CASC17

Summary

CASC17 (cancer susceptibility 17, HGNC:43911) is a long non-coding RNA gene on chromosome 17q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43911
Approved symbol	CASC17
Name	cancer susceptibility 17
Location	17q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00600
Ensembl gene	ENSG00000260785
Ensembl biotype	lncRNA
Entrez	101928165
RNAcentral	URS000075E2D4 — lncRNA, 2077 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000569074, ENST00000659322, ENST00000659670, ENST00000662323, ENST00000662349, ENST00000664372, ENST00000664398, ENST00000665992, ENST00000667642, ENST00000668160, ENST00000668920, ENST00000669182, ENST00000669562, ENST00000671130

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000569074 — 4 exons

Exon	Start	End
ENSE00002575583	71185596	71185655
ENSE00002585228	71132390	71132470
ENSE00002588316	71202104	71202177
ENSE00002589961	71097775	71099618

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 80.47.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0099 / max 8.1195, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
167835	0.0099	3

Top tissues by expression

171 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.47	silver quality
sperm	CL:0000019	74.32	silver quality
right testis	UBERON:0004534	66.31	gold quality
left testis	UBERON:0004533	65.62	gold quality
testis	UBERON:0000473	64.04	gold quality
ganglionic eminence	UBERON:0004023	63.17	gold quality
ventricular zone	UBERON:0003053	61.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.98	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	54.96	gold quality
monocyte	CL:0000576	51.57	silver quality
prefrontal cortex	UBERON:0000451	49.32	silver quality
islet of Langerhans	UBERON:0000006	49.05	gold quality
calcaneal tendon	UBERON:0003701	48.54	silver quality
muscle of leg	UBERON:0001383	47.88	gold quality
skin of hip	UBERON:0001554	47.66	silver quality
upper leg skin	UBERON:0004262	47.53	silver quality
pancreas	UBERON:0001264	47.07	gold quality
body of pancreas	UBERON:0001150	46.83	gold quality
gastrocnemius	UBERON:0001388	46.39	gold quality
skin of leg	UBERON:0001511	45.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	44.35	gold quality
adrenal gland	UBERON:0002369	44.14	gold quality
anatomical system	UBERON:0000467	43.55	gold quality
material anatomical entity	UBERON:0000465	43.38	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
multicellular organism	UBERON:0000468	43.31	gold quality
cortex of kidney	UBERON:0001225	43.20	silver quality
anterior cingulate cortex	UBERON:0009835	43.10	gold quality
cerebellar hemisphere	UBERON:0002245	42.91	gold quality
neocortex	UBERON:0001950	42.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.61

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.