CCDC144NL-AS1

Summary

CCDC144NL-AS1 (CCDC144NL antisense RNA 1, HGNC:51340) is a long non-coding RNA gene on chromosome 17p11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51340
Approved symbol	CCDC144NL-AS1
Name	CCDC144NL antisense RNA 1
Location	17p11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233098
Ensembl biotype	lncRNA
Entrez	440416
RNAcentral	URS0000E60B33 — lncRNA, 3371 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 70 — 70 lncRNA

ENST00000417232, ENST00000423473, ENST00000433763, ENST00000437829, ENST00000439794, ENST00000443508, ENST00000577537, ENST00000577841, ENST00000577860, ENST00000577968, ENST00000579168, ENST00000580056, ENST00000580278, ENST00000581673, ENST00000581958, ENST00000582324, ENST00000582583, ENST00000583481, ENST00000583962, ENST00000584433, ENST00000662319, ENST00000692309, ENST00000692759, ENST00000717326, ENST00000737554, ENST00000737555, ENST00000737556, ENST00000737557, ENST00000737558, ENST00000737559, ENST00000737560, ENST00000737561, ENST00000737562, ENST00000737563, ENST00000737564, ENST00000737565, ENST00000737566, ENST00000737567, ENST00000737568, ENST00000737569, ENST00000737570, ENST00000737571, ENST00000737572, ENST00000737573, ENST00000737574, ENST00000737575, ENST00000737576, ENST00000737577, ENST00000737578, ENST00000737579, ENST00000737580, ENST00000737581, ENST00000737582, ENST00000737583, ENST00000737584, ENST00000737585, ENST00000737586, ENST00000737587, ENST00000737588, ENST00000737589, ENST00000737590, ENST00000737591, ENST00000737592, ENST00000737593, ENST00000737594, ENST00000737595, ENST00000737596, ENST00000737597, ENST00000737598, ENST00000737599

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417232 — 5 exons

Exon	Start	End
ENSE00001614216	20924359	20924833
ENSE00001780940	20892230	20892432
ENSE00002712753	20887592	20887849
ENSE00004071977	20929431	20930041
ENSE00004072032	20868456	20868685

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 89.49.

FANTOM5 (CAGE): breadth broad, TPM avg 4.3808 / max 429.4280, expressed in 298 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
159885	4.0740	259
159884	0.1798	101
159888	0.0729	18
159887	0.0444	8
159889	0.0097	3

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	89.49	gold quality
right coronary artery	UBERON:0001625	88.43	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.62	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.29	gold quality
left testis	UBERON:0004533	85.99	gold quality
right testis	UBERON:0004534	85.85	gold quality
testis	UBERON:0000473	83.71	gold quality
body of uterus	UBERON:0009853	83.66	gold quality
saphenous vein	UBERON:0007318	82.47	gold quality
myometrium	UBERON:0001296	80.19	gold quality
buccal mucosa cell	CL:0002336	79.17	gold quality
left coronary artery	UBERON:0001626	78.17	gold quality
left uterine tube	UBERON:0001303	78.06	gold quality
coronary artery	UBERON:0001621	77.41	gold quality
colonic epithelium	UBERON:0000397	77.08	gold quality
apex of heart	UBERON:0002098	76.00	gold quality
smooth muscle tissue	UBERON:0001135	75.98	gold quality
tibial artery	UBERON:0007610	75.41	gold quality
popliteal artery	UBERON:0002250	75.39	gold quality
ascending aorta	UBERON:0001496	74.97	gold quality
aorta	UBERON:0000947	74.83	gold quality
thoracic aorta	UBERON:0001515	74.49	gold quality
stromal cell of endometrium	CL:0002255	72.27	gold quality
right atrium auricular region	UBERON:0006631	71.05	gold quality
sural nerve	UBERON:0015488	70.85	gold quality
cardiac atrium	UBERON:0002081	70.25	gold quality
left ovary	UBERON:0002119	70.25	gold quality
gall bladder	UBERON:0002110	69.94	gold quality
calcaneal tendon	UBERON:0003701	69.32	gold quality
right ovary	UBERON:0002118	68.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• CCDC144NL-AS1-knockdown human PSCs reveal naive-like pluripotency features, such as elevated expression of naive pluripotency-associated genes, increased developmental capacity, analogous transcriptional profiles to human naive PSCs, and global reduction of repressive chromatin modification marks. (PMID:31358062)
• Long non-coding RNA CCDC144NL-AS1 sponges miR-143-3p and regulates MAP3K7 by acting as a competing endogenous RNA in gastric cancer. (PMID:32647147)
• LncRNA CCDC144NL-AS1 Serves as a Prognosis Biomarker for Non-small Cell Lung Cancer and Promotes Cellular Function by Targeting miR-490-3p. (PMID:34115289)
• Identification of lncRNA-associated competing endogenous RNA networks for occurrence and prognosis of gastric carcinoma. (PMID:34704289)
• Study on the Regulation of Trophoblast Activity by Abnormally Expressed lncRNA CCDC144NL-AS1 in Patients with Gestational Diabetes Mellitus. (PMID:37295416)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.