CCDC26

Summary

CCDC26 (CCDC26 long non-coding RNA, HGNC:28416) is a long non-coding RNA gene on chromosome 8q24.21.

Implicated in brain cancer and high grade glioma.

Source: NCBI Gene 137196 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28416
Approved symbol	CCDC26
Name	CCDC26 long non-coding RNA
Location	8q24.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC27434, RAM
Ensembl gene	ENSG00000229140
Ensembl biotype	lncRNA
OMIM	613040
Entrez	137196
RNAcentral	URS00008120D0 — lncRNA, 1718 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 167 — 167 lncRNA

ENST00000446592, ENST00000509893, ENST00000520048, ENST00000522667, ENST00000523151, ENST00000625513, ENST00000628064, ENST00000630386, ENST00000642958, ENST00000643616, ENST00000644194, ENST00000644557, ENST00000645432, ENST00000646849, ENST00000646877, ENST00000647094, ENST00000652914, ENST00000652971, ENST00000653363, ENST00000653401, ENST00000653764, ENST00000654421, ENST00000654987, ENST00000655629, ENST00000656242, ENST00000656316, ENST00000657046, ENST00000657069, ENST00000657251, ENST00000657400, ENST00000657409, ENST00000657647, ENST00000658740, ENST00000658861, ENST00000660109, ENST00000660163, ENST00000660652, ENST00000661447, ENST00000662033, ENST00000662207, ENST00000662317, ENST00000662350, ENST00000662908, ENST00000663066, ENST00000663521, ENST00000663572, ENST00000663716, ENST00000663991, ENST00000664043, ENST00000664162, ENST00000664599, ENST00000664632, ENST00000664936, ENST00000665348, ENST00000665364, ENST00000665685, ENST00000665935, ENST00000666088, ENST00000666317, ENST00000666725, ENST00000666849, ENST00000666882, ENST00000667341, ENST00000667643, ENST00000667962, ENST00000667974, ENST00000668446, ENST00000668777, ENST00000668791, ENST00000669617, ENST00000669935, ENST00000669940, ENST00000670054, ENST00000670148, ENST00000670386, ENST00000670588, ENST00000670803, ENST00000671311, ENST00000671347, ENST00000671439, ENST00000671632, ENST00000674580, ENST00000674599, ENST00000674639, ENST00000674656, ENST00000674711, ENST00000674741, ENST00000674750, ENST00000674762, ENST00000674766, ENST00000674863, ENST00000674877, ENST00000674882, ENST00000674883, ENST00000674893, ENST00000674906, ENST00000674940, ENST00000675044, ENST00000675072, ENST00000675097, ENST00000675109, ENST00000675166, ENST00000675183, ENST00000675186, ENST00000675208, ENST00000675290, ENST00000675316, ENST00000675388, ENST00000675393, ENST00000675432, ENST00000675435, ENST00000675449, ENST00000675496, ENST00000675498, ENST00000675506, ENST00000675522, ENST00000675527, ENST00000675532, ENST00000675589, ENST00000675599, ENST00000675658, ENST00000675669, ENST00000675722, ENST00000675815, ENST00000675867, ENST00000675878, ENST00000675913, ENST00000675948, ENST00000675970, ENST00000676030, ENST00000676060, ENST00000676069, ENST00000676099, ENST00000676108, ENST00000676129, ENST00000676148, ENST00000676238, ENST00000676248, ENST00000676273, ENST00000676294, ENST00000676350, ENST00000676405, ENST00000676407, ENST00000701662, ENST00000729445, ENST00000822084, ENST00000826890, ENST00000826891, ENST00000835909, ENST00000835910, ENST00000835911, ENST00000835912, ENST00000835913, ENST00000835914, ENST00000835915, ENST00000835916, ENST00000836259, ENST00000836260, ENST00000836261, ENST00000847585, ENST00000847586, ENST00000847587, ENST00000847588, ENST00000847589, ENST00000847590, ENST00000847591, ENST00000847592

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000446592 — 4 exons

Exon	Start	End
ENSE00001675438	129351691	129352980
ENSE00002053087	129370307	129370377
ENSE00002061479	129480643	129480690
ENSE00002063024	129679928	129680239

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 90.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.8147 / max 246.6234, expressed in 171 samples.

FANTOM5 promoters (16 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94975	0.7017	69
94970	0.3770	78
94955	0.1897	8
94950	0.1861	58
94966	0.1231	28
94969	0.1116	32
94964	0.0944	25
94968	0.0622	22
94973	0.0592	29
94974	0.0562	26

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.44	gold quality
colonic epithelium	UBERON:0000397	89.73	gold quality
bone marrow cell	CL:0002092	84.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.48	gold quality
sural nerve	UBERON:0015488	76.43	gold quality
spleen	UBERON:0002106	72.64	gold quality
lower esophagus mucosa	UBERON:0035834	71.83	gold quality
monocyte	CL:0000576	70.58	gold quality
leukocyte	CL:0000738	70.09	gold quality
tonsil	UBERON:0002372	64.98	gold quality
adrenal tissue	UBERON:0018303	64.57	gold quality
ventricular zone	UBERON:0003053	64.24	gold quality
stromal cell of endometrium	CL:0002255	63.83	gold quality
cortical plate	UBERON:0005343	63.02	gold quality
esophagus mucosa	UBERON:0002469	62.37	gold quality
ganglionic eminence	UBERON:0004023	61.18	gold quality
calcaneal tendon	UBERON:0003701	60.02	gold quality
bone marrow	UBERON:0002371	59.10	gold quality
granulocyte	CL:0000094	58.87	gold quality
skin of leg	UBERON:0001511	58.78	gold quality
skin of abdomen	UBERON:0001416	57.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.61	gold quality
uterine cervix	UBERON:0000002	57.16	gold quality
zone of skin	UBERON:0000014	56.59	gold quality
esophagus	UBERON:0001043	56.53	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	55.44	gold quality
liver	UBERON:0002107	55.28	gold quality
corpus callosum	UBERON:0002336	54.81	gold quality
lymph node	UBERON:0000029	54.25	gold quality
blood	UBERON:0000178	54.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• RAM (retinoic acid modulator) is RA-regulated and insertions at this locus desensitize multiple cell lines to RA or TRAIL mediated apoptosis (PMID:16449964)
• we identify RAM as a novel RA-dependent modulator of myeloid differentiation and death (PMID:16449964)
• CCDC26 is encoded on double minute chromosomes of HL-60 human acute leukemia cells and suppressed with differentiation of the cells. (PMID:18243251)
• (rs4295627, a genetic variant of CCDC26 was one of 3 genetic variants implicated in a pool of US epidemiologic studies of glioma risk (PMID:21920947)
• Genetic polymorphism of CCDC26 is associated with myeloid malignancies with mutant IDH1 and IDH2 differentially. (PMID:22116548)
• we found three protective alleles for glioma patients, including the allele ‘‘G’’ of rs6470745 in CCDC26 gene by recessive model analysis (PMID:22369735)
• Study found rs891835 in CCDC26 to be associated with glioblastoma susceptibility in a Han Chinese population. (PMID:24870769)
• our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia. (PMID:25245984)
• CCDC26 controls growth of myeloid leukemia cells through regulation of KIT expression. (PMID:25928165)
• CCDC26 controls growth of myeloid leukemia cells through regulation of KIT expression. CCDC26 knockdown in K562 cells results in lowered growth in medium with high concentration of serum and inhibition of apoptosis in serum depleted medium. Activation of KIT expression in KD cells was observed. A tyrosine kinase inhibitor specific to KIT eliminated these effects. (PMID:25928165)
• Single nucleotide polymorphisms in CDKN2BAS are associated with increased susceptibility to pediatric brain tumors. (PMID:26014354)
• Meta-analysis suggests that the rs4295627 SNP is associated with an increased risk of glioma. (PMID:26505354)
• CCDC26 may be identified as a novel oncogene in pancreatic cancer. (PMID:27470572)
• show that the G allele of the CCDC26 rs4295627 polymorphism significantly increases the risk of glioma (PMID:29264887)
• No differences were found between the combined AML patient populations and the healthy controls with respect to the expression levels of PVT1, CCDC26, and CCAT1. Compared with the healthy controls, -M2 and AML-M4/M5 patients had higher CCDC26 expression (p < 0.001 and p = 0.02, respectively). (PMID:30222365)
• Findings suggest a possible participation of rs891835, rs6470745, and rs55705857 as risk factors to develop glioma. Review. (PMID:30778791)
• Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins. (PMID:33340546)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.