CARD8-AS1

Summary

CARD8-AS1 (CARD8 antisense RNA 1, HGNC:51408) is a long non-coding RNA gene on chromosome 19q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51408
Approved symbol	CARD8-AS1
Name	CARD8 antisense RNA 1
Location	19q13.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC100505812, AC008392.1
Ensembl gene	ENSG00000268001
Ensembl biotype	lncRNA
Entrez	100505812
RNAcentral	URS000075C250 — lncRNA, 1984 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000602172

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000602172 — 2 exons

Exon	Start	End
ENSE00002989167	48255675	48255794
ENSE00003187454	48256351	48258199

Expression profiles

Bgee: expression breadth ubiquitous, 202 present calls, max score 87.41.

FANTOM5 (CAGE): breadth broad, TPM avg 3.5295 / max 61.4733, expressed in 874 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176753	3.5295	874

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
leukocyte	CL:0000738	87.41	gold quality
monocyte	CL:0000576	87.23	gold quality
blood	UBERON:0000178	85.68	gold quality
superficial temporal artery	UBERON:0001614	84.14	gold quality
granulocyte	CL:0000094	83.89	gold quality
visceral pleura	UBERON:0002401	83.31	gold quality
lymph node	UBERON:0000029	82.31	gold quality
epithelium of nasopharynx	UBERON:0001951	82.06	gold quality
spleen	UBERON:0002106	80.98	gold quality
parietal pleura	UBERON:0002400	80.45	gold quality
vermiform appendix	UBERON:0001154	80.43	gold quality
epithelial cell of pancreas	CL:0000083	80.02	silver quality
bone marrow	UBERON:0002371	79.46	gold quality
ileal mucosa	UBERON:0000331	79.44	gold quality
trabecular bone tissue	UBERON:0002483	78.91	gold quality
palpebral conjunctiva	UBERON:0001812	77.87	gold quality
germinal epithelium of ovary	UBERON:0001304	76.37	gold quality
lower lobe of lung	UBERON:0008949	75.53	gold quality
bone marrow cell	CL:0002092	75.36	gold quality
amniotic fluid	UBERON:0000173	75.11	gold quality
caecum	UBERON:0001153	75.07	gold quality
endothelial cell	CL:0000115	74.68	silver quality
tonsil	UBERON:0002372	72.91	gold quality
adipose tissue	UBERON:0001013	72.30	gold quality
thymus	UBERON:0002370	71.92	gold quality
colonic epithelium	UBERON:0000397	71.63	gold quality
jejunal mucosa	UBERON:0000399	71.37	gold quality
adipose tissue of abdominal region	UBERON:0007808	70.93	gold quality
smooth muscle tissue	UBERON:0001135	70.54	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Identification of LncRNA CARD8-AS1 as a Potential Prognostic Biomarker Associated With Progression of Lung Adenocarcinoma. (PMID:35996500)
• LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1. (PMID:38153696)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.