CAPN7

Summary

CAPN7 (calpain 7, HGNC:1484) is a protein-coding gene on chromosome 3p25.1, encoding Calpain-7 (Q9Y6W3). Calcium-regulated non-lysosomal thiol-protease.

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity.

Source: NCBI Gene 23473 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 116 total
• MANE Select transcript: NM_014296

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1484
Approved symbol	CAPN7
Name	calpain 7
Location	3p25.1
Locus type	gene with protein product
Status	Approved
Aliases	PalBH
Ensembl gene	ENSG00000131375
Ensembl biotype	protein_coding
OMIM	606400
Entrez	23473

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 9 protein_coding, 3 nonsense_mediated_decay, 2 retained_intron

ENST00000253693, ENST00000415565, ENST00000418994, ENST00000443567, ENST00000457023, ENST00000463417, ENST00000472400, ENST00000901140, ENST00000901141, ENST00000901142, ENST00000901143, ENST00000901144, ENST00000928381, ENST00000965910

RefSeq mRNA: 7 — MANE Select: NM_014296 NM_001376086, NM_001376087, NM_001376089, NM_001376090, NM_001376091, NM_001376093, NM_014296

CCDS: CCDS2624

Canonical transcript exons

ENST00000253693 — 21 exons

Exon	Start	End
ENSE00000901305	15206246	15206597
ENSE00000901319	15241453	15241588
ENSE00001149507	15220781	15220981
ENSE00001241433	15251116	15252916
ENSE00001640361	15240754	15240853
ENSE00001653102	15232519	15232665
ENSE00001665389	15230442	15230535
ENSE00001700421	15227839	15227965
ENSE00001713631	15223475	15223561
ENSE00001731020	15235025	15235145
ENSE00001776600	15233867	15233973
ENSE00001780897	15240473	15240617
ENSE00001803695	15228974	15229059
ENSE00003471875	15245526	15245671
ENSE00003553936	15217425	15217582
ENSE00003583169	15218473	15218540
ENSE00003590494	15247327	15247457
ENSE00003593199	15242178	15242253
ENSE00003595244	15250931	15251023
ENSE00003659474	15246732	15246794
ENSE00003690393	15212104	15212212

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 98.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.1236 / max 89.6429, expressed in 1783 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
35495	11.8209	1781
35494	0.3027	139

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	98.13	gold quality
oocyte	CL:0000023	95.57	gold quality
calcaneal tendon	UBERON:0003701	95.16	gold quality
adrenal tissue	UBERON:0018303	93.90	gold quality
left ovary	UBERON:0002119	92.65	gold quality
tibia	UBERON:0000979	92.58	gold quality
mucosa of stomach	UBERON:0001199	92.28	gold quality
popliteal artery	UBERON:0002250	91.74	gold quality
tibial artery	UBERON:0007610	91.74	gold quality
gastrocnemius	UBERON:0001388	91.65	gold quality
endocervix	UBERON:0000458	91.62	gold quality
artery	UBERON:0001637	91.31	gold quality
right ovary	UBERON:0002118	91.24	gold quality
body of uterus	UBERON:0009853	91.19	gold quality
ovary	UBERON:0000992	91.05	gold quality
muscle of leg	UBERON:0001383	90.96	gold quality
aorta	UBERON:0000947	90.93	gold quality
tibial nerve	UBERON:0001323	90.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	90.76	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.67	gold quality
cerebellar hemisphere	UBERON:0002245	90.66	gold quality
cerebellar cortex	UBERON:0002129	90.60	gold quality
left lobe of thyroid gland	UBERON:0001120	90.55	gold quality
right uterine tube	UBERON:0001302	90.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.53	gold quality
lower esophagus	UBERON:0013473	90.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.51	gold quality
ventricular zone	UBERON:0003053	90.41	gold quality
thyroid gland	UBERON:0002046	90.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.96

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

132 targeting CAPN7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502

Literature-anchored findings (GeneRIF, showing 6)

• Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1. (PMID:20849418)
• The detected enhancement of autolysis of mGFP-fused calpain-7 by coexpression with CHMP1B and observed further activation by additional coexpression of IST1 in HEK293T cells. (PMID:21616915)
• Mutational analysis of calpain-7 reveals the importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity. (PMID:23497113)
• Data indicate that CAPN 7 promotes endometrial stromal cell (hESC) migration and invasion by increasing the activity of MMP-2 via an increased ratio of MMP-2 to TIMP-2. (PMID:23855590)
• The proteolytic activity of CAPN7 is important for the acceleration of EGFR degradation via the endosomal sorting pathway. (PMID:24953135)
• Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1. (PMID:35191464)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	capn7	ENSDARG00000102987
mus_musculus	Capn7	ENSMUSG00000021893
rattus_norvegicus	Capn7	ENSRNOG00000019273
caenorhabditis_elegans		WBGENE00000543

Paralogs (20): CAPN1 (ENSG00000014216), SRI (ENSG00000075142), CAPN6 (ENSG00000077274), CAPN3 (ENSG00000092529), CAPN15 (ENSG00000103326), GCA (ENSG00000115271), ADGB (ENSG00000118492), CAPNS1 (ENSG00000126247), CAPN9 (ENSG00000135773), CAPN11 (ENSG00000137225), CAPN10 (ENSG00000142330), CAPN5 (ENSG00000149260), PEF1 (ENSG00000162517), CAPN2 (ENSG00000162909), CAPN13 (ENSG00000162949), CAPN12 (ENSG00000182472), CAPN8 (ENSG00000203697), CAPN14 (ENSG00000214711), PDCD6 (ENSG00000249915), CAPNS2 (ENSG00000256812)

Protein

Protein identifiers

Calpain-7 — Q9Y6W3 (reviewed: Q9Y6W3)

Alternative names: PalB homolog

All UniProt accessions (5): F8WCZ1, F8WDQ3, H7C0F1, H7C1B7, Q9Y6W3

UniProt curated annotations — full annotation on UniProt →

Function. Calcium-regulated non-lysosomal thiol-protease.

Subcellular location. Nucleus.

Tissue specificity. Ubiquitous.

Similarity. Belongs to the peptidase C2 family.

RefSeq proteins (7): NP_001363015, NP_001363016, NP_001363018, NP_001363019, NP_001363020, NP_001363022, NP_055111* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001300	Peptidase_C2_calpain_cat	Domain
IPR007330	MIT_dom	Domain
IPR022682	Calpain_domain_III	Domain
IPR022683	Calpain_III	Domain
IPR022684	Calpain_cysteine_protease	Family
IPR036181	MIT_dom_sf	Homologous_superfamily
IPR036213	Calpain_III_sf	Homologous_superfamily
IPR038765	Papain-like_cys_pep_sf	Homologous_superfamily
IPR051297	PalB/RIM13	Family

Pfam: PF00648, PF01067, PF04212

Enzyme classification (BRENDA):

• EC 3.4.22.B27 — (BRENDA: organisms, substrates, inhibitors, Km, kcat entries)

UniProt features (27 total): strand 9, helix 8, active site 3, region of interest 2, modified residue 2, chain 1, domain 1, turn 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
2QFE	X-RAY DIFFRACTION	1.45
8UC6	X-RAY DIFFRACTION	2.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y6W3-F1	88.88	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 290; 458; 478

Post-translational modifications (2): 1, 95

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-1474228	Degradation of the extracellular matrix
R-HSA-1474244	Extracellular matrix organization

MSigDB gene sets: 131 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, KAAB_FAILED_HEART_ATRIUM_DN, GOBP_REGULATION_OF_EPITHELIAL_CELL_MIGRATION, GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION, GOBP_TISSUE_MIGRATION, GOMF_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION, ACTTTAT_MIR1425P, JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN, BURTON_ADIPOGENESIS_12, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, PARENT_MTOR_SIGNALING_UP, TAATTA_CHX10_01

GO Biological Process (3): proteolysis (GO:0006508), positive regulation of epithelial cell migration (GO:0010634), self proteolysis (GO:0097264)

GO Molecular Function (8): endopeptidase activity (GO:0004175), cysteine-type endopeptidase activity (GO:0004197), calcium-dependent cysteine-type endopeptidase activity (GO:0004198), MIT domain binding (GO:0090541), protein binding (GO:0005515), peptidase activity (GO:0008233), cysteine-type peptidase activity (GO:0008234), hydrolase activity (GO:0016787)

GO Cellular Component (4): nucleus (GO:0005634), centrosome (GO:0005813), cytosol (GO:0005829), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Extracellular matrix organization	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidase activity	2
protein metabolic process	1
epithelial cell migration	1
regulation of epithelial cell migration	1
positive regulation of cell migration	1
proteolysis	1
endopeptidase activity	1
cysteine-type peptidase activity	1
cysteine-type endopeptidase activity	1
protein domain specific binding	1
binding	1
hydrolase activity	1
catalytic activity, acting on a protein	1
catalytic activity	1
intracellular membrane-bounded organelle	1
centriole	1
microtubule organizing center	1
cytoplasm	1
cellular anatomical structure	1
extracellular vesicle	1

Protein interactions and networks

STRING

1449 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CAPN7	OXNAD1	Q96HP4	891
CAPN7	XIRP1	Q702N8	832
CAPN7	TTR	P02766	637
CAPN7	CAST	P20810	590
CAPN7	CAPNS1	P04632	567
CAPN7	CAV3	P56539	553
CAPN7	CAPNS2	Q96L46	543
CAPN7	TFAP2A	P05549	514
CAPN7	CHMP1B	Q7LBR1	474
CAPN7	IST1	P53990	432
CAPN7	TMEM132E	Q6IEE7	400
CAPN7	RIBC1	Q8N443	394
CAPN7	MTURN	Q8N3F0	380
CAPN7	TOPAZ1	Q8N9V7	377
CAPN7	MROH7	Q68CQ1	375

IntAct

64 interactions, top by confidence:

A	B	Type	Score
CAPN7	IST1	psi-mi:“MI:0915”(physical association)	0.680
IST1	CAPN7	psi-mi:“MI:0407”(direct interaction)	0.680
IST1	CAPN7	psi-mi:“MI:0915”(physical association)	0.680
CAPN7	ZNF655	psi-mi:“MI:0915”(physical association)	0.560
TNFAIP1	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
IFT88	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
PPP1R13B	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
PRPSAP1	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
CEP63	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
GOLGA2	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
TRIM27	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
MAGED1	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
CTBP2	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
MAD1L1	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
AXIN2	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
ARNT2	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
ZNF655	CAPN7	psi-mi:“MI:0915”(physical association)	0.560
VHL	EGLN3	psi-mi:“MI:0915”(physical association)	0.370
CAPN7		psi-mi:“MI:0915”(physical association)	0.370
Spast		psi-mi:“MI:0914”(association)	0.350
Ptpn23	UMAD1	psi-mi:“MI:0914”(association)	0.350
Vps4b	CNOT1	psi-mi:“MI:0914”(association)	0.350
CHMP4B	ELOC	psi-mi:“MI:0914”(association)	0.350
HTRA2	VWA8	psi-mi:“MI:0914”(association)	0.350
IMMP1L	EIF1AY	psi-mi:“MI:0914”(association)	0.350
CFAP184	TARS3	psi-mi:“MI:0914”(association)	0.350
PTGES3	SBNO1	psi-mi:“MI:0914”(association)	0.350

BioGRID (47): CAPN7 (Two-hybrid), CAPN7 (Two-hybrid), CAPN7 (Two-hybrid), ZFYVE19 (Two-hybrid), UBL7 (Two-hybrid), ZBTB9 (Two-hybrid), CAPN7 (Affinity Capture-MS), CAPN7 (Affinity Capture-MS), CAPN7 (Affinity Capture-MS), CAPN7 (Affinity Capture-MS), CAPN7 (Affinity Capture-MS), CAPN7 (Affinity Capture-MS), CAPN7 (Affinity Capture-MS), CAPN7 (Proximity Label-MS), CAPN7 (Two-hybrid)

ESM2 similar proteins: A0A0G2QC33, A0FKG7, A6H7H7, F1N9S8, O95453, P0C0T1, P42694, P50747, P69341, Q0IIH8, Q0VGM9, Q13572, Q28559, Q4R528, Q5BJZ6, Q5F480, Q5R699, Q5RC51, Q5ZIA0, Q5ZIW7, Q640G7, Q6DDJ3, Q6DFV5, Q6DG88, Q6DJB3, Q6GR37, Q6NYU2, Q6PZ02, Q6PZ03, Q6PZ05, Q7T0P6, Q80UY1, Q80YV4, Q811C2, Q8BGE6, Q8BYN3, Q8C9S8, Q8N4J0, Q8VDG3, Q8WYN0

Diamond homologs: A0FKG7, G3UZ78, P27398, Q00204, Q55FS2, Q78EJ9, Q8RVL1, Q9R1S8, Q9Y6W3, Q9Y6Z8, A6NHC0, A8MX76, O08529, O08688, O14815, O15484, O35350, O35920, O75808, P00789, P06814, P07384, P17655, P20807, P27730, P35750, P97571, Q07009, Q11002, Q27970, Q27971, Q4V8Q1, Q5NVS7, Q6J756, Q6ZFZ4, Q6ZSI9, Q8IAA9, Q8R4C0, Q8RVL2, Q91VA3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

116 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	88
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3042 predictions. Top by Δscore:

Variant	Effect	Δscore
3:15206593:ACAAG:A	donor_loss	1.0000
3:15206594:CAAG:C	donor_loss	1.0000
3:15206595:AAGGT:A	donor_loss	1.0000
3:15206596:AGG:A	donor_loss	1.0000
3:15206597:GGTAG:G	donor_loss	1.0000
3:15206599:T:G	donor_loss	1.0000
3:15211060:G:GT	donor_gain	1.0000
3:15211091:A:AG	donor_gain	1.0000
3:15212097:T:G	acceptor_gain	1.0000
3:15212208:AGCAG:A	donor_loss	1.0000
3:15212209:GCAG:G	donor_gain	1.0000
3:15212209:GCAGG:G	donor_loss	1.0000
3:15212210:CAGG:C	donor_loss	1.0000
3:15212212:GGTT:G	donor_loss	1.0000
3:15212213:G:A	donor_loss	1.0000
3:15217419:T:G	acceptor_gain	1.0000
3:15217422:TA:T	acceptor_loss	1.0000
3:15217423:A:AG	acceptor_gain	1.0000
3:15217424:G:GA	acceptor_gain	1.0000
3:15217424:GTT:G	acceptor_gain	1.0000
3:15217424:GTTC:G	acceptor_gain	1.0000
3:15217424:GTTCA:G	acceptor_gain	1.0000
3:15217560:C:G	donor_gain	1.0000
3:15217579:AACA:A	donor_gain	1.0000
3:15217580:ACA:A	donor_gain	1.0000
3:15217581:CA:C	donor_gain	1.0000
3:15217583:GT:G	donor_gain	1.0000
3:15217600:T:G	donor_gain	1.0000
3:15217609:A:G	donor_gain	1.0000
3:15218468:TTAAG:T	acceptor_loss	1.0000

AlphaMissense

5351 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:15212107:G:C	A36P	1.000
3:15217481:G:C	A90P	1.000
3:15217491:T:C	L93P	1.000
3:15217550:T:G	Y113D	1.000
3:15217559:G:C	A116P	1.000
3:15218530:G:C	A143P	1.000
3:15227894:T:A	W261R	1.000
3:15227894:T:C	W261R	1.000
3:15227965:G:C	Q284H	1.000
3:15227965:G:T	Q284H	1.000
3:15228989:T:C	C290R	1.000
3:15228990:G:A	C290Y	1.000
3:15228991:C:G	C290W	1.000
3:15229008:T:C	L296P	1.000
3:15229010:G:C	A297P	1.000
3:15229019:G:C	A300P	1.000
3:15230484:T:A	N327K	1.000
3:15230484:T:G	N327K	1.000
3:15230497:T:G	Y332D	1.000
3:15230520:T:A	N339K	1.000
3:15230520:T:G	N339K	1.000
3:15230531:G:C	R343T	1.000
3:15230532:A:C	R343S	1.000
3:15230532:A:T	R343S	1.000
3:15232597:T:A	W371R	1.000
3:15232597:T:C	W371R	1.000
3:15232614:A:C	E376D	1.000
3:15232614:A:T	E376D	1.000
3:15232648:T:C	F388L	1.000
3:15232650:T:A	F388L	1.000

dbSNP variants (sampled 300 via entrez): RS1000067855 (3:15223995 G>A), RS1000080514 (3:15219706 T>C), RS1000120044 (3:15223779 G>A), RS1000237992 (3:15237698 C>T), RS1000290101 (3:15231474 A>G), RS1000296083 (3:15244137 A>G), RS1000401019 (3:15212692 G>A), RS1000555634 (3:15219414 A>G,T), RS1000563974 (3:15237385 A>G), RS1000740815 (3:15204585 G>A), RS1000753477 (3:15210269 A>T), RS1000764969 (3:15214170 A>G), RS1000808085 (3:15250428 G>C), RS1000854131 (3:15251993 A>G), RS1000937745 (3:15247681 A>G)

Disease associations

OMIM: gene MIM:606400 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009391_250	Metabolite levels	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010495	guanosine monophosphate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, decreases expression	2
dicrotophos	decreases expression	1
2,4,6-tribromophenol	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, increases activity, increases expression	1
bisphenol A	decreases expression	1
tetrabromobisphenol A	decreases expression	1
MDL 201053	decreases expression, decreases reaction, increases degradation	1
di-n-butylphosphoric acid	affects expression	1
glycidamide	increases expression	1
CGP 52608	affects binding, increases reaction	1
aloxistatin	decreases expression, decreases reaction, increases degradation	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
jinfukang	decreases expression	1
Sunitinib	increases expression	1
Calcitriol	increases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Methyl Methanesulfonate	increases expression	1
Piroxicam	decreases expression	1
Selenium	decreases expression	1
Tobacco Smoke Pollution	affects expression	1
Vitamin E	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	increases expression	1
Asbestos, Crocidolite	decreases expression	1
Antirheumatic Agents	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.