CASC8

Summary

CASC8 (cancer susceptibility 8, HGNC:45129) is a long non-coding RNA gene on chromosome 8q24.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45129
Approved symbol	CASC8
Name	cancer susceptibility 8
Location	8q24.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00860, CARLo-1
Ensembl gene	ENSG00000246228
Ensembl biotype	lncRNA
OMIM	617701
Entrez	727677
RNAcentral	URS0000230AD4 — lncRNA, 1412 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000501396, ENST00000502056, ENST00000502082, ENST00000523825, ENST00000842817, ENST00000842818, ENST00000842819, ENST00000842820, ENST00000842821, ENST00000842822, ENST00000842823, ENST00000842824

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000501396 — 3 exons

Exon	Start	End
ENSE00001983536	127323015	127323154
ENSE00004268280	127420829	127421374
ENSE00004268283	127289679	127290060

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 68.54.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0464 / max 14.8232, expressed in 15 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94909	0.0464	15

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	68.54	gold quality
ganglionic eminence	UBERON:0004023	64.84	gold quality
minor salivary gland	UBERON:0001830	64.23	gold quality
saliva-secreting gland	UBERON:0001044	63.72	gold quality
granulocyte	CL:0000094	62.23	gold quality
leukocyte	CL:0000738	61.95	gold quality
mucosa of transverse colon	UBERON:0004991	61.74	gold quality
monocyte	CL:0000576	60.94	gold quality
esophagus mucosa	UBERON:0002469	60.92	gold quality
endometrium	UBERON:0001295	60.88	gold quality
lower esophagus mucosa	UBERON:0035834	58.83	gold quality
esophagus	UBERON:0001043	57.91	gold quality
blood	UBERON:0000178	57.69	gold quality
thoracic mammary gland	UBERON:0005200	56.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.36	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.24	silver quality
calcaneal tendon	UBERON:0003701	56.07	silver quality
body of stomach	UBERON:0001161	54.61	gold quality
liver	UBERON:0002107	54.57	silver quality
gall bladder	UBERON:0002110	54.38	gold quality
muscle tissue	UBERON:0002385	54.24	gold quality
stomach	UBERON:0000945	53.92	gold quality
prefrontal cortex	UBERON:0000451	53.72	gold quality
islet of Langerhans	UBERON:0000006	53.28	gold quality
duodenum	UBERON:0002114	53.23	gold quality
tonsil	UBERON:0002372	53.18	silver quality
corpus callosum	UBERON:0002336	51.97	gold quality
lymph node	UBERON:0000029	51.80	gold quality
bone marrow	UBERON:0002371	51.52	gold quality
rectum	UBERON:0001052	51.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.19

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• Meta-analysis suggested that for CASC8 gene, SNP of rs7837328 and rs6983267 are risk factors for colorectal cancer among both Caucasians and Asians whereas rs7014346 and rs10505477 are risky gene polymorphisms only among Caucasians. (PMID:26579801)
• study showed that lncRNA CASC8 rs10505477 polymorphism was significantly related to lung cancer susceptibility and overall severe toxicity induced by platinum-based chemotherapy in lung cancers. (PMID:27249003)
• CASC8 reduced the glycolysis of bladder cancer cells via interacting with the fibroblast growth factor receptor 1. (PMID:28759252)
• Results show no association of CASC8 rs1447295 with colorectal cancer in Iranian population. (PMID:28887158)
• association of CASC8 gene polymorphisms with the occurrence and progression of hepatocellular carcinoma (PMID:31398859)
• Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population. (PMID:32034808)
• Long non-coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population. (PMID:32875717)
• Contribution of lncRNA CASC8, CASC11, and PVT1 Genetic Variants to the Susceptibility of Coronary Heart Disease. (PMID:34001726)
• Association of TCF7L2, CASC8 and GREM1 Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus. (PMID:35893034)
• The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma. (PMID:35982900)
• TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population. (PMID:36800588)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.