CARHSP1

Summary

CARHSP1 (calcium regulated heat stable protein 1, HGNC:17150) is a protein-coding gene on chromosome 16p13.2, encoding Calcium-regulated heat-stable protein 1 (Q9Y2V2). Binds mRNA and regulates the stability of target mRNA.

Enables mRNA 3’-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule; cytoplasmic exosome (RNase complex); and cytosol. Predicted to be active in cytoplasm.

Source: NCBI Gene 23589 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 74 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_014316

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17150
Approved symbol	CARHSP1
Name	calcium regulated heat stable protein 1
Location	16p13.2
Locus type	gene with protein product
Status	Approved
Aliases	CRHSP-24, CSDC1
Ensembl gene	ENSG00000153048
Ensembl biotype	protein_coding
OMIM	616885
Entrez	23589

Gene structure

Transcript identifiers

Ensembl transcripts: 77 — 73 protein_coding, 3 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000311052, ENST00000396593, ENST00000561530, ENST00000562586, ENST00000562843, ENST00000563815, ENST00000565287, ENST00000567554, ENST00000567626, ENST00000567908, ENST00000568117, ENST00000568968, ENST00000569398, ENST00000569572, ENST00000570125, ENST00000610831, ENST00000611932, ENST00000614449, ENST00000618335, ENST00000619881, ENST00000857704, ENST00000857705, ENST00000857706, ENST00000857707, ENST00000857708, ENST00000857709, ENST00000857710, ENST00000857711, ENST00000857712, ENST00000857713, ENST00000857714, ENST00000857715, ENST00000857716, ENST00000857717, ENST00000857718, ENST00000857719, ENST00000857720, ENST00000857721, ENST00000857722, ENST00000857723, ENST00000857724, ENST00000857725, ENST00000857726, ENST00000857727, ENST00000857728, ENST00000857729, ENST00000857730, ENST00000857731, ENST00000857732, ENST00000857733, ENST00000857734, ENST00000857735, ENST00000857736, ENST00000857737, ENST00000857738, ENST00000857739, ENST00000922317, ENST00000922318, ENST00000922319, ENST00000922320, ENST00000922321, ENST00000922322, ENST00000922323, ENST00000922324, ENST00000922325, ENST00000922326, ENST00000922327, ENST00000922328, ENST00000922329, ENST00000922330, ENST00000922331, ENST00000922332, ENST00000922333, ENST00000954682, ENST00000954683, ENST00000954684, ENST00000954685

RefSeq mRNA: 9 — MANE Select: NM_014316 NM_001042476, NM_001278260, NM_001278261, NM_001278262, NM_001278263, NM_001278264, NM_001278265, NM_001278266, NM_014316

CCDS: CCDS10537

Canonical transcript exons

ENST00000311052 — 4 exons

Exon	Start	End
ENSE00001425906	8868966	8869006
ENSE00002580049	8852947	8855326
ENSE00003497814	8858350	8858472
ENSE00003650612	8859171	8859335

Expression profiles

Bgee: expression breadth ubiquitous, 282 present calls, max score 99.43.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 76.0713 / max 497.7950, expressed in 1821 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
156171	72.2005	1819
156170	1.7662	964
156169	1.1673	732
156165	0.3302	138
156164	0.2232	90
156172	0.1950	77
156167	0.1076	8
156168	0.0467	10
156166	0.0346	4

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	99.43	gold quality
left testis	UBERON:0004533	99.42	gold quality
ganglionic eminence	UBERON:0004023	99.16	gold quality
ventricular zone	UBERON:0003053	99.12	gold quality
lower esophagus mucosa	UBERON:0035834	98.37	gold quality
right adrenal gland	UBERON:0001233	97.93	gold quality
cortical plate	UBERON:0005343	97.78	gold quality
right adrenal gland cortex	UBERON:0035827	97.69	gold quality
left adrenal gland	UBERON:0001234	97.62	gold quality
left adrenal gland cortex	UBERON:0035825	97.55	gold quality
esophagus mucosa	UBERON:0002469	97.54	gold quality
embryo	UBERON:0000922	97.33	gold quality
right lobe of liver	UBERON:0001114	97.30	gold quality
adrenal cortex	UBERON:0001235	97.09	gold quality
testis	UBERON:0000473	97.04	gold quality
right lung	UBERON:0002167	96.78	gold quality
metanephros cortex	UBERON:0010533	96.77	gold quality
pharyngeal mucosa	UBERON:0000355	96.64	gold quality
omental fat pad	UBERON:0010414	96.55	gold quality
peritoneum	UBERON:0002358	96.52	gold quality
upper lobe of left lung	UBERON:0008952	96.46	gold quality
adrenal gland	UBERON:0002369	96.38	gold quality
type B pancreatic cell	CL:0000169	96.37	silver quality
tibial nerve	UBERON:0001323	96.22	gold quality
upper lobe of lung	UBERON:0008948	95.99	gold quality
minor salivary gland	UBERON:0001830	95.95	gold quality
nucleus accumbens	UBERON:0001882	95.95	gold quality
oral cavity	UBERON:0000167	95.73	gold quality
ectocervix	UBERON:0012249	95.63	gold quality
pericardium	UBERON:0002407	95.62	gold quality

Single-cell (SCXA)

Detected in 15 experiment(s), a significant marker in 10.

Experiment	Marker?	Max mean expression
E-MTAB-10855	yes	709.01
E-CURD-112	yes	41.60
E-GEOD-134144	yes	32.31
E-CURD-122	yes	24.82
E-ANND-3	yes	15.82
E-CURD-114	yes	11.59
E-MTAB-10042	yes	10.43
E-GEOD-135922	yes	10.08
E-MTAB-10553	yes	7.70
E-CURD-88	yes	5.99
E-MTAB-11121	no	313.42
E-ENAD-20	no	54.26
E-CURD-120	no	7.28
E-MTAB-10137	no	4.89
E-HCAD-13	no	3.28

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

69 targeting CARHSP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-4320	99.75	65.80	793
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-519A-3P	99.67	71.67	1868
HSA-MIR-519B-3P	99.67	71.67	1868
HSA-MIR-519C-3P	99.67	71.67	1870
HSA-MIR-9851-3P	99.63	69.68	1110
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-106A-3P	99.53	67.58	995
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-6727-3P	99.49	65.92	1333
HSA-MIR-4687-3P	99.48	66.41	968
HSA-MIR-766-3P	99.47	65.24	1811
HSA-MIR-889-5P	99.41	68.75	1025
HSA-MIR-4786-3P	99.36	68.35	1390
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-155-5P	99.35	70.16	1509

Literature-anchored findings (GeneRIF, showing 5)

• Data suggest that CARHSP1 is a TNF-alpha mRNA stability enhancer required for effective TNF-alpha production, demonstrating the importance of both stabilization and destabilization pathways in regulating the TNF-alpha mRNA half-life. (PMID:21078874)
• CRHSP-24 participates in oxidative stress response via a dynamic and temporal association between stress granules and processing bodies. (PMID:21177848)
• CARHSP1 inhibits hepatic gluconeogenic gene expression via repression of PPARalpha (PMID:21990353)
• Increased miR-155 relieves chronic inflammation by a negative feedback loop and plays a protective role during atherosclerosis-associated foam cell formation by signaling through the miR-155-CARHSP1-TNF-alpha pathway. (PMID:26899994)
• Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma. (PMID:34290231)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	carhsp1	ENSDARG00000053129
mus_musculus	Carhsp1	ENSMUSG00000008393
rattus_norvegicus	Carhsp1	ENSRNOG00000002610
drosophila_melanogaster	CG9705	FBGN0036661

Paralogs (1): CSDC2 (ENSG00000172346)

Protein

Protein identifiers

Calcium-regulated heat-stable protein 1 — Q9Y2V2 (reviewed: Q9Y2V2)

Alternative names: Calcium-regulated heat-stable protein of 24 kDa

All UniProt accessions (8): Q9Y2V2, H3BNU9, H3BPY5, H3BQY0, H3BSW7, H3BTK3, H3BUY4, I3L3X8

UniProt curated annotations — full annotation on UniProt →

Function. Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).

Subunit / interactions. Homodimer. Interacts with STYX.

Subcellular location. Cytoplasm. P-body. Cytoplasmic granule.

Post-translational modifications. Dephosphorylated by calcineurin in a Ca(2+) dependent manner. Can be phosphorylated by DYRK2 (in vitro).

RefSeq proteins (9): NP_001035941, NP_001265189, NP_001265190, NP_001265191, NP_001265192, NP_001265193, NP_001265194, NP_001265195, NP_055131* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002059	CSP_DNA-bd	Domain
IPR011129	CSD	Domain
IPR012340	NA-bd_OB-fold	Homologous_superfamily
IPR019844	CSD_CS	Conserved_site
IPR052069	Ca-reg_mRNA-binding_domain	Family

Pfam: PF00313

UniProt features (27 total): modified residue 9, strand 7, mutagenesis site 2, helix 2, initiator methionine 1, chain 1, sequence conflict 1, turn 1, domain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3AQQ	X-RAY DIFFRACTION	2.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2V2-F1	84.61	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 52, 58, 146, 147, 2, 30, 32, 41, 45

Mutagenesis-validated functional residues (2):

Position	Phenotype
41	reduced affinity for single-stranded dna. abolishes location at cytoplasmic stress granules.
76	reduced affinity for single-stranded dna.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 196 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_UP, GSE45365_NK_CELL_VS_CD8A_DC_UP, GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOLDRATH_ANTIGEN_RESPONSE, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_UP, MCBRYAN_PUBERTAL_BREAST_4_5WK_DN, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOBP_REGULATION_OF_CATABOLIC_PROCESS, MCBRYAN_PUBERTAL_BREAST_3_4WK_UP, TSENG_IRS1_TARGETS_DN, FISCHER_DREAM_TARGETS

GO Biological Process (2): intracellular signal transduction (GO:0035556), regulation of mRNA stability (GO:0043488)

GO Molecular Function (5): mRNA 3’-UTR binding (GO:0003730), phosphatase binding (GO:0019902), nucleic acid binding (GO:0003676), RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (5): cytoplasmic exosome (RNase complex) (GO:0000177), P-body (GO:0000932), cytoplasm (GO:0005737), cytosol (GO:0005829), P granule (GO:0043186)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular anatomical structure	2
binding	2
cytoplasm	2
cytoplasmic ribonucleoprotein granule	2
cellular anatomical structure	2
signal transduction	1
regulation of RNA stability	1
regulation of mRNA catabolic process	1
mRNA binding	1
enzyme binding	1
nucleic acid binding	1
exosome (RNase complex)	1
germ plasm	1

Protein interactions and networks

STRING

1736 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CARHSP1	LITAFD	A0A1B0GVX0	494
CARHSP1	SPNS3	Q6ZMD2	481
CARHSP1	RAB3IL1	Q8TBN0	452
CARHSP1	HAPSTR1	Q14CZ0	446
CARHSP1	SLC38A7	Q9NVC3	438
CARHSP1	PARD6A	Q9NPB6	423
CARHSP1	PDXDC1	Q6P996	420
CARHSP1	OR6N1	Q8NGY5	410
CARHSP1	ATP11C	Q8NB49	406
CARHSP1	COPS7A	Q9UBW8	404
CARHSP1	DOCK7	Q96N67	402
CARHSP1	CDIP1	Q9H305	402
CARHSP1	PNPO	Q9NVS9	398
CARHSP1	GFI1B	Q5VTD9	394
CARHSP1	OR6N2	Q8NGY6	389

IntAct

69 interactions, top by confidence:

A	B	Type	Score
KRTAP10-8	CARHSP1	psi-mi:“MI:0915”(physical association)	0.720
CARHSP1	KRTAP10-8	psi-mi:“MI:0915”(physical association)	0.720
	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
TRAF1	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
NOTCH2NLA	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
CARHSP1	PNMA1	psi-mi:“MI:0915”(physical association)	0.560
DOCK8	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
CARHSP1		psi-mi:“MI:0915”(physical association)	0.560
CARHSP1	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
PNMA1	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
CARHSP1	DOCK8	psi-mi:“MI:0915”(physical association)	0.560
NOTCH2NLC	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP6-3	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
MID2	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560
PPP2R1A	CARHSP1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (70): CARHSP1 (Two-hybrid), CARHSP1 (Two-hybrid), DOCK8 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-8 (Two-hybrid), KRTAP10-3 (Two-hybrid), NOTCH2NL (Two-hybrid), CARHSP1 (Co-fractionation), CARHSP1 (Co-fractionation), CARHSP1 (Co-fractionation), CARHSP1 (Co-fractionation), FKBP2 (Co-fractionation), IMPA2 (Co-fractionation), PCBP1 (Co-fractionation), CARHSP1 (Biochemical Activity)

ESM2 similar proteins: A3KMV1, A8JAM0, B7PXE3, B9EHT4, B9FS74, F4HX15, F4IAE9, F5HB62, O46072, O70161, P0C5J9, P34442, P35228, P53904, Q257B3, Q3MHJ7, Q3V0G7, Q4FE47, Q5I6B8, Q5R686, Q5U243, Q5VVW2, Q63430, Q65XV2, Q66HD5, Q6NRL1, Q6P5D3, Q6P7W2, Q6TNT2, Q6YUL8, Q76K24, Q7JVP4, Q7XI08, Q8BFX3, Q8BTZ5, Q8BXK8, Q8CI96, Q8IY37, Q8N3C7, Q8TBC3

Diamond homologs: A0R5E1, E0J1Q3, E0J500, E1WGN1, O30875, O67327, P0A352, P0A353, P0A354, P0A362, P0A363, P0A968, P0A969, P0A970, P0A971, P0A972, P0A973, P0A974, P0A975, P0A978, P0A979, P0A980, P0A981, P0A986, P0A987, P0A9X9, P0A9Y0, P0A9Y1, P0A9Y2, P0A9Y3, P0A9Y4, P0A9Y5, P0A9Y6, P0A9Y7, P0A9Y8, P0A9Y9, P0A9Z0, P0CL01, P27484, P36995

SIGNOR signaling

7 interactions.

A	Effect	B	Mechanism
AKT	unknown	CARHSP1	phosphorylation
DYRK2	unknown	CARHSP1	phosphorylation
RPS6KA1	unknown	CARHSP1	phosphorylation
AKT1	unknown	CARHSP1	phosphorylation
RPS6K	unknown	CARHSP1	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	63
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2500242	NC_000016.9:g.(?8160554)(9074348_?)del	Pathogenic

SpliceAI

594 predictions. Top by Δscore:

Variant	Effect	Δscore
16:8855322:CCACA:C	acceptor_gain	1.0000
16:8855323:CACAC:C	acceptor_gain	1.0000
16:8855325:CA:C	acceptor_gain	1.0000
16:8855327:C:CC	acceptor_gain	1.0000
16:8858345:CTCA:C	donor_gain	1.0000
16:8858348:A:AC	donor_gain	1.0000
16:8858349:C:CT	donor_gain	1.0000
16:8858349:CT:C	donor_gain	1.0000
16:8858468:CCGTC:C	acceptor_gain	1.0000
16:8858469:CGTCC:C	acceptor_gain	1.0000
16:8858471:TC:T	acceptor_gain	1.0000
16:8858472:CC:C	acceptor_gain	1.0000
16:8858477:C:CT	acceptor_gain	1.0000
16:8859169:A:AC	donor_gain	1.0000
16:8859170:C:CC	donor_gain	1.0000
16:8859170:CG:C	donor_gain	1.0000
16:8855323:CACA:C	acceptor_gain	0.9900
16:8855325:CACTA:C	acceptor_loss	0.9900
16:8855326:ACTAC:A	acceptor_loss	0.9900
16:8855327:CTAC:C	acceptor_loss	0.9900
16:8858344:A:AC	donor_gain	0.9900
16:8858344:ACT:A	donor_loss	0.9900
16:8858345:C:CC	donor_gain	0.9900
16:8858346:T:TC	donor_loss	0.9900
16:8858347:CACTC:C	donor_loss	0.9900
16:8858348:A:C	donor_loss	0.9900
16:8858348:ACT:A	donor_gain	0.9900
16:8858349:CTC:C	donor_gain	0.9900
16:8858349:CTCA:C	donor_gain	0.9900
16:8858349:CTCAG:C	donor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000037467 (16:8869291 G>A,C,T), RS1000247347 (16:8853685 A>G), RS1000345225 (16:8859616 G>A,C), RS1000425285 (16:8864158 CAT>C), RS1000518554 (16:8868370 G>C,T), RS1000540789 (16:8868766 C>A), RS1000859057 (16:8856387 C>G,T), RS1000867434 (16:8861585 T>C), RS1000902709 (16:8861455 C>T), RS1001007757 (16:8854600 A>C), RS1001149375 (16:8858266 T>C), RS1001376781 (16:8860801 A>C), RS1001379369 (16:8855906 A>C,G), RS1001410616 (16:8864873 G>A), RS1001463607 (16:8855811 A>C)

Disease associations

OMIM: gene MIM:616885 | disease phenotypes: MIM:613163

GenCC curated gene-disease

Mondo (2): GABA aminotransaminase deficiency (MONDO:0013166), Hao-Fountain syndrome (MONDO:0014805)

Orphanet (2): Gamma-aminobutyric acid transaminase deficiency (Orphanet:2066), Hao-Fountain syndrome (Orphanet:643549)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005576_4	Intracranial aneurysm	9.000000e-07
GCST011352_5	Alanine aminotransferase levels	8.000000e-09

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C535407	Gamma aminobutyric acid transaminase deficiency (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067431 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.52	Kd	3011	nM	CHEMBL5653589
5.52	ED50	3011	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2147998: Binding affinity to human CARHSP1 incubated for 45 mins by Kinobead based pull down assay	kd	3.0110	uM

CTD chemical–gene interactions

70 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases methylation, decreases expression	3
Cadmium Chloride	increases abundance, increases expression	3
sodium arsenite	decreases expression, increases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases expression, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Valproic Acid	decreases expression, increases methylation	2
Cyclosporine	decreases expression	2
FR900359	affects phosphorylation	1
2,4,6-tribromophenol	decreases expression	1
methylmercuric chloride	decreases expression	1
alpha phellandrene	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
sodium arsenate	decreases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, decreases expression, affects localization, increases expression	1
trichostatin A	affects expression	1
arsenite	affects binding, increases reaction	1
sulforaphane	decreases expression	1
cobaltous chloride	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
coumarin	decreases phosphorylation	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
perfluorooctane sulfonic acid	decreases expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
nutlin 3	increases secretion, affects cotreatment	1
bisphenol B	increases expression	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651040	Binding	Binding affinity to human CARHSP1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.