CCDC140

Summary

CCDC140 (CCDC140 long non-coding RNA, HGNC:26514) is a long non-coding RNA gene on chromosome 2q36.1.

This gene encodes a protein that appears to be restricted to select higher primate species. This protein contains a C-terminal coiled-coil domain, which is a versatile structural motif consisting of multiple amphipathic alpha-helices that twist around each other to form a supercoil.

Source: NCBI Gene 151278 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26514
Approved symbol	CCDC140
Name	CCDC140 long non-coding RNA
Location	2q36.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ32447
Ensembl gene	ENSG00000163081
Ensembl biotype	lncRNA
Entrez	151278
RNAcentral	URS0000DBA68C — lncRNA, 1699 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000440903, ENST00000647762

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000440903 — 2 exons

Exon	Start	End
ENSE00001677292	222303746	222303953
ENSE00001706838	222302978	222303210

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 65.36.

Top tissues by expression

174 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
superficial temporal artery	UBERON:0001614	65.36	gold quality
epithelium of nasopharynx	UBERON:0001951	64.48	gold quality
mucosa of paranasal sinus	UBERON:0005030	64.42	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.51	gold quality
calcaneal tendon	UBERON:0003701	60.77	gold quality
gingival epithelium	UBERON:0001949	59.99	gold quality
secondary oocyte	CL:0000655	57.81	gold quality
vena cava	UBERON:0004087	57.46	gold quality
tonsil	UBERON:0002372	56.82	gold quality
omental fat pad	UBERON:0010414	56.77	gold quality
saphenous vein	UBERON:0007318	56.43	gold quality
peritoneum	UBERON:0002358	56.31	gold quality
nipple	UBERON:0002030	56.30	gold quality
superior surface of tongue	UBERON:0007371	56.21	gold quality
lower lobe of lung	UBERON:0008949	55.47	silver quality
ventral tegmental area	UBERON:0002691	55.30	gold quality
trigeminal ganglion	UBERON:0001675	55.23	gold quality
superior vestibular nucleus	UBERON:0007227	55.05	gold quality
subthalamic nucleus	UBERON:0001906	54.98	gold quality
pericardium	UBERON:0002407	54.97	gold quality
urethra	UBERON:0000057	54.96	gold quality
upper lobe of lung	UBERON:0008948	54.90	silver quality
layer of synovial tissue	UBERON:0007616	54.87	gold quality
tongue	UBERON:0001723	54.86	gold quality
dorsal plus ventral thalamus	UBERON:0001897	54.86	gold quality
adrenal cortex	UBERON:0001235	54.82	gold quality
uterine cervix	UBERON:0000002	54.80	gold quality
medulla oblongata	UBERON:0001896	54.80	gold quality
trachea	UBERON:0003126	54.75	gold quality
lymph node	UBERON:0000029	54.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.