CARINH

Summary

CARINH (colitis associated IRF1 antisense regulator of intestinal homeostasis, HGNC:33838) is a long non-coding RNA gene on chromosome 5q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33838
Approved symbol	CARINH
Name	colitis associated IRF1 antisense regulator of intestinal homeostasis
Location	5q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000197536
Ensembl biotype	lncRNA
Entrez	441108
RNAcentral	URS0000E60A9C — lncRNA, 649 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 lncRNA, 1 retained_intron

ENST00000337752, ENST00000378947, ENST00000378953, ENST00000407797, ENST00000461203, ENST00000612967, ENST00000621237, ENST00000753207

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000337752 — 4 exons

Exon	Start	End
ENSE00001368673	132460562	132465109
ENSE00001409191	132449650	132449689
ENSE00001416447	132410981	132411041
ENSE00003827541	132419823	132419940

Expression profiles

Bgee: expression breadth ubiquitous, 239 present calls, max score 94.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.4912 / max 215.6569, expressed in 1367 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58448	10.4912	1367

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	94.61	gold quality
bone marrow cell	CL:0002092	93.23	gold quality
pancreatic ductal cell	CL:0002079	91.99	silver quality
blood	UBERON:0000178	91.23	gold quality
colonic epithelium	UBERON:0000397	90.84	gold quality
sural nerve	UBERON:0015488	89.87	gold quality
apex of heart	UBERON:0002098	89.85	gold quality
spleen	UBERON:0002106	89.50	gold quality
leukocyte	CL:0000738	89.31	gold quality
monocyte	CL:0000576	89.30	gold quality
right uterine tube	UBERON:0001302	88.17	gold quality
tibialis anterior	UBERON:0001385	87.89	silver quality
seminal vesicle	UBERON:0000998	87.87	gold quality
lymph node	UBERON:0000029	87.84	gold quality
thymus	UBERON:0002370	87.58	gold quality
myocardium	UBERON:0002349	87.41	silver quality
ileal mucosa	UBERON:0000331	86.97	gold quality
small intestine Peyer’s patch	UBERON:0003454	86.95	gold quality
right lobe of thyroid gland	UBERON:0001119	86.94	gold quality
left lobe of thyroid gland	UBERON:0001120	86.91	gold quality
thyroid gland	UBERON:0002046	86.64	gold quality
left ovary	UBERON:0002119	86.61	gold quality
small intestine	UBERON:0002108	86.58	gold quality
upper lobe of left lung	UBERON:0008952	86.34	gold quality
right lung	UBERON:0002167	86.13	gold quality
muscle layer of sigmoid colon	UBERON:0035805	86.01	gold quality
deltoid	UBERON:0001476	85.81	silver quality
body of uterus	UBERON:0009853	85.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	85.54	gold quality
lower esophagus	UBERON:0013473	85.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.88

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation? (PMID:34314424)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.