CATIP-AS2

Summary

CATIP-AS2 (CATIP antisense RNA 2, HGNC:41079) is a long non-coding RNA gene on chromosome 2q35.

At a glance

• Gene type: non-coding (lncRNA) — no protein product.
• Sense gene: antisense to CATIP — the sense gene carries 3 GWAS associations, 56 ClinVar variants (the sense gene’s biology, not this transcript’s)
• GTEx eGene: eQTL in 2 tissues, sQTL in 0 (q < 0.05)

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41079
Approved symbol	CATIP-AS2
Name	CATIP antisense RNA 2
Location	2q35
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237281
Ensembl biotype	lncRNA
Entrez	103689911
RNAcentral	URS00007E3352 — lncRNA, 1183 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 3: 1

ENST00000411433, ENST00000833955, ENST00000833956, ENST00000833957, ENST00000833958

RefSeq mRNA: 0

Canonical transcript exons

ENST00000411433 — 4 exons

Exon	Start	End
ENSE00001748604	218327804	218327959
ENSE00001779059	218351160	218351226
ENSE00004251055	218326247	218327147
ENSE00004251070	218357914	218357992

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 80.22.

Highest expression (Bgee): male germ line stem cell (sensu Vertebrata) in testis, bone marrow cell, tonsil, lymph node, placenta.

Genetic regulation across tissues (GTEx eQTL / sQTL)

CATIP-AS2 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 2 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

2 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Thyroid	eqtl	1.8e-08	-0.33	2:218355117:G:A
Pituitary	eqtl	3.3e-06	-0.60	2:218341922:A:G

Top tissues by expression

showing 100 of 108 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.22	silver quality
bone marrow cell	CL:0002092	68.37	silver quality
tonsil	UBERON:0002372	65.69	gold quality
lymph node	UBERON:0000029	64.56	gold quality
placenta	UBERON:0001987	61.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.95	gold quality
adult mammalian kidney	UBERON:0000082	60.91	gold quality
monocyte	CL:0000576	60.85	gold quality
bone marrow	UBERON:0002371	60.70	gold quality
leukocyte	CL:0000738	60.53	gold quality
islet of Langerhans	UBERON:0000006	59.83	gold quality
myometrium	UBERON:0001296	59.81	gold quality
kidney	UBERON:0002113	58.95	gold quality
skeletal muscle tissue	UBERON:0001134	57.65	gold quality
vermiform appendix	UBERON:0001154	55.92	gold quality
blood	UBERON:0000178	55.56	gold quality
cortex of kidney	UBERON:0001225	54.97	gold quality
stromal cell of endometrium	CL:0002255	54.65	silver quality
liver	UBERON:0002107	54.41	gold quality
gall bladder	UBERON:0002110	52.87	gold quality
superior frontal gyrus	UBERON:0002661	52.08	gold quality
thyroid gland	UBERON:0002046	51.67	gold quality
right lobe of liver	UBERON:0001114	51.59	gold quality
left lobe of thyroid gland	UBERON:0001120	51.29	gold quality
muscle of leg	UBERON:0001383	50.82	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	50.76	gold quality
right lobe of thyroid gland	UBERON:0001119	50.66	gold quality
pancreas	UBERON:0001264	50.27	gold quality
metanephros cortex	UBERON:0010533	49.96	gold quality
prefrontal cortex	UBERON:0000451	49.72	gold quality
body of stomach	UBERON:0001161	49.20	gold quality
stomach	UBERON:0000945	49.17	gold quality
gastrocnemius	UBERON:0001388	49.02	gold quality
right ovary	UBERON:0002118	48.48	gold quality
descending thoracic aorta	UBERON:0002345	48.24	gold quality
primary visual cortex	UBERON:0002436	48.08	silver quality
ovary	UBERON:0000992	47.98	gold quality
left ovary	UBERON:0002119	47.85	gold quality
fundus of stomach	UBERON:0001160	47.81	gold quality
urinary bladder	UBERON:0001255	47.48	gold quality
left adrenal gland cortex	UBERON:0035825	47.33	gold quality
heart left ventricle	UBERON:0002084	47.32	gold quality
adrenal gland	UBERON:0002369	47.11	gold quality
left adrenal gland	UBERON:0001234	46.85	gold quality
multicellular organism	UBERON:0000468	46.67	gold quality
right lung	UBERON:0002167	46.45	gold quality
lung	UBERON:0002048	46.18	gold quality
adrenal tissue	UBERON:0018303	46.01	silver quality
body of pancreas	UBERON:0001150	45.54	gold quality
endometrium	UBERON:0001295	45.23	gold quality
pituitary gland	UBERON:0000007	45.02	gold quality
upper lobe of left lung	UBERON:0008952	44.99	gold quality
heart	UBERON:0000948	44.91	gold quality
prostate gland	UBERON:0002367	44.80	gold quality
spleen	UBERON:0002106	44.39	gold quality
body of uterus	UBERON:0009853	44.26	silver quality
cerebellar cortex	UBERON:0002129	44.08	silver quality
fallopian tube	UBERON:0003889	43.97	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	43.85	gold quality
thoracic aorta	UBERON:0001515	43.83	gold quality
thoracic mammary gland	UBERON:0005200	43.67	silver quality
minor salivary gland	UBERON:0001830	43.59	gold quality
colon	UBERON:0001155	43.54	gold quality
temporal lobe	UBERON:0001871	43.52	gold quality
cerebellar hemisphere	UBERON:0002245	43.51	silver quality
ascending aorta	UBERON:0001496	43.44	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	43.40	gold quality
intestine	UBERON:0000160	43.18	gold quality
rectum	UBERON:0001052	43.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	43.14	gold quality
tibial artery	UBERON:0007610	43.13	silver quality
right adrenal gland	UBERON:0001233	43.08	gold quality
brain	UBERON:0000955	43.05	gold quality
caudate nucleus	UBERON:0001873	42.91	silver quality
adenohypophysis	UBERON:0002196	42.90	gold quality
omental fat pad	UBERON:0010414	42.71	gold quality
amygdala	UBERON:0001876	42.63	gold quality
adipose tissue	UBERON:0001013	42.62	gold quality
right atrium auricular region	UBERON:0006631	42.51	gold quality
nucleus accumbens	UBERON:0001882	42.41	gold quality
putamen	UBERON:0001874	42.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	42.06	silver quality
transverse colon	UBERON:0001157	41.94	silver quality
small intestine	UBERON:0002108	41.94	gold quality
Ammon’s horn	UBERON:0001954	41.91	silver quality
muscle layer of sigmoid colon	UBERON:0035805	41.73	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	41.70	silver quality
substantia nigra	UBERON:0002038	41.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	41.43	silver quality
small intestine Peyer’s patch	UBERON:0003454	41.41	silver quality
lower esophagus	UBERON:0013473	41.35	silver quality
skin of abdomen	UBERON:0001416	41.29	silver quality
tibial nerve	UBERON:0001323	41.10	silver quality
hypothalamus	UBERON:0001898	40.88	silver quality
esophagus mucosa	UBERON:0002469	40.85	silver quality
skin of leg	UBERON:0001511	40.84	silver quality
right hemisphere of cerebellum	UBERON:0014890	40.35	silver quality
anterior cingulate cortex	UBERON:0009835	40.34	silver quality
mucosa of transverse colon	UBERON:0004991	39.63	silver quality
left uterine tube	UBERON:0001303	39.46	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.59

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
MIR6810	ncRNA	102466197
PNKD	protein-coding	25953
CATIP	protein-coding	375307
MIR26B	ncRNA	407017
CTDSP1	protein-coding	58190
SLC11A1	protein-coding	6556
AAMP	protein-coding	14
GPBAR1	protein-coding	151306
TMBIM1	protein-coding	64114
CATIP-AS1	ncRNA	101928513
MIR6513	ncRNA	102465256
USP37	protein-coding	57695
VIL1	protein-coding	7429

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 2 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

chr2q35, DESCARTES_MAIN_FETAL_PARIETAL_AND_CHIEF_CELLS

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

showing 16 of 19 interaction partners:

Partner	Partner type	Level	Source
IFT74	mRNA	RNA-RNA	RISE database
USF2	protein	RNA-Protein	High-throughput data
ZC3HAV1	protein	RNA-Protein	High-throughput data
ZMAT3	protein	RNA-Protein	High-throughput data
SP1	protein	RNA-Protein	High-throughput data
DDX6	protein	RNA-Protein	High-throughput data
PCBP1	protein	RNA-Protein	High-throughput data
EWSR1	protein	RNA-Protein	High-throughput data
IGF2BP3	protein	RNA-Protein	High-throughput data
RBMX	protein	RNA-Protein	High-throughput data
SOX2	protein	RNA-Protein	High-throughput data
YBX1	protein	RNA-Protein	High-throughput data
GEMIN5	protein	RNA-Protein	High-throughput data
IGF2BP1	protein	RNA-Protein	High-throughput data
AGO2	protein	RNA-Protein	High-throughput data
DHX36	protein	RNA-Protein	High-throughput data

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.