CCNDBP1

Summary

CCNDBP1 (cyclin D1 binding protein 1, HGNC:1587) is a protein-coding gene on chromosome 15q15.2, encoding Cyclin-D1-binding protein 1 (O95273). May negatively regulate cell cycle progression.

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene.

Source: NCBI Gene 23582 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 71 total — 1 pathogenic, 1 likely-pathogenic
• Druggable target: yes
• MANE Select transcript: NM_012142

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1587
Approved symbol	CCNDBP1
Name	cyclin D1 binding protein 1
Location	15q15.2
Locus type	gene with protein product
Status	Approved
Aliases	DIP1, GCIP, HHM
Ensembl gene	ENSG00000166946
Ensembl biotype	protein_coding
OMIM	607089
Entrez	23582

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 7 retained_intron, 7 nonsense_mediated_decay, 6 protein_coding

ENST00000300213, ENST00000444658, ENST00000562553, ENST00000563065, ENST00000564630, ENST00000565296, ENST00000565958, ENST00000566515, ENST00000566833, ENST00000566882, ENST00000567434, ENST00000567690, ENST00000568507, ENST00000568936, ENST00000569745, ENST00000864042, ENST00000864043, ENST00000915942, ENST00000915943, ENST00000958193

RefSeq mRNA: 1 — MANE Select: NM_012142 NM_012142

CCDS: CCDS10092

Canonical transcript exons

ENST00000300213 — 11 exons

Exon	Start	End
ENSE00001930284	43185403	43185607
ENSE00003493259	43194727	43197177
ENSE00003496958	43190325	43190398
ENSE00003500207	43191395	43191675
ENSE00003523679	43194415	43194461
ENSE00003533585	43190055	43190151
ENSE00003607755	43192743	43192803
ENSE00003633577	43185820	43185879
ENSE00003660645	43190966	43191042
ENSE00003677031	43186154	43186233
ENSE00003693373	43189199	43189280

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 98.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 42.1320 / max 868.3864, expressed in 1826 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
146292	36.5084	1823
146296	2.7584	715
146293	1.5885	875
146295	0.6589	328
146291	0.5311	281
146294	0.0866	26

Top tissues by expression

263 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
trabecular bone tissue	UBERON:0002483	98.44	gold quality
ileal mucosa	UBERON:0000331	98.06	gold quality
cardiac muscle of right atrium	UBERON:0003379	98.04	gold quality
calcaneal tendon	UBERON:0003701	98.02	gold quality
bone marrow	UBERON:0002371	97.88	gold quality
right uterine tube	UBERON:0001302	97.73	gold quality
blood	UBERON:0000178	97.68	gold quality
left ventricle myocardium	UBERON:0006566	97.44	gold quality
placenta	UBERON:0001987	97.38	gold quality
upper arm skin	UBERON:0004263	97.29	gold quality
leukocyte	CL:0000738	97.24	gold quality
monocyte	CL:0000576	97.21	gold quality
bone element	UBERON:0001474	97.21	gold quality
granulocyte	CL:0000094	97.01	gold quality
tibialis anterior	UBERON:0001385	96.61	gold quality
bone marrow cell	CL:0002092	96.60	gold quality
myocardium	UBERON:0002349	96.34	gold quality
pons	UBERON:0000988	96.16	gold quality
thoracic aorta	UBERON:0001515	96.11	gold quality
descending thoracic aorta	UBERON:0002345	96.11	gold quality
right coronary artery	UBERON:0001625	96.10	gold quality
ascending aorta	UBERON:0001496	96.09	gold quality
spleen	UBERON:0002106	96.06	gold quality
lower esophagus mucosa	UBERON:0035834	95.97	gold quality
right lung	UBERON:0002167	95.95	gold quality
aorta	UBERON:0000947	95.93	gold quality
right adrenal gland cortex	UBERON:0035827	95.90	gold quality
right adrenal gland	UBERON:0001233	95.87	gold quality
bronchial epithelial cell	CL:0002328	95.82	gold quality
left coronary artery	UBERON:0001626	95.82	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	42.63
E-MTAB-6701	yes	39.34
E-MTAB-10042	yes	34.39
E-MTAB-9221	yes	11.19
E-HCAD-9	yes	6.96
E-HCAD-10	yes	4.09
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

109 targeting CCNDBP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-3941	99.86	70.54	2735

Literature-anchored findings (GeneRIF, showing 14)

• In transgenic mice, GCIP functions as a transcriptional suppressor, regulates cyclin D1 expression, inhibits cell growth and colony formation in human HepG2 cells, suggesting GCIP plays a significant role in tumor initiation and development. (PMID:16501603)
• CT847 interacts with mammalian Grap2 cyclin D-interacting protein (PMID:17532760)
• P0 overexpression may cause tumorigenesis in breast and liver tissues at least in part by inhibiting GCIP-mediated tumor suppression. (PMID:17621266)
• Data suggest that HHM/Maid regulates a subset of TGF-beta target genes including the Olig1-Smad synexpression group. (PMID:18923419)
• decreased expression of GCIP in vivo is present in human breast carcinoma. (PMID:18983464)
• Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator (PMID:19153449)
• It is proposed for the first time that Rad may promote carcinogenesis at least in part by inhibiting GCIP-mediated tumor suppression. (PMID:20460530)
• The first structure of a free-standing human dominant-negative helix-loop-helix protein (DIP1) was reported. DIP1 adopts a V-shaped conformation, with N-terminal and C-terminal five-helix bundles connected by the HLH region. (PMID:22453338)
• Data indicate that grap2 and cyclin D1 interacting protein (GCIP) and inhibitor of of DNA binding/differentiation 1 (Id1) are inversely expressed in non-small cell lung cancer (NSCLC) cell lines and specimens. (PMID:24970809)
• Data suggest MAID/CCNDBP1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); MAID does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis. (PMID:26002959)
• GCIP underexpression is associated with Osteosarcoma. (PMID:26107195)
• MEK2 is a critical modulating mechanism to down-regulate GCIP stability and function in cancer cells. (PMID:31907980)
• Grap2 cyclin D interacting protein negatively regulates CREBbinding protein, inhibiting fibroblastlike synoviocyte growth. (PMID:33576455)
• rs66651343 and rs12909095 confer lung cancer risk by regulating CCNDBP1 expression. (PMID:37058478)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	ccndbp1	ENSDARG00000039328
mus_musculus	Ccndbp1	ENSMUSG00000023572
rattus_norvegicus	Ccndbp1	ENSRNOG00000011379

Protein

Protein identifiers

Cyclin-D1-binding protein 1 — O95273 (reviewed: O95273)

Alternative names: Grap2 and cyclin-D-interacting protein, Human homolog of Maid

All UniProt accessions (4): O95273, H3BQA6, H3BR23, H3BUF4

UniProt curated annotations — full annotation on UniProt →

Function. May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.

Subunit / interactions. Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.

Post-translational modifications. Phosphorylated.

Induction. Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.

Similarity. Belongs to the CCNDBP1 family.

Isoforms (4)

UniProt ID	Names	Canonical?
O95273-1	1	yes
O95273-2	2
O95273-3	3
O95273-4	4

RefSeq proteins (1): NP_036274* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026907	GCIP-like	Family
IPR049317	GCIP-like_N	Domain
IPR049318	GCIP_C	Domain

Pfam: PF13324, PF20936

UniProt features (38 total): helix 13, sequence conflict 9, splice variant 5, region of interest 5, strand 2, initiator methionine 1, chain 1, turn 1, modified residue 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3AY5	X-RAY DIFFRACTION	2.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95273-F1	87.38	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 114 (showing top): MODULE_151, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, ONKEN_UVEAL_MELANOMA_UP, APPIERTO_RESPONSE_TO_FENRETINIDE_DN, DOUGLAS_BMI1_TARGETS_DN, MODULE_114, GOCC_NUCLEAR_BODY, DOANE_BREAST_CANCER_CLASSES_UP, WGTTNNNNNAAA_UNKNOWN, SCGGAAGY_ELK1_02, WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BRUINS_UVC_RESPONSE_LATE, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN, WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), nuclear body (GO:0016604)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
nucleoplasm	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1287 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CCNDBP1	SYF2	O95926	955
CCNDBP1	GRAP2	O75791	914
CCNDBP1	CCND1	P24385	549
CCNDBP1	CDK4	P11802	543
CCNDBP1	OLIG1	Q8TAK6	535
CCNDBP1	TFPT	P0C1Z6	532
CCNDBP1	E2F1	Q01094	500
CCNDBP1	MRPL55	Q7Z7F7	455
CCNDBP1	BEAN1	Q3B7T3	415
CCNDBP1	GUCA1C	O95843	406
CCNDBP1	RPLP0	P05388	399
CCNDBP1	DDX43	Q9NXZ2	397
CCNDBP1	SLCO6A1	Q86UG4	390
CCNDBP1	GUCA1A	P43080	374
CCNDBP1	LRRC57	Q8N9N7	363

IntAct

477 interactions, top by confidence:

A	B	Type	Score
CCNDBP1	RPLP0	psi-mi:“MI:0915”(physical association)	0.800
RPLP0	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.800
RPL28	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.780
CCNDBP1	TRAPPC5	psi-mi:“MI:0915”(physical association)	0.780
ZNF707	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.780
MRPL15	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.780
CCNDBP1	RPL28	psi-mi:“MI:0915”(physical association)	0.780
CCNDBP1	ZNF707	psi-mi:“MI:0915”(physical association)	0.780
TRAPPC5	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.780
CCNDBP1	MRPL15	psi-mi:“MI:0915”(physical association)	0.780
IMP3	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.760
CCNDBP1	IMP3	psi-mi:“MI:0915”(physical association)	0.760
PSMB10	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.740
ZNF136	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.740
CCNDBP1	ZNF627	psi-mi:“MI:0915”(physical association)	0.740
THAP10	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.740
CCNDBP1	PSMB10	psi-mi:“MI:0915”(physical association)	0.740
CCNDBP1	ZNF136	psi-mi:“MI:0915”(physical association)	0.740

BioGRID (217): CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid), CCNDBP1 (Two-hybrid)

ESM2 similar proteins: A2CEI4, A3KNI7, B7ZC77, E7FBU4, G8JYB2, O35095, O43156, O46037, O75800, O88327, O95273, P0DX19, P26231, P35220, P35221, Q08CY4, Q0V9L1, Q14746, Q2KIZ9, Q2KJ97, Q3MHM6, Q3TVC7, Q4R809, Q59I72, Q5BK06, Q5RC06, Q5RFN4, Q5U4I3, Q65CL1, Q69ZR2, Q6GPP1, Q6NVK9, Q6NY52, Q7T006, Q803M5, Q8BTG3, Q8C3S2, Q8JGR7, Q8K2Z4, Q91V83

Diamond homologs: A3KNI7, O95273, Q2KIZ9, Q3TVC7, Q4R809, Q5BK06, Q5RFN4, Q5U4I3, Q2HJB9, Q6INX1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 64 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Major pathway of rRNA processing in the nucleolus and cytosol	5	8.6×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	1
Uncertain significance	51
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
154069	GRCh38/hg38 15q15.2-15.3(chr15:42785627-43342260)x1	Pathogenic
980033	GRCh37/hg19 15q15.2-15.3(chr15:43135272-43744542)x1	Likely pathogenic

SpliceAI

1126 predictions. Top by Δscore:

Variant	Effect	Δscore
15:43185605:GGG:G	donor_gain	1.0000
15:43185606:GG:G	donor_gain	1.0000
15:43185606:GGG:G	donor_gain	1.0000
15:43185607:GG:G	donor_gain	1.0000
15:43185608:G:C	donor_loss	1.0000
15:43185608:G:GG	donor_gain	1.0000
15:43185609:T:A	donor_loss	1.0000
15:43185790:C:A	acceptor_gain	1.0000
15:43189279:GG:G	donor_gain	1.0000
15:43189280:GG:G	donor_gain	1.0000
15:43189280:GGTA:G	donor_loss	1.0000
15:43189281:G:GG	donor_gain	1.0000
15:43189281:GTA:G	donor_loss	1.0000
15:43189282:T:TC	donor_loss	1.0000
15:43189290:A:G	donor_gain	1.0000
15:43190123:G:GT	donor_gain	1.0000
15:43190123:G:T	donor_gain	1.0000
15:43190323:A:AG	acceptor_gain	1.0000
15:43190324:G:GC	acceptor_gain	1.0000
15:43190324:GCCCT:G	acceptor_gain	1.0000
15:43190395:AGAGG:A	donor_loss	1.0000
15:43190396:GAG:G	donor_gain	1.0000
15:43190397:AGGT:A	donor_loss	1.0000
15:43190400:TGAG:T	donor_loss	1.0000
15:43190958:A:AG	acceptor_gain	1.0000
15:43190959:C:G	acceptor_gain	1.0000
15:43190963:T:G	acceptor_gain	1.0000
15:43190963:TA:T	acceptor_loss	1.0000
15:43190964:A:AC	acceptor_loss	1.0000
15:43190964:A:AG	acceptor_gain	1.0000

AlphaMissense

2378 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:43191668:A:C	S285R	0.989
15:43191670:C:A	S285R	0.989
15:43191670:C:G	S285R	0.989
15:43191022:G:C	A187P	0.982
15:43191638:G:C	D275H	0.980
15:43194425:T:C	L311P	0.979
15:43191545:T:C	C244R	0.978
15:43191555:T:C	L247P	0.978
15:43192762:A:C	S294R	0.978
15:43192764:C:A	S294R	0.978
15:43192764:C:G	S294R	0.978
15:43191534:T:C	L240P	0.974
15:43191512:T:A	W233R	0.973
15:43191512:T:C	W233R	0.973
15:43189280:G:A	G111R	0.971
15:43189280:G:C	G111R	0.971
15:43191395:G:C	A194P	0.970
15:43189280:G:T	G111W	0.969
15:43191636:T:C	L274P	0.969
15:43194731:A:C	S325R	0.969
15:43194733:T:A	S325R	0.969
15:43194733:T:G	S325R	0.969
15:43191023:C:A	A187E	0.968
15:43191639:A:T	D275V	0.967
15:43192793:T:A	V304E	0.967
15:43192796:G:C	R305P	0.964
15:43190977:G:C	A172P	0.963
15:43190079:G:C	R119P	0.962
15:43191014:T:A	V184E	0.962
15:43191547:C:G	C244W	0.962

dbSNP variants (sampled 300 via entrez): RS1000290912 (15:43195853 T>G), RS1000395794 (15:43185269 A>C), RS1000851707 (15:43192189 A>G), RS1000882624 (15:43192577 A>G), RS1001087700 (15:43188005 G>T), RS1001120282 (15:43188366 G>A), RS1001457705 (15:43188326 T>C), RS1001604468 (15:43184675 A>G), RS1002090215 (15:43189572 C>G), RS1002122822 (15:43189976 T>C), RS1002163447 (15:43196480 GT>G), RS1002470725 (15:43197575 C>T), RS1002702186 (15:43193158 C>A,T), RS1002794074 (15:43195124 T>C), RS1002880184 (15:43183973 A>G)

Disease associations

OMIM: gene MIM:607089 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4742266 (PROTEIN-PROTEIN INTERACTION)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	2
Estradiol	decreases expression	2
Tretinoin	increases expression	2
Valproic Acid	affects expression, decreases expression	2
aristolochic acid I	increases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
butyraldehyde	decreases expression	1
pentanal	decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
(+)-JQ1 compound	increases expression	1
Temozolomide	increases expression	1
Decitabine	affects expression	1
Air Pollutants	decreases expression, increases abundance	1
Air Pollutants, Occupational	affects expression	1
Aldehydes	decreases expression	1
Arsenic	increases abundance, decreases expression	1
Cannabidiol	decreases expression	1
Carbon Tetrachloride	decreases response to substance	1
Cisplatin	affects expression	1
Copper	affects binding, increases expression	1
Diethylnitrosamine	decreases response to substance	1
Dimethyl Sulfoxide	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Smoke	decreases expression	1
Testosterone	increases expression	1
Thiosemicarbazones	affects binding, increases expression	1
Urethane	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4713784	Binding	Protac activity at CRBN/CCNDBP1 in human BxPC-3 cells assessed as CCNDBP1 degradation incubated for 16 hrs by proteomic analysis	Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.