CASC21

Summary

CASC21 (cancer susceptibility 21, HGNC:49836) is a long non-coding RNA gene on chromosome 8q24.21.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 2 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49836
Approved symbol	CASC21
Name	cancer susceptibility 21
Location	8q24.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	CARLo-2
OMIM	617702
Entrez	103021164
RNAcentral	URS000075BF52 — lncRNA, 585 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis. (PMID:31731190)
• CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6. (PMID:32584787)
• LncRNA CASC21 induces HGH1 to mediate colorectal cancer cell proliferation, migration, EMT and stemness. (PMID:34375566)
• The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer. (PMID:38465665)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000023795 (8:127294815 A>C,T), RS1000032748 (8:127339738 C>T), RS1000037278 (8:127278100 A>G), RS1000055146 (8:127295151 G>T), RS1000086463 (8:127316641 C>A), RS1000096225 (8:127265858 G>A), RS1000097223 (8:127292855 GAAGAA>G), RS1000126370 (8:127387139 A>G), RS1000156129 (8:127249121 G>A), RS1000191798 (8:127370651 A>T), RS1000249026 (8:127325335 T>G), RS1000261439 (8:127342673 T>G), RS1000279995 (8:127248878 G>A), RS1000287637 (8:127301005 C>G,T), RS1000301286 (8:127246158 G>A)

Disease associations

OMIM: gene MIM:617702 | disease phenotypes: MIM:176807

GenCC curated gene-disease

Mondo (1): prostate cancer, hereditary (MONDO:0700275)

Orphanet (1): Familial prostate cancer (Orphanet:1331)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003586_9	Prostate cancer	2.000000e-09

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C537243	Prostate cancer, familial (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Lactic Acid	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.