG lacks a nuclear export sequence present in structurally related proteins (PMID:12637565)
• importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion (PMID:15454578)
• CapG is a new tumor suppressor gene involved in the tumorigenic progression of certain cancers (PMID:16767159)
• Comprehension of the mobility and compartmentalization of the CapG protein in normal and in cancer cells in vivo could constitute a new basis to characterize the invasiveness and metastasizing potential of breast cancer. (PMID:18059028)
• Dysregulated expression of gelsolin-like actin capping protein(CapG) was found in premalignant and malignant oral carcinogenesis. (PMID:18237446)
• Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG. (PMID:18266911)
• CapG mobility in cell nuclei of live breast cancer cells (PMID:18461482)
• the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as prognostic factors for patients with stage III serous ovarian adenocarcinomas. (PMID:18709641)
• These results suggest that filamentous actin in the nucleolus might be regulated by actin binding proteins such as CapG. (PMID:18938132)
• several genes that are known to be regulated by DNA methylation were up-regulated dramatically by integrin alpha6beta4 expression, including S100A4, FST, PDLIM4, CAPG, and Nkx2.2. (PMID:19011242)
• A role for the actin-binding protein CapG as a mediator of cross-talk between the actin cytoskeleton and microtubule-based organelles that regulate cell division was proposed. (PMID:19166812)
• Hypoxia-inducible factor 1alpha up-regulated CapG protein expression under normoxia. Knockdown of HIF-1alpha expression in hPASMCs also inhibited hypoxia-induced CapG up-regulation. (PMID:19188659)
• CapG was upregulated in the stroma cells of nasopharyngeal carcinoma (NPC) compared with normal nasopharyngeal epithelial tissues. CapG possibly plays a role in the complex interaction between NPC cells and the surrounding host tissue. (PMID:19242827)
• Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosis. (PMID:19439302)
• strong down-regulation of MCK activity contributes to F-actin instability and induces post-translational modification of alphaB-crystallin and desmin (PMID:21768101)
• These results suggest that overexpression of CapG may be associated with progression of lung adenocarcinoma. (PMID:21908955)
• CapG was identified as a novel candidate biomarker to predict response to gemcitabine treatment and survival in cholangiocarcinoma. (PMID:22155129)
• Expression of CapG, gelsolin, and P-gp was found to be associated with an increased risk of death from non-small cell lung cancer. (PMID:22190510)
• CapG is involved in the process of metastasis by promoting the invasiveness of tumor cells. (PMID:23085225)
• CapG was up-regulated in the tumor tissues of patients with lymph node metastasis (LNM), whereas it showed an equivalent expression level between non-tumor and tumor tissues of patients without LNM. (PMID:23782053)
• A single nucleotide polymorphism rs6886 inside the CapG gene was identified, affecting a CapG phosphorylation site and thus potentially modifying CapG function. (PMID:24804218)
• On the basis of these results, we propose a model in which dynamic vimentin filaments target CARMIL2 to critical membrane-associated locations, where CARMIL2 regulates CP, and thus actin assembly, to create cell protrusions (PMID:26466680)
• Overexpression of CAPG is associated with glioma. (PMID:26663173)
• The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment. (PMID:26757732)
• The combination of CTNB1, XPO2, and CAPG achieved 95% sensitivity and 96% specificity for the discrimination of these subtypes. We developed two uterine aspirate-based signatures to diagnose Endometrial cancer and classify tumors in the most prevalent histologic subtypes. This will improve diagnosis and assist in the prediction of the optimal surgical treatment (PMID:28790116)
• Results revealed that CapG is a novel independent prognostic predictor for glioma patients and highlight a key role of CapG in proliferation and metastasis of glioma. (PMID:29399702)
• CAPG competes with the transcriptional repressor arginine methyltransferase 5 (PRMT5) for binding to the STC-1 promoter. (PMID:29721098)
• it is demonstrated that CapG is expressed in the cytoplasm and could be used as a prognostic or diagnostic biomarker for mHCC in clinical specimens (PMID:29970516)
• Study suggested that CapG could be used as a biomarker for metastatic CRC in the clinical specimens. Moreover, our in vitro study demonstrated that CapG might contribute on tumor metastasis in human CRCs. (PMID:30155403)
• CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50. (PMID:31660072)
• The Association Between Gelsolin-like Actin-capping Protein (CapG) Overexpression and Bladder Cancer Prognosis. (PMID:32309867)
• The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies? (PMID:32619075)
• Oncogenic potential of macrophagecapping protein in clear cell renal cell carcinoma. (PMID:33236143)
• The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG. (PMID:33711419)
• CAPG facilitates diffuse large B-cell lymphoma cell progression through PI3K/AKT signaling pathway. (PMID:36244872)
• CAPG interference induces apoptosis and ferroptosis in colorectal cancer cells through the P53 pathway. (PMID:37468079)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	capga	ENSDARG00000035560
danio_rerio	capgb	ENSDARG00000099672
mus_musculus	Capg	ENSMUSG00000056737
rattus_norvegicus	Capg	ENSRNOG00000013668
drosophila_melanogaster	Gel	FBGN0010225
caenorhabditis_elegans		WBGENE00010593

Paralogs (7): SCIN (ENSG00000006747), VIL1 (ENSG00000127831), AVIL (ENSG00000135407), VILL (ENSG00000136059), GSN (ENSG00000148180), FLII (ENSG00000177731), SVIL (ENSG00000197321)

Protein

Protein identifiers

Macrophage-capping protein — P40121 (reviewed: P40121)

Alternative names: Actin regulatory protein CAP-G

All UniProt accessions (7): A0A979HLS1, A0A979HLS2, B8ZZL6, E7ENU9, P40121, H7C0X8, V9HW69

UniProt curated annotations — full annotation on UniProt →

Function. Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Subunit / interactions. Interacts with NUP62. Interacts with NUTF2 and RAN; involved in CAPG nuclear import.

Subcellular location. Nucleus. Cytoplasm. Melanosome. Cell projection. Lamellipodium. Ruffle.

Tissue specificity. Macrophages and macrophage-like cells.

Post-translational modifications. The N-terminus is blocked.

Similarity. Belongs to the villin/gelsolin family.

Isoforms (2)

UniProt ID	Names	Canonical?
P40121-1	1	yes
P40121-2	2

RefSeq proteins (6): NP_001243068, NP_001243069, NP_001307661, NP_001307662, NP_001307663, NP_001738* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007122	Villin/Gelsolin	Family
IPR007123	Gelsolin-like_dom	Domain
IPR029006	ADF-H/Gelsolin-like_dom_sf	Homologous_superfamily

Pfam: PF00626

UniProt features (45 total): strand 22, helix 8, turn 4, repeat 3, sequence variant 3, modified residue 2, chain 1, short sequence motif 1, splice variant 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
1J72	X-RAY DIFFRACTION	2.5
1JHW	X-RAY DIFFRACTION	2.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P40121-F1	86.89	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 1, 337

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 409 (showing top): GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, MCLACHLAN_DENTAL_CARIES_UP, PAL_PRMT5_TARGETS_UP, ENK_UV_RESPONSE_KERATINOCYTE_UP, MODULE_45, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_BARBED_END_ACTIN_FILAMENT_CAPPING, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP, MORI_IMMATURE_B_LYMPHOCYTE_UP, GOBP_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION, GOCC_RUFFLE

GO Biological Process (7): central nervous system development (GO:0007417), actin polymerization or depolymerization (GO:0008154), cell projection assembly (GO:0030031), actin filament severing (GO:0051014), barbed-end actin filament capping (GO:0051016), protein-containing complex assembly (GO:0065003), actin filament capping (GO:0051693)

GO Molecular Function (7): phosphatidylinositol-4,5-bisphosphate binding (GO:0005546), protein domain specific binding (GO:0019904), protein-containing complex binding (GO:0044877), cadherin binding (GO:0045296), actin filament binding (GO:0051015), actin binding (GO:0003779), protein binding (GO:0005515)

GO Cellular Component (15): ruffle (GO:0001726), nucleus (GO:0005634), nucleoplasm (GO:0005654), chromosome (GO:0005694), nucleolus (GO:0005730), cytoplasm (GO:0005737), centriole (GO:0005814), F-actin capping protein complex (GO:0008290), actin cytoskeleton (GO:0015629), lamellipodium (GO:0030027), melanosome (GO:0042470), extracellular exosome (GO:0070062), mitotic spindle (GO:0072686), Flemming body (GO:0090543), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
intracellular membraneless organelle	3
cellular component assembly	2
binding	2
cell leading edge	2
plasma membrane bounded cell projection	2
nuclear lumen	2
nervous system development	1
system development	1
actin filament organization	1
cell projection organization	1
actin filament-based process	1
actin filament capping	1
protein-containing complex organization	1
negative regulation of actin filament depolymerization	1
negative regulation of actin filament polymerization	1
phosphatidylinositol phosphate binding	1
phosphatidylinositol bisphosphate binding	1
protein binding	1
cell adhesion molecule binding	1
actin binding	1
protein-containing complex binding	1
cytoskeletal protein binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
microtubule organizing center	1
actin cytoskeleton	1
protein-containing complex	1
cytoskeleton	1
pigment granule	1
extracellular vesicle	1
spindle	1
midbody	1

Protein interactions and networks

STRING

1014 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CAPG	CFL1	P23528	559
CAPG	CFL2	Q9Y281	518
CAPG	LCP1	P13796	448
CAPG	GIPC1	O14908	447
CAPG	ENPEP	Q07075	428
CAPG	CAPS	Q13938	423
CAPG	AKR1B1	P15121	406
CAPG	HLA-DPB1	P01916	353
CAPG	GPNMB	Q14956	353
CAPG	TGFBI	Q15582	352
CAPG	APLP2	Q06481	348
CAPG	GHSR	Q92847	347
CAPG	BMP2	P12643	347
CAPG	ANXA2	P07355	343
CAPG	SYK	P43405	333

IntAct

72 interactions, top by confidence:

A	B	Type	Score
OAZ3	AZIN1	psi-mi:“MI:0914”(association)	0.800
PSMD10	PSMD11	psi-mi:“MI:0914”(association)	0.800
CNOT3	CNOT1	psi-mi:“MI:0914”(association)	0.740
SIAH1	CAPG	psi-mi:“MI:0915”(physical association)	0.560
TSC1	CAPG	psi-mi:“MI:0915”(physical association)	0.560
CAPG	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
TBC1D22B	A2ML1	psi-mi:“MI:0914”(association)	0.530
CAPG	HSPA8	psi-mi:“MI:0914”(association)	0.530
SETMAR	HSPA8	psi-mi:“MI:0914”(association)	0.530
TRUB1	CAPG	psi-mi:“MI:0914”(association)	0.500
TRUB1	CAPG	psi-mi:“MI:0915”(physical association)	0.500
ACTA1	CAPG	psi-mi:“MI:0407”(direct interaction)	0.440
CAPG		psi-mi:“MI:0915”(physical association)	0.400
CAPG	HMGN2	psi-mi:“MI:0915”(physical association)	0.400
CCNYL1	A2ML1	psi-mi:“MI:0914”(association)	0.350
CDK15	A2ML1	psi-mi:“MI:0914”(association)	0.350
DDX19B	IGLL5	psi-mi:“MI:0914”(association)	0.350
ZSCAN20	ZNF197	psi-mi:“MI:0914”(association)	0.350
BMI1	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
BMI1	MEIS3P1	psi-mi:“MI:0914”(association)	0.350
NEK8	TGM5	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (102): SIAH1 (Two-hybrid), CAPG (Two-hybrid), CAPG (Affinity Capture-MS), CAPG (Affinity Capture-MS), ADK (Co-fractionation), CFL1 (Co-fractionation), CRIP1 (Co-fractionation), DAZAP1 (Co-fractionation), ETFB (Co-fractionation), FUBP1 (Co-fractionation), MIF (Co-fractionation), PIR (Co-fractionation), PRDX6 (Co-fractionation), SNX3 (Co-fractionation), TKT (Co-fractionation)

ESM2 similar proteins: A0A6B9KZ40, A8XV95, B3DJT0, B8ATT7, B8AY58, D3ZGS3, F8WK50, O61270, O65570, O75366, O81643, O81644, O88398, O89040, P10733, P16885, P19686, P24452, P34268, P36418, P40121, Q01968, Q02108, Q07171, Q0DKN3, Q0J716, Q0JAD9, Q21253, Q23989, Q24020, Q24800, Q27319, Q2KHZ2, Q4ZHS0, Q5R6Y0, Q67U26, Q69ZS7, Q6AXM7, Q6AYC4, Q6GM14

Diamond homologs: A0A6B9KZ40, A8XV95, B8ATT7, F8WK50, O15195, O61270, O65570, O75366, O81643, O81644, O81645, O88398, O93510, P02640, P06396, P09327, P10733, P13020, P14885, P20305, P24452, P34268, P40121, Q07171, Q0J716, Q0JAD9, Q10L71, Q13045, Q21253, Q24020, Q24800, Q27319, Q28046, Q28372, Q29261, Q29297, Q3SX14, Q3SZP7, Q5ZIV9, Q60604

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	4
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1500 predictions. Top by Δscore:

Variant	Effect	Δscore
2:85395532:CCTCA:C	donor_loss	1.0000
2:85395534:TCA:T	donor_loss	1.0000
2:85395535:CA:C	donor_loss	1.0000
2:85395536:ACCT:A	donor_loss	1.0000
2:85395623:CGCC:C	acceptor_gain	1.0000
2:85395624:GCCC:G	acceptor_loss	1.0000
2:85395625:CC:C	acceptor_gain	1.0000
2:85395626:CC:C	acceptor_gain	1.0000
2:85395627:C:CC	acceptor_gain	1.0000
2:85395633:C:CT	acceptor_gain	1.0000
2:85398015:CGTA:C	donor_loss	1.0000
2:85398016:GTA:G	donor_loss	1.0000
2:85398017:TA:T	donor_loss	1.0000
2:85398018:A:AC	donor_gain	1.0000
2:85398018:A:C	donor_loss	1.0000
2:85398018:AC:A	donor_gain	1.0000
2:85398018:ACC:A	donor_gain	1.0000
2:85398019:C:CT	donor_gain	1.0000
2:85398019:CC:C	donor_gain	1.0000
2:85398019:CCC:C	donor_gain	1.0000
2:85398019:CCCTT:C	donor_gain	1.0000
2:85398023:T:TA	donor_gain	1.0000
2:85398150:GACC:G	acceptor_loss	1.0000
2:85398153:C:CA	acceptor_loss	1.0000
2:85398154:T:G	acceptor_loss	1.0000
2:85399158:T:TA	donor_gain	1.0000
2:85399159:C:CA	donor_gain	1.0000
2:85399160:C:A	donor_gain	1.0000
2:85399202:A:AC	donor_gain	1.0000
2:85399203:C:CC	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000123860 (2:85412531 CAAT>C), RS1000170206 (2:85407953 G>A), RS1000201222 (2:85407521 T>C), RS1000281400 (2:85391756 T>C), RS1000344355 (2:85398034 A>G), RS1000526352 (2:85409524 C>T), RS1000539080 (2:85420821 C>A,T), RS1000556530 (2:85420492 G>A,C), RS1000724498 (2:85413952 C>T), RS1000920358 (2:85401788 T>C), RS1001061969 (2:85414436 T>A,C), RS1001131351 (2:85408173 T>C), RS1001179628 (2:85420346 C>G), RS1001288105 (2:85415048 G>A), RS1001402088 (2:85415380 T>C)

Disease associations

OMIM: gene MIM:153615 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006585_2188	Blood protein levels	1.000000e-48

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066906 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs3770102	Toxicity	3	vincristine	Drug Toxicity;Neurotoxicity Syndromes

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs3770102	CAPG	3	3.00	1	vincristine

CTD chemical–gene interactions

70 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, decreases expression, decreases methylation	4
sodium arsenite	increases abundance, increases expression	2
methacrylaldehyde	increases abundance, affects cotreatment, increases oxidation	2
bisphenol S	affects expression, increases expression	2
(+)-JQ1 compound	affects binding, decreases expression	2
Acrolein	affects cotreatment, increases oxidation, increases abundance	2
Arsenic	decreases response to substance, increases abundance, increases expression	2
Benzo(a)pyrene	increases expression, affects cotreatment, decreases expression	2
Cisplatin	affects cotreatment, increases expression	2
Ozone	affects cotreatment, increases oxidation, increases abundance	2
Smoke	decreases expression	2
Tetrachlorodibenzodioxin	increases expression	2
Tobacco Smoke Pollution	increases expression, affects expression	2
Tretinoin	increases expression	2
Valproic Acid	affects expression, increases methylation	2
aristolochic acid I	increases expression	1
bisphenol F	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
propionaldehyde	increases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, decreases expression	1
beta-lapachone	increases expression	1
sodium bichromate	decreases expression	1
sulforaphane	increases expression	1
butyraldehyde	increases expression	1
perfluorooctanoic acid	increases expression	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
benazol P	affects expression	1
pentanal	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651032	Binding	Binding affinity to human CAPG incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1M3	Abcam HeLa CAPG KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.