CARMAL

Summary

CARMAL (coronary artery disease region linked MFGE8 regulatory lncRNA, HGNC:55102) is a long non-coding RNA gene on chromosome 15q26.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55102
Approved symbol	CARMAL
Name	coronary artery disease region linked MFGE8 regulatory lncRNA
Location	15q26.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-326A19.4
Ensembl gene	ENSG00000260123
Ensembl biotype	lncRNA
Entrez	102724566
RNAcentral	URS00026A22FF — lncRNA, 4825 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000565938, ENST00000668304, ENST00000757230, ENST00000757231, ENST00000757232, ENST00000757233, ENST00000757234, ENST00000757235, ENST00000757236

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000565938 — 4 exons

Exon	Start	End
ENSE00002584530	89075296	89075384
ENSE00002603008	89070091	89070191
ENSE00004108131	89041010	89041300
ENSE00004108138	89082491	89082826

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 87.90.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0479 / max 5.3863, expressed in 24 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148318	0.0479	24

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right coronary artery	UBERON:0001625	87.90	gold quality
popliteal artery	UBERON:0002250	86.57	gold quality
tibial artery	UBERON:0007610	86.54	gold quality
left coronary artery	UBERON:0001626	83.22	gold quality
descending thoracic aorta	UBERON:0002345	81.06	gold quality
thoracic aorta	UBERON:0001515	79.27	gold quality
ascending aorta	UBERON:0001496	79.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.56	gold quality
hindlimb stylopod muscle	UBERON:0004252	71.93	gold quality
left uterine tube	UBERON:0001303	67.93	gold quality
mucosa of stomach	UBERON:0001199	66.13	gold quality
ectocervix	UBERON:0012249	65.63	gold quality
body of uterus	UBERON:0009853	63.56	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.44	gold quality
endocervix	UBERON:0000458	63.43	gold quality
cortical plate	UBERON:0005343	63.09	gold quality
smooth muscle tissue	UBERON:0001135	63.08	gold quality
myometrium	UBERON:0001296	63.00	gold quality
calcaneal tendon	UBERON:0003701	62.91	gold quality
ganglionic eminence	UBERON:0004023	62.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.56	gold quality
adipose tissue	UBERON:0001013	61.16	gold quality
omental fat pad	UBERON:0010414	60.75	gold quality
lower esophagus	UBERON:0013473	60.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.18	gold quality
thoracic mammary gland	UBERON:0005200	59.03	gold quality
fallopian tube	UBERON:0003889	58.99	gold quality
vermiform appendix	UBERON:0001154	58.44	gold quality
skeletal muscle tissue	UBERON:0001134	58.21	gold quality
tibial nerve	UBERON:0001323	57.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.61

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.