CASC20

Summary

CASC20 (cancer susceptibility 20, HGNC:49477) is a long non-coding RNA gene on chromosome 20p12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49477
Approved symbol	CASC20
Name	cancer susceptibility 20
Location	20p12.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229876
Ensembl biotype	lncRNA
Entrez	101929244
RNAcentral	URS000075ACC6 — lncRNA, 1563 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000415932, ENST00000722184, ENST00000722185, ENST00000722186, ENST00000722187

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415932 — 3 exons

Exon	Start	End
ENSE00001731217	6473539	6473655
ENSE00001785606	6527194	6528459
ENSE00001792809	6446723	6446823

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 80.93.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.93	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.84	gold quality
adrenal gland	UBERON:0002369	54.88	gold quality
blood	UBERON:0000178	54.26	gold quality
pancreas	UBERON:0001264	53.65	gold quality
monocyte	CL:0000576	49.30	silver quality
myometrium	UBERON:0001296	48.30	silver quality
zone of skin	UBERON:0000014	46.66	silver quality
omental fat pad	UBERON:0010414	46.66	gold quality
adipose tissue	UBERON:0001013	46.48	gold quality
endometrium	UBERON:0001295	46.25	silver quality
islet of Langerhans	UBERON:0000006	46.18	silver quality
muscle of leg	UBERON:0001383	45.72	silver quality
placenta	UBERON:0001987	45.53	gold quality
small intestine	UBERON:0002108	45.09	silver quality
colon	UBERON:0001155	44.95	silver quality
hypothalamus	UBERON:0001898	43.76	silver quality
stomach	UBERON:0000945	43.61	gold quality
heart left ventricle	UBERON:0002084	43.26	silver quality
gastrocnemius	UBERON:0001388	43.23	silver quality
gall bladder	UBERON:0002110	43.20	silver quality
Ammon’s horn	UBERON:0001954	43.19	silver quality
spleen	UBERON:0002106	43.13	silver quality
subcutaneous adipose tissue	UBERON:0002190	42.19	gold quality
upper lobe of left lung	UBERON:0008952	41.73	silver quality
esophagus mucosa	UBERON:0002469	41.54	silver quality
right atrium auricular region	UBERON:0006631	41.34	silver quality
lower esophagus muscularis layer	UBERON:0035833	41.34	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	41.28	silver quality
tibial artery	UBERON:0007610	40.89	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA cancer susceptibility 20 regulates the metastasis of human gastric cancer cells via the miR-143-5p/MEMO1 molecular axis. (PMID:35581960)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.