CCDC88B

Summary

CCDC88B (coiled-coil and HOOK domain protein 88B, HGNC:26757) is a protein-coding gene on chromosome 11q13.1, encoding Coiled-coil domain-containing protein 88B (A6NC98). Acts as a positive regulator of T-cell maturation and inflammatory function.

This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules.

Source: NCBI Gene 283234 — RefSeq curated summary.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 309 total
• MANE Select transcript: NM_032251

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26757
Approved symbol	CCDC88B
Name	coiled-coil and HOOK domain protein 88B
Location	11q13.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ37970, BRLZ, HkRP3, FLJ00354, GIPIE
Ensembl gene	ENSG00000168071
Ensembl biotype	protein_coding
OMIM	611205
Entrez	283234

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding_CDS_not_defined, 3 protein_coding

ENST00000356786, ENST00000359902, ENST00000463837, ENST00000472524, ENST00000473405, ENST00000479965, ENST00000492980, ENST00000494080, ENST00000494566, ENST00000971518

RefSeq mRNA: 1 — MANE Select: NM_032251 NM_032251

CCDS: CCDS8072

Canonical transcript exons

ENST00000356786 — 27 exons

Exon	Start	End
ENSE00001818105	64357039	64357534
ENSE00003474725	64343778	64343914
ENSE00003478300	64352744	64352887
ENSE00003478396	64355194	64355400
ENSE00003481174	64341599	64341742
ENSE00003483990	64342294	64342375
ENSE00003487269	64349551	64349668
ENSE00003545794	64340907	64341018
ENSE00003555804	64341109	64341178
ENSE00003578450	64341270	64341328
ENSE00003589035	64341994	64342139
ENSE00003593272	64351476	64351616
ENSE00003595943	64355560	64355628
ENSE00003598759	64353715	64353813
ENSE00003614379	64343997	64345157
ENSE00003614910	64342522	64342680
ENSE00003624092	64341421	64341504
ENSE00003630673	64343507	64343615
ENSE00003638117	64343179	64343325
ENSE00003650835	64351160	64351255
ENSE00003653068	64353351	64353496
ENSE00003657138	64352130	64352386
ENSE00003657451	64354004	64354170
ENSE00003657483	64340204	64340326
ENSE00003660362	64349331	64349458
ENSE00003660820	64353054	64353240
ENSE00003688799	64340607	64340752

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 98.54.

FANTOM5 (CAGE): breadth broad, TPM avg 10.5424 / max 2305.5955, expressed in 910 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
114954	8.7809	520
114955	0.9598	261
114964	0.4525	266
114963	0.1774	57
114959	0.0892	32
114958	0.0519	15
114961	0.0204	4
114962	0.0103	4

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	98.54	gold quality
cerebellar hemisphere	UBERON:0002245	97.75	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.66	gold quality
cerebellar cortex	UBERON:0002129	97.58	gold quality
cerebellum	UBERON:0002037	95.94	gold quality
spleen	UBERON:0002106	95.50	gold quality
vermiform appendix	UBERON:0001154	94.33	gold quality
monocyte	CL:0000576	94.04	gold quality
leukocyte	CL:0000738	93.98	gold quality
bone marrow cell	CL:0002092	93.91	gold quality
blood	UBERON:0000178	93.77	gold quality
mucosa of transverse colon	UBERON:0004991	92.85	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.14	gold quality
lymph node	UBERON:0000029	89.25	gold quality
lower esophagus mucosa	UBERON:0035834	87.85	gold quality
transverse colon	UBERON:0001157	87.35	gold quality
upper lobe of left lung	UBERON:0008952	87.10	gold quality
small intestine	UBERON:0002108	87.02	gold quality
tendon of biceps brachii	UBERON:0008188	86.67	silver quality
apex of heart	UBERON:0002098	86.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.97	gold quality
right testis	UBERON:0004534	85.84	gold quality
minor salivary gland	UBERON:0001830	85.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.81	gold quality
right lung	UBERON:0002167	85.71	gold quality
bone marrow	UBERON:0002371	85.58	gold quality
left testis	UBERON:0004533	85.54	gold quality
caecum	UBERON:0001153	85.06	gold quality
gall bladder	UBERON:0002110	85.06	gold quality
right adrenal gland cortex	UBERON:0035827	84.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.06

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting CCDC88B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-361-3P	99.19	66.45	1381
HSA-MIR-6829-5P	98.86	65.12	1480
HSA-MIR-615-5P	98.10	63.76	591
HSA-MIR-6765-3P	97.83	64.59	1165
HSA-MIR-1587	96.95	64.03	932
HSA-MIR-4749-3P	96.40	66.24	798

Literature-anchored findings (GeneRIF, showing 4)

• Data show that a novel Girdin family protein, Gipie, is expressed in endothelial cells, where it interacts with GRP78, a master regulator of the UPR, and that Gipie/GRP78 interaction controls the IRE1-JNK signaling pathway. (PMID:21289099)
• A genotype dataset found a sarcoidosis risk locus on chromosome 11q13.1, a risk region for Crohn disease. An allele-dependent expression of CCDC88B was found in bronchoalveolar lavage samples of German, Swedish and Czech patients with sarcoidosis. (PMID:22837380)
• results demonstrate an important role for HkRP3 in regulating the clustering of lytic granules and MTOC repositioning during the development of NK cell-mediated killing. (PMID:25762780)
• A critical function of CCDC88B in colonic inflammation and inflammatory bowel disease (PMID:29030607)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	ccdc88b	ENSDARG00000076189
mus_musculus	Ccdc88b	ENSMUSG00000047810
rattus_norvegicus	Ccdc88b	ENSRNOG00000024931
drosophila_melanogaster	hook	FBGN0001202
drosophila_melanogaster	Girdin	FBGN0283724
caenorhabditis_elegans		WBGENE00006997
caenorhabditis_elegans		WBGENE00013082

Paralogs (5): CCDC88C (ENSG00000015133), HOOK2 (ENSG00000095066), CCDC88A (ENSG00000115355), HOOK1 (ENSG00000134709), HOOK3 (ENSG00000168172)

Protein

Protein identifiers

Coiled-coil domain-containing protein 88B — A6NC98 (reviewed: A6NC98)

Alternative names: Brain leucine zipper domain-containing protein, Gipie, Hook-related protein 3

All UniProt accessions (2): A6NC98, H7BY33

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation. Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC. Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis.

Subunit / interactions. Homodimer. Interacts with DOCK8. Interacts (via C-terminus) with intact microtubules. Interacts with dynein-dynactin motor complex. Interacts (via C-terminus) with HSPA5.

Subcellular location. Membrane. Cytoplasm. Cytoskeleton. Microtubule organizing center. Endoplasmic reticulum. Golgi apparatus.

Tissue specificity. Expressed in endothelium (at protein level). Expressed in NK cells (at protein level).

Induction. By endoplasmic reticulum stress.

Similarity. Belongs to the CCDC88 family.

Isoforms (6)

UniProt ID	Names	Canonical?
A6NC98-1	1	yes
A6NC98-2	2
A6NC98-3	3
A6NC98-4	4
A6NC98-5	5
A6NC98-6	6

RefSeq proteins (1): NP_115627* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR036872	CH_dom_sf	Homologous_superfamily
IPR043936	HOOK_N	Domain

Pfam: PF19047

UniProt features (33 total): splice variant 12, compositionally biased region 5, region of interest 4, modified residue 4, sequence variant 3, sequence conflict 2, coiled-coil region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NC98-F1	70.19	0.38

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 436, 596, 1348, 1379

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 150 (showing top): GOBP_REGULATION_OF_CELL_ACTIVATION, GOBP_REGULATION_OF_LEUKOCYTE_PROLIFERATION, GOBP_CYTOPLASMIC_MICROTUBULE_ORGANIZATION, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION, chr11q13, GOCC_MICROTUBULE_ORGANIZING_CENTER, COUP_01, GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION, GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION, GOBP_CELL_CELL_ADHESION, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_LEUKOCYTE_PROLIFERATION, GOBP_RESPONSE_TO_PROTOZOAN, GOBP_CYTOKINE_PRODUCTION

GO Biological Process (6): positive regulation of cytokine production (GO:0001819), cytoskeleton-dependent intracellular transport (GO:0030705), cytoplasmic microtubule organization (GO:0031122), positive regulation of T cell proliferation (GO:0042102), defense response to protozoan (GO:0042832), positive regulation of T cell activation (GO:0050870)

GO Molecular Function (3): microtubule binding (GO:0008017), dynein light intermediate chain binding (GO:0051959), protein binding (GO:0005515)

GO Cellular Component (9): nucleoplasm (GO:0005654), cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), centrosome (GO:0005813), cytosol (GO:0005829), membrane (GO:0016020), microtubule organizing center (GO:0005815), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
cytoplasm	3
endomembrane system	2
intracellular membrane-bounded organelle	2
cytokine production	1
regulation of cytokine production	1
positive regulation of gene expression	1
positive regulation of multicellular organismal process	1
intracellular transport	1
microtubule cytoskeleton organization	1
supramolecular fiber organization	1
T cell proliferation	1
regulation of T cell proliferation	1
positive regulation of lymphocyte proliferation	1
positive regulation of T cell activation	1
response to protozoan	1
defense response to other organism	1
T cell activation	1
regulation of T cell activation	1
positive regulation of lymphocyte activation	1
positive regulation of leukocyte cell-cell adhesion	1
tubulin binding	1
protein binding	1
binding	1
nuclear lumen	1
intracellular anatomical structure	1
centriole	1
microtubule organizing center	1
microtubule cytoskeleton	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1691 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CCDC88B	HOOK1	Q9UJC3	762
CCDC88B	GNAI3	P08754	655
CCDC88B	COPB1	P53618	520
CCDC88B	GPR137	Q96N19	496
CCDC88B	MYH1	P12882	493
CCDC88B	HSPA5	P11021	490
CCDC88B	KCNK4	Q9NYG8	485
CCDC88B	PUS7L	Q9H0K6	439
CCDC88B	ITSN1	Q15811	433
CCDC88B	TRMT112	Q9UI30	412
CCDC88B	MEX3C	Q5U5Q3	397
CCDC88B	ASB2	Q96Q27	379
CCDC88B	CCDC122	Q5T0U0	373
CCDC88B	FAM151B	Q6UXP7	364
CCDC88B	ZNF684	Q5T5D7	354

IntAct

121 interactions, top by confidence:

A	B	Type	Score
CCDC88B	ZC2HC1C	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	GEM	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	LNX1	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	RBM7	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	TSG101	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	HCK	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	LMO1	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	TBC1D22B	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	NME7	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	RINT1	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	JAKMIP2	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	EXOSC5	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	FAM161A	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	LMNB2	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	DEF6	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	BEX2	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	TXLNB	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	FAM161B	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	TSGA10IP	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	TSHZ2	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	AIRIM	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	CCHCR1	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	KANK2	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	SH3KBP1	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	SH2D4A	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	LMNB1	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	TRAF3IP3	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	RALBP1	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	PPP1R18	psi-mi:“MI:0915”(physical association)	0.560
CCDC88B	PIN1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (44): CCDC88B (Biochemical Activity), CCDC88B (Affinity Capture-MS), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid), CCDC88B (Two-hybrid)

ESM2 similar proteins: A0A140LIT1, A0A1B0GVG4, A0JNH6, A1A5D9, A6NC98, A6NGB0, A6NJZ7, A6NNM3, F6XLV1, O15049, O54887, P0C7N4, P58660, P60531, Q0D2H9, Q0P5D1, Q2KJ21, Q2TAC2, Q3LUD3, Q3T1I3, Q3TMW1, Q3V0F0, Q4QRL3, Q5JTB6, Q5RD60, Q66HR5, Q6NSJ2, Q6PHN1, Q6QZQ4, Q80VM7, Q8BP01, Q8C7U1, Q8CB62, Q8CGU1, Q8CHW5, Q8K2I2, Q8N137, Q8N283, Q8N6Y0, Q8R370

Diamond homologs: A0A2R8QCI3, A6NC98, B4KE73, F3Y5P4, O61493, P85120, Q3V6T2, Q4QRL3, Q5SNZ0, Q6VGS5, Q7PWT9, Q86VS8, Q8BUK6, Q9P219, B4N1C2, Q7TMK6, B0WPU9, B3MNR6, B3NL60, B4I5P7, B4PAF2, B4Q9E6, Q24185, Q6GQ73

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

309 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	276
Likely benign	9
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

3936 predictions. Top by Δscore:

Variant	Effect	Δscore
11:64341107:A:AG	acceptor_gain	1.0000
11:64341108:G:GG	acceptor_gain	1.0000
11:64341268:A:AG	acceptor_gain	1.0000
11:64341269:G:GT	acceptor_gain	1.0000
11:64341269:GAA:G	acceptor_gain	1.0000
11:64341329:G:GG	donor_gain	1.0000
11:64341329:GTG:G	donor_loss	1.0000
11:64341419:A:AG	acceptor_gain	1.0000
11:64341419:AGT:A	acceptor_gain	1.0000
11:64341419:AGTGT:A	acceptor_gain	1.0000
11:64341420:G:GG	acceptor_gain	1.0000
11:64341420:GT:G	acceptor_gain	1.0000
11:64341420:GTG:G	acceptor_gain	1.0000
11:64341420:GTGT:G	acceptor_gain	1.0000
11:64341420:GTGTG:G	acceptor_gain	1.0000
11:64341502:G:GT	donor_gain	1.0000
11:64341721:G:GT	donor_gain	1.0000
11:64341723:A:T	donor_gain	1.0000
11:64341741:AG:A	donor_loss	1.0000
11:64341742:GG:G	donor_loss	1.0000
11:64341743:GTAG:G	donor_loss	1.0000
11:64341744:T:G	donor_loss	1.0000
11:64341991:CAGC:C	acceptor_loss	1.0000
11:64341992:A:AG	acceptor_gain	1.0000
11:64341992:AGC:A	acceptor_gain	1.0000
11:64341992:AGCG:A	acceptor_gain	1.0000
11:64341993:G:GT	acceptor_gain	1.0000
11:64341993:GC:G	acceptor_gain	1.0000
11:64341993:GCG:G	acceptor_gain	1.0000
11:64341993:GCGG:G	acceptor_gain	1.0000

AlphaMissense

9333 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:64353397:T:C	L1245P	0.995
11:64353364:T:C	L1234P	0.994
11:64353765:T:C	I1295T	0.994
11:64340324:T:A	W20R	0.993
11:64340324:T:C	W20R	0.993
11:64340326:G:C	W20C	0.993
11:64340326:G:T	W20C	0.993
11:64353753:T:C	L1291P	0.993
11:64341497:T:A	I175N	0.992
11:64354028:G:C	K1319N	0.992
11:64354028:G:T	K1319N	0.992
11:64353352:T:C	L1230P	0.990
11:64353765:T:G	I1295S	0.990
11:64341485:T:C	L171P	0.989
11:64341497:T:C	I175T	0.989
11:64352377:T:C	L1116P	0.989
11:64341440:T:C	F156S	0.988
11:64341452:T:C	I160T	0.988
11:64353391:G:C	R1243P	0.988
11:64355319:T:C	F1409L	0.988
11:64355321:C:A	F1409L	0.988
11:64355321:C:G	F1409L	0.988
11:64355349:T:C	F1419L	0.987
11:64355351:C:A	F1419L	0.987
11:64355351:C:G	F1419L	0.987
11:64352339:G:C	K1103N	0.986
11:64352339:G:T	K1103N	0.986
11:64353224:T:C	L1224P	0.986
11:64353439:T:C	L1259P	0.986
11:64341452:T:A	I160N	0.985

dbSNP variants (sampled 300 via entrez): RS1000167890 (11:64342443 C>T), RS1000173374 (11:64349207 A>C,G), RS1000383749 (11:64343798 C>A,G,T), RS1000436154 (11:64355197 C>A), RS1000475294 (11:64354960 T>C), RS1000504309 (11:64350434 C>T), RS1000519783 (11:64342660 G>C), RS1000610478 (11:64356407 T>A), RS1000686696 (11:64354261 C>G,T), RS1000764334 (11:64350634 C>T), RS1000976139 (11:64354401 C>A,T), RS1001499368 (11:64343878 G>A,C,T), RS1001944855 (11:64350876 A>G), RS1002004708 (11:64349670 T>A), RS1002034754 (11:64338404 G>A)

Disease associations

OMIM: gene MIM:611205 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST001622_1	Sarcoidosis	3.000000e-18
GCST001725_12	Inflammatory bowel disease	4.000000e-11
GCST002772_15	Leprosy	9.000000e-14
GCST003129_14	Primary biliary cholangitis	2.000000e-09
GCST004030_14	Primary sclerosing cholangitis	2.000000e-13
GCST004132_98	Crohn’s disease	5.000000e-06
GCST007932_47	Medication use (thyroid preparations)	2.000000e-09
GCST008870_33	Keratinocyte cancer (MTAG)	2.000000e-09
GCST008871_27	Basal cell carcinoma	3.000000e-10
GCST010173_19	Triglyceride levels	2.000000e-21
GCST90013410_25	Basal cell carcinoma	2.000000e-09
GCST90013445_3	Type 1 diabetes	3.000000e-09
GCST90013445_63	Type 1 diabetes	3.000000e-09
GCST90020025_1869	Waist-to-hip ratio adjusted for BMI	3.000000e-29
GCST90020026_501	Hip index	2.000000e-18
GCST90020027_1471	Waist-hip index	2.000000e-29
GCST90020028_1986	Hip circumference adjusted for BMI	1.000000e-14

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0009933	Thyroid preparation use measurement
EFO:0010176	keratinocyte carcinoma
EFO:0004530	triglyceride measurement
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, decreases methylation	2
sodium arsenite	increases expression	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
Cisplatin	decreases expression, increases expression	2
Particulate Matter	decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
bromovanin	decreases expression	1
jinfukang	increases expression	1
(+)-JQ1 compound	decreases expression	1
Acetaminophen	increases expression	1
Arsenic	affects methylation	1
Camptothecin	increases expression	1
Diuron	decreases expression	1
Estradiol	decreases expression	1
Ozone	affects expression, increases abundance	1
Tobacco Smoke Pollution	affects expression	1
Tretinoin	increases expression	1
Valproic Acid	increases methylation	1
Antirheumatic Agents	decreases expression	1
Cadmium Chloride	increases expression	1
Copper Sulfate	decreases expression	1
Acrylamide	increases expression	1
Vitamin K 3	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.