CASC15

Summary

CASC15 (cancer susceptibility 15, HGNC:28245) is a long non-coding RNA gene on chromosome 6p22.3.

This gene produces a long non-coding RNA that may regulate cell proliferation. This RNA is upregulated in hepatocellular carcinoma, where it is thought to function as an oncogene. However, some splice variants of this gene may function as a tumor suppressor in neuroblastoma and other tumor types. Circular RNA variants were observed at this gene.

Source: NCBI Gene 401237 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28245
Approved symbol	CASC15
Name	cancer susceptibility 15
Location	6p22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-SOX4-1
Ensembl gene	ENSG00000272168
Ensembl biotype	lncRNA
OMIM	616610
Entrez	401237
RNAcentral	URS0000CCE117 — lncRNA, 3353 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 326 — 326 lncRNA

ENST00000444265, ENST00000561912, ENST00000567753, ENST00000605917, ENST00000606197, ENST00000606336, ENST00000606851, ENST00000607048, ENST00000636388, ENST00000650720, ENST00000650782, ENST00000651007, ENST00000651125, ENST00000651277, ENST00000651481, ENST00000651569, ENST00000651620, ENST00000651751, ENST00000651758, ENST00000652000, ENST00000652081, ENST00000652256, ENST00000652717, ENST00000653010, ENST00000653161, ENST00000653246, ENST00000653320, ENST00000653763, ENST00000653997, ENST00000654262, ENST00000654774, ENST00000654782, ENST00000654807, ENST00000654918, ENST00000654942, ENST00000655154, ENST00000655292, ENST00000655498, ENST00000655700, ENST00000655702, ENST00000655824, ENST00000655886, ENST00000657548, ENST00000657660, ENST00000657825, ENST00000657828, ENST00000658187, ENST00000658810, ENST00000658841, ENST00000658974, ENST00000659237, ENST00000659457, ENST00000659720, ENST00000659780, ENST00000659886, ENST00000660187, ENST00000660518, ENST00000660934, ENST00000661200, ENST00000661662, ENST00000661722, ENST00000661893, ENST00000662172, ENST00000662187, ENST00000662510, ENST00000662805, ENST00000663874, ENST00000663957, ENST00000663998, ENST00000664020, ENST00000664406, ENST00000664431, ENST00000664500, ENST00000664560, ENST00000664625, ENST00000664716, ENST00000664756, ENST00000664780, ENST00000664808, ENST00000664889, ENST00000665014, ENST00000665902, ENST00000666108, ENST00000666201, ENST00000666379, ENST00000666875, ENST00000667176, ENST00000667291, ENST00000667719, ENST00000667830, ENST00000668137, ENST00000668219, ENST00000668355, ENST00000668404, ENST00000668839, ENST00000669171, ENST00000669448, ENST00000669670, ENST00000669942, ENST00000670293, ENST00000670467, ENST00000671013, ENST00000671160, ENST00000671524, ENST00000671659, ENST00000685576, ENST00000687332, ENST00000688254, ENST00000691204, ENST00000691572, ENST00000692274, ENST00000822125, ENST00000822126, ENST00000822127, ENST00000822767, ENST00000822768, ENST00000822769, ENST00000822770, ENST00000822771, ENST00000822772, ENST00000822773, ENST00000822774, ENST00000822775, ENST00000822776, ENST00000822777, ENST00000822778, ENST00000822779, ENST00000822780, ENST00000822781, ENST00000822782, ENST00000822783, ENST00000822784, ENST00000822785, ENST00000822786, ENST00000822787, ENST00000822788, ENST00000822789, ENST00000822790, ENST00000822791, ENST00000822792, ENST00000822793, ENST00000822794, ENST00000822795, ENST00000822796, ENST00000822797, ENST00000822798, ENST00000822799, ENST00000822800, ENST00000822801, ENST00000822802, ENST00000822803, ENST00000822804, ENST00000822805, ENST00000822806, ENST00000822807, ENST00000822808, ENST00000822809, ENST00000822810, ENST00000822811, ENST00000822812, ENST00000822813, ENST00000822814, ENST00000822815, ENST00000822816, ENST00000822817, ENST00000822818, ENST00000822819, ENST00000822820, ENST00000822821, ENST00000822822, ENST00000822823, ENST00000822824, ENST00000822825, ENST00000822826, ENST00000822827, ENST00000822828, ENST00000822829, ENST00000822830, ENST00000822831, ENST00000822832, ENST00000822833, ENST00000822834, ENST00000822835, ENST00000822836, ENST00000822837, ENST00000822838, ENST00000822839, ENST00000822840, ENST00000822841, ENST00000822842, ENST00000822843, ENST00000822844, ENST00000822845, ENST00000822846, ENST00000822847, ENST00000822848, ENST00000822849, ENST00000822850, ENST00000822851, ENST00000822852, ENST00000822853, ENST00000822854, ENST00000822855, ENST00000822856, ENST00000822857, ENST00000822858, ENST00000822859, ENST00000822860, ENST00000822861, ENST00000822862, ENST00000822863, ENST00000822864, ENST00000822865, ENST00000822866, ENST00000822867, ENST00000822868, ENST00000822869, ENST00000822870, ENST00000822871, ENST00000822872, ENST00000822873, ENST00000822874, ENST00000822875, ENST00000822876, ENST00000822877, ENST00000822878, ENST00000822879, ENST00000822880, ENST00000822881, ENST00000822882, ENST00000822883, ENST00000822884, ENST00000822885, ENST00000822886, ENST00000822887, ENST00000822888, ENST00000822889, ENST00000822890, ENST00000822891, ENST00000822892, ENST00000822893, ENST00000822894, ENST00000822895, ENST00000822896, ENST00000822897, ENST00000822898, ENST00000822899, ENST00000822900, ENST00000822901, ENST00000822902, ENST00000822903, ENST00000822904, ENST00000822905, ENST00000822906, ENST00000822907, ENST00000822908, ENST00000822909, ENST00000822910, ENST00000822911, ENST00000822912, ENST00000822913, ENST00000822914, ENST00000822915, ENST00000822916, ENST00000822917, ENST00000822918, ENST00000822919, ENST00000822920, ENST00000822921, ENST00000822922, ENST00000822923, ENST00000822924, ENST00000822925, ENST00000822926, ENST00000822927, ENST00000822928, ENST00000822929, ENST00000822930, ENST00000822931, ENST00000822932, ENST00000822933, ENST00000822934, ENST00000822935, ENST00000822936, ENST00000822937, ENST00000822938, ENST00000822939, ENST00000822940, ENST00000822941, ENST00000822942, ENST00000822943, ENST00000822944, ENST00000822945, ENST00000822946, ENST00000822947, ENST00000822948, ENST00000822949, ENST00000822950, ENST00000822951, ENST00000822952, ENST00000822953, ENST00000822954, ENST00000822955, ENST00000822956, ENST00000822957, ENST00000822958, ENST00000822959, ENST00000822960, ENST00000822961, ENST00000822962, ENST00000822963, ENST00000822964, ENST00000822965, ENST00000822966, ENST00000822967, ENST00000822968, ENST00000822969, ENST00000822970, ENST00000822971, ENST00000822972, ENST00000846434, ENST00000846435, ENST00000846436, ENST00000846437, ENST00000846438, ENST00000846439

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000444265 — 11 exons

Exon	Start	End
ENSE00001625624	22110747	22110920
ENSE00001636146	22056546	22056690
ENSE00003695005	22214307	22214505
ENSE00003696426	21898720	21898784
ENSE00003696652	22194045	22194116
ENSE00003697457	22020339	22020542
ENSE00003698139	22205185	22205259
ENSE00003698157	22063020	22063240
ENSE00003700366	21978945	21979062
ENSE00003700899	21909470	21909603
ENSE00003701862	22191567	22191656

Expression profiles

Bgee: expression breadth ubiquitous, 223 present calls, max score 94.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.3074 / max 377.7889, expressed in 1020 samples.

FANTOM5 promoters (27 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66326	2.6785	560
66353	1.6678	330
66341	0.9866	230
66354	0.7089	261
66355	0.4152	160
66363	0.3482	74
66328	0.3208	148
66358	0.2965	108
66357	0.2328	95
66345	0.2164	120

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	94.61	gold quality
ventricular zone	UBERON:0003053	91.35	gold quality
sural nerve	UBERON:0015488	91.35	gold quality
kidney epithelium	UBERON:0004819	91.21	silver quality
vena cava	UBERON:0004087	90.19	silver quality
cortical plate	UBERON:0005343	88.90	gold quality
corpus epididymis	UBERON:0004359	87.78	gold quality
left ventricle myocardium	UBERON:0006566	87.66	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.94	gold quality
left ovary	UBERON:0002119	86.68	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	86.24	silver quality
body of tongue	UBERON:0011876	85.17	silver quality
buccal mucosa cell	CL:0002336	84.99	silver quality
epithelial cell of pancreas	CL:0000083	84.75	silver quality
heart right ventricle	UBERON:0002080	84.19	silver quality
prefrontal cortex	UBERON:0000451	83.87	gold quality
colonic epithelium	UBERON:0000397	83.63	gold quality
right ovary	UBERON:0002118	83.35	gold quality
ovary	UBERON:0000992	83.13	gold quality
pons	UBERON:0000988	82.94	gold quality
calcaneal tendon	UBERON:0003701	82.64	gold quality
body of uterus	UBERON:0009853	82.39	gold quality
corpus callosum	UBERON:0002336	82.36	gold quality
right adrenal gland cortex	UBERON:0035827	82.36	gold quality
thymus	UBERON:0002370	82.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.23	gold quality
neocortex	UBERON:0001950	81.85	gold quality
amygdala	UBERON:0001876	81.81	gold quality
frontal cortex	UBERON:0001870	81.67	gold quality
anterior cingulate cortex	UBERON:0009835	81.67	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	886.36
E-HCAD-25	yes	877.75
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 26)

• We observed a significant association between neuroblastoma and the common minor alleles of three consecutive single-nucleotide polymorphisms (SNPs) at chromosome band 6p22 and containing the predicted genes FLJ22536 and FLJ44180 (PMID:18463370)
• CASC15-S is a tumor suppressor lncRNA at the 6p22 neuroblastoma susceptibility locus.CASC15-S is a mediator of neural growth and differentiation, which impacts neuroblastoma initiation and progression. (PMID:26100672)
• CASC15 plays an important role in the progression of HCC, acting as an oncogene. High expression of CASC15 is correlated with a poor prognosis. (PMID:29075788)
• LncRNA CASC15 could promote the proliferation of gastric cancer cells and was expected to become the molecular marker for prediction and prognosis of gastric cancer, as well as a potential therapeutic target. (PMID:29272000)
• the knockdown of CASC15 triggered the silencing of ZEB1 in cytoplasm, which was shown to be associated with the competitive binding of CASC15 to miR-33a-5p. (PMID:29489064)
• upregulated in tongue squamous cell carcinoma tissues and cell lines; overexpression promoted cell proliferation, cycle, and migration (PMID:29804249)
• knockdown of CASC15 significantly inhibited the proliferation, migration and invasion of colon cancer cells in vitro and in vivo. Following mechanistic experiments, CASC15 was observed to act as a sponge to suppress microRNA (miR)4310 that targeted LGR5. (PMID:29956772)
• the positive feedback loop of KLF5/CASC15/miR-153-3p/KLF5 in the acceleration of breast cancer malignant behaviors and tumorigenesis, is reported. (PMID:30389133)
• Higher lncRNA CASC15 expression predicts poor prognosis and associates with tumor growth in cervical cancer. (PMID:30720157)
• CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer. (PMID:31378128)
• CASC15 could promote EMT and facilitate malignancy of HCC cells by increasing TWIST1 gene expression via miR-33a-5p sponging (PMID:31401158)
• CASC15 and miR-124 predict TSCC [tongue squamous cell carcinoma ] patients’ survival and CASC15 may downregulate miR-124 to inhibit TSCC cell migration and invasion. (PMID:31665008)
• Long Non-Coding RNA-CASC15 Promotes Cell Proliferation, Migration, and Invasion by Activating Wnt/beta-Catenin Signaling Pathway in Melanoma. (PMID:31838468)
• Long Non-Coding RNA (LncRNA) CASC15 Is Upregulated in Diabetes-Induced Chronic Renal Failure and Regulates Podocyte Apoptosis. (PMID:32053576)
• CASC15 polymorphisms are correlated with cervical cancer susceptibility in Chinese women. (PMID:32329235)
• The long non-coding RNA Cancer Susceptibility 15 (CASC15) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia. (PMID:33054061)
• Long noncoding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTOmediated demethylation. (PMID:33650646)
• lncRNACASC15 promotes osteosarcoma proliferation and metastasis by regulating epithelialmesenchymal transition via the Wnt/betacatenin signaling pathway. (PMID:33760218)
• A study of the prognostic value of long non-coding RNA CASC15 in human solid tumors utilizing The Cancer Genome Atlas (TCGA) datasets and a meta-analysis. (PMID:35103883)
• LncRNA CASC15 regulates breast cancer cell stemness via the miR-654-5p/MEF2D axis. (PMID:35235236)
• LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer. (PMID:35342355)
• [Clinical Significance of Low Expression of LncRNA CASC15 in Acute Myeloid Leukemia with NPM1 Mutations]. (PMID:35680788)
• CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children. (PMID:35819658)
• LncRNA-CASC15 knockdown inhibits the progression of esophageal squamous cell carcinoma through targeting miR-33a-5p/PTGS2 axis. (PMID:36111503)
• Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer Progression via EMT. (PMID:37680149)
• Prognostic value of CASC15 and LINC01600 as competitive endogenous RNAs in lung adenocarcinoma: An observational study. (PMID:37960753)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.