CCEPR

Summary

CCEPR (cervical carcinoma expressed PCNA regulatory lncRNA, HGNC:51693) is a long non-coding RNA gene on chromosome 10q21.1.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51693
Approved symbol	CCEPR
Name	cervical carcinoma expressed PCNA regulatory lncRNA
Location	10q21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	CCHE1
Entrez	105682749
RNAcentral	URS00008E3A78 — lncRNA, 2502 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• long noncoding RNA CCHE1 may serve as a candidate prognostic biomarker and target for new therapies in human hepatocellular carcinoma. (PMID:27427851)
• CCEPR upregulates the expression of PCNA in mRNA and protein level to promote cancer growth. (PMID:28574830)
• These findings signify that lncRNA-CCHE1 is a key oncogene possibly involved in colorectal cancer development and progression by modulating ERK/COX-2 pathway and cell proliferation activity. (PMID:30484108)
• CCEPR is a novel clinical biomarker for prognosis and regulates cell proliferation through PCNA in osteosarcoma. (PMID:30861164)
• Data advised that the lncRNA-CCHE1 gene may influence cervical malignancy progression, held as a prognostic marker and useful curative target. (PMID:31364021)
• CCHE1 accelerated the initiation of oral squamous cell carcinoma through enhancing PAK2 expression by sponging miR-922. (PMID:31981240)
• Upregulation of long noncoding RNA CCEPR is associated with poor prognosis and contributes to the progression of ovarian cancer through regulating the Wnt/betacatenin signaling pathway. (PMID:32319633)
• Long non-coding RNA CCHE1 participates in postoperative distant recurrence but not local recurrence of osteosarcoma possibly by interacting with ROCK1. (PMID:32660450)
• Downregulation of lncRNA CCHE1 inhibits cell proliferation, migration and invasion by suppressing MEK/ERK/c-MYC pathway in nasopharyngeal carcinoma. (PMID:32964977)
• LncRNA CCHE1 Participates in the Postoperative Distant Recurrence of Urothelial Bladder Cancer Possibly by Regulating ROCK1 Expression. (PMID:36017913)
• Expression and clinical diagnostic value of CCHE1 in breast cancer. (PMID:38150355)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 3 (showing top): chr10q21, LIAO_METASTASIS, DODD_NASOPHARYNGEAL_CARCINOMA_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000123463 (10:59175473 T>C), RS1000484565 (10:59173907 C>A,T), RS1000931918 (10:59175456 T>C), RS1001655938 (10:59173818 C>T), RS1001924967 (10:59178446 A>G), RS1001926839 (10:59174744 A>G), RS1001991595 (10:59173546 A>G), RS1002444591 (10:59175058 C>A), RS1002944021 (10:59178105 A>G), RS1002959233 (10:59177239 CG>C), RS1003758579 (10:59177773 C>G), RS1004042934 (10:59174488 C>T), RS1004561786 (10:59174717 A>G), RS1006843707 (10:59177592 T>A), RS1006874704 (10:59178089 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.