CCND2-AS1

Summary

CCND2-AS1 (CCND2 antisense RNA 1, HGNC:49398) is a long non-coding RNA gene on chromosome 12p13.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49398
Approved symbol	CCND2-AS1
Name	CCND2 antisense RNA 1
Location	12p13.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255920
Ensembl biotype	lncRNA
Entrez	103752584
RNAcentral	URS00007E3987 — lncRNA, 553 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 16 lncRNA, 1 retained_intron

ENST00000537370, ENST00000539135, ENST00000646138, ENST00000646245, ENST00000646756, ENST00000656828, ENST00000663068, ENST00000752990, ENST00000752991, ENST00000752992, ENST00000752993, ENST00000752994, ENST00000752995, ENST00000752996, ENST00000752997, ENST00000752998, ENST00000752999

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000537370 — 3 exons

Exon	Start	End
ENSE00004099709	4252367	4253185
ENSE00004099713	4248767	4249193
ENSE00004099714	4275022	4275422

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 88.40.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2586 / max 14.3536, expressed in 134 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129014	0.2586	134

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	88.40	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.12	gold quality
caudate nucleus	UBERON:0001873	80.97	gold quality
nucleus accumbens	UBERON:0001882	79.33	gold quality
putamen	UBERON:0001874	78.43	gold quality
amygdala	UBERON:0001876	77.01	gold quality
temporal lobe	UBERON:0001871	76.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.32	gold quality
lower esophagus	UBERON:0013473	76.30	gold quality
popliteal artery	UBERON:0002250	76.26	gold quality
tibial artery	UBERON:0007610	76.24	gold quality
right uterine tube	UBERON:0001302	76.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	75.83	gold quality
anterior cingulate cortex	UBERON:0009835	75.65	gold quality
primary visual cortex	UBERON:0002436	75.59	gold quality
right coronary artery	UBERON:0001625	75.44	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	75.28	gold quality
right frontal lobe	UBERON:0002810	75.02	gold quality
Ammon’s horn	UBERON:0001954	74.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.53	gold quality
descending thoracic aorta	UBERON:0002345	74.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.41	gold quality
ascending aorta	UBERON:0001496	74.20	gold quality
adenohypophysis	UBERON:0002196	74.16	gold quality
thoracic aorta	UBERON:0001515	74.06	gold quality
pituitary gland	UBERON:0000007	73.96	gold quality
sural nerve	UBERON:0015488	73.68	gold quality
myometrium	UBERON:0001296	73.56	gold quality
ventricular zone	UBERON:0003053	73.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CCND2-AS1 expression was significantly over-expressed in papillary thyroid carcinoma cell lines compared to normal thyroid epithelial cells. (PMID:29366479)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.