CASC18

Summary

CASC18 (cancer susceptibility 18, HGNC:49463) is a long non-coding RNA gene on chromosome 12q23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49463
Approved symbol	CASC18
Name	cancer susceptibility 18
Location	12q23.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC101929110
Ensembl gene	ENSG00000257859
Ensembl biotype	lncRNA
Entrez	101929110
RNAcentral	URS000055ECA4 — lncRNA, 2521 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000547465, ENST00000548557, ENST00000656319, ENST00000670167

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000547465 — 2 exons

Exon	Start	End
ENSE00002381677	105706774	105706856
ENSE00002399383	105741756	105742229

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 90.79.

Top tissues by expression

224 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.79	gold quality
secondary oocyte	CL:0000655	74.09	gold quality
sural nerve	UBERON:0015488	65.47	gold quality
cortical plate	UBERON:0005343	65.10	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.15	gold quality
ascending aorta	UBERON:0001496	60.82	gold quality
descending thoracic aorta	UBERON:0002345	60.81	gold quality
thoracic aorta	UBERON:0001515	60.62	gold quality
ventricular zone	UBERON:0003053	60.00	gold quality
ganglionic eminence	UBERON:0004023	59.20	silver quality
myocardium	UBERON:0002349	59.18	gold quality
oocyte	CL:0000023	58.03	silver quality
aorta	UBERON:0000947	57.89	gold quality
esophagus squamous epithelium	UBERON:0006920	57.55	gold quality
popliteal artery	UBERON:0002250	55.98	gold quality
tibial artery	UBERON:0007610	55.94	gold quality
prefrontal cortex	UBERON:0000451	55.38	gold quality
stromal cell of endometrium	CL:0002255	55.20	silver quality
tendon of biceps brachii	UBERON:0008188	54.51	gold quality
monocyte	CL:0000576	54.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	54.29	gold quality
right coronary artery	UBERON:0001625	54.11	gold quality
islet of Langerhans	UBERON:0000006	52.48	gold quality
mucosa of stomach	UBERON:0001199	52.29	gold quality
tendon	UBERON:0000043	52.24	silver quality
deltoid	UBERON:0001476	51.99	gold quality
muscle of leg	UBERON:0001383	51.75	gold quality
endothelial cell	CL:0000115	51.50	gold quality
left coronary artery	UBERON:0001626	50.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	50.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma. (PMID:34362313)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.