CASC6

Summary

CASC6 (cancer susceptibility 6, HGNC:49076) is a long non-coding RNA gene on chromosome 6q15.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49076
Approved symbol	CASC6
Name	cancer susceptibility 6
Location	6q15
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224944
Ensembl biotype	lncRNA
Entrez	101929083
RNAcentral	URS000075B846 — lncRNA, 1608 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000437768, ENST00000655239, ENST00000656997, ENST00000760409, ENST00000760410, ENST00000760411, ENST00000760412

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000437768 — 4 exons

Exon	Start	End
ENSE00001604859	91685048	91685192
ENSE00001730012	91690311	91690428
ENSE00004113937	91633681	91633835
ENSE00004113939	91629896	91630229

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 61.59.

Top tissues by expression

191 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.59	gold quality
adrenal tissue	UBERON:0018303	55.81	gold quality
Ammon’s horn	UBERON:0001954	54.80	gold quality
stromal cell of endometrium	CL:0002255	53.93	silver quality
monocyte	CL:0000576	53.51	gold quality
calcaneal tendon	UBERON:0003701	52.70	silver quality
islet of Langerhans	UBERON:0000006	50.89	gold quality
right lobe of liver	UBERON:0001114	48.85	silver quality
lymph node	UBERON:0000029	47.01	gold quality
prefrontal cortex	UBERON:0000451	47.00	silver quality
cortex of kidney	UBERON:0001225	46.50	silver quality
muscle of leg	UBERON:0001383	46.38	silver quality
gastrocnemius	UBERON:0001388	45.80	silver quality
amygdala	UBERON:0001876	45.46	gold quality
cerebellar cortex	UBERON:0002129	45.38	silver quality
pancreas	UBERON:0001264	45.32	gold quality
cerebellar hemisphere	UBERON:0002245	45.28	silver quality
popliteal artery	UBERON:0002250	45.24	silver quality
descending thoracic aorta	UBERON:0002345	45.23	gold quality
tibial artery	UBERON:0007610	45.23	silver quality
cerebral cortex	UBERON:0000956	45.10	gold quality
right coronary artery	UBERON:0001625	44.71	gold quality
aorta	UBERON:0000947	44.12	silver quality
right hemisphere of cerebellum	UBERON:0014890	44.01	silver quality
adrenal gland	UBERON:0002369	43.98	gold quality
body of pancreas	UBERON:0001150	43.81	silver quality
heart left ventricle	UBERON:0002084	43.79	silver quality
forebrain	UBERON:0001890	43.37	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
brain	UBERON:0000955	43.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.