CASC11

Summary

CASC11 (cancer susceptibility 11, HGNC:48939) is a long non-coding RNA gene on chromosome 8q24.21.

Enables chromatin-protein adaptor activity and promoter-enhancer loop anchoring activity. Involved in chromatin looping and positive regulation of transcription by RNA polymerase II. Is active in nucleus.

Source: NCBI Gene 100270680 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48939
Approved symbol	CASC11
Name	cancer susceptibility 11
Location	8q24.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00014535, LINC00990, CARLo-7, ENST00000518376, MYMLR
Ensembl gene	ENSG00000249375
Ensembl biotype	lncRNA
OMIM	617704
Entrez	100270680
RNAcentral	URS0000392533 — lncRNA, 872 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000502463, ENST00000518376, ENST00000519071, ENST00000672637, ENST00000672942, ENST00000774797, ENST00000774798, ENST00000774799, ENST00000774800, ENST00000774801, ENST00000774802, ENST00000774803, ENST00000774804, ENST00000774805, ENST00000774806, ENST00000774807, ENST00000774808, ENST00000774809, ENST00000774810, ENST00000774811

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000502463 — 3 exons

Exon	Start	End
ENSE00002038150	127733825	127733967
ENSE00002047991	127686343	127689423
ENSE00003437271	127691790	127691866

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 75.93.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.93	gold quality
ventricular zone	UBERON:0003053	63.03	gold quality
monocyte	CL:0000576	57.97	gold quality
testis	UBERON:0000473	57.94	gold quality
stromal cell of endometrium	CL:0002255	57.47	gold quality
skeletal muscle tissue	UBERON:0001134	57.21	gold quality
muscle tissue	UBERON:0002385	57.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.95	gold quality
lymph node	UBERON:0000029	54.86	gold quality
calcaneal tendon	UBERON:0003701	53.41	silver quality
cortex of kidney	UBERON:0001225	53.00	gold quality
blood	UBERON:0000178	52.16	gold quality
prefrontal cortex	UBERON:0000451	51.95	gold quality
placenta	UBERON:0001987	51.42	gold quality
mucosa of transverse colon	UBERON:0004991	51.21	gold quality
tonsil	UBERON:0002372	50.91	gold quality
bone marrow	UBERON:0002371	50.52	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	50.26	gold quality
muscle of leg	UBERON:0001383	50.18	gold quality
granulocyte	CL:0000094	50.13	silver quality
smooth muscle tissue	UBERON:0001135	50.03	gold quality
vermiform appendix	UBERON:0001154	49.93	gold quality
pancreas	UBERON:0001264	49.72	gold quality
gastrocnemius	UBERON:0001388	49.67	gold quality
primary visual cortex	UBERON:0002436	49.67	gold quality
duodenum	UBERON:0002114	49.60	gold quality
liver	UBERON:0002107	49.54	gold quality
body of pancreas	UBERON:0001150	49.46	gold quality
gall bladder	UBERON:0002110	49.26	gold quality
endometrium	UBERON:0001295	48.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• CASC11 can target heterogeneous ribonucleoprotein K (hnRNP-K) to activate WNT/beta-catenin signaling in colorectal cancer cells to promote tumor growth and metastasis. (PMID:27012187)
• CASC11 epigenetically silenced PTEN by binding with EZH2 in hepatocellular carcinoma cells (PMID:30503497)
• High levels of CASC11 in the hepatocellular carcinoma tissues were significantly correlated with poor survival.CASC11 regulates miR-188-5p expression in the hepatocellular carcinoma. (PMID:30910841)
• Interactions of PVT1 and CASC11 on Prostate Cancer Risk in African Americans. (PMID:30914434)
• CASC11 may improve atherosclerosis by downregulating IL-9 and regulating VSMC apoptosis and proliferation (PMID:30915898)
• lncRNA CASC11 promotes cancer cell proliferation in bladder cancer through miRNA-150. (PMID:30916832)
• lncRNA CASC11 promotes TGF-beta1, increases cancer cell stemness and predicts postoperative survival in small cell lung cancer. (PMID:30965130)
• the miR-498 was found to target the 3’-UTR of lncRNA CASC11 and FOXK1 mRNA. (PMID:31121483)
• CASC11 is upregulated in ovarian squamous cell carcinoma (OSCC), and overexpression of CASC11 in OSCC mediated the development of cancer cell resistance to chemotherapy. (PMID:31181314)
• MYMLR was identified to maintain MYC transcriptional activity and cell cycle progression despite low levels of expression. A proteomic search for MYMLR-binding proteins identified PCBP2, while it was also found that MYMLR places a 557-kb upstream enhancer region in the proximity of the MYC promoter in cooperation with PCBP2. These findings implicate a crucial role for MYMLR in regulation MYC oncogene. (PMID:31361039)
• LncRNA CASC11 promotes the development of lung cancer through targeting microRNA-302/CDK1 axis. (PMID:31378894)
• The CASC11 was shown to target the miR-498/FOXO3 axis via a canonical competing endogenous RNA (ceRNA). (PMID:31537383)
• CASC11 is upregulated in POP and is correlated with TNF-alpha. (PMID:31571846)
• Silencing CASC11 curbs neonatal neuroblastoma progression through modulating microRNA-676-3p/nucleolar protein 4 like (NOL4L) axis. (PMID:31645055)
• LncRNA CASC11 promotes the development of esophageal carcinoma by regulating KLF6. (PMID:31696474)
• LncRNA CASC11 was downregulated in coronary artery disease and inhibits transforming growth factor-beta1. (PMID:32223575)
• CASC11 promotes aggressiveness of prostate cancer cells through miR-145/IGF1R axis. (PMID:33753875)
• Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease. (PMID:34001726)
• [Role of LncRNA CASC11 in the malignant transformation of 16HBE cells induced by glycidyl methacrylate]. (PMID:34949331)
• Long noncoding RNA CASC11 interacts with YBX1 to promote prostate cancer progression by suppressing the p53 pathway. (PMID:35904175)
• LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p. (PMID:36206098)
• Correlation between plasma lncRNA CASC11 and malignancy in lung adenocarcinoma patients and the prognostic value of lncRNA CASC11. (PMID:36705085)
• LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells. (PMID:37096653)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.