CCDC15
gene geneOn this page
Also known as FLJ13215
Summary
CCDC15 (coiled-coil domain containing 15, HGNC:25798) is a protein-coding gene on chromosome 11q24.2, encoding Coiled-coil domain-containing protein 15 (Q0P6D6). Plays an important role in primary cilium assembly, maintenance, and length regulation.
Involved in cilium assembly and positive regulation of centriole elongation. Located in centriole and centrosome.
Source: NCBI Gene 80071 — RefSeq curated summary.
At a glance
- GWAS associations: 2
- Clinical variants (ClinVar): 157 total — 3 pathogenic
- MANE Select transcript:
NM_025004
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:25798 |
| Approved symbol | CCDC15 |
| Name | coiled-coil domain containing 15 |
| Location | 11q24.2 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | FLJ13215 |
| Ensembl gene | ENSG00000149548 |
| Ensembl biotype | protein_coding |
| OMIM | 621146 |
| Entrez | 80071 |
Gene structure
Transcript identifiers
Ensembl transcripts: 10 — 8 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined
ENST00000344762, ENST00000524471, ENST00000529051, ENST00000530061, ENST00000892371, ENST00000921761, ENST00000921762, ENST00000921763, ENST00000921764, ENST00000921765
RefSeq mRNA: 1 — MANE Select: NM_025004
NM_025004
CCDS: CCDS44756
Canonical transcript exons
ENST00000344762 — 16 exons
| Exon | Start | End |
|---|---|---|
| ENSE00000991211 | 124954724 | 124954909 |
| ENSE00000991212 | 124959115 | 124959264 |
| ENSE00000991213 | 124959815 | 124960003 |
| ENSE00000991214 | 124975096 | 124975209 |
| ENSE00000991215 | 124977478 | 124977600 |
| ENSE00000991216 | 124986742 | 124986888 |
| ENSE00000991218 | 124991461 | 124991583 |
| ENSE00001325847 | 125005109 | 125005212 |
| ENSE00001374710 | 124992580 | 124992687 |
| ENSE00001376326 | 124993169 | 124993243 |
| ENSE00001428014 | 124987127 | 124988134 |
| ENSE00001506001 | 125003867 | 125003959 |
| ENSE00002170966 | 125040590 | 125041489 |
| ENSE00003475566 | 125038921 | 125039069 |
| ENSE00003650071 | 125038431 | 125038604 |
| ENSE00003844056 | 124954202 | 124954370 |
Expression profiles
Bgee: expression breadth ubiquitous, 188 present calls, max score 93.24.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.8583 / max 78.0778, expressed in 1401 samples.
FANTOM5 promoters (4 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 117424 | 2.5599 | 937 |
| 117423 | 1.6334 | 916 |
| 117425 | 0.5905 | 339 |
| 117422 | 0.0745 | 17 |
Top tissues by expression
280 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| oocyte | CL:0000023 | 93.24 | gold quality |
| secondary oocyte | CL:0000655 | 92.66 | gold quality |
| sperm | CL:0000019 | 86.59 | gold quality |
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 86.09 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 85.44 | gold quality |
| male germ cell | CL:0000015 | 84.33 | gold quality |
| left testis | UBERON:0004533 | 80.40 | gold quality |
| right testis | UBERON:0004534 | 80.27 | gold quality |
| testis | UBERON:0000473 | 79.58 | gold quality |
| ganglionic eminence | UBERON:0004023 | 74.34 | gold quality |
| buccal mucosa cell | CL:0002336 | 73.60 | gold quality |
| ventricular zone | UBERON:0003053 | 73.45 | gold quality |
| calcaneal tendon | UBERON:0003701 | 72.94 | gold quality |
| minor salivary gland | UBERON:0001830 | 70.03 | gold quality |
| bone marrow | UBERON:0002371 | 69.80 | gold quality |
| skin of abdomen | UBERON:0001416 | 67.80 | gold quality |
| stromal cell of endometrium | CL:0002255 | 67.78 | gold quality |
| saliva-secreting gland | UBERON:0001044 | 67.73 | gold quality |
| skin of leg | UBERON:0001511 | 67.61 | gold quality |
| right uterine tube | UBERON:0001302 | 66.75 | gold quality |
| zone of skin | UBERON:0000014 | 66.72 | gold quality |
| mouth mucosa | UBERON:0003729 | 66.70 | gold quality |
| granulocyte | CL:0000094 | 66.38 | gold quality |
| trabecular bone tissue | UBERON:0002483 | 66.23 | silver quality |
| tibia | UBERON:0000979 | 65.76 | silver quality |
| adrenal tissue | UBERON:0018303 | 65.50 | gold quality |
| bronchial epithelial cell | CL:0002328 | 64.90 | silver quality |
| leukocyte | CL:0000738 | 64.48 | gold quality |
| hair follicle | UBERON:0002073 | 64.41 | gold quality |
| embryo | UBERON:0000922 | 64.17 | gold quality |
Single-cell (SCXA)
Detected in 2 experiment(s), a significant marker in 0.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-MTAB-8060 | no | 70.03 |
| E-ANND-3 | no | 4.86 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
51 targeting CCDC15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-190A-3P | 100.00 | 80.35 | 5520 |
| HSA-LET-7A-3P | 100.00 | 74.03 | 3932 |
| HSA-LET-7B-3P | 100.00 | 74.08 | 3913 |
| HSA-LET-7F-1-3P | 100.00 | 74.02 | 3928 |
| HSA-MIR-98-3P | 100.00 | 74.08 | 3907 |
| HSA-MIR-513B-5P | 99.99 | 69.96 | 2150 |
| HSA-MIR-371B-5P | 99.99 | 75.34 | 4759 |
| HSA-MIR-373-5P | 99.98 | 75.36 | 4753 |
| HSA-MIR-616-5P | 99.98 | 75.58 | 4775 |
| HSA-MIR-5696 | 99.98 | 72.36 | 4487 |
| HSA-MIR-3148 | 99.97 | 75.06 | 6478 |
| HSA-MIR-2110 | 99.96 | 66.68 | 1930 |
| HSA-MIR-205-3P | 99.92 | 69.92 | 3165 |
| HSA-MIR-450B-5P | 99.92 | 71.48 | 3175 |
| HSA-MIR-627-3P | 99.90 | 71.42 | 3316 |
| HSA-MIR-30A-3P | 99.87 | 69.74 | 2928 |
| HSA-MIR-30D-3P | 99.87 | 69.92 | 2917 |
| HSA-MIR-30E-3P | 99.87 | 69.68 | 2942 |
| HSA-MIR-579-3P | 99.86 | 71.66 | 3628 |
| HSA-MIR-664B-3P | 99.84 | 71.65 | 3590 |
| HSA-MIR-944 | 99.82 | 70.85 | 3042 |
| HSA-MIR-6875-3P | 99.82 | 70.26 | 2983 |
| HSA-MIR-4659A-3P | 99.80 | 72.62 | 4248 |
| HSA-MIR-4659B-3P | 99.80 | 72.62 | 4248 |
| HSA-MIR-4524A-3P | 99.72 | 66.85 | 2406 |
| HSA-MIR-10393-5P | 99.65 | 68.01 | 1368 |
| HSA-MIR-5197-5P | 99.64 | 69.08 | 1494 |
| HSA-MIR-3682-3P | 99.58 | 67.63 | 865 |
| HSA-MIR-4762-5P | 99.57 | 68.54 | 1424 |
| HSA-MIR-4328 | 99.57 | 71.06 | 4094 |
Literature-anchored findings (GeneRIF, showing 1)
- CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity. (PMID:37934472)
Cross-species orthologs
3 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | ccdc15 | ENSDARG00000067517 |
| mus_musculus | Ccdc15 | ENSMUSG00000034303 |
| rattus_norvegicus | Slc37a2 | ENSRNOG00000039390 |
Protein
Protein identifiers
Coiled-coil domain-containing protein 15 — Q0P6D6 (reviewed: Q0P6D6)
All UniProt accessions (2): Q0P6D6, E9PKB1
UniProt curated annotations — full annotation on UniProt →
Function. Plays an important role in primary cilium assembly, maintenance, and length regulation. Interacts with centriole inner scaffold proteins to promote proper centriole size and integrity and assembly of functional cilia. Required for the recruitment of both the inner scaffold protein POC1B and the distal SFI1/CETN2 complex to centrioles.
Subunit / interactions. Interacts with POC5, POC1B, CETN2 and FAM161A.
Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole. Centriolar satellite.
RefSeq proteins (1): NP_079280* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR037693 | CCDC15 | Family |
UniProt features (10 total): coiled-coil region 4, sequence variant 3, sequence conflict 2, chain 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q0P6D6-F1 | 50.02 | 0.09 |
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 91 (showing top):
GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, MULLIGHAN_NPM1_SIGNATURE_3_UP, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_REGULATION_OF_CENTRIOLE_REPLICATION, GOBP_CENTRIOLE_ASSEMBLY, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, CATTTCA_MIR203, WANG_LMO4_TARGETS_DN, GOBP_CILIUM_ORGANIZATION, GOBP_REGULATION_OF_CELL_CYCLE
GO Biological Process (3): cilium assembly (GO:0060271), positive regulation of centriole elongation (GO:1903724), cell projection organization (GO:0030030)
GO Molecular Function (0):
GO Cellular Component (5): centrosome (GO:0005813), centriole (GO:0005814), centriolar satellite (GO:0034451), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| microtubule organizing center | 2 |
| intracellular membraneless organelle | 2 |
| cellular anatomical structure | 2 |
| axoneme assembly | 1 |
| intraciliary transport involved in cilium assembly | 1 |
| cilium organization | 1 |
| protein localization to cilium | 1 |
| organelle assembly | 1 |
| trans-Golgi to periciliary membrane compartment transport | 1 |
| plasma membrane bounded cell projection assembly | 1 |
| ciliary transition zone assembly | 1 |
| positive regulation of centriole replication | 1 |
| centriole elongation | 1 |
| regulation of centriole elongation | 1 |
| cellular component organization | 1 |
| centriole | 1 |
| centrosome | 1 |
| intracellular anatomical structure | 1 |
Protein interactions and networks
STRING
314 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| CCDC15 | A6NDT3 | A6NDT3 | 571 |
| CCDC15 | SH2D4A | Q9H788 | 557 |
| CCDC15 | RELL2 | Q8NC24 | 528 |
| CCDC15 | SCML2 | Q9UQR0 | 495 |
| CCDC15 | CCDC102B | Q68D86 | 486 |
| CCDC15 | CCDC106 | Q9BWC9 | 453 |
| CCDC15 | CCDC154 | A6NI56 | 446 |
| CCDC15 | SPATC1 | Q76KD6 | 446 |
| CCDC15 | DNASE1L2 | Q92874 | 436 |
| CCDC15 | IFI30 | P13284 | 427 |
| CCDC15 | ZNF227 | Q86WZ6 | 418 |
| CCDC15 | SYCE2 | Q6PIF2 | 399 |
| CCDC15 | NEDD4 | P46934 | 392 |
| CCDC15 | SLC24A3 | Q9HC58 | 390 |
| CCDC15 | ZGRF1 | Q86YA3 | 374 |
IntAct
5 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| TRIM44 | ODAD3 | psi-mi:“MI:0914”(association) | 0.530 |
| MEF2A | REV3L | psi-mi:“MI:0914”(association) | 0.350 |
| TIAM1 | CCDC15 | psi-mi:“MI:0915”(physical association) | 0.000 |
BioGRID (18): CCDC15 (Proximity Label-MS), CCDC15 (Proximity Label-MS), CCDC15 (Affinity Capture-MS), CCDC15 (Affinity Capture-MS), CCDC15 (Affinity Capture-RNA), CCDC15 (Affinity Capture-MS), CCDC15 (Proximity Label-MS), CCDC15 (Proximity Label-MS), CCDC15 (Affinity Capture-MS), CCDC15 (Two-hybrid), CCDC15 (Cross-Linking-MS (XL-MS)), CCDC15 (Cross-Linking-MS (XL-MS)), CCDC15 (Affinity Capture-RNA), CCDC15 (Proximity Label-MS), CCDC15 (Proximity Label-MS)
ESM2 similar proteins: A0A087WUL8, A0A0J9YWL9, A0A0J9YY54, A0A0U1RQI7, A6NJ88, A6QL64, B4DH59, D3ZVV1, E9Q6E9, F1LWT0, O04492, O88799, P0DKJ7, P0DKJ8, P0DKL2, P0DPF3, P18583, P53353, Q08AG5, Q0P6D6, Q2EG98, Q3BBV2, Q4ZJZ1, Q5HY64, Q5JPF3, Q5QGU6, Q5TAG4, Q5TI25, Q5XHX6, Q6P3W6, Q6P902, Q6XPR3, Q6ZQX7, Q86T75, Q86VE3, Q86VQ3, Q8N2N9, Q8N660, Q8N693, Q96EQ9
Diamond homologs: Q0P6D6, Q8C9M2
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
157 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 3 |
| Likely pathogenic | 0 |
| Uncertain significance | 131 |
| Likely benign | 9 |
| Benign | 1 |
Top pathogenic / likely-pathogenic (3)
| Variant ID | HGVS | Classification |
|---|---|---|
| 395037 | GRCh37/hg19 11q24.2(chr11:124254553-125315622)x1 | Pathogenic |
| 563884 | GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 | Pathogenic |
| 625808 | GRCh37/hg19 11q23.3-25(chr11:116700253-134904063) | Pathogenic |
SpliceAI
2484 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 11:124954844:GC:G | donor_gain | 1.0000 |
| 11:124959105:A:AG | acceptor_gain | 1.0000 |
| 11:124959106:T:G | acceptor_gain | 1.0000 |
| 11:124959111:A:AG | acceptor_gain | 1.0000 |
| 11:124959112:A:G | acceptor_gain | 1.0000 |
| 11:124959112:AAG:A | acceptor_loss | 1.0000 |
| 11:124959113:A:G | acceptor_gain | 1.0000 |
| 11:124959114:G:GG | acceptor_gain | 1.0000 |
| 11:124959114:G:GT | acceptor_loss | 1.0000 |
| 11:124959261:AAGA:A | donor_gain | 1.0000 |
| 11:124959262:AGAG:A | donor_loss | 1.0000 |
| 11:124959263:GA:G | donor_gain | 1.0000 |
| 11:124959264:AGT:A | donor_loss | 1.0000 |
| 11:124959265:G:GG | donor_gain | 1.0000 |
| 11:124959266:TAAG:T | donor_loss | 1.0000 |
| 11:124959999:AGGCT:A | donor_gain | 1.0000 |
| 11:124960000:GGCTG:G | donor_gain | 1.0000 |
| 11:124960001:GCT:G | donor_gain | 1.0000 |
| 11:124960002:CT:C | donor_gain | 1.0000 |
| 11:124960004:G:GG | donor_gain | 1.0000 |
| 11:124960005:TAAG:T | donor_loss | 1.0000 |
| 11:124960008:G:GG | donor_gain | 1.0000 |
| 11:124986737:TTTA:T | acceptor_loss | 1.0000 |
| 11:124986739:TAG:T | acceptor_loss | 1.0000 |
| 11:124986740:A:AG | acceptor_gain | 1.0000 |
| 11:124986740:AG:A | acceptor_gain | 1.0000 |
| 11:124986741:G:A | acceptor_gain | 1.0000 |
| 11:124986741:G:GG | acceptor_gain | 1.0000 |
| 11:124986741:GGA:G | acceptor_gain | 1.0000 |
| 11:124986741:GGAA:G | acceptor_gain | 1.0000 |
AlphaMissense
6330 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 11:125039035:T:G | C900W | 0.990 |
| 11:125038938:G:C | R868P | 0.989 |
| 11:125039033:T:C | C900R | 0.989 |
| 11:125039045:T:C | C904R | 0.989 |
| 11:125039047:T:G | C904W | 0.989 |
| 11:125039051:T:C | F906L | 0.989 |
| 11:125039053:C:A | F906L | 0.989 |
| 11:125039053:C:G | F906L | 0.989 |
| 11:125005137:G:C | R779P | 0.988 |
| 11:125038991:T:C | C886R | 0.988 |
| 11:124959206:G:C | R90P | 0.987 |
| 11:125038993:C:G | C886W | 0.987 |
| 11:125039034:G:A | C900Y | 0.986 |
| 11:125038997:T:C | C888R | 0.985 |
| 11:125039033:T:A | C900S | 0.985 |
| 11:125039034:G:C | C900S | 0.985 |
| 11:124959184:T:C | F83L | 0.984 |
| 11:124959186:T:A | F83L | 0.984 |
| 11:124959186:T:G | F83L | 0.984 |
| 11:125038931:G:C | A866P | 0.984 |
| 11:125038998:G:A | C888Y | 0.984 |
| 11:125039009:T:C | F892L | 0.984 |
| 11:125039011:T:A | F892L | 0.984 |
| 11:125039011:T:G | F892L | 0.984 |
| 11:125039012:T:A | W893R | 0.983 |
| 11:125039012:T:C | W893R | 0.983 |
| 11:125039052:T:C | F906S | 0.983 |
| 11:125040605:T:C | L917P | 0.983 |
| 11:125038999:T:G | C888W | 0.982 |
| 11:125040592:T:G | Y913D | 0.982 |
dbSNP variants (sampled 300 via entrez): RS1000034363 (11:124970186 C>G), RS1000038016 (11:125009047 C>T), RS1000047309 (11:125016009 A>G), RS1000109721 (11:125009286 A>G), RS1000123018 (11:124981193 G>A), RS1000127143 (11:124983039 G>T), RS1000159031 (11:125039851 A>G), RS1000219609 (11:124980805 T>A), RS1000236668 (11:125028233 G>A), RS1000322046 (11:125002352 C>T), RS1000425148 (11:124970473 A>G), RS1000514880 (11:124960747 A>G), RS1000566443 (11:124974641 G>T), RS1000567330 (11:125027999 C>T), RS1000575980 (11:125019214 C>T)
Disease associations
OMIM: gene MIM:621146 | disease phenotypes:
GenCC curated gene-disease
Mondo (2): breast ductal adenocarcinoma (MONDO:0005590), neurodevelopmental disorder (MONDO:0700092)
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
2 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST002282_21 | Parasitemia in Tripanosoma cruzi seropositivity | 1.000000e-07 |
| GCST002861_2 | Breast cancer (survival) | 1.000000e-09 |
EFO canonical traits (2, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0005528 | parasitemia measurement |
| EFO:0000714 | survival time |
MeSH disease descriptors (2)
| Descriptor | Name | Tree numbers |
|---|---|---|
| D018270 | Carcinoma, Ductal, Breast | C04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390 |
| D065886 | Neurodevelopmental Disorders | F03.625 |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
35 total (human), top 30 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Valproic Acid | affects expression, decreases expression, increases expression | 4 |
| Cyclosporine | decreases expression | 3 |
| Tetrachlorodibenzodioxin | decreases expression | 2 |
| methylmercuric chloride | decreases expression | 1 |
| triphenyl phosphate | affects expression | 1 |
| propionaldehyde | decreases expression | 1 |
| bisphenol A | decreases expression | 1 |
| trichostatin A | increases expression | 1 |
| potassium chromate(VI) | decreases expression | 1 |
| beta-methylcholine | affects expression | 1 |
| CGP 52608 | affects binding, increases reaction | 1 |
| abrine | decreases expression | 1 |
| incobotulinumtoxinA | decreases expression | 1 |
| 2,3,5-trichloro-6-phenyl-(1,4)benzoquinone | increases expression | 1 |
| Resveratrol | affects cotreatment, increases expression | 1 |
| Vorinostat | increases expression | 1 |
| Leflunomide | decreases expression | 1 |
| Azathioprine | decreases expression | 1 |
| Benzo(a)pyrene | increases expression | 1 |
| Calcitriol | decreases expression, affects cotreatment | 1 |
| Cisplatin | increases expression | 1 |
| Cytarabine | increases expression | 1 |
| Ethyl Methanesulfonate | increases expression | 1 |
| Formaldehyde | increases expression | 1 |
| Methyl Methanesulfonate | increases expression | 1 |
| Plant Extracts | affects cotreatment, increases expression | 1 |
| Quercetin | decreases expression | 1 |
| Dihydrotestosterone | increases expression | 1 |
| Testosterone | affects cotreatment, decreases expression | 1 |
| Tobacco Smoke Pollution | decreases expression | 1 |
Clinical trials (associated diseases)
213 trials via MONDO — disease-level, not drug-specific.
| Trial | Phase | Status | Title |
|---|---|---|---|
| NCT04586348 | PHASE4 | UNKNOWN | Prenatal Iodine Supplementation and Early Childhood Neurodevelopment |
| NCT04873115 | PHASE4 | UNKNOWN | Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties, |
| NCT03414970 | PHASE3 | ACTIVE_NOT_RECRUITING | Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer |
| NCT02559102 | PHASE3 | COMPLETED | Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants |
| NCT02757079 | PHASE3 | COMPLETED | Study of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders |
| NCT06915480 | PHASE3 | RECRUITING | Reducing Missed Appointments |
| NCT07377032 | PHASE3 | RECRUITING | TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders |
| NCT00461344 | PHASE2 | TERMINATED | Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer |
| NCT07499999 | PHASE2 | NOT_YET_RECRUITING | Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer |
| NCT02909959 | PHASE2 | COMPLETED | Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder |
| NCT06081348 | PHASE2 | RECRUITING | Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders |
| NCT06352372 | PHASE2 | COMPLETED | Safety and Efficacy of tPBM for Epileptiform Activity in Autism |
| NCT00503191 | PHASE1 | COMPLETED | NeuroModulation Technique Treatment of Autism |
| NCT04475848 | PHASE1 | COMPLETED | A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants |
| NCT06300398 | PHASE1 | COMPLETED | IAMA-6 Oral Dose Study in Healthy Adults |
| NCT00637364 | PHASE1/PHASE2 | SUSPENDED | High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain |
| NCT02779855 | PHASE1/PHASE2 | COMPLETED | Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer |
| NCT01753908 | EARLY_PHASE1 | COMPLETED | Broccoli Sprout Extract in Treating Patients With Breast Cancer |
| NCT01796041 | EARLY_PHASE1 | COMPLETED | Intraoperative Imaging of Breast Cancer With Indocyanine Green |
| NCT01208974 | Not specified | ACTIVE_NOT_RECRUITING | Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction |
| NCT01875198 | Not specified | TERMINATED | Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer |
| NCT03543397 | Not specified | UNKNOWN | MRI in Ductal Carcinoma in Situ (DCIS) |
| NCT03834532 | Not specified | COMPLETED | Living Well After Breast Surgery |
| NCT01783041 | PHASE2/PHASE3 | COMPLETED | Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants |
| NCT05767385 | PHASE2/PHASE3 | RECRUITING | Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior |
| NCT05675098 | EARLY_PHASE1 | NOT_YET_RECRUITING | Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy |
| NCT00783783 | Not specified | COMPLETED | CYP2D6 Pharmacogenetics in Risperidone-Treated Children |
| NCT01778504 | Not specified | RECRUITING | Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders |
| NCT01850784 | Not specified | UNKNOWN | High Energy Formula Feeding in Infants With Congenital Heart Disease |
| NCT01922791 | Not specified | COMPLETED | Nutrition and Pregnancy Intervention Study |
| NCT01942525 | Not specified | UNKNOWN | Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants |
| NCT02003170 | Not specified | COMPLETED | Etiology and Early Diagnosis of Neurodevelopmental Disorders |
| NCT02118649 | Not specified | ACTIVE_NOT_RECRUITING | Enhancing Behavior and Brain Response to Visual Targets Using a Computer Game |
| NCT02557191 | Not specified | TERMINATED | Biomarkers, Neurodevelopment and Preterm Infants |
| NCT02690675 | Not specified | COMPLETED | Iron Supplement Effect on Child Development |
| NCT02694003 | Not specified | COMPLETED | Better Nights, Better Days for Children With Neurodevelopment Disorders |
| NCT02792894 | Not specified | COMPLETED | Family Networks (FaNs) for Children With Developmental Disorders and Delays |
| NCT02871674 | Not specified | UNKNOWN | Good Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial |
| NCT02887157 | Not specified | COMPLETED | Analyzing Retinal Microanatomy in ROP |
| NCT02898298 | Not specified | COMPLETED | Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder |
Related Atlas pages
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): estrogen-receptor negative breast cancer