CASC22

Summary

CASC22 (cancer susceptibility 22, HGNC:50627) is a long non-coding RNA gene on chromosome 16q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50627
Approved symbol	CASC22
Name	cancer susceptibility 22
Location	16q12.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00024290, LincRNA-ENST00000515084
Ensembl gene	ENSG00000260887
Ensembl biotype	lncRNA
Entrez	283854
RNAcentral	URS000027C6D6 — lncRNA, 386 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000569713, ENST00000628396, ENST00000653084, ENST00000656784, ENST00000660275, ENST00000661626, ENST00000661876, ENST00000662008, ENST00000665777, ENST00000668506, ENST00000668976, ENST00000670500, ENST00000717485

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000569713 — 3 exons

Exon	Start	End
ENSE00002588537	52279609	52279690
ENSE00004032636	52258564	52258583
ENSE00004032638	52280016	52280299

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 81.74.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0170 / max 17.5923, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154051	0.0170	3

Top tissues by expression

183 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.74	gold quality
left testis	UBERON:0004533	77.93	gold quality
right testis	UBERON:0004534	76.86	gold quality
testis	UBERON:0000473	74.71	gold quality
sperm	CL:0000019	68.48	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.91	gold quality
monocyte	CL:0000576	57.24	gold quality
adult mammalian kidney	UBERON:0000082	56.72	gold quality
right lobe of liver	UBERON:0001114	56.44	gold quality
cortex of kidney	UBERON:0001225	55.58	gold quality
hindlimb stylopod muscle	UBERON:0004252	53.65	gold quality
sural nerve	UBERON:0015488	52.91	silver quality
kidney	UBERON:0002113	52.56	gold quality
buccal mucosa cell	CL:0002336	52.36	gold quality
nasal cavity epithelium	UBERON:0005384	52.02	gold quality
omental fat pad	UBERON:0010414	50.80	gold quality
peritoneum	UBERON:0002358	50.58	gold quality
right frontal lobe	UBERON:0002810	50.29	gold quality
gall bladder	UBERON:0002110	49.64	gold quality
skin of abdomen	UBERON:0001416	49.44	gold quality
muscle of leg	UBERON:0001383	48.92	gold quality
metanephros cortex	UBERON:0010533	48.72	gold quality
liver	UBERON:0002107	48.21	gold quality
tibial nerve	UBERON:0001323	47.86	gold quality
adipose tissue of abdominal region	UBERON:0007808	47.68	gold quality
gastrocnemius	UBERON:0001388	47.56	gold quality
body of uterus	UBERON:0009853	47.48	gold quality
islet of Langerhans	UBERON:0000006	46.94	gold quality
right adrenal gland cortex	UBERON:0035827	46.45	gold quality
body of pancreas	UBERON:0001150	46.41	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.