CATIP-AS1

Summary

CATIP-AS1 (CATIP antisense RNA 1, HGNC:41080) is a long non-coding RNA gene on chromosome 2q35.

At a glance

• Gene type: non-coding (lncRNA) — no protein product.
• Sense gene: antisense to CATIP — the sense gene carries 3 GWAS associations, 56 ClinVar variants (the sense gene’s biology, not this transcript’s)
• GTEx eGene: eQTL in 4 tissues, sQTL in 0 (q < 0.05)

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41080
Approved symbol	CATIP-AS1
Name	CATIP antisense RNA 1
Location	2q35
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225062
Ensembl biotype	lncRNA
Entrez	101928513
RNAcentral	URS000075D700 — lncRNA, 547 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 lncRNA, 1 retained_intron

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 4: 1

ENST00000425481, ENST00000441749, ENST00000828657, ENST00000828658, ENST00000828659

RefSeq mRNA: 0

Canonical transcript exons

ENST00000425481 — 2 exons

Exon	Start	End
ENSE00001679783	218366927	218367322
ENSE00001784707	218366666	218366798

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 86.57.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1352 / max 71.3364, expressed in 255 samples.

Highest expression (Bgee): male germ line stem cell (sensu Vertebrata) in testis, lung, granulocyte, bone marrow cell, colonic epithelium.

Genetic regulation across tissues (GTEx eQTL / sQTL)

CATIP-AS1 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 4 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

4 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Whole Blood	eqtl	2.7e-13	-0.31	2:218363142:G:A
Spleen	eqtl	1.1e-02	-0.29	2:218345488:G:C
Adipose Subcutaneous	eqtl	2.8e-02	-0.26	2:217833600:A:G
Adipose Visceral Omentum	eqtl	4.8e-02	-0.88	2:218870064:C:T

FANTOM5 promoters

5 alternative TSS:

Promoter ID	TPM avg	Samples expressed
33957	0.4185	164
33956	0.2745	88
33955	0.2285	74
33953	0.1180	63
33954	0.0956	52

Top tissues by expression

showing 100 of 236 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.57	silver quality
right lung	UBERON:0002167	75.70	gold quality
granulocyte	CL:0000094	73.88	gold quality
bone marrow cell	CL:0002092	73.39	gold quality
colonic epithelium	UBERON:0000397	72.05	gold quality
right lobe of thyroid gland	UBERON:0001119	71.55	gold quality
blood	UBERON:0000178	71.21	gold quality
left lobe of thyroid gland	UBERON:0001120	70.57	gold quality
upper lobe of left lung	UBERON:0008952	70.54	gold quality
right lobe of liver	UBERON:0001114	70.52	gold quality
upper lobe of lung	UBERON:0008948	69.60	gold quality
thyroid gland	UBERON:0002046	69.42	gold quality
leukocyte	CL:0000738	69.28	gold quality
monocyte	CL:0000576	69.09	gold quality
spleen	UBERON:0002106	67.59	gold quality
corpus epididymis	UBERON:0004359	66.29	gold quality
body of stomach	UBERON:0001161	66.27	gold quality
lung	UBERON:0002048	64.25	gold quality
stomach	UBERON:0000945	63.97	gold quality
adult mammalian kidney	UBERON:0000082	63.70	gold quality
left adrenal gland	UBERON:0001234	63.49	gold quality
liver	UBERON:0002107	63.42	gold quality
left adrenal gland cortex	UBERON:0035825	63.27	gold quality
right adrenal gland	UBERON:0001233	63.05	gold quality
body of pancreas	UBERON:0001150	62.98	gold quality
caput epididymis	UBERON:0004358	62.30	gold quality
left uterine tube	UBERON:0001303	61.80	gold quality
prostate gland	UBERON:0002367	61.62	gold quality
adrenal gland	UBERON:0002369	61.54	gold quality
pancreas	UBERON:0001264	61.38	gold quality
adrenal cortex	UBERON:0001235	61.27	gold quality
right adrenal gland cortex	UBERON:0035827	61.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	61.16	gold quality
body of uterus	UBERON:0009853	61.07	gold quality
vermiform appendix	UBERON:0001154	60.66	gold quality
mucosa of transverse colon	UBERON:0004991	60.62	gold quality
omental fat pad	UBERON:0010414	60.45	gold quality
left ovary	UBERON:0002119	60.43	gold quality
peritoneum	UBERON:0002358	60.39	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	59.63	gold quality
adipose tissue of abdominal region	UBERON:0007808	59.62	gold quality
spinal cord	UBERON:0002240	59.12	gold quality
islet of Langerhans	UBERON:0000006	58.53	gold quality
placenta	UBERON:0001987	58.43	gold quality
ovary	UBERON:0000992	57.84	gold quality
endocervix	UBERON:0000458	57.76	gold quality
right atrium auricular region	UBERON:0006631	57.68	gold quality
fundus of stomach	UBERON:0001160	57.64	gold quality
prefrontal cortex	UBERON:0000451	57.49	gold quality
smooth muscle tissue	UBERON:0001135	57.38	gold quality
cardiac atrium	UBERON:0002081	57.22	gold quality
right ovary	UBERON:0002118	57.14	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.02	gold quality
heart left ventricle	UBERON:0002084	56.94	gold quality
adipose tissue	UBERON:0001013	56.92	gold quality
kidney	UBERON:0002113	56.73	gold quality
cardiac ventricle	UBERON:0002082	56.68	gold quality
left coronary artery	UBERON:0001626	56.54	gold quality
heart	UBERON:0000948	56.24	gold quality
caecum	UBERON:0001153	56.18	gold quality
cortex of kidney	UBERON:0001225	56.07	gold quality
fallopian tube	UBERON:0003889	55.85	gold quality
lower lobe of lung	UBERON:0008949	55.74	silver quality
ectocervix	UBERON:0012249	55.72	gold quality
oviduct epithelium	UBERON:0004804	55.71	silver quality
thoracic aorta	UBERON:0001515	55.29	gold quality
ascending aorta	UBERON:0001496	55.11	gold quality
coronary artery	UBERON:0001621	55.09	gold quality
nasal cavity epithelium	UBERON:0005384	54.92	gold quality
parotid gland	UBERON:0001831	54.91	gold quality
descending thoracic aorta	UBERON:0002345	54.87	gold quality
anatomical system	UBERON:0000467	54.83	gold quality
metanephros cortex	UBERON:0010533	54.79	gold quality
multicellular organism	UBERON:0000468	54.75	gold quality
heart right ventricle	UBERON:0002080	54.75	gold quality
material anatomical entity	UBERON:0000465	54.73	gold quality
substantia nigra	UBERON:0002038	54.73	gold quality
myometrium	UBERON:0001296	54.33	gold quality
uterine cervix	UBERON:0000002	54.23	gold quality
bone marrow	UBERON:0002371	54.20	gold quality
seminal vesicle	UBERON:0000998	54.03	silver quality
female reproductive system	UBERON:0000474	53.74	gold quality
aorta	UBERON:0000947	53.61	gold quality
minor salivary gland	UBERON:0001830	53.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	53.53	gold quality
saliva-secreting gland	UBERON:0001044	53.49	gold quality
anterior cingulate cortex	UBERON:0009835	53.44	gold quality
gall bladder	UBERON:0002110	53.17	gold quality
midbrain	UBERON:0001891	53.07	gold quality
hypothalamus	UBERON:0001898	53.00	gold quality
amygdala	UBERON:0001876	52.98	gold quality
apex of heart	UBERON:0002098	52.89	gold quality
pituitary gland	UBERON:0000007	52.83	gold quality
tibial nerve	UBERON:0001323	52.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	52.83	gold quality
Brodmann (1909) area 23	UBERON:0013554	52.76	gold quality
lymph node	UBERON:0000029	52.73	gold quality
putamen	UBERON:0001874	52.72	gold quality
calcaneal tendon	UBERON:0003701	52.71	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA CATIP antisense RNA 1 (lncRNA CATIP-AS1) downregulation contributes to the progression and metastasis of thyroid cancer via epithelial-mesenchymal transition (EMT) pathway. (PMID:35264071)

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
CATIP-AS2	ncRNA	103689911
PNKD	protein-coding	25953
CATIP	protein-coding	375307
MIR6513	ncRNA	102465256
MIR6810	ncRNA	102466197
CTDSP1	protein-coding	58190
TMBIM1	protein-coding	64114
SLC11A1	protein-coding	6556
MIR26B	ncRNA	407017
USP37	protein-coding	57695
VIL1	protein-coding	7429
AAMP	protein-coding	14
GPBAR1	protein-coding	151306

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 10 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

CREB3L4_TARGET_GENES, FOXD2_TARGET_GENES, RBM34_TARGET_GENES, ZNF92_TARGET_GENES, chr2q35, DESCARTES_MAIN_FETAL_IGFBP1_DKK1_POSITIVE_CELLS, HOXA1_TARGET_GENES, LHX2_TARGET_GENES, ADNP_TARGET_GENES, BARX2_TARGET_GENES

Disease & clinical

ncRNA disease associations

Curated non-coding-RNA → disease associations (LncRNADisease, HMDD) — these are RNA-level associations for this gene, not the positional variant data omitted above.

1 ncRNA–disease associations:

Disease	Causal?	Validated by
Thyroid Neoplasms	Yes	In Vivo Experiment, RNA Pull-Down, Western Blot, CCK8, qRT-PCR, RIP, Luciferase Report Assay, Cell Apoptosis Assay, Colony Formation Assay, Bioinformatics Analysis, Transwell Assay

Drugs & pharmacology

ncRNA–drug associations

Curated non-coding-RNA → drug associations (drug response / resistance / target).

1 ncRNA–drug associations:

Drug	Relation	Effect	Condition
Gemcitabine	drug_resistance	sensitive	cell line (SNU-245)