CCDC15

gene
On this page

Also known as FLJ13215

Summary

CCDC15 (coiled-coil domain containing 15, HGNC:25798) is a protein-coding gene on chromosome 11q24.2, encoding Coiled-coil domain-containing protein 15 (Q0P6D6). Plays an important role in primary cilium assembly, maintenance, and length regulation.

Involved in cilium assembly and positive regulation of centriole elongation. Located in centriole and centrosome.

Source: NCBI Gene 80071 — RefSeq curated summary.

At a glance

  • GWAS associations: 2
  • Clinical variants (ClinVar): 157 total — 3 pathogenic
  • MANE Select transcript: NM_025004

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:25798
Approved symbolCCDC15
Namecoiled-coil domain containing 15
Location11q24.2
Locus typegene with protein product
StatusApproved
AliasesFLJ13215
Ensembl geneENSG00000149548
Ensembl biotypeprotein_coding
OMIM621146
Entrez80071

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000344762, ENST00000524471, ENST00000529051, ENST00000530061, ENST00000892371, ENST00000921761, ENST00000921762, ENST00000921763, ENST00000921764, ENST00000921765

RefSeq mRNA: 1 — MANE Select: NM_025004 NM_025004

CCDS: CCDS44756

Canonical transcript exons

ENST00000344762 — 16 exons

ExonStartEnd
ENSE00000991211124954724124954909
ENSE00000991212124959115124959264
ENSE00000991213124959815124960003
ENSE00000991214124975096124975209
ENSE00000991215124977478124977600
ENSE00000991216124986742124986888
ENSE00000991218124991461124991583
ENSE00001325847125005109125005212
ENSE00001374710124992580124992687
ENSE00001376326124993169124993243
ENSE00001428014124987127124988134
ENSE00001506001125003867125003959
ENSE00002170966125040590125041489
ENSE00003475566125038921125039069
ENSE00003650071125038431125038604
ENSE00003844056124954202124954370

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 93.24.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.8583 / max 78.0778, expressed in 1401 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter IDTPM avgSamples expressed
1174242.5599937
1174231.6334916
1174250.5905339
1174220.074517

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
oocyteCL:000002393.24gold quality
secondary oocyteCL:000065592.66gold quality
spermCL:000001986.59gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099186.09gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047385.44gold quality
male germ cellCL:000001584.33gold quality
left testisUBERON:000453380.40gold quality
right testisUBERON:000453480.27gold quality
testisUBERON:000047379.58gold quality
ganglionic eminenceUBERON:000402374.34gold quality
buccal mucosa cellCL:000233673.60gold quality
ventricular zoneUBERON:000305373.45gold quality
calcaneal tendonUBERON:000370172.94gold quality
minor salivary glandUBERON:000183070.03gold quality
bone marrowUBERON:000237169.80gold quality
skin of abdomenUBERON:000141667.80gold quality
stromal cell of endometriumCL:000225567.78gold quality
saliva-secreting glandUBERON:000104467.73gold quality
skin of legUBERON:000151167.61gold quality
right uterine tubeUBERON:000130266.75gold quality
zone of skinUBERON:000001466.72gold quality
mouth mucosaUBERON:000372966.70gold quality
granulocyteCL:000009466.38gold quality
trabecular bone tissueUBERON:000248366.23silver quality
tibiaUBERON:000097965.76silver quality
adrenal tissueUBERON:001830365.50gold quality
bronchial epithelial cellCL:000232864.90silver quality
leukocyteCL:000073864.48gold quality
hair follicleUBERON:000207364.41gold quality
embryoUBERON:000092264.17gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-MTAB-8060no70.03
E-ANND-3no4.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

51 targeting CCDC15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-190A-3P100.0080.355520
HSA-LET-7A-3P100.0074.033932
HSA-LET-7B-3P100.0074.083913
HSA-LET-7F-1-3P100.0074.023928
HSA-MIR-98-3P100.0074.083907
HSA-MIR-513B-5P99.9969.962150
HSA-MIR-371B-5P99.9975.344759
HSA-MIR-373-5P99.9875.364753
HSA-MIR-616-5P99.9875.584775
HSA-MIR-569699.9872.364487
HSA-MIR-314899.9775.066478
HSA-MIR-211099.9666.681930
HSA-MIR-205-3P99.9269.923165
HSA-MIR-450B-5P99.9271.483175
HSA-MIR-627-3P99.9071.423316
HSA-MIR-30A-3P99.8769.742928
HSA-MIR-30D-3P99.8769.922917
HSA-MIR-30E-3P99.8769.682942
HSA-MIR-579-3P99.8671.663628
HSA-MIR-664B-3P99.8471.653590
HSA-MIR-94499.8270.853042
HSA-MIR-6875-3P99.8270.262983
HSA-MIR-4659A-3P99.8072.624248
HSA-MIR-4659B-3P99.8072.624248
HSA-MIR-4524A-3P99.7266.852406
HSA-MIR-10393-5P99.6568.011368
HSA-MIR-5197-5P99.6469.081494
HSA-MIR-3682-3P99.5867.63865
HSA-MIR-4762-5P99.5768.541424
HSA-MIR-432899.5771.064094

Literature-anchored findings (GeneRIF, showing 1)

  • CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity. (PMID:37934472)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_rerioccdc15ENSDARG00000067517
mus_musculusCcdc15ENSMUSG00000034303
rattus_norvegicusSlc37a2ENSRNOG00000039390

Protein

Protein identifiers

Coiled-coil domain-containing protein 15Q0P6D6 (reviewed: Q0P6D6)

All UniProt accessions (2): Q0P6D6, E9PKB1

UniProt curated annotations — full annotation on UniProt →

Function. Plays an important role in primary cilium assembly, maintenance, and length regulation. Interacts with centriole inner scaffold proteins to promote proper centriole size and integrity and assembly of functional cilia. Required for the recruitment of both the inner scaffold protein POC1B and the distal SFI1/CETN2 complex to centrioles.

Subunit / interactions. Interacts with POC5, POC1B, CETN2 and FAM161A.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole. Centriolar satellite.

RefSeq proteins (1): NP_079280* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR037693CCDC15Family

UniProt features (10 total): coiled-coil region 4, sequence variant 3, sequence conflict 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q0P6D6-F150.020.09

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 91 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, MULLIGHAN_NPM1_SIGNATURE_3_UP, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_REGULATION_OF_CENTRIOLE_REPLICATION, GOBP_CENTRIOLE_ASSEMBLY, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, CATTTCA_MIR203, WANG_LMO4_TARGETS_DN, GOBP_CILIUM_ORGANIZATION, GOBP_REGULATION_OF_CELL_CYCLE

GO Biological Process (3): cilium assembly (GO:0060271), positive regulation of centriole elongation (GO:1903724), cell projection organization (GO:0030030)

GO Molecular Function (0):

GO Cellular Component (5): centrosome (GO:0005813), centriole (GO:0005814), centriolar satellite (GO:0034451), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
microtubule organizing center2
intracellular membraneless organelle2
cellular anatomical structure2
axoneme assembly1
intraciliary transport involved in cilium assembly1
cilium organization1
protein localization to cilium1
organelle assembly1
trans-Golgi to periciliary membrane compartment transport1
plasma membrane bounded cell projection assembly1
ciliary transition zone assembly1
positive regulation of centriole replication1
centriole elongation1
regulation of centriole elongation1
cellular component organization1
centriole1
centrosome1
intracellular anatomical structure1

Protein interactions and networks

STRING

314 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
CCDC15A6NDT3A6NDT3571
CCDC15SH2D4AQ9H788557
CCDC15RELL2Q8NC24528
CCDC15SCML2Q9UQR0495
CCDC15CCDC102BQ68D86486
CCDC15CCDC106Q9BWC9453
CCDC15CCDC154A6NI56446
CCDC15SPATC1Q76KD6446
CCDC15DNASE1L2Q92874436
CCDC15IFI30P13284427
CCDC15ZNF227Q86WZ6418
CCDC15SYCE2Q6PIF2399
CCDC15NEDD4P46934392
CCDC15SLC24A3Q9HC58390
CCDC15ZGRF1Q86YA3374

IntAct

5 interactions, top by confidence:

ABTypeScore
TRIM44ODAD3psi-mi:“MI:0914”(association)0.530
MEF2AREV3Lpsi-mi:“MI:0914”(association)0.350
TIAM1CCDC15psi-mi:“MI:0915”(physical association)0.000

BioGRID (18): CCDC15 (Proximity Label-MS), CCDC15 (Proximity Label-MS), CCDC15 (Affinity Capture-MS), CCDC15 (Affinity Capture-MS), CCDC15 (Affinity Capture-RNA), CCDC15 (Affinity Capture-MS), CCDC15 (Proximity Label-MS), CCDC15 (Proximity Label-MS), CCDC15 (Affinity Capture-MS), CCDC15 (Two-hybrid), CCDC15 (Cross-Linking-MS (XL-MS)), CCDC15 (Cross-Linking-MS (XL-MS)), CCDC15 (Affinity Capture-RNA), CCDC15 (Proximity Label-MS), CCDC15 (Proximity Label-MS)

ESM2 similar proteins: A0A087WUL8, A0A0J9YWL9, A0A0J9YY54, A0A0U1RQI7, A6NJ88, A6QL64, B4DH59, D3ZVV1, E9Q6E9, F1LWT0, O04492, O88799, P0DKJ7, P0DKJ8, P0DKL2, P0DPF3, P18583, P53353, Q08AG5, Q0P6D6, Q2EG98, Q3BBV2, Q4ZJZ1, Q5HY64, Q5JPF3, Q5QGU6, Q5TAG4, Q5TI25, Q5XHX6, Q6P3W6, Q6P902, Q6XPR3, Q6ZQX7, Q86T75, Q86VE3, Q86VQ3, Q8N2N9, Q8N660, Q8N693, Q96EQ9

Diamond homologs: Q0P6D6, Q8C9M2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

157 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic3
Likely pathogenic0
Uncertain significance131
Likely benign9
Benign1

Top pathogenic / likely-pathogenic (3)

Variant IDHGVSClassification
395037GRCh37/hg19 11q24.2(chr11:124254553-125315622)x1Pathogenic
563884GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3Pathogenic
625808GRCh37/hg19 11q23.3-25(chr11:116700253-134904063)Pathogenic

SpliceAI

2484 predictions. Top by Δscore:

VariantEffectΔscore
11:124954844:GC:Gdonor_gain1.0000
11:124959105:A:AGacceptor_gain1.0000
11:124959106:T:Gacceptor_gain1.0000
11:124959111:A:AGacceptor_gain1.0000
11:124959112:A:Gacceptor_gain1.0000
11:124959112:AAG:Aacceptor_loss1.0000
11:124959113:A:Gacceptor_gain1.0000
11:124959114:G:GGacceptor_gain1.0000
11:124959114:G:GTacceptor_loss1.0000
11:124959261:AAGA:Adonor_gain1.0000
11:124959262:AGAG:Adonor_loss1.0000
11:124959263:GA:Gdonor_gain1.0000
11:124959264:AGT:Adonor_loss1.0000
11:124959265:G:GGdonor_gain1.0000
11:124959266:TAAG:Tdonor_loss1.0000
11:124959999:AGGCT:Adonor_gain1.0000
11:124960000:GGCTG:Gdonor_gain1.0000
11:124960001:GCT:Gdonor_gain1.0000
11:124960002:CT:Cdonor_gain1.0000
11:124960004:G:GGdonor_gain1.0000
11:124960005:TAAG:Tdonor_loss1.0000
11:124960008:G:GGdonor_gain1.0000
11:124986737:TTTA:Tacceptor_loss1.0000
11:124986739:TAG:Tacceptor_loss1.0000
11:124986740:A:AGacceptor_gain1.0000
11:124986740:AG:Aacceptor_gain1.0000
11:124986741:G:Aacceptor_gain1.0000
11:124986741:G:GGacceptor_gain1.0000
11:124986741:GGA:Gacceptor_gain1.0000
11:124986741:GGAA:Gacceptor_gain1.0000

AlphaMissense

6330 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
11:125039035:T:GC900W0.990
11:125038938:G:CR868P0.989
11:125039033:T:CC900R0.989
11:125039045:T:CC904R0.989
11:125039047:T:GC904W0.989
11:125039051:T:CF906L0.989
11:125039053:C:AF906L0.989
11:125039053:C:GF906L0.989
11:125005137:G:CR779P0.988
11:125038991:T:CC886R0.988
11:124959206:G:CR90P0.987
11:125038993:C:GC886W0.987
11:125039034:G:AC900Y0.986
11:125038997:T:CC888R0.985
11:125039033:T:AC900S0.985
11:125039034:G:CC900S0.985
11:124959184:T:CF83L0.984
11:124959186:T:AF83L0.984
11:124959186:T:GF83L0.984
11:125038931:G:CA866P0.984
11:125038998:G:AC888Y0.984
11:125039009:T:CF892L0.984
11:125039011:T:AF892L0.984
11:125039011:T:GF892L0.984
11:125039012:T:AW893R0.983
11:125039012:T:CW893R0.983
11:125039052:T:CF906S0.983
11:125040605:T:CL917P0.983
11:125038999:T:GC888W0.982
11:125040592:T:GY913D0.982

dbSNP variants (sampled 300 via entrez): RS1000034363 (11:124970186 C>G), RS1000038016 (11:125009047 C>T), RS1000047309 (11:125016009 A>G), RS1000109721 (11:125009286 A>G), RS1000123018 (11:124981193 G>A), RS1000127143 (11:124983039 G>T), RS1000159031 (11:125039851 A>G), RS1000219609 (11:124980805 T>A), RS1000236668 (11:125028233 G>A), RS1000322046 (11:125002352 C>T), RS1000425148 (11:124970473 A>G), RS1000514880 (11:124960747 A>G), RS1000566443 (11:124974641 G>T), RS1000567330 (11:125027999 C>T), RS1000575980 (11:125019214 C>T)

Disease associations

OMIM: gene MIM:621146 | disease phenotypes:

GenCC curated gene-disease

Mondo (2): breast ductal adenocarcinoma (MONDO:0005590), neurodevelopmental disorder (MONDO:0700092)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

StudyTraitp-value
GCST002282_21Parasitemia in Tripanosoma cruzi seropositivity1.000000e-07
GCST002861_2Breast cancer (survival)1.000000e-09

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0005528parasitemia measurement
EFO:0000714survival time

MeSH disease descriptors (2)

DescriptorNameTree numbers
D018270Carcinoma, Ductal, BreastC04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390
D065886Neurodevelopmental DisordersF03.625

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects expression, decreases expression, increases expression4
Cyclosporinedecreases expression3
Tetrachlorodibenzodioxindecreases expression2
methylmercuric chloridedecreases expression1
triphenyl phosphateaffects expression1
propionaldehydedecreases expression1
bisphenol Adecreases expression1
trichostatin Aincreases expression1
potassium chromate(VI)decreases expression1
beta-methylcholineaffects expression1
CGP 52608affects binding, increases reaction1
abrinedecreases expression1
incobotulinumtoxinAdecreases expression1
2,3,5-trichloro-6-phenyl-(1,4)benzoquinoneincreases expression1
Resveratrolaffects cotreatment, increases expression1
Vorinostatincreases expression1
Leflunomidedecreases expression1
Azathioprinedecreases expression1
Benzo(a)pyreneincreases expression1
Calcitrioldecreases expression, affects cotreatment1
Cisplatinincreases expression1
Cytarabineincreases expression1
Ethyl Methanesulfonateincreases expression1
Formaldehydeincreases expression1
Methyl Methanesulfonateincreases expression1
Plant Extractsaffects cotreatment, increases expression1
Quercetindecreases expression1
Dihydrotestosteroneincreases expression1
Testosteroneaffects cotreatment, decreases expression1
Tobacco Smoke Pollutiondecreases expression1

Clinical trials (associated diseases)

213 trials via MONDO — disease-level, not drug-specific.

TrialPhaseStatusTitle
NCT04586348PHASE4UNKNOWNPrenatal Iodine Supplementation and Early Childhood Neurodevelopment
NCT04873115PHASE4UNKNOWNDouble-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
NCT03414970PHASE3ACTIVE_NOT_RECRUITINGHypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT02559102PHASE3COMPLETEDDexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
NCT02757079PHASE3COMPLETEDStudy of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders
NCT06915480PHASE3RECRUITINGReducing Missed Appointments
NCT07377032PHASE3RECRUITINGTAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
NCT00461344PHASE2TERMINATEDDocetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
NCT07499999PHASE2NOT_YET_RECRUITINGRandomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
NCT02909959PHASE2COMPLETEDSulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
NCT06081348PHASE2RECRUITINGSertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
NCT06352372PHASE2COMPLETEDSafety and Efficacy of tPBM for Epileptiform Activity in Autism
NCT00503191PHASE1COMPLETEDNeuroModulation Technique Treatment of Autism
NCT04475848PHASE1COMPLETEDA Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants
NCT06300398PHASE1COMPLETEDIAMA-6 Oral Dose Study in Healthy Adults
NCT00637364PHASE1/PHASE2SUSPENDEDHigh Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
NCT02779855PHASE1/PHASE2COMPLETEDTalimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
NCT01753908EARLY_PHASE1COMPLETEDBroccoli Sprout Extract in Treating Patients With Breast Cancer
NCT01796041EARLY_PHASE1COMPLETEDIntraoperative Imaging of Breast Cancer With Indocyanine Green
NCT01208974Not specifiedACTIVE_NOT_RECRUITINGNipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction
NCT01875198Not specifiedTERMINATEDOncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
NCT03543397Not specifiedUNKNOWNMRI in Ductal Carcinoma in Situ (DCIS)
NCT03834532Not specifiedCOMPLETEDLiving Well After Breast Surgery
NCT01783041PHASE2/PHASE3COMPLETEDEffect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
NCT05767385PHASE2/PHASE3RECRUITINGFetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
NCT05675098EARLY_PHASE1NOT_YET_RECRUITINGCentral Nervous System Stimulants and Physical Function in Children With Cerebral Palsy
NCT00783783Not specifiedCOMPLETEDCYP2D6 Pharmacogenetics in Risperidone-Treated Children
NCT01778504Not specifiedRECRUITINGStudying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
NCT01850784Not specifiedUNKNOWNHigh Energy Formula Feeding in Infants With Congenital Heart Disease
NCT01922791Not specifiedCOMPLETEDNutrition and Pregnancy Intervention Study
NCT01942525Not specifiedUNKNOWNInfluence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
NCT02003170Not specifiedCOMPLETEDEtiology and Early Diagnosis of Neurodevelopmental Disorders
NCT02118649Not specifiedACTIVE_NOT_RECRUITINGEnhancing Behavior and Brain Response to Visual Targets Using a Computer Game
NCT02557191Not specifiedTERMINATEDBiomarkers, Neurodevelopment and Preterm Infants
NCT02690675Not specifiedCOMPLETEDIron Supplement Effect on Child Development
NCT02694003Not specifiedCOMPLETEDBetter Nights, Better Days for Children With Neurodevelopment Disorders
NCT02792894Not specifiedCOMPLETEDFamily Networks (FaNs) for Children With Developmental Disorders and Delays
NCT02871674Not specifiedUNKNOWNGood Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial
NCT02887157Not specifiedCOMPLETEDAnalyzing Retinal Microanatomy in ROP
NCT02898298Not specifiedCOMPLETEDPositive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder
  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): estrogen-receptor negative breast cancer