CC2D1B

Summary

CC2D1B (coiled-coil and C2 domain containing 1B, HGNC:29386) is a protein-coding gene on chromosome 1p32.3, encoding Coiled-coil and C2 domain-containing protein 1B (Q5T0F9). Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm.

Source: NCBI Gene 200014 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 209 total
• MANE Select transcript: NM_001330585

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29386
Approved symbol	CC2D1B
Name	coiled-coil and C2 domain containing 1B
Location	1p32.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1836, Freud-2, Lgd1
Ensembl gene	ENSG00000154222
Ensembl biotype	protein_coding
Entrez	200014

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 17 protein_coding, 4 retained_intron, 3 protein_coding_CDS_not_defined

ENST00000284376, ENST00000371586, ENST00000438021, ENST00000450942, ENST00000460261, ENST00000460370, ENST00000470844, ENST00000485966, ENST00000491136, ENST00000492426, ENST00000494789, ENST00000886668, ENST00000886669, ENST00000886670, ENST00000886671, ENST00000886672, ENST00000886673, ENST00000917745, ENST00000917746, ENST00000917747, ENST00000941872, ENST00000941873, ENST00000941874, ENST00000941875

RefSeq mRNA: 2 — MANE Select: NM_001330585 NM_001330585, NM_032449

CCDS: CCDS30714, CCDS81323

Canonical transcript exons

ENST00000284376 — 25 exons

Exon	Start	End
ENSE00001455561	52366069	52366205
ENSE00003485570	52359027	52359157
ENSE00003487208	52360074	52360233
ENSE00003497330	52355398	52355449
ENSE00003499544	52358331	52358461
ENSE00003532226	52360974	52361132
ENSE00003534620	52355608	52355666
ENSE00003544003	52357781	52357898
ENSE00003550865	52358686	52358758
ENSE00003566489	52360424	52360549
ENSE00003591018	52355771	52355844
ENSE00003598142	52354840	52354939
ENSE00003598527	52356186	52356302
ENSE00003601162	52357001	52357126
ENSE00003608846	52356384	52356442
ENSE00003613067	52359250	52359357
ENSE00003640241	52361513	52361616
ENSE00003642739	52359705	52359883
ENSE00003650152	52357526	52357698
ENSE00003655178	52359459	52359534
ENSE00003663204	52354608	52354698
ENSE00003667083	52364552	52364634
ENSE00003669199	52362602	52362746
ENSE00003675746	52353518	52353647
ENSE00003906340	52350597	52353223

Expression profiles

Bgee: expression breadth ubiquitous, 226 present calls, max score 95.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.4628 / max 133.8733, expressed in 1811 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12357	12.4628	1811

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	95.80	gold quality
right lobe of thyroid gland	UBERON:0001119	95.22	gold quality
metanephros cortex	UBERON:0010533	94.91	gold quality
nerve	UBERON:0001021	94.88	gold quality
tibial nerve	UBERON:0001323	94.88	gold quality
left lobe of thyroid gland	UBERON:0001120	94.80	gold quality
lower esophagus mucosa	UBERON:0035834	94.36	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.11	gold quality
pituitary gland	UBERON:0000007	94.07	gold quality
upper lobe of left lung	UBERON:0008952	93.40	gold quality
thyroid gland	UBERON:0002046	93.29	gold quality
granulocyte	CL:0000094	93.05	gold quality
right ovary	UBERON:0002118	92.67	gold quality
left testis	UBERON:0004533	92.54	gold quality
left ovary	UBERON:0002119	92.41	gold quality
right testis	UBERON:0004534	92.38	gold quality
upper lobe of lung	UBERON:0008948	92.37	gold quality
spinal cord	UBERON:0002240	91.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.90	gold quality
minor salivary gland	UBERON:0001830	91.72	gold quality
mucosa of transverse colon	UBERON:0004991	91.68	gold quality
adrenal tissue	UBERON:0018303	91.68	gold quality
body of uterus	UBERON:0009853	91.54	gold quality
right uterine tube	UBERON:0001302	91.32	gold quality
right adrenal gland cortex	UBERON:0035827	91.19	gold quality
body of pancreas	UBERON:0001150	90.95	gold quality
spleen	UBERON:0002106	90.83	gold quality
cerebellar hemisphere	UBERON:0002245	90.83	gold quality
right lung	UBERON:0002167	90.80	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.75	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.04
E-MTAB-6058	no	99.05

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
HTR1A	Repression

miRNA regulators (miRDB)

133 targeting CC2D1B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780

Literature-anchored findings (GeneRIF, showing 5)

• Paper describes a function of Cc2d1b/Cc2d1a and their Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking. (PMID:17084358)
• Human Freud-2/CC2D1B binds to the 5-HT1A dual repressor element and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons. (PMID:19423080)
• CC2D1B regulates degradation and signaling of EGFR and TLR4. (PMID:27769858)
• CC2D1B is essential for ESCRT-III activity during mitotic reformation of the nuclear envelope. (PMID:30513301)
• Unravelling of Hidden Secrets: The Tumour Suppressor Lethal (2) Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer. (PMID:33034024)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	cc2d1b	ENSDARG00000099445
mus_musculus	Cc2d1b	ENSMUSG00000028582
rattus_norvegicus	Cc2d1b	ENSRNOG00000008634
drosophila_melanogaster	l(2)gd1	FBGN0261983
caenorhabditis_elegans	ccct-1	WBGENE00012578

Paralogs (1): CC2D1A (ENSG00000132024)

Protein

Protein identifiers

Coiled-coil and C2 domain-containing protein 1B — Q5T0F9 (reviewed: Q5T0F9)

Alternative names: Five prime repressor element under dual repression-binding protein 2

All UniProt accessions (3): Q5T0F9, H0Y517, H7C1U3

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.

Subunit / interactions. Interacts with CHMP4B.

Subcellular location. Nucleus.

Tissue specificity. Widely distributed in brain and peripheral tissues.

Similarity. Belongs to the CC2D1 family.

Isoforms (5)

UniProt ID	Names	Canonical?
Q5T0F9-1	1	yes
Q5T0F9-2	2
Q5T0F9-3	3
Q5T0F9-4	4
Q5T0F9-5	5

RefSeq proteins (2): NP_001317514, NP_115825 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000008	C2_dom	Domain
IPR006608	CC2D1A/B_DM14	Domain
IPR035892	C2_domain_sf	Homologous_superfamily
IPR037772	C2_Freud	Domain
IPR039725	CC2D1A/B	Family

Pfam: PF00168, PF21528

UniProt features (24 total): splice variant 7, region of interest 5, compositionally biased region 4, modified residue 3, coiled-coil region 2, chain 1, domain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T0F9-F1	71.98	0.32

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 209, 593, 596

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-9668328	Sealing of the nuclear envelope (NE) by ESCRT-III
R-HSA-1640170	Cell Cycle
R-HSA-2555396	Mitotic Metaphase and Anaphase
R-HSA-2995410	Nuclear Envelope (NE) Reassembly
R-HSA-68882	Mitotic Anaphase
R-HSA-68886	M Phase
R-HSA-69278	Cell Cycle, Mitotic

MSigDB gene sets: 109 (showing top): TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GTGCCTT_MIR506, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOCC_NUCLEAR_ENVELOPE, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOCC_ORGANELLE_ENVELOPE, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE, REACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY, REACTOME_M_PHASE, STK33_NOMO_UP, STK33_UP, GSE13522_WT_VS_IFNG_KO_SKING_T_CRUZI_Y_STRAIN_INF_DN

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of transcription by RNA polymerase II (GO:0000122)

GO Molecular Function (4): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), nuclear envelope (GO:0005635), nucleoplasm (GO:0005654), cytosol (GO:0005829), endosome membrane (GO:0010008)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Nuclear Envelope (NE) Reassembly	1
M Phase	1
Mitotic Anaphase	1
Mitotic Metaphase and Anaphase	1
Cell Cycle, Mitotic	1
Cell Cycle	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
cellular anatomical structure	2
regulation of DNA-templated transcription	1
negative regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
binding	1
intracellular membrane-bounded organelle	1
nucleus	1
endomembrane system	1
organelle envelope	1
nuclear lumen	1
cytoplasm	1
endosome	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1

Protein interactions and networks

STRING

1247 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CC2D1B	CHMP4C	Q96CF2	580
CC2D1B	CHMP4A	Q9BY43	571
CC2D1B	GPATCH3	Q96I76	570
CC2D1B	CHMP7	Q8WUX9	475
CC2D1B	PRPF38A	Q8NAV1	472
CC2D1B	AMMECR1L	Q6DCA0	447
CC2D1B	IST1	P53990	443
CC2D1B	CHMP6	Q96FZ7	440
CC2D1B	PURB	Q96QR8	414
CC2D1B	PHGDH	O43175	410
CC2D1B	SPINK8	P0C7L1	406
CC2D1B	FCF1	Q9Y324	399
CC2D1B	ZC3H14	Q6PJT7	398
CC2D1B	BCL7C	Q8WUZ0	398
CC2D1B	ZKSCAN5	Q9Y2L8	396

IntAct

22 interactions, top by confidence:

A	B	Type	Score
SHKBP1	CUL3	psi-mi:“MI:0914”(association)	0.850
CASP7	XIAP	psi-mi:“MI:0914”(association)	0.840
RFX3	RFX1	psi-mi:“MI:0914”(association)	0.730
TRIM27	KPNA1	psi-mi:“MI:0914”(association)	0.640
MDFI	CC2D1B	psi-mi:“MI:0915”(physical association)	0.560
CC2D1B	MDFI	psi-mi:“MI:0915”(physical association)	0.560
BMX	ARIH2	psi-mi:“MI:0914”(association)	0.530
CC2D1B	H2BC9	psi-mi:“MI:0915”(physical association)	0.400
CC2D1B	H2BC21	psi-mi:“MI:0915”(physical association)	0.400
CC2D1B	H2BC5	psi-mi:“MI:0915”(physical association)	0.400
CC2D1B	H2BC14	psi-mi:“MI:0915”(physical association)	0.400
CC2D1B	CKM	psi-mi:“MI:0915”(physical association)	0.400
CHMP4B	CC2D1B	psi-mi:“MI:0914”(association)	0.350
SKAP1	MYO9A	psi-mi:“MI:0914”(association)	0.350
KCNE3	PIK3R2	psi-mi:“MI:0914”(association)	0.350
CC2D1B	PCDH7	psi-mi:“MI:0914”(association)	0.350
BLOC1S5	SRGAP2	psi-mi:“MI:0914”(association)	0.350
CD55	CCNB1	psi-mi:“MI:0914”(association)	0.350
DDX28	UBA6	psi-mi:“MI:0914”(association)	0.350
ZNF843	PMPCA	psi-mi:“MI:0914”(association)	0.350

BioGRID (48): CC2D1B (Two-hybrid), DCTN1 (Co-fractionation), CC2D1B (Affinity Capture-MS), CC2D1B (Affinity Capture-MS), CC2D1B (Affinity Capture-MS), CC2D1B (Affinity Capture-MS), CC2D1B (Affinity Capture-MS), CC2D1B (Affinity Capture-MS), CC2D1B (Protein-RNA), CC2D1B (Two-hybrid), CC2D1B (Proximity Label-MS), CC2D1B (Proximity Label-MS), HIST1H2BM (Proximity Label-MS), HIST1H2BH (Proximity Label-MS), CC2D1B (Proximity Label-MS)

ESM2 similar proteins: A0A0G2JV04, B0V207, D3Z8X7, D3ZFJ3, D3ZND0, F1LM81, G9CGD6, O00499, O08539, O08839, O12940, O60308, O60784, O75674, O88746, P42567, P55194, Q05DH4, Q0GNC1, Q0IHV1, Q27J81, Q3B7M3, Q3UN70, Q4KLN4, Q505K2, Q5FVK6, Q5T0F9, Q5U3K5, Q66HA5, Q68EF0, Q6P1N0, Q6P5E6, Q6P9Q4, Q6P9Q6, Q80V31, Q80V94, Q8BMI3, Q8BRN9, Q8K1A6, Q8R0H9

Diamond homologs: Q29M42, Q5FVK6, Q5T0F9, Q66HA5, Q6P1N0, Q6PF54, Q8BRN9, Q8K1A6, Q9U2M8, Q9VKJ9

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
CC2D1B	“down-regulates quantity by repression”	HTR1A	“transcriptional regulation”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 30 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Assembly of the ORC complex at the origin of replication	5	36.0×	4e-05
Condensation of Prophase Chromosomes	5	34.0×	4e-05
G2/M DNA damage checkpoint	5	26.1×	9e-05
HCMV Late Events	5	21.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

209 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	167
Likely benign	11
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

4095 predictions. Top by Δscore:

Variant	Effect	Δscore
1:52353646:ACCT:A	acceptor_loss	1.0000
1:52353648:C:A	acceptor_loss	1.0000
1:52353649:T:A	acceptor_loss	1.0000
1:52354629:A:AC	donor_gain	1.0000
1:52354630:C:CC	donor_gain	1.0000
1:52354630:CA:C	donor_gain	1.0000
1:52354630:CACT:C	donor_gain	1.0000
1:52354834:CCTCA:C	donor_loss	1.0000
1:52354835:CTCA:C	donor_loss	1.0000
1:52354836:TCA:T	donor_loss	1.0000
1:52354837:CACCC:C	donor_loss	1.0000
1:52354838:A:AC	donor_gain	1.0000
1:52354838:A:AT	donor_loss	1.0000
1:52354838:AC:A	donor_gain	1.0000
1:52354839:C:CC	donor_gain	1.0000
1:52354839:CC:C	donor_gain	1.0000
1:52354935:AAATT:A	acceptor_gain	1.0000
1:52354936:AATT:A	acceptor_gain	1.0000
1:52354937:ATT:A	acceptor_gain	1.0000
1:52354938:TT:T	acceptor_gain	1.0000
1:52354940:C:CC	acceptor_gain	1.0000
1:52354940:CT:C	acceptor_loss	1.0000
1:52354941:T:A	acceptor_loss	1.0000
1:52354944:C:CT	acceptor_gain	1.0000
1:52354945:A:T	acceptor_gain	1.0000
1:52355853:A:T	acceptor_gain	1.0000
1:52356190:CAGT:C	donor_gain	1.0000
1:52356298:CAAAT:C	acceptor_gain	1.0000
1:52356299:AAAT:A	acceptor_gain	1.0000
1:52356300:AAT:A	acceptor_gain	1.0000

AlphaMissense

5495 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:52353613:A:G	L828P	0.998
1:52355809:A:G	L703P	0.998
1:52357029:A:G	L623P	0.997
1:52358755:A:C	Y421D	0.997
1:52353595:A:G	L834P	0.996
1:52355636:A:T	V726E	0.996
1:52355648:A:G	L722P	0.996
1:52353548:A:G	W850R	0.995
1:52353548:A:T	W850R	0.995
1:52354918:A:G	L760P	0.995
1:52355785:A:G	L711P	0.995
1:52359037:C:G	R416P	0.995
1:52359766:G:T	A294D	0.995
1:52360509:C:G	R173P	0.995
1:52354670:C:G	G796R	0.994
1:52358700:A:G	L439S	0.994
1:52358746:C:G	A424P	0.994
1:52358754:T:G	Y421S	0.994
1:52359779:A:C	Y290D	0.994
1:52354669:C:T	G796D	0.993
1:52354690:A:G	F789S	0.993
1:52356258:A:G	L667P	0.993
1:52357017:A:G	L627P	0.993
1:52359038:G:T	R416S	0.993
1:52360498:A:C	Y177D	0.993
1:52353613:A:C	L828R	0.992
1:52355785:A:C	L711R	0.992
1:52355794:C:T	G708E	0.992
1:52355795:C:G	G708R	0.992
1:52355795:C:T	G708R	0.992

dbSNP variants (sampled 300 via entrez): RS1000283233 (1:52358521 C>T), RS1000300011 (1:52364203 C>G), RS1000635840 (1:52365770 G>A,C), RS1000659872 (1:52353750 C>T), RS1000688113 (1:52365532 C>T), RS1000927185 (1:52359622 C>T), RS1001306228 (1:52362992 C>A), RS1001482401 (1:52357642 G>A), RS1001695280 (1:52357402 G>A), RS1001731691 (1:52352333 C>G,T), RS1001784048 (1:52352321 T>TC), RS1001805315 (1:52351838 C>T), RS1001864969 (1:52367428 C>T), RS1001944253 (1:52357392 C>T), RS1002068795 (1:52353470 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
mercuric bromide	increases expression, affects cotreatment	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
tetrahydropalmatine	decreases expression	1
beta-lapachone	increases expression	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	increases expression	1
Sunitinib	increases expression	1
Vehicle Emissions	affects expression, increases abundance	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Cadmium	increases expression, increases abundance	1
Methapyrilene	increases methylation	1
Phthalic Acids	increases expression	1
Quercetin	increases expression	1
Smoke	decreases expression	1
Cadmium Chloride	increases abundance, increases expression	1
Particulate Matter	increases abundance, affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.