CASC23

Summary

CASC23 (cancer susceptibility 23, HGNC:50865) is a long non-coding RNA gene on chromosome 11p15.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50865
Approved symbol	CASC23
Name	cancer susceptibility 23
Location	11p15.4
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC01464
Ensembl gene	ENSG00000255420
Ensembl biotype	lncRNA
Entrez	103581031
RNAcentral	URS00007E4DDF — lncRNA, 1583 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000534076

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000534076 — 3 exons

Exon	Start	End
ENSE00002160326	8016075	8016520
ENSE00002161189	8013574	8013730
ENSE00002181289	8011278	8012268

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 85.53.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0289 / max 22.1598, expressed in 4 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118487	0.0289	4

Top tissues by expression

168 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	85.53	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.70	gold quality
left testis	UBERON:0004533	72.59	gold quality
right testis	UBERON:0004534	72.13	gold quality
testis	UBERON:0000473	70.16	gold quality
ganglionic eminence	UBERON:0004023	55.92	silver quality
upper leg skin	UBERON:0004262	49.85	silver quality
monocyte	CL:0000576	49.00	silver quality
islet of Langerhans	UBERON:0000006	47.82	silver quality
tibial nerve	UBERON:0001323	46.99	gold quality
gastrocnemius	UBERON:0001388	46.72	gold quality
amniotic fluid	UBERON:0000173	46.06	gold quality
epithelium of nasopharynx	UBERON:0001951	45.89	gold quality
deltoid	UBERON:0001476	44.58	gold quality
anatomical system	UBERON:0000467	44.57	gold quality
vastus lateralis	UBERON:0001379	44.51	gold quality
quadriceps femoris	UBERON:0001377	44.40	gold quality
material anatomical entity	UBERON:0000465	44.30	gold quality
buccal mucosa cell	CL:0002336	44.28	gold quality
multicellular organism	UBERON:0000468	44.20	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
adult organism	UBERON:0007023	43.15	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
blood	UBERON:0000178	42.12	gold quality
heart left ventricle	UBERON:0002084	41.97	gold quality
heart	UBERON:0000948	41.76	gold quality
skeletal muscle tissue	UBERON:0001134	41.63	gold quality
mammary duct	UBERON:0001765	41.51	gold quality
prefrontal cortex	UBERON:0000451	41.35	gold quality
adult mammalian kidney	UBERON:0000082	41.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.